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Liver Epithelioid Hemangioendothelioma

MedGen UID:
473525
Concept ID:
C2064402
Neoplastic Process
Synonyms: Epithelioid hemangioendothelioma of liver; Hepatic Epithelioid Hemangioendothelioma
SNOMED CT: Epithelioid hemangioendothelioma of liver (860831008)

Definition

A low-grade malignant blood vessel neoplasm that arises from the liver. It is characterized by the presence of epithelioid endothelial cells. The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma. Patients may be asymptomatic or present with an abdominal mass, ascites, and jaundice. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Epithelioid Hemangioendothelioma

Professional guidelines

PubMed

Chahrour MA, Khachfe HH, Habib JR, El-Asmar R, Saifi O, Jamali FR
World J Surg 2021 Sep;45(9):2886-2894. Epub 2021 May 17 doi: 10.1007/s00268-021-06165-6. PMID: 33999226
Rosenberg A, Agulnik M
Curr Treat Options Oncol 2018 Mar 15;19(4):19. doi: 10.1007/s11864-018-0536-y. PMID: 29546487
Harman M, Nart D, Acar T, Elmas N
Abdom Imaging 2015 Jun;40(5):1316-30. doi: 10.1007/s00261-014-0268-9. PMID: 25311993

Recent clinical studies

Etiology

Liu H, Wang J, Lang J, Zhang X
J Comput Assist Tomogr 2021 Sep-Oct 01;45(5):788-794. doi: 10.1097/RCT.0000000000001194. PMID: 34546683
Onishi Y, Kusumoto M, Motoi N, Hiraoka N, Sugawara S, Itou C, Sone M
Acad Radiol 2021 Jun;28(6):778-782. Epub 2020 May 18 doi: 10.1016/j.acra.2020.04.015. PMID: 32434692
Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM
Semin Diagn Pathol 1986 Nov;3(4):259-87. PMID: 3303234

Diagnosis

Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892
Torres Jurado MJ, López Sánchez J, Quiñones Sampedro JE, Muñoz Bellvís L
Rev Esp Enferm Dig 2022 Dec;114(12):744-745. doi: 10.17235/reed.2022.8878/2022. PMID: 35607922
Mundada AD, Deodhar K, Ramadwar M, Bal M, Kumar R
Indian J Pathol Microbiol 2022 Jan-Mar;65(1):133-136. doi: 10.4103/ijpm.ijpm_350_21. PMID: 35074978
Chavhan GB, Siddiqui I, Ingley KM, Gupta AA
Pediatr Radiol 2019 Oct;49(11):1404-1421. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04402-8. PMID: 31620842
Rosenberg A, Agulnik M
Curr Treat Options Oncol 2018 Mar 15;19(4):19. doi: 10.1007/s11864-018-0536-y. PMID: 29546487

Therapy

Rosenberg A, Agulnik M
Curr Treat Options Oncol 2018 Mar 15;19(4):19. doi: 10.1007/s11864-018-0536-y. PMID: 29546487
Treska V, Daum O, Svajdler M, Liska V, Ferda J, Baxa J
In Vivo 2017 Jul-Aug;31(4):763-767. doi: 10.21873/invivo.11128. PMID: 28652454Free PMC Article
Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Ravi V, Patel S
Curr Oncol Rep 2013 Aug;15(4):347-55. doi: 10.1007/s11912-013-0328-2. PMID: 23852636

Prognosis

Mundada AD, Deodhar K, Ramadwar M, Bal M, Kumar R
Indian J Pathol Microbiol 2022 Jan-Mar;65(1):133-136. doi: 10.4103/ijpm.ijpm_350_21. PMID: 35074978
Chahrour MA, Khachfe HH, Habib JR, El-Asmar R, Saifi O, Jamali FR
World J Surg 2021 Sep;45(9):2886-2894. Epub 2021 May 17 doi: 10.1007/s00268-021-06165-6. PMID: 33999226
Chavhan GB, Siddiqui I, Ingley KM, Gupta AA
Pediatr Radiol 2019 Oct;49(11):1404-1421. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04402-8. PMID: 31620842
Studer LL, Selby DM
Arch Pathol Lab Med 2018 Feb;142(2):263-267. doi: 10.5858/arpa.2016-0171-RS. PMID: 29372848
Ravi V, Patel S
Curr Oncol Rep 2013 Aug;15(4):347-55. doi: 10.1007/s11912-013-0328-2. PMID: 23852636

Clinical prediction guides

Paulson KG, Ravi V, Rubin BP, Park M, Loggers ET, Cranmer LD, Wagner MJ
Cancer Med 2023 Jul;12(14):15101-15106. Epub 2023 Jun 1 doi: 10.1002/cam4.6181. PMID: 37260142Free PMC Article
Ajay PS, Tsagkalidis V, Casabianca A, Burchard PR, Melucci AD, Chacon A, Goyal S, Switchenko JM, Kooby DA, Carpizo DR, Shah MM
J Surg Oncol 2022 Dec;126(8):1423-1429. Epub 2022 Aug 17 doi: 10.1002/jso.27066. PMID: 35975699Free PMC Article
Mundada AD, Deodhar K, Ramadwar M, Bal M, Kumar R
Indian J Pathol Microbiol 2022 Jan-Mar;65(1):133-136. doi: 10.4103/ijpm.ijpm_350_21. PMID: 35074978
Onishi Y, Kusumoto M, Motoi N, Hiraoka N, Sugawara S, Itou C, Sone M
Acad Radiol 2021 Jun;28(6):778-782. Epub 2020 May 18 doi: 10.1016/j.acra.2020.04.015. PMID: 32434692
Ravi V, Patel S
Curr Oncol Rep 2013 Aug;15(4):347-55. doi: 10.1007/s11912-013-0328-2. PMID: 23852636

Recent systematic reviews

Martins ACA, Costa Neto DCD, Silva JDDE, Moraes YM, LeÃo CS, Martins C
Rev Col Bras Cir 2020;47:e20202647. Epub 2020 Nov 30 doi: 10.1590/0100-6991e-20202647. PMID: 33263653
Mcculloch M, Russin M, Nachat A
Perm J 2016 Summer;20(3):15-152. Epub 2016 Jul 25 doi: 10.7812/TPP/15-152. PMID: 27479949Free PMC Article
Palma AF, Oberkofler CE, Raptis DA, Eshmuminov D, de Rougemont O, Schnyder A, Dimitroulis D, Lesurtel M, Dutkowski P, Clavien PA
Transpl Int 2014 Feb;27(2):204-10. Epub 2013 Dec 2 doi: 10.1111/tri.12238. PMID: 24289717
Ercolani G, Grazi GL, Pinna AD
Dig Surg 2010;27(1):68-75. Epub 2010 Apr 1 doi: 10.1159/000268628. PMID: 20357454

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