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Secondary malignant neoplasm

MedGen UID:
473807
•Concept ID:
C3266877
•
Neoplastic Process
Synonyms: Secondary Cancer; secondary cancer; Secondary Malignancy; secondary malignancy; Secondary Malignant Neoplasm; secondary malignant neoplasm
 
Monarch Initiative: MONDO:0024881

Definition

A malignant neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary malignant neoplasm

Professional guidelines

PubMed

Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients.
Hong KT, Lee DH, Kim BK, An HY, Choi JY, Phi JH, Cheon JE, Kang HJ, Kim SK, Kim JY, Park SH, Kim IH, Shin HY
BMC Cancer 2020 Oct 9;20(1):979. doi: 10.1186/s12885-020-07484-y. PMID: 33036578Free PMC Article
Comparison of secondary and primary thyroid cancer in adolescents and young adults.
Goldfarb M, Freyer DR
Cancer 2014 Apr 15;120(8):1155-61. Epub 2014 Feb 24 doi: 10.1002/cncr.28463. PMID: 24615715
Incidence and costs of treatment-related complications among patients with advanced squamous cell carcinoma of the head and neck.
Lang K, Sussman M, Friedman M, Su J, Kan HJ, Mauro D, Tafesse E, Menzin J
Arch Otolaryngol Head Neck Surg 2009 Jun;135(6):582-8. doi: 10.1001/archoto.2009.46. PMID: 19528407

Recent clinical studies

Etiology

Overall survival and secondary malignant neoplasms in children receiving passively scattered proton or photon craniospinal irradiation for medulloblastoma.
Paulino AC, Ludmir EB, Grosshans DR, Su JM, McGovern SL, Okcu MF, McAleer MF, Baxter PA, Mahajan A, Chintagumpala MM
Cancer 2021 Oct 15;127(20):3865-3871. Epub 2021 Jul 13 doi: 10.1002/cncr.33783. PMID: 34254296
Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant neoplasms, overall and progression-free survival: individual participant data analysis.
Franklin J, Eichenauer DA, Becker I, Monsef I, Engert A
Cochrane Database Syst Rev 2017 Sep 13;9(9):CD008814. doi: 10.1002/14651858.CD008814.pub2. PMID: 28901021Free PMC Article
Risk factors for subsequent endocrine-related cancer in childhood cancer survivors.
Wijnen M, van den Heuvel-Eibrink MM, Medici M, Peeters RP, van der Lely AJ, Neggers SJ
Endocr Relat Cancer 2016 Jun;23(6):R299-321. Epub 2016 May 26 doi: 10.1530/ERC-16-0113. PMID: 27229933
Secondary malignant neoplasms among children, adolescents, and young adults with osteosarcoma.
Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE
Cancer 2014 Dec 15;120(24):3987-93. Epub 2014 Aug 12 doi: 10.1002/cncr.28936. PMID: 25116228
Comparison of secondary and primary thyroid cancer in adolescents and young adults.
Goldfarb M, Freyer DR
Cancer 2014 Apr 15;120(8):1155-61. Epub 2014 Feb 24 doi: 10.1002/cncr.28463. PMID: 24615715

Diagnosis

Tandem High-Dose Chemotherapy Increases the Risk of Secondary Malignant Neoplasm in Pediatric Solid Tumors.
Lim H, Im M, Seo ES, Cho HW, Ju HY, Yoo KH, Cho SY, Kim JW, Lim DH, Sung KW, Lee JW
Cancer Res Treat 2024 Apr;56(2):642-651. Epub 2023 Nov 24 doi: 10.4143/crt.2023.999. PMID: 37997325Free PMC Article
Health Care Utilization and Costs Associated With Systemic First-Line Metastatic Melanoma Therapies in the United States.
van Boemmel-Wegmann S, Brown JD, Diaby V, Huo J, Silver N, Park H
JCO Oncol Pract 2022 Jan;18(1):e163-e174. Epub 2021 Jul 6 doi: 10.1200/OP.21.00140. PMID: 34228489
Incidence, Risk Factors, and Mortality Associated With Second Malignant Neoplasms Among Survivors of Adolescent and Young Adult Cancer.
Chao C, Bhatia S, Xu L, Cannavale KL, Wong FL, Huang PS, Cooper R, Armenian SH
JAMA Netw Open 2019 Jun 5;2(6):e195536. doi: 10.1001/jamanetworkopen.2019.5536. PMID: 31173129Free PMC Article
Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant neoplasms, overall and progression-free survival: individual participant data analysis.
Franklin J, Eichenauer DA, Becker I, Monsef I, Engert A
Cochrane Database Syst Rev 2017 Sep 13;9(9):CD008814. doi: 10.1002/14651858.CD008814.pub2. PMID: 28901021Free PMC Article
Secondary malignant neoplasms among children, adolescents, and young adults with osteosarcoma.
Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE
Cancer 2014 Dec 15;120(24):3987-93. Epub 2014 Aug 12 doi: 10.1002/cncr.28936. PMID: 25116228

Therapy

Late effects in pediatric Hodgkin lymphoma survivors after uniform treatment with ABVD with or without radiotherapy.
Mittal A, Bhethanabhotla S, Ganguly S, Vishnubhatla S, Khadgawat R, Patel C, Mohan A, Biswas A, Bakhshi S
Pediatr Blood Cancer 2021 Nov;68(11):e29293. Epub 2021 Aug 25 doi: 10.1002/pbc.29293. PMID: 34431211
Overall survival and secondary malignant neoplasms in children receiving passively scattered proton or photon craniospinal irradiation for medulloblastoma.
Paulino AC, Ludmir EB, Grosshans DR, Su JM, McGovern SL, Okcu MF, McAleer MF, Baxter PA, Mahajan A, Chintagumpala MM
Cancer 2021 Oct 15;127(20):3865-3871. Epub 2021 Jul 13 doi: 10.1002/cncr.33783. PMID: 34254296
Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant neoplasms, overall and progression-free survival: individual participant data analysis.
Franklin J, Eichenauer DA, Becker I, Monsef I, Engert A
Cochrane Database Syst Rev 2017 Sep 13;9(9):CD008814. doi: 10.1002/14651858.CD008814.pub2. PMID: 28901021Free PMC Article
Secondary malignant neoplasms following radiotherapy for primary cancer in children and young adults.
Harbron RW, Feltbower RG, Glaser A, Lilley J, Pearce MS
Pediatr Hematol Oncol 2014 Apr;31(3):259-67. Epub 2013 Oct 2 doi: 10.3109/08880018.2013.838723. PMID: 24087931
Risk of secondary malignant neoplasms from proton therapy and intensity-modulated x-ray therapy for early-stage prostate cancer.
Fontenot JD, Lee AK, Newhauser WD
Int J Radiat Oncol Biol Phys 2009 Jun 1;74(2):616-22. doi: 10.1016/j.ijrobp.2009.01.001. PMID: 19427561Free PMC Article

Prognosis

Tandem High-Dose Chemotherapy Increases the Risk of Secondary Malignant Neoplasm in Pediatric Solid Tumors.
Lim H, Im M, Seo ES, Cho HW, Ju HY, Yoo KH, Cho SY, Kim JW, Lim DH, Sung KW, Lee JW
Cancer Res Treat 2024 Apr;56(2):642-651. Epub 2023 Nov 24 doi: 10.4143/crt.2023.999. PMID: 37997325Free PMC Article
Late effects in pediatric Hodgkin lymphoma survivors after uniform treatment with ABVD with or without radiotherapy.
Mittal A, Bhethanabhotla S, Ganguly S, Vishnubhatla S, Khadgawat R, Patel C, Mohan A, Biswas A, Bakhshi S
Pediatr Blood Cancer 2021 Nov;68(11):e29293. Epub 2021 Aug 25 doi: 10.1002/pbc.29293. PMID: 34431211
Incidence, Risk Factors, and Mortality Associated With Second Malignant Neoplasms Among Survivors of Adolescent and Young Adult Cancer.
Chao C, Bhatia S, Xu L, Cannavale KL, Wong FL, Huang PS, Cooper R, Armenian SH
JAMA Netw Open 2019 Jun 5;2(6):e195536. doi: 10.1001/jamanetworkopen.2019.5536. PMID: 31173129Free PMC Article
Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant neoplasms, overall and progression-free survival: individual participant data analysis.
Franklin J, Eichenauer DA, Becker I, Monsef I, Engert A
Cochrane Database Syst Rev 2017 Sep 13;9(9):CD008814. doi: 10.1002/14651858.CD008814.pub2. PMID: 28901021Free PMC Article
Secondary malignant neoplasms among children, adolescents, and young adults with osteosarcoma.
Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE
Cancer 2014 Dec 15;120(24):3987-93. Epub 2014 Aug 12 doi: 10.1002/cncr.28936. PMID: 25116228

Clinical prediction guides

Does the SORG Machine-learning Algorithm for Extremity Metastases Generalize to a Contemporary Cohort of Patients? Temporal Validation From 2016 to 2020.
de Groot TM, Ramsey D, Groot OQ, Fourman M, Karhade AV, Twining PK, Berner EA, Fenn BP, Collins AK, Raskin K, Lozano S, Newman E, Ferrone M, Doornberg JN, Schwab JH
Clin Orthop Relat Res 2023 Dec 1;481(12):2419-2430. Epub 2023 May 25 doi: 10.1097/CORR.0000000000002698. PMID: 37229565Free PMC Article
Clinicopathologic predictors of outcomes in children with stage I testicular germ cell tumors: A pooled post hoc analysis of trials from the Children's Oncology Group.
Singla N, Wong J, Singla S, Krailo M, Huang L, Shaikh F, Billmire D, Rescorla F, Ross J, Dicken B, Amatruda JF, Lindsay Frazier A, Bagrodia A
J Pediatr Urol 2022 Aug;18(4):505-511. Epub 2022 May 7 doi: 10.1016/j.jpurol.2022.04.022. PMID: 35606324Free PMC Article
Health Care Utilization and Costs Associated With Systemic First-Line Metastatic Melanoma Therapies in the United States.
van Boemmel-Wegmann S, Brown JD, Diaby V, Huo J, Silver N, Park H
JCO Oncol Pract 2022 Jan;18(1):e163-e174. Epub 2021 Jul 6 doi: 10.1200/OP.21.00140. PMID: 34228489
Late effects in pediatric Hodgkin lymphoma survivors after uniform treatment with ABVD with or without radiotherapy.
Mittal A, Bhethanabhotla S, Ganguly S, Vishnubhatla S, Khadgawat R, Patel C, Mohan A, Biswas A, Bakhshi S
Pediatr Blood Cancer 2021 Nov;68(11):e29293. Epub 2021 Aug 25 doi: 10.1002/pbc.29293. PMID: 34431211
Risk factors for subsequent endocrine-related cancer in childhood cancer survivors.
Wijnen M, van den Heuvel-Eibrink MM, Medici M, Peeters RP, van der Lely AJ, Neggers SJ
Endocr Relat Cancer 2016 Jun;23(6):R299-321. Epub 2016 May 26 doi: 10.1530/ERC-16-0113. PMID: 27229933

Recent systematic reviews

The Risk of Clonal Evolution of Granulocyte Colony-Stimulating Factor for Acquired Aplastic Anemia: A Systematic Review and Meta-Analysis.
Ding SX, Chen T, Wang T, Liu CY, Lu WL, Fu R
Acta Haematol 2018;140(3):141-145. Epub 2018 Sep 25 doi: 10.1159/000491816. PMID: 30253387
Optimisation of chemotherapy and radiotherapy for untreated Hodgkin lymphoma patients with respect to second malignant neoplasms, overall and progression-free survival: individual participant data analysis.
Franklin J, Eichenauer DA, Becker I, Monsef I, Engert A
Cochrane Database Syst Rev 2017 Sep 13;9(9):CD008814. doi: 10.1002/14651858.CD008814.pub2. PMID: 28901021Free PMC Article
Risk factors for subsequent endocrine-related cancer in childhood cancer survivors.
Wijnen M, van den Heuvel-Eibrink MM, Medici M, Peeters RP, van der Lely AJ, Neggers SJ
Endocr Relat Cancer 2016 Jun;23(6):R299-321. Epub 2016 May 26 doi: 10.1530/ERC-16-0113. PMID: 27229933

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