U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Podagra

MedGen UID:
450998
Concept ID:
C0221168
Disease or Syndrome
Synonyms: Arthritis of great toe due to gout; Gout of big toe; Gouty arthritis of great toe
SNOMED CT: Podagra (67148009); Gouty arthritis of great toe (67148009); Arthritis of great toe due to gout (67148009)
 
HPO: HP:0001854

Definition

Gout affecting the Metatarsophalangeal joint of big toe. [from HPO]

Term Hierarchy

Conditions with this feature

Lesch-Nyhan syndrome
MedGen UID:
9721
Concept ID:
C0023374
Disease or Syndrome
HPRT1 disorders, caused by deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGprt), are typically associated with clinical evidence for overproduction of uric acid (hyperuricemia, nephrolithiasis, and/or gouty arthritis) and varying degrees of neurologic and/or behavioral problems. Historically, three phenotypes were identified in the spectrum of HPRT1 disorders: Lesch-Nyhan disease (LND) at the most severe end with motor dysfunction resembling severe cerebral palsy, intellectual disability, and self-injurious behavior; HPRT1-related neurologic dysfunction (HND) in the intermediate range with similar but fewer severe neurologic findings than LND and no self-injurious behavior; and HPRT1-related hyperuricemia (HRH) at the mild end without overt neurologic deficits. It is now recognized that these neurobehavioral phenotypes cluster along a continuum from severe to mild.
Partial hypoxanthine-guanine phosphoribosyltransferase deficiency
MedGen UID:
82770
Concept ID:
C0268117
Disease or Syndrome
HPRT1 disorders, caused by deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGprt), are typically associated with clinical evidence for overproduction of uric acid (hyperuricemia, nephrolithiasis, and/or gouty arthritis) and varying degrees of neurologic and/or behavioral problems. Historically, three phenotypes were identified in the spectrum of HPRT1 disorders: Lesch-Nyhan disease (LND) at the most severe end with motor dysfunction resembling severe cerebral palsy, intellectual disability, and self-injurious behavior; HPRT1-related neurologic dysfunction (HND) in the intermediate range with similar but fewer severe neurologic findings than LND and no self-injurious behavior; and HPRT1-related hyperuricemia (HRH) at the mild end without overt neurologic deficits. It is now recognized that these neurobehavioral phenotypes cluster along a continuum from severe to mild.

Professional guidelines

PubMed

Rakieh C, Conaghan PG
Practitioner 2011 Dec;255(1746):17-20, 2-3. PMID: 22272526
Keith MP, Gilliland WR
Am J Med 2007 Mar;120(3):221-4. doi: 10.1016/j.amjmed.2006.02.044. PMID: 17349440
Nuki G, Simkin PA
Arthritis Res Ther 2006;8 Suppl 1(Suppl 1):S1. Epub 2006 Apr 12 doi: 10.1186/ar1906. PMID: 16820040Free PMC Article

Recent clinical studies

Etiology

Rakieh C, Conaghan PG
Practitioner 2011 Dec;255(1746):17-20, 2-3. PMID: 22272526
Becker MA, Ruoff GE
J Fam Pract 2010 Jun;59(6 Suppl):S1-8. PMID: 20544070
Keith MP, Gilliland WR
Am J Med 2007 Mar;120(3):221-4. doi: 10.1016/j.amjmed.2006.02.044. PMID: 17349440
Zhang W, Doherty M, Pascual E, Bardin T, Barskova V, Conaghan P, Gerster J, Jacobs J, Leeb B, Lioté F, McCarthy G, Netter P, Nuki G, Perez-Ruiz F, Pignone A, Pimentão J, Punzi L, Roddy E, Uhlig T, Zimmermann-Gòrska I; EULAR Standing Committee for International Clinical Studies Including Therapeutics
Ann Rheum Dis 2006 Oct;65(10):1301-11. Epub 2006 May 17 doi: 10.1136/ard.2006.055251. PMID: 16707533Free PMC Article
Craig MH, Poole GV, Hauser CJ
Am Surg 1995 Jan;61(1):56-9. PMID: 7832383

Diagnosis

Abhishek A, Roddy E, Doherty M
Clin Med (Lond) 2017 Feb;17(1):54-59. doi: 10.7861/clinmedicine.17-1-54. PMID: 28148582Free PMC Article
Chabra I, Singh R
Cutis 2013 Oct;92(4):190-2. PMID: 24195091
Rakieh C, Conaghan PG
Practitioner 2011 Dec;255(1746):17-20, 2-3. PMID: 22272526
Keith MP, Gilliland WR
Am J Med 2007 Mar;120(3):221-4. doi: 10.1016/j.amjmed.2006.02.044. PMID: 17349440
Craig MH, Poole GV, Hauser CJ
Am Surg 1995 Jan;61(1):56-9. PMID: 7832383

Therapy

Rakieh C, Conaghan PG
Practitioner 2011 Dec;255(1746):17-20, 2-3. PMID: 22272526
Becker MA, Ruoff GE
J Fam Pract 2010 Jun;59(6 Suppl):S1-8. PMID: 20544070
Keith MP, Gilliland WR
Am J Med 2007 Mar;120(3):221-4. doi: 10.1016/j.amjmed.2006.02.044. PMID: 17349440
Craig MH, Poole GV, Hauser CJ
Am Surg 1995 Jan;61(1):56-9. PMID: 7832383
Kanterewicz E, Sanmartí R, Riba J, Trias I, Autonell J, Brugués J
Ann Rheum Dis 1992 Apr;51(4):536-8. doi: 10.1136/ard.51.4.536. PMID: 1586257Free PMC Article

Prognosis

Elfishawi MM, Zleik N, Kvrgic Z, Michet CJ Jr, Crowson CS, Matteson EL, Bongartz T
J Rheumatol 2020 Apr;47(4):613-618. Epub 2019 Jul 15 doi: 10.3899/jrheum.190346. PMID: 31308206Free PMC Article
Singh JA
Arthritis Res Ther 2013;15(6):R224. doi: 10.1186/ar4425. PMID: 24377421Free PMC Article
Vázquez-Mellado J, Hernández-Cuevas CB, Alvarez-Hernández E, Ventura-Rios L, Peláez-Ballestas I, Casasola-Vargas J, García-Méndez S, Burgos-Vargas R
Clin Rheumatol 2012 Mar;31(3):429-34. Epub 2011 Oct 7 doi: 10.1007/s10067-011-1873-4. PMID: 21979446
Keith MP, Gilliland WR
Am J Med 2007 Mar;120(3):221-4. doi: 10.1016/j.amjmed.2006.02.044. PMID: 17349440
Craig MH, Poole GV, Hauser CJ
Am Surg 1995 Jan;61(1):56-9. PMID: 7832383

Clinical prediction guides

Singh JA
Arthritis Res Ther 2013;15(6):R224. doi: 10.1186/ar4425. PMID: 24377421Free PMC Article
Vázquez-Mellado J, Hernández-Cuevas CB, Alvarez-Hernández E, Ventura-Rios L, Peláez-Ballestas I, Casasola-Vargas J, García-Méndez S, Burgos-Vargas R
Clin Rheumatol 2012 Mar;31(3):429-34. Epub 2011 Oct 7 doi: 10.1007/s10067-011-1873-4. PMID: 21979446
Peláez-Ballestas I, Hernández Cuevas C, Burgos-Vargas R, Hernández Roque L, Terán L, Espinoza J, Esquivel-Valerio JA, Goycochea-Robles MV, Aceves FJ, Bernard AG, Ventura L, Shumsky C, Hernández Garduño A, Vázquez-Mellado J
J Rheumatol 2010 Aug 1;37(8):1743-8. Epub 2010 Jun 15 doi: 10.3899/jrheum.091385. PMID: 20551101
Dirken-Heukensfeldt KJ, Teunissen TA, van de Lisdonk H, Lagro-Janssen AL
Clin Rheumatol 2010 Jun;29(6):575-82. Epub 2010 Jan 19 doi: 10.1007/s10067-009-1362-1. PMID: 20084441Free PMC Article
Zhang W, Doherty M, Pascual E, Bardin T, Barskova V, Conaghan P, Gerster J, Jacobs J, Leeb B, Lioté F, McCarthy G, Netter P, Nuki G, Perez-Ruiz F, Pignone A, Pimentão J, Punzi L, Roddy E, Uhlig T, Zimmermann-Gòrska I; EULAR Standing Committee for International Clinical Studies Including Therapeutics
Ann Rheum Dis 2006 Oct;65(10):1301-11. Epub 2006 May 17 doi: 10.1136/ard.2006.055251. PMID: 16707533Free PMC Article

Recent systematic reviews

Dirken-Heukensfeldt KJ, Teunissen TA, van de Lisdonk H, Lagro-Janssen AL
Clin Rheumatol 2010 Jun;29(6):575-82. Epub 2010 Jan 19 doi: 10.1007/s10067-009-1362-1. PMID: 20084441Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...