Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Generalized epilepsy

MedGen UID:: 4507
•Concept ID:: C0014548
•: Disease or Syndrome

Synonyms:	Epilepsies, Generalized; Epilepsy, Generalized; Generalized Epilepsies; Generalized Epilepsy; Generalized Seizure Disorder; Generalized Seizure Disorders; Seizure Disorder, Generalized; Seizure Disorders, Generalized
SNOMED CT:	Generalized epilepsy (19598007)

Definition

A type of epilepsy with only generalized onset epileptic seizures. [from SNOMEDCT_US]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGeneralized epilepsy

Disease
- Disorder by Site
  - Disorder of nervous system
    - Disorder of the central nervous system
      - Brain disorder
        Epilepsy
        Generalized epilepsy
        Absence seizure
        Epilepsy, childhood absence 2
        Epilepsy, childhood absence 4
        Epilepsy, childhood absence, susceptibility to, 1
        Epilepsy, childhood absence, susceptibility to, 5
        Epilepsy, childhood absence, susceptibility to, 6
        Epilepsy with generalized tonic-clonic seizures
        Generalized epilepsy with febrile seizures plus
        Juvenile absence epilepsy
        myoclonic epilepsy
        Juvenile myoclonic epilepsy
        Epilepsy, idiopathic generalized, susceptibility to, 7
        Epilepsy, idiopathic generalized, susceptibility to, 9
        Epilepsy, idiopathic generalized, susceptibility to, 11
        Epilepsy, idiopathic generalized, susceptibility to, 13
        Epilepsy, juvenile myoclonic 7
        Epilepsy, juvenile myoclonic 8
        Epilepsy, juvenile myoclonic, susceptibility to, 6
        Juvenile Myoclonic Epilepsy, Intractable, without Status Epilepticus
        Myoclonic epilepsy, juvenile, susceptibility to, 1
        Myoclonic epilepsy, juvenile, susceptibility to, 3
        Myoclonic epilepsy, juvenile, susceptibility to, 4
        Progressive myoclonic epilepsy
        Adult neuronal ceroid lipofuscinosis
        Congenital neuronal ceroid lipofuscinosis
        Early-onset Lafora body disease
        Epilepsy, progressive myoclonic, 1B
        Familial encephalopathy with neuroserpin inclusion bodies
        Infantile neuronal ceroid lipofuscinosis
        Juvenile neuronal ceroid lipofuscinosis
        Lafora disease
        Late-infantile neuronal ceroid lipofuscinosis
        MERRF syndrome
        Neuronal ceroid lipofuscinosis 8 northern epilepsy variant
        Progressive myoclonic epilepsy type 5
        Progressive myoclonic epilepsy type 6
        Progressive myoclonic epilepsy type 7
        Progressive myoclonic epilepsy type 8
        Progressive myoclonic epilepsy type 9
        Spinal muscular atrophy-progressive myoclonic epilepsy syndrome
        Unverricht-Lundborg syndrome
        Nodding Syndrome
        West syndrome

Professional guidelines

PubMed

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions.

Hirsch E, French J, Scheffer IE, Bogacz A, Alsaadi T, Sperling MR, Abdulla F, Zuberi SM, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst JM, Auvin S, Wiebe S, Perucca E, Moshé SL, Tinuper P, Wirrell EC
Epilepsia 2022 Jun;63(6):1475-1499. Epub 2022 May 3 doi: 10.1111/epi.17236. PMID: 35503716

Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications.

Johannesen KM, Liu Y, Koko M, Gjerulfsen CE, Sonnenberg L, Schubert J, Fenger CD, Eltokhi A, Rannap M, Koch NA, Lauxmann S, Krüger J, Kegele J, Canafoglia L, Franceschetti S, Mayer T, Rebstock J, Zacher P, Ruf S, Alber M, Sterbova K, Lassuthová P, Vlckova M, Lemke JR, Platzer K, Krey I, Heine C, Wieczorek D, Kroell-Seger J, Lund C, Klein KM, Au PYB, Rho JM, Ho AW, Masnada S, Veggiotti P, Giordano L, Accorsi P, Hoei-Hansen CE, Striano P, Zara F, Verhelst H, Verhoeven JS, Braakman HMH, van der Zwaag B, Harder AVE, Brilstra E, Pendziwiat M, Lebon S, Vaccarezza M, Le NM, Christensen J, Grønborg S, Scherer SW, Howe J, Fazeli W, Howell KB, Leventer R, Stutterd C, Walsh S, Gerard M, Gerard B, Matricardi S, Bonardi CM, Sartori S, Berger A, Hoffman-Zacharska D, Mastrangelo M, Darra F, Vøllo A, Motazacker MM, Lakeman P, Nizon M, Betzler C, Altuzarra C, Caume R, Roubertie A, Gélisse P, Marini C, Guerrini R, Bilan F, Tibussek D, Koch-Hogrebe M, Perry MS, Ichikawa S, Dadali E, Sharkov A, Mishina I, Abramov M, Kanivets I, Korostelev S, Kutsev S, Wain KE, Eisenhauer N, Wagner M, Savatt JM, Müller-Schlüter K, Bassan H, Borovikov A, Nassogne MC, Destrée A, Schoonjans AS, Meuwissen M, Buzatu M, Jansen A, Scalais E, Srivastava S, Tan WH, Olson HE, Loddenkemper T, Poduri A, Helbig KL, Helbig I, Fitzgerald MP, Goldberg EM, Roser T, Borggraefe I, Brünger T, May P, Lal D, Lederer D, Rubboli G, Heyne HO, Lesca G, Hedrich UBS, Benda J, Gardella E, Lerche H, Møller RS
Brain 2022 Sep 14;145(9):2991-3009. doi: 10.1093/brain/awab321. PMID: 34431999 Free PMC Article

Genetic Landscape of Common Epilepsies: Advancing towards Precision in Treatment.

Thakran S, Guin D, Singh P, Singh P, Kukal S, Rawat C, Yadav S, Kushwaha SS, Srivastava AK, Hasija Y, Saso L, Ramachandran S, Kukreti R
Int J Mol Sci 2020 Oct 21;21(20) doi: 10.3390/ijms21207784. PMID: 33096746 Free PMC Article

See all (153)

Curated

UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

Recent clinical studies

Etiology

Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.

Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432 Free PMC Article

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.

Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570

Antiseizure Medications for Adults With Epilepsy: A Review.

Kanner AM, Bicchi MM
JAMA 2022 Apr 5;327(13):1269-1281. doi: 10.1001/jama.2022.3880. PMID: 35380580

Electroclinical spectrum of generalized paroxysmal fast activity in adults without epileptic encephalopathy.

Das Pektezel L, Tezer FI, Saygi S
Neurol Sci 2022 Jun;43(6):3857-3866. Epub 2022 Jan 16 doi: 10.1007/s10072-021-05808-9. PMID: 35034232

Genetic Landscape of Common Epilepsies: Advancing towards Precision in Treatment.

See all (2112)

Diagnosis

Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.

Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432 Free PMC Article

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.

Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570

Antiseizure Medications for Adults With Epilepsy: A Review.

Kanner AM, Bicchi MM
JAMA 2022 Apr 5;327(13):1269-1281. doi: 10.1001/jama.2022.3880. PMID: 35380580

Electroclinical spectrum of generalized paroxysmal fast activity in adults without epileptic encephalopathy.

Das Pektezel L, Tezer FI, Saygi S
Neurol Sci 2022 Jun;43(6):3857-3866. Epub 2022 Jan 16 doi: 10.1007/s10072-021-05808-9. PMID: 35034232

Focal EEG abnormalities and focal ictal semiology in generalized epilepsy.

Fernandez-Baca Vaca G, Park JT
Seizure 2020 Apr;77:7-14. Epub 2019 Dec 20 doi: 10.1016/j.seizure.2019.12.013. PMID: 31882201

See all (2014)

Therapy

Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.

Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432 Free PMC Article

Neurostimulation in generalized epilepsy: A systematic review and meta-analysis.

Haneef Z, Skrehot HC
Epilepsia 2023 Apr;64(4):811-820. Epub 2023 Feb 16 doi: 10.1111/epi.17524. PMID: 36727550

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.

Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570

Antiseizure Medications for Adults With Epilepsy: A Review.

Kanner AM, Bicchi MM
JAMA 2022 Apr 5;327(13):1269-1281. doi: 10.1001/jama.2022.3880. PMID: 35380580

Doose syndrome (myoclonic-astatic epilepsy): 40 years of progress.

Kelley SA, Kossoff EH
Dev Med Child Neurol 2010 Nov;52(11):988-93. Epub 2010 Aug 16 doi: 10.1111/j.1469-8749.2010.03744.x. PMID: 20722665

See all (1616)

Prognosis

Drug-resistant idiopathic generalized epilepsy: A meta-analysis of prevalence and risk factors.

Jiang T, Zhang X, Zhang M, Liu M, Zhu H, Sun Y
Epilepsy Behav 2023 Sep;146:109364. Epub 2023 Jul 29 doi: 10.1016/j.yebeh.2023.109364. PMID: 37523796

Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.

Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432 Free PMC Article

Genetic Landscape of Common Epilepsies: Advancing towards Precision in Treatment.

Epilepsy (generalised).

Maguire M, Marson AG, Ramaratnam S
BMJ Clin Evid 2012 Feb 20;2012 PMID: 22348419 Free PMC Article

The etiologic classification of epilepsy.

Shorvon SD
Epilepsia 2011 Jun;52(6):1052-7. Epub 2011 Mar 30 doi: 10.1111/j.1528-1167.2011.03041.x. PMID: 21449936

See all (1094)

Clinical prediction guides

Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.

Fang Y, Si X, Wang J, Wang Z, Chen Y, Liu Y, Yan Y, Tian J, Zhang B, Pu J
Neurology 2023 Jul 25;101(4):e399-e409. Epub 2023 May 24 doi: 10.1212/WNL.0000000000207423. PMID: 37225432 Free PMC Article

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.

Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570

Antiseizure Medications for Adults With Epilepsy: A Review.

Kanner AM, Bicchi MM
JAMA 2022 Apr 5;327(13):1269-1281. doi: 10.1001/jama.2022.3880. PMID: 35380580

Epilepsy With Eyelid Myoclonia (Jeavons Syndrome).

Zawar I, Knight EP
Pediatr Neurol 2021 Aug;121:75-80. Epub 2020 Dec 1 doi: 10.1016/j.pediatrneurol.2020.11.018. PMID: 34167046

Genetic Landscape of Common Epilepsies: Advancing towards Precision in Treatment.

See all (1301)

Recent systematic reviews

Antiseizure medications for idiopathic generalized epilepsies: a systematic review and network meta-analysis.

Chu H, Zhang X, Shi J, Zhou Z, Yang X
J Neurol 2023 Oct;270(10):4713-4728. Epub 2023 Jun 28 doi: 10.1007/s00415-023-11834-8. PMID: 37378757 Free PMC Article

Neurostimulation in generalized epilepsy: A systematic review and meta-analysis.

Haneef Z, Skrehot HC
Epilepsia 2023 Apr;64(4):811-820. Epub 2023 Feb 16 doi: 10.1111/epi.17524. PMID: 36727550

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.

Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570

Epilepsy (generalised).

Maguire M, Marson AG, Ramaratnam S
BMJ Clin Evid 2012 Feb 20;2012 PMID: 22348419 Free PMC Article

Epilepsy.

Marson AG, Maguire M, Ramaratnam S
BMJ Clin Evid 2009 Jan 28;2009 PMID: 19445769

See all (81)

MedGen

National Center for Biotechnology Information

Send to:

Generalized epilepsy

Definition

Term Hierarchy

Professional guidelines

PubMed

Curated

UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Curated

Consumer resources

Reviews

Related information

Recent activity