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Nociceptive Pain

MedGen UID:
465234
•Concept ID:
C3178766
•
Sign or Symptom
Synonyms: Nociceptive Pains; Pain, Nociceptive; Pains, Nociceptive

Definition

Dull or sharp aching pain caused by stimulated NOCICEPTORS due to tissue injury, inflammation or diseases. It can be divided into somatic or tissue pain and VISCERAL PAIN. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNociceptive Pain

Professional guidelines

PubMed

Pain Perception and Management: Where do We Stand?
Afridi B, Khan H, Akkol EK, Aschner M
Curr Mol Pharmacol 2021;14(5):678-688. doi: 10.2174/1874467213666200611142438. PMID: 32525788Free PMC Article
Bone Pain in Cancer Patients: Mechanisms and Current Treatment.
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267Free PMC Article
Neuropathic cancer pain: prevalence, pathophysiology, and management.
Yoon SY, Oh J
Korean J Intern Med 2018 Nov;33(6):1058-1069. Epub 2018 Jun 25 doi: 10.3904/kjim.2018.162. PMID: 29929349Free PMC Article

Recent clinical studies

Etiology

Opioid Management in CKD.
Lu E, Schell JO, Koncicki HM
Am J Kidney Dis 2021 May;77(5):786-795. Epub 2020 Oct 22 doi: 10.1053/j.ajkd.2020.08.018. PMID: 33500128
Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis.
Busse JW, Wang L, Kamaleldin M, Craigie S, Riva JJ, Montoya L, Mulla SM, Lopes LC, Vogel N, Chen E, Kirmayr K, De Oliveira K, Olivieri L, Kaushal A, Chaparro LE, Oyberman I, Agarwal A, Couban R, Tsoi L, Lam T, Vandvik PO, Hsu S, Bala MM, Schandelmaier S, Scheidecker A, Ebrahim S, Ashoorion V, Rehman Y, Hong PJ, Ross S, Johnston BC, Kunz R, Sun X, Buckley N, Sessler DI, Guyatt GH
JAMA 2018 Dec 18;320(23):2448-2460. doi: 10.1001/jama.2018.18472. PMID: 30561481Free PMC Article
Neuropathic cancer pain: prevalence, pathophysiology, and management.
Yoon SY, Oh J
Korean J Intern Med 2018 Nov;33(6):1058-1069. Epub 2018 Jun 25 doi: 10.3904/kjim.2018.162. PMID: 29929349Free PMC Article
Hypermobility, the Ehlers-Danlos syndromes and chronic pain.
Syx D, De Wandele I, Rombaut L, Malfait F
Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 107(5):116-122. Epub 2017 Sep 28 PMID: 28967365
Low back pain: guidelines for the clinical classification of predominant neuropathic, nociceptive, or central sensitization pain.
Nijs J, Apeldoorn A, Hallegraeff H, Clark J, Smeets R, Malfliet A, Girbes EL, De Kooning M, Ickmans K
Pain Physician 2015 May-Jun;18(3):E333-46. PMID: 26000680

Diagnosis

Nociplastic pain: towards an understanding of prevalent pain conditions.
Fitzcharles MA, Cohen SP, Clauw DJ, Littlejohn G, Usui C, Häuser W
Lancet 2021 May 29;397(10289):2098-2110. doi: 10.1016/S0140-6736(21)00392-5. PMID: 34062144
Neuropathic cancer pain: prevalence, pathophysiology, and management.
Yoon SY, Oh J
Korean J Intern Med 2018 Nov;33(6):1058-1069. Epub 2018 Jun 25 doi: 10.3904/kjim.2018.162. PMID: 29929349Free PMC Article
Neuropathic pain.
Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB, Eccleston C, Kalso E, Bennett DL, Dworkin RH, Raja SN
Nat Rev Dis Primers 2017 Feb 16;3:17002. doi: 10.1038/nrdp.2017.2. PMID: 28205574Free PMC Article
Low back pain: guidelines for the clinical classification of predominant neuropathic, nociceptive, or central sensitization pain.
Nijs J, Apeldoorn A, Hallegraeff H, Clark J, Smeets R, Malfliet A, Girbes EL, De Kooning M, Ickmans K
Pain Physician 2015 May-Jun;18(3):E333-46. PMID: 26000680
Neuropathic pain: mechanisms and their clinical implications.
Cohen SP, Mao J
BMJ 2014 Feb 5;348:f7656. doi: 10.1136/bmj.f7656. PMID: 24500412

Therapy

JAK/STAT pathway and nociceptive cytokine signalling in rheumatoid arthritis and psoriatic arthritis.
Crispino N, Ciccia F
Clin Exp Rheumatol 2021 May-Jun;39(3):668-675. Epub 2020 Oct 30 doi: 10.55563/clinexprheumatol/e7ayu8. PMID: 33200731
Bone Pain in Cancer Patients: Mechanisms and Current Treatment.
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267Free PMC Article
General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation.
Yam MF, Loh YC, Tan CS, Khadijah Adam S, Abdul Manan N, Basir R
Int J Mol Sci 2018 Jul 24;19(8) doi: 10.3390/ijms19082164. PMID: 30042373Free PMC Article
Neuropathic cancer pain: prevalence, pathophysiology, and management.
Yoon SY, Oh J
Korean J Intern Med 2018 Nov;33(6):1058-1069. Epub 2018 Jun 25 doi: 10.3904/kjim.2018.162. PMID: 29929349Free PMC Article
Neuropathic pain.
Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB, Eccleston C, Kalso E, Bennett DL, Dworkin RH, Raja SN
Nat Rev Dis Primers 2017 Feb 16;3:17002. doi: 10.1038/nrdp.2017.2. PMID: 28205574Free PMC Article

Prognosis

Review of Opioid Pharmacogenetics and Considerations for Pain Management.
Owusu Obeng A, Hamadeh I, Smith M
Pharmacotherapy 2017 Sep;37(9):1105-1121. Epub 2017 Sep 6 doi: 10.1002/phar.1986. PMID: 28699646
Pain in amyotrophic lateral sclerosis.
Chiò A, Mora G, Lauria G
Lancet Neurol 2017 Feb;16(2):144-157. Epub 2016 Dec 8 doi: 10.1016/S1474-4422(16)30358-1. PMID: 27964824
Pancreatic pain.
Moran RA, James T, Pasricha PJ
Curr Opin Gastroenterol 2015 Sep;31(5):407-15. doi: 10.1097/MOG.0000000000000204. PMID: 26154428
Neuropathic pain: mechanisms and their clinical implications.
Cohen SP, Mao J
BMJ 2014 Feb 5;348:f7656. doi: 10.1136/bmj.f7656. PMID: 24500412
Thalamotomy.
Tasker RR
Neurosurg Clin N Am 1990 Oct;1(4):841-64. PMID: 2136173

Clinical prediction guides

Nociplastic pain: towards an understanding of prevalent pain conditions.
Fitzcharles MA, Cohen SP, Clauw DJ, Littlejohn G, Usui C, Häuser W
Lancet 2021 May 29;397(10289):2098-2110. doi: 10.1016/S0140-6736(21)00392-5. PMID: 34062144
JAK/STAT pathway and nociceptive cytokine signalling in rheumatoid arthritis and psoriatic arthritis.
Crispino N, Ciccia F
Clin Exp Rheumatol 2021 May-Jun;39(3):668-675. Epub 2020 Oct 30 doi: 10.55563/clinexprheumatol/e7ayu8. PMID: 33200731
Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis.
Busse JW, Wang L, Kamaleldin M, Craigie S, Riva JJ, Montoya L, Mulla SM, Lopes LC, Vogel N, Chen E, Kirmayr K, De Oliveira K, Olivieri L, Kaushal A, Chaparro LE, Oyberman I, Agarwal A, Couban R, Tsoi L, Lam T, Vandvik PO, Hsu S, Bala MM, Schandelmaier S, Scheidecker A, Ebrahim S, Ashoorion V, Rehman Y, Hong PJ, Ross S, Johnston BC, Kunz R, Sun X, Buckley N, Sessler DI, Guyatt GH
JAMA 2018 Dec 18;320(23):2448-2460. doi: 10.1001/jama.2018.18472. PMID: 30561481Free PMC Article
Review of Opioid Pharmacogenetics and Considerations for Pain Management.
Owusu Obeng A, Hamadeh I, Smith M
Pharmacotherapy 2017 Sep;37(9):1105-1121. Epub 2017 Sep 6 doi: 10.1002/phar.1986. PMID: 28699646
Identifying and Managing Pain in People with Alzheimer's Disease and Other Types of Dementia: A Systematic Review.
Husebo BS, Achterberg W, Flo E
CNS Drugs 2016 Jun;30(6):481-97. doi: 10.1007/s40263-016-0342-7. PMID: 27240869Free PMC Article

Recent systematic reviews

Efficacy of epidural analgesia for intractable cancer pain: A systematic review.
Hsieh YL, Chen HY, Lin CR, Wang CF
Pain Pract 2023 Nov;23(8):956-969. Epub 2023 Jul 16 doi: 10.1111/papr.13273. PMID: 37455298
Prevalence of chronic pain after spinal cord injury: a systematic review and meta-analysis.
Hunt C, Moman R, Peterson A, Wilson R, Covington S, Mustafa R, Murad MH, Hooten WM
Reg Anesth Pain Med 2021 Apr;46(4):328-336. Epub 2021 Jan 6 doi: 10.1136/rapm-2020-101960. PMID: 33408161
Prescription of exercises for the treatment of chronic pain along the continuum of nociplastic pain: A systematic review with meta-analysis.
Ferro Moura Franco K, Lenoir D, Dos Santos Franco YR, Jandre Reis FJ, Nunes Cabral CM, Meeus M
Eur J Pain 2021 Jan;25(1):51-70. Epub 2020 Oct 16 doi: 10.1002/ejp.1666. PMID: 32976664
Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis.
Busse JW, Wang L, Kamaleldin M, Craigie S, Riva JJ, Montoya L, Mulla SM, Lopes LC, Vogel N, Chen E, Kirmayr K, De Oliveira K, Olivieri L, Kaushal A, Chaparro LE, Oyberman I, Agarwal A, Couban R, Tsoi L, Lam T, Vandvik PO, Hsu S, Bala MM, Schandelmaier S, Scheidecker A, Ebrahim S, Ashoorion V, Rehman Y, Hong PJ, Ross S, Johnston BC, Kunz R, Sun X, Buckley N, Sessler DI, Guyatt GH
JAMA 2018 Dec 18;320(23):2448-2460. doi: 10.1001/jama.2018.18472. PMID: 30561481Free PMC Article
Identifying and Managing Pain in People with Alzheimer's Disease and Other Types of Dementia: A Systematic Review.
Husebo BS, Achterberg W, Flo E
CNS Drugs 2016 Jun;30(6):481-97. doi: 10.1007/s40263-016-0342-7. PMID: 27240869Free PMC Article

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