U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Subcutaneous hemorrhage

MedGen UID:
451073
Concept ID:
C0854107
Disease or Syndrome
Synonyms: Bleeding below the skin; Subcutaneous haemorrhage
 
HPO: HP:0001933

Definition

This term refers to an abnormally increased susceptibility to bruising (purpura, petechiae, or ecchymoses). [from HPO]

Conditions with this feature

SLC35A1-congenital disorder of glycosylation
MedGen UID:
370234
Concept ID:
C1970344
Disease or Syndrome
An extremely rare form of carbohydrate deficient glycoprotein syndrome characterized clinically in the single reported case by repeated hemorrhagic incidents, including severe pulmonary hemorrhage.
Bleeding disorder, platelet-type, 22
MedGen UID:
1673822
Concept ID:
C5193111
Disease or Syndrome
Platelet-type bleeding disorder-22 (BDPLT22) is an autosomal recessive bleeding disorder resulting from impaired platelet aggregation due to intracellular signaling defects. Patients present in the first decade with spontaneous subcutaneous bleeding and excessive bleeding after minor injuries. Platelet counts are usually normal, although platelets show abnormal morphology (summary by Berrou et al., 2018).

Professional guidelines

PubMed

Sharma R, Sagoo NS, Haider AS, Sharma N, Haider M, Sharma IK, Igbinigie M, Aya KL, Aoun SG, Vira S
Surg Oncol 2021 Sep;38:101618. Epub 2021 Jun 10 doi: 10.1016/j.suronc.2021.101618. PMID: 34153905
Yao Y, Li Z, Jiao D, Zhou X, Li J, Han X
Diagn Interv Radiol 2021 Jul;27(4):558-563. doi: 10.5152/dir.2021.20769. PMID: 33769288Free PMC Article
Banshodani M, Kawanishi H, Moriishi M, Shintaku S, Sato T, Tsuchiya S
Ther Apher Dial 2014 Jun;18(3):284-90. Epub 2013 Sep 30 doi: 10.1111/1744-9987.12106. PMID: 24118763

Recent clinical studies

Etiology

Schultz NH, Søraas AVL, Sørvoll IH, Akkök ÇA, Vetlesen A, Bhamra JS, Ahlen MT, Holme PA, Aamodt AH, Skagen K, Skattør TH, Skjelland M, Wiedmann MK
J Stroke Cerebrovasc Dis 2023 Jan;32(1):106860. Epub 2022 Nov 17 doi: 10.1016/j.jstrokecerebrovasdis.2022.106860. PMID: 36403363Free PMC Article
Yamagata H, Nishida N, Izumiyama T, Asahi R, Koike M, Mihara A, Imajo Y, Suzuki H, Funaba M, Sugimoto S, Fukushima M, Sakai T
Sci Rep 2022 Jun 24;12(1):10732. doi: 10.1038/s41598-022-14607-x. PMID: 35750719Free PMC Article
Anderson KD, Rask DMG, Bates TJ, Nuelle JAV
Mil Med 2022 Aug 25;187(9-10):1059-1064. doi: 10.1093/milmed/usac055. PMID: 35284924
Banshodani M, Kawanishi H, Moriishi M, Shintaku S, Sato T, Tsuchiya S
Ther Apher Dial 2014 Jun;18(3):284-90. Epub 2013 Sep 30 doi: 10.1111/1744-9987.12106. PMID: 24118763
DiNicolantonio JJ, D'Ascenzo F, Tomek A, Chatterjee S, Niazi AK, Biondi-Zoccai G
Int J Cardiol 2013 Oct 3;168(3):1739-44. Epub 2013 Jul 29 doi: 10.1016/j.ijcard.2013.06.135. PMID: 23907035

Diagnosis

Wang Y, Xu J, Li P, Xu Y, Xue H, Liu P
Ann Hematol 2024 Feb;103(2):499-510. Epub 2023 Nov 14 doi: 10.1007/s00277-023-05498-7. PMID: 37957370
Shen L, Liu X, Chen L, Gao X, Xu Y
BMC Cardiovasc Disord 2022 Aug 3;22(1):351. doi: 10.1186/s12872-022-02796-2. PMID: 35922765Free PMC Article
Li C, Cao G, Jin F, Ning X
Endocrine 2021 Nov;74(2):281-284. Epub 2021 Aug 26 doi: 10.1007/s12020-021-02844-5. PMID: 34448100
Chen L, Chen Q, Zhu M, Zhuang Z
J Coll Physicians Surg Pak 2021 Mar;31(3):294-297. doi: 10.29271/jcpsp.2021.03.294. PMID: 33775018
Mimasaka S, Oshima T, Ohtani M
Leg Med (Tokyo) 2012 Jan;14(1):6-10. Epub 2011 Dec 20 doi: 10.1016/j.legalmed.2011.09.007. PMID: 22192757

Therapy

Shen L, Liu X, Chen L, Gao X, Xu Y
BMC Cardiovasc Disord 2022 Aug 3;22(1):351. doi: 10.1186/s12872-022-02796-2. PMID: 35922765Free PMC Article
Yamagata H, Nishida N, Izumiyama T, Asahi R, Koike M, Mihara A, Imajo Y, Suzuki H, Funaba M, Sugimoto S, Fukushima M, Sakai T
Sci Rep 2022 Jun 24;12(1):10732. doi: 10.1038/s41598-022-14607-x. PMID: 35750719Free PMC Article
Anderson KD, Rask DMG, Bates TJ, Nuelle JAV
Mil Med 2022 Aug 25;187(9-10):1059-1064. doi: 10.1093/milmed/usac055. PMID: 35284924
Tam CS, Trotman J, Opat S, Burger JA, Cull G, Gottlieb D, Harrup R, Johnston PB, Marlton P, Munoz J, Seymour JF, Simpson D, Tedeschi A, Elstrom R, Yu Y, Tang Z, Han L, Huang J, Novotny W, Wang L, Roberts AW
Blood 2019 Sep 12;134(11):851-859. Epub 2019 Jul 24 doi: 10.1182/blood.2019001160. PMID: 31340982Free PMC Article
DiNicolantonio JJ, D'Ascenzo F, Tomek A, Chatterjee S, Niazi AK, Biondi-Zoccai G
Int J Cardiol 2013 Oct 3;168(3):1739-44. Epub 2013 Jul 29 doi: 10.1016/j.ijcard.2013.06.135. PMID: 23907035

Prognosis

Fang J, Pan G, Bao X, Wang Y
Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211038682. doi: 10.1177/10760296211038682. PMID: 34541913Free PMC Article
Nukita S, Nakano S, Morimoto Y, Shiramoto H
Blood Press Monit 2020 Feb;25(1):39-41. doi: 10.1097/MBP.0000000000000418. PMID: 31764011
Zhang L, Liu P, Dong X, Zhou D, Shi X
Biomed Mater Eng 2014;24(6):3455-62. doi: 10.3233/BME-141170. PMID: 25227057
Zhang YY, Tang Z, Chen DM, Gong DH, Ji DX, Liu ZH
BMC Nephrol 2014 Aug 3;15:128. doi: 10.1186/1471-2369-15-128. PMID: 25086644Free PMC Article
DiNicolantonio JJ, D'Ascenzo F, Tomek A, Chatterjee S, Niazi AK, Biondi-Zoccai G
Int J Cardiol 2013 Oct 3;168(3):1739-44. Epub 2013 Jul 29 doi: 10.1016/j.ijcard.2013.06.135. PMID: 23907035

Clinical prediction guides

Wang Y, Xu J, Li P, Xu Y, Xue H, Liu P
Ann Hematol 2024 Feb;103(2):499-510. Epub 2023 Nov 14 doi: 10.1007/s00277-023-05498-7. PMID: 37957370
Schultz NH, Søraas AVL, Sørvoll IH, Akkök ÇA, Vetlesen A, Bhamra JS, Ahlen MT, Holme PA, Aamodt AH, Skagen K, Skattør TH, Skjelland M, Wiedmann MK
J Stroke Cerebrovasc Dis 2023 Jan;32(1):106860. Epub 2022 Nov 17 doi: 10.1016/j.jstrokecerebrovasdis.2022.106860. PMID: 36403363Free PMC Article
Shen L, Liu X, Chen L, Gao X, Xu Y
BMC Cardiovasc Disord 2022 Aug 3;22(1):351. doi: 10.1186/s12872-022-02796-2. PMID: 35922765Free PMC Article
Tam CS, Trotman J, Opat S, Burger JA, Cull G, Gottlieb D, Harrup R, Johnston PB, Marlton P, Munoz J, Seymour JF, Simpson D, Tedeschi A, Elstrom R, Yu Y, Tang Z, Han L, Huang J, Novotny W, Wang L, Roberts AW
Blood 2019 Sep 12;134(11):851-859. Epub 2019 Jul 24 doi: 10.1182/blood.2019001160. PMID: 31340982Free PMC Article
Gottschalk M, Segura M, Xu J
Anim Health Res Rev 2007 Jun;8(1):29-45. doi: 10.1017/S1466252307001247. PMID: 17692141

Recent systematic reviews

Sharma R, Sagoo NS, Haider AS, Sharma N, Haider M, Sharma IK, Igbinigie M, Aya KL, Aoun SG, Vira S
Surg Oncol 2021 Sep;38:101618. Epub 2021 Jun 10 doi: 10.1016/j.suronc.2021.101618. PMID: 34153905

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...