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Pruritus ani

MedGen UID:
46173
•Concept ID:
C0033775
•
Sign or Symptom
Synonym: Pruritus Ani
SNOMED CT: Pruritus ani (90446007); Anal itch (90446007)

Definition

Intense chronic itching in the anal area. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPruritus ani

Professional guidelines

PubMed

Evaluation, management and future perspectives of anal pruritus: a narrative review.
Jakubauskas M, Dulskas A
Eur J Med Res 2023 Feb 2;28(1):57. doi: 10.1186/s40001-023-01018-5. PMID: 36732860Free PMC Article
Pruritus ani: diagnosis and treatment.
Nasseri YY, Osborne MC
Gastroenterol Clin North Am 2013 Dec;42(4):801-13. Epub 2013 Nov 7 doi: 10.1016/j.gtc.2013.09.002. PMID: 24280401
Pruritus ani: etiology and management.
Markell KW, Billingham RP
Surg Clin North Am 2010 Feb;90(1):125-35, Table of Contents. doi: 10.1016/j.suc.2009.09.007. PMID: 20109637

Recent clinical studies

Etiology

Efficacy and safety of methylene blue injection for intractable idiopathic pruritus ani: a single-arm metaanalysis and systematic review.
Jia W, Li Q, Ni J, Zhang Y, Wu L, Xu L
Tech Coloproctol 2023 Oct;27(10):813-825. Epub 2023 Jun 12 doi: 10.1007/s10151-023-02825-y. PMID: 37306793
The role of capsaicin in dermatology.
Boyd K, Shea SM, Patterson JW
Prog Drug Res 2014;68:293-306. doi: 10.1007/978-3-0348-0828-6_12. PMID: 24941674
Chemotherapy of enterobiasis (oxyuriasis).
St Georgiev V
Expert Opin Pharmacother 2001 Feb;2(2):267-75. doi: 10.1517/14656566.2.2.267. PMID: 11336585
Pruritus ani. Causes and concerns.
Daniel GL, Longo WE, Vernava AM 3rd
Dis Colon Rectum 1994 Jul;37(7):670-4. doi: 10.1007/BF02054410. PMID: 8026233
Common anorectal disorders.
Lieberman DA
Ann Intern Med 1984 Dec;101(6):837-46. doi: 10.7326/0003-4819-101-6-837. PMID: 6388455

Diagnosis

Benign anal disease.
Clark SJ
JAAPA 2016 Nov;29(11):23-29. doi: 10.1097/01.JAA.0000502857.05728.98. PMID: 27749400
Pruritus ani.
MacLean J, Russell D
Aust Fam Physician 2010 Jun;39(6):366-70. PMID: 20628673
Pruritus ani.
Siddiqi S, Vijay V, Ward M, Mahendran R, Warren S
Ann R Coll Surg Engl 2008 Sep;90(6):457-63. doi: 10.1308/003588408X317940. PMID: 18765023Free PMC Article
Pruritus ani.
Heard S
Aust Fam Physician 2004 Jul;33(7):511-3. PMID: 15301168
Pruritus ani.
Giordano M, Rebesco B, Torelli I, Blanco G, Cattarini G
Minerva Chir 1999 Dec;54(12):885-91. PMID: 10736994

Therapy

Evaluation, management and future perspectives of anal pruritus: a narrative review.
Jakubauskas M, Dulskas A
Eur J Med Res 2023 Feb 2;28(1):57. doi: 10.1186/s40001-023-01018-5. PMID: 36732860Free PMC Article
The role of capsaicin in dermatology.
Boyd K, Shea SM, Patterson JW
Prog Drug Res 2014;68:293-306. doi: 10.1007/978-3-0348-0828-6_12. PMID: 24941674
Pruritus ani.
Siddiqi S, Vijay V, Ward M, Mahendran R, Warren S
Ann R Coll Surg Engl 2008 Sep;90(6):457-63. doi: 10.1308/003588408X317940. PMID: 18765023Free PMC Article
Pruritus ani.
Heard S
Aust Fam Physician 2004 Jul;33(7):511-3. PMID: 15301168
Enterobiasis.
Libbus MK
Nurse Pract 1983 Sep;8(8):17-8. PMID: 6633980

Prognosis

Causes and Management of Pruritus Ani.
Sacks OA, Beresneva O
Dis Colon Rectum 2023 Jan 1;66(1):10-13. Epub 2022 Oct 27 doi: 10.1097/DCR.0000000000002661. PMID: 36515511
Pruritus ani.
Heard S
Aust Fam Physician 2004 Jul;33(7):511-3. PMID: 15301168
An approach to the treatment of anogenital pruritus.
Weichert GE
Dermatol Ther 2004;17(1):129-33. doi: 10.1111/j.1396-0296.2004.04013.x. PMID: 14756897
Treatment of persistent pruritus ani in a combined colorectal and dermatological clinic.
Dasan S, Neill SM, Donaldson DR, Scott HJ
Br J Surg 1999 Oct;86(10):1337-40. doi: 10.1046/j.1365-2168.1999.01231.x. PMID: 10540145
Pruritus ani. Classification and management.
Hanno R, Murphy P
Dermatol Clin 1987 Oct;5(4):811-6. PMID: 3315360

Clinical prediction guides

Efficacy and safety of methylene blue injection for intractable idiopathic pruritus ani: a single-arm metaanalysis and systematic review.
Jia W, Li Q, Ni J, Zhang Y, Wu L, Xu L
Tech Coloproctol 2023 Oct;27(10):813-825. Epub 2023 Jun 12 doi: 10.1007/s10151-023-02825-y. PMID: 37306793
Clinical Efficacy of Tacrolimus Ointment + 3% Boric Acid Lotion Joint Chinese Angelica Decoction in Chronic Perianal Eczema.
Gao W, Qiao X, Zhu J, Jin X, Wei Y
Comput Math Methods Med 2021;2021:1016108. Epub 2021 Oct 21 doi: 10.1155/2021/1016108. PMID: 34721653Free PMC Article
Long-term follow-up of intradermal injection of methylene blue for intractable, idiopathic pruritus ani.
Kim JH, Kim DH, Lee YP
Tech Coloproctol 2019 Feb;23(2):143-149. Epub 2019 Feb 7 doi: 10.1007/s10151-019-01934-x. PMID: 30734161Free PMC Article
Systematic review of topical capsaicin in the treatment of pruritus.
Gooding SM, Canter PH, Coelho HF, Boddy K, Ernst E
Int J Dermatol 2010 Aug;49(8):858-65. doi: 10.1111/j.1365-4632.2010.04537.x. PMID: 21128913
Treatment of intractable pruritus ani.
Eusebio EB, Graham J, Mody N
Dis Colon Rectum 1990 Sep;33(9):770-2. doi: 10.1007/BF02052324. PMID: 2390913

Recent systematic reviews

Efficacy and safety of methylene blue injection for intractable idiopathic pruritus ani: a single-arm metaanalysis and systematic review.
Jia W, Li Q, Ni J, Zhang Y, Wu L, Xu L
Tech Coloproctol 2023 Oct;27(10):813-825. Epub 2023 Jun 12 doi: 10.1007/s10151-023-02825-y. PMID: 37306793
Systematic review of topical capsaicin in the treatment of pruritus.
Gooding SM, Canter PH, Coelho HF, Boddy K, Ernst E
Int J Dermatol 2010 Aug;49(8):858-65. doi: 10.1111/j.1365-4632.2010.04537.x. PMID: 21128913
Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery.
Jayaraman S, Colquhoun PH, Malthaner RA
Dis Colon Rectum 2007 Sep;50(9):1297-305. doi: 10.1007/s10350-007-0308-4. PMID: 17665254

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