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Stage II Gastric Gastrointestinal Stromal Tumor

MedGen UID:
453638
•Concept ID:
C2981411
•
Neoplastic Process
Synonym: Stage II Gastric Gastrointestinal Stromal Tumor AJCC v7

Definition

Stage II includes: (T1, N0, M0, Mitotic rate: High); (T2, N0, M0, Mitotic rate: High); (T4, N0, M0, Mitotic rate: Low). T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm, but not more than 5 cm, in greatest dimension. T4: Tumor more than 10 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage II Gastric Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

Clinical utility of the new American Joint Committee on Cancer staging system for gastrointestinal stromal tumors: current overall survival after primary tumor resection.
Rutkowski P, Wozniak A, Dębiec-Rychter M, Kąkol M, Dziewirski W, Zdzienicki M, Ptaszynski K, Jurkowska M, Limon J, Siedlecki JA
Cancer 2011 Nov 1;117(21):4916-24. Epub 2011 Mar 31 doi: 10.1002/cncr.26079. PMID: 21456019

Recent clinical studies

Etiology

Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis.
Xing X, Shi J, Jia Y, Dou Y, Li Z, Dong B, Guo T, Cheng X, Li X, Du H, Hu Y, Jia S, Zhang J, Li Z, Ji J
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-003984. PMID: 35361730Free PMC Article
Radiographical assessment of tumour stroma and treatment outcomes using deep learning: a retrospective, multicohort study.
Jiang Y, Liang X, Han Z, Wang W, Xi S, Li T, Chen C, Yuan Q, Li N, Yu J, Xie Y, Xu Y, Zhou Z, Poultsides GA, Li G, Li R
Lancet Digit Health 2021 Jun;3(6):e371-e382. doi: 10.1016/S2589-7500(21)00065-0. PMID: 34045003
Gastrointestinal stromal tumors. A clinicopathological study.
Alghamdi HM, Amr SS, Shawarby MA, Sheikh SS, Alsayyah AA, Alamri AM, Ismail MH, Almarhabi A, Alrefaee MA, Ahmed MI
Saudi Med J 2019 Feb;40(2):126-130. doi: 10.15537/smj.2019.2.23913. PMID: 30723856Free PMC Article
Laparoscopic versus open resection of gastrointestinal stromal tumors: survival outcomes from the NCDB.
Inaba CS, Dosch A, Koh CY, Sujatha-Bhaskar S, Pejcinovska M, Smith BR, Nguyen NT
Surg Endosc 2019 Mar;33(3):923-932. Epub 2018 Aug 31 doi: 10.1007/s00464-018-6393-8. PMID: 30171396
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update.
Duffy MJ, Lamerz R, Haglund C, Nicolini A, Kalousová M, Holubec L, Sturgeon C
Int J Cancer 2014 Jun 1;134(11):2513-22. Epub 2013 Aug 27 doi: 10.1002/ijc.28384. PMID: 23852704Free PMC Article

Diagnosis

Colorectal paragangliomas with immunohistochemical deficiency of succinate dehydrogenase subunit B.
Kimura N, Ishikawa M, Shigematsu K
Endocr J 2022 May 30;69(5):523-528. Epub 2021 Dec 1 doi: 10.1507/endocrj.EJ21-0630. PMID: 34853215
Radiographical assessment of tumour stroma and treatment outcomes using deep learning: a retrospective, multicohort study.
Jiang Y, Liang X, Han Z, Wang W, Xi S, Li T, Chen C, Yuan Q, Li N, Yu J, Xie Y, Xu Y, Zhou Z, Poultsides GA, Li G, Li R
Lancet Digit Health 2021 Jun;3(6):e371-e382. doi: 10.1016/S2589-7500(21)00065-0. PMID: 34045003
Somatic SDHA mutations in paragangliomas in siblings: Case report of 2 cases.
Huang YC, Chang HH, Chen MH, Huang KH, Li AF, Lin CH, Shyr YM, Fang WL
Medicine (Baltimore) 2020 Oct 9;99(41):e22497. doi: 10.1097/MD.0000000000022497. PMID: 33031286Free PMC Article
Gastrointestinal stromal tumors. A clinicopathological study.
Alghamdi HM, Amr SS, Shawarby MA, Sheikh SS, Alsayyah AA, Alamri AM, Ismail MH, Almarhabi A, Alrefaee MA, Ahmed MI
Saudi Med J 2019 Feb;40(2):126-130. doi: 10.15537/smj.2019.2.23913. PMID: 30723856Free PMC Article
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update.
Duffy MJ, Lamerz R, Haglund C, Nicolini A, Kalousová M, Holubec L, Sturgeon C
Int J Cancer 2014 Jun 1;134(11):2513-22. Epub 2013 Aug 27 doi: 10.1002/ijc.28384. PMID: 23852704Free PMC Article

Therapy

Gastric tumorigenesis after radical resection combined with adjuvant chemotherapy for colorectal cancer: two case reports and a literature review.
Li T, Liu G, Li J, Cui J, Wang X, Li W, Zhao Z, Zhang K, Liu T
J Int Med Res 2021 Apr;49(4):3000605211007050. doi: 10.1177/03000605211007050. PMID: 33858250Free PMC Article
Laparoscopic versus open resection of gastrointestinal stromal tumors: survival outcomes from the NCDB.
Inaba CS, Dosch A, Koh CY, Sujatha-Bhaskar S, Pejcinovska M, Smith BR, Nguyen NT
Surg Endosc 2019 Mar;33(3):923-932. Epub 2018 Aug 31 doi: 10.1007/s00464-018-6393-8. PMID: 30171396
Oesophagectomy for tumours and dysplasia of the oesophagus and gastro-oesophageal junction.
Epari K, Cade R
ANZ J Surg 2009 Apr;79(4):251-7. doi: 10.1111/j.1445-2197.2009.04855.x. PMID: 19432710

Prognosis

Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis.
Xing X, Shi J, Jia Y, Dou Y, Li Z, Dong B, Guo T, Cheng X, Li X, Du H, Hu Y, Jia S, Zhang J, Li Z, Ji J
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-003984. PMID: 35361730Free PMC Article
Colorectal paragangliomas with immunohistochemical deficiency of succinate dehydrogenase subunit B.
Kimura N, Ishikawa M, Shigematsu K
Endocr J 2022 May 30;69(5):523-528. Epub 2021 Dec 1 doi: 10.1507/endocrj.EJ21-0630. PMID: 34853215
Evaluation of the role of soluble B7-H3 in association with membrane B7-H3 expression in gastric adenocarcinoma.
Huang L, Zhou Y, Sun Q, Cao L, Zhang X
Cancer Biomark 2022;33(1):123-129. doi: 10.3233/CBM-210178. PMID: 34459388
Radiographical assessment of tumour stroma and treatment outcomes using deep learning: a retrospective, multicohort study.
Jiang Y, Liang X, Han Z, Wang W, Xi S, Li T, Chen C, Yuan Q, Li N, Yu J, Xie Y, Xu Y, Zhou Z, Poultsides GA, Li G, Li R
Lancet Digit Health 2021 Jun;3(6):e371-e382. doi: 10.1016/S2589-7500(21)00065-0. PMID: 34045003
Clinical utility of the new American Joint Committee on Cancer staging system for gastrointestinal stromal tumors: current overall survival after primary tumor resection.
Rutkowski P, Wozniak A, Dębiec-Rychter M, Kąkol M, Dziewirski W, Zdzienicki M, Ptaszynski K, Jurkowska M, Limon J, Siedlecki JA
Cancer 2011 Nov 1;117(21):4916-24. Epub 2011 Mar 31 doi: 10.1002/cncr.26079. PMID: 21456019

Clinical prediction guides

Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis.
Xing X, Shi J, Jia Y, Dou Y, Li Z, Dong B, Guo T, Cheng X, Li X, Du H, Hu Y, Jia S, Zhang J, Li Z, Ji J
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-003984. PMID: 35361730Free PMC Article
Evaluation of the role of soluble B7-H3 in association with membrane B7-H3 expression in gastric adenocarcinoma.
Huang L, Zhou Y, Sun Q, Cao L, Zhang X
Cancer Biomark 2022;33(1):123-129. doi: 10.3233/CBM-210178. PMID: 34459388
Radiographical assessment of tumour stroma and treatment outcomes using deep learning: a retrospective, multicohort study.
Jiang Y, Liang X, Han Z, Wang W, Xi S, Li T, Chen C, Yuan Q, Li N, Yu J, Xie Y, Xu Y, Zhou Z, Poultsides GA, Li G, Li R
Lancet Digit Health 2021 Jun;3(6):e371-e382. doi: 10.1016/S2589-7500(21)00065-0. PMID: 34045003
Laparoscopic versus open resection of gastrointestinal stromal tumors: survival outcomes from the NCDB.
Inaba CS, Dosch A, Koh CY, Sujatha-Bhaskar S, Pejcinovska M, Smith BR, Nguyen NT
Surg Endosc 2019 Mar;33(3):923-932. Epub 2018 Aug 31 doi: 10.1007/s00464-018-6393-8. PMID: 30171396
Long-Term Surgical Outcome of 1057 Gastric GISTs According to 7th UICC/AJCC TNM System: Multicenter Observational Study From Korea and Japan.
Kim MC, Yook JH, Yang HK, Lee HJ, Sohn TS, Hyung WJ, Ryu SW, Kurokawa Y, Kim YW, Han SU, Kim HH, Park DJ, Kim W, Lee SI, Cho H, Cho GS, Kim JJ, Kim KH, Yoo MW
Medicine (Baltimore) 2015 Oct;94(41):e1526. doi: 10.1097/MD.0000000000001526. PMID: 26469894Free PMC Article

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