U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Digestive System Neuroendocrine Tumor G2

MedGen UID:
474250
Concept ID:
C3272617
Neoplastic Process
Synonyms: Gastrointestinal NET G2; Gastrointestinal Neuroendocrine Tumor G2

Definition

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent. [from NCI]

Professional guidelines

PubMed

Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Recent clinical studies

Etiology

Simon CT, Ehrlich P, Hryhorczuk A, Rabah R, Sedig L, Stoll T, Heider A
Pediatr Dev Pathol 2023 May-Jun;26(3):250-258. Epub 2023 Feb 21 doi: 10.1177/10935266221146001. PMID: 37334832
Oka N, Kasajima A, Konukiewitz B, Sakurada A, Okada Y, Kameya T, Weichert W, Ishikawa Y, Suzuki H, Sasano H, Klöppel G
Neuroendocrinology 2020;110(5):393-403. Epub 2019 Aug 19 doi: 10.1159/000502776. PMID: 31422400
Zhang XF, Wu XN, Tsilimigras DI, Poultsides G, Rocha F, Abbott DE, Fields R, Idrees K, Cho C, Maithel SK, Pawlik TM; other members of the US Neuroendocrine Tumor Study Group
J Surg Oncol 2019 Dec;120(8):1302-1310. Epub 2019 Nov 3 doi: 10.1002/jso.25753. PMID: 31680243Free PMC Article
La Rosa S, Vanoli A
J Clin Pathol 2014 Nov;67(11):938-48. Epub 2014 Jul 22 doi: 10.1136/jclinpath-2014-202515. PMID: 25053544
Poiană C, Neamţu MC, Avramescu ET, Carşote M, Trifănescu R, Terzea D, Neamţu OM, Ferechide D, Dănciulescu Miulescu R
Rom J Morphol Embryol 2013;54(3 Suppl):717-20. PMID: 24322017

Diagnosis

Simon CT, Ehrlich P, Hryhorczuk A, Rabah R, Sedig L, Stoll T, Heider A
Pediatr Dev Pathol 2023 May-Jun;26(3):250-258. Epub 2023 Feb 21 doi: 10.1177/10935266221146001. PMID: 37334832
Oka N, Kasajima A, Konukiewitz B, Sakurada A, Okada Y, Kameya T, Weichert W, Ishikawa Y, Suzuki H, Sasano H, Klöppel G
Neuroendocrinology 2020;110(5):393-403. Epub 2019 Aug 19 doi: 10.1159/000502776. PMID: 31422400
Kim JY, Hong SM
Arch Pathol Lab Med 2016 May;140(5):437-48. doi: 10.5858/arpa.2015-0314-RA. PMID: 27128301
La Rosa S, Vanoli A
J Clin Pathol 2014 Nov;67(11):938-48. Epub 2014 Jul 22 doi: 10.1136/jclinpath-2014-202515. PMID: 25053544
Poiană C, Neamţu MC, Avramescu ET, Carşote M, Trifănescu R, Terzea D, Neamţu OM, Ferechide D, Dănciulescu Miulescu R
Rom J Morphol Embryol 2013;54(3 Suppl):717-20. PMID: 24322017

Therapy

Salemi R, Vivarelli S, Ricci D, Scillato M, Santagati M, Gattuso G, Falzone L, Libra M
J Transl Med 2023 Mar 14;21(1):195. doi: 10.1186/s12967-023-04036-3. PMID: 36918929Free PMC Article
Merola E, Dal Buono A, Denecke T, Arsenic R, Pape UF, Jann H, Wiedenmann B, Pavel ME
Pancreas 2020 Aug;49(7):912-917. doi: 10.1097/MPA.0000000000001593. PMID: 32658073
Zhang M, Zhao P, Shi X, Zhao A, Zhang L, Zhou L
BMC Endocr Disord 2017 Jul 13;17(1):39. doi: 10.1186/s12902-017-0190-6. PMID: 28705205Free PMC Article
Hasegawa S, Kobayashi N, Tokuhisa M, Goto A, Takano S, Takada Y, Kaneta T, Mori R, Matsuyama R, Endo I, Yamanaka S, Nakajima A, Inoue T, Ichikawa Y
Digestion 2017;96(1):13-20. Epub 2017 Jun 14 doi: 10.1159/000470838. PMID: 28609761
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Prognosis

Mafficini A, Scarpa A
Endocr Rev 2019 Apr 1;40(2):506-536. doi: 10.1210/er.2018-00160. PMID: 30657883Free PMC Article
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009
Kim JY, Hong SM
Arch Pathol Lab Med 2016 May;140(5):437-48. doi: 10.5858/arpa.2015-0314-RA. PMID: 27128301
La Rosa S, Vanoli A
J Clin Pathol 2014 Nov;67(11):938-48. Epub 2014 Jul 22 doi: 10.1136/jclinpath-2014-202515. PMID: 25053544
Poiană C, Neamţu MC, Avramescu ET, Carşote M, Trifănescu R, Terzea D, Neamţu OM, Ferechide D, Dănciulescu Miulescu R
Rom J Morphol Embryol 2013;54(3 Suppl):717-20. PMID: 24322017

Clinical prediction guides

Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Goo JJ, Baek DH, Kim HW, Lee HS, Lee JY, Park SB, Song GA, Lee SH, Lee JH; Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS)
Surg Endosc 2023 Jul;37(7):5196-5204. Epub 2023 Mar 22 doi: 10.1007/s00464-023-09999-4. PMID: 36947224
Aoyama N, Wada M, Taniguchi Y, Inokuma T, Nakanishi Y, Fukuda A, Seno H
Clin J Gastroenterol 2023 Apr;16(2):171-179. Epub 2022 Dec 21 doi: 10.1007/s12328-022-01739-w. PMID: 36542298
Rindi G, Klersy C, Inzani F, Fellegara G, Ampollini L, Ardizzoni A, Campanini N, Carbognani P, De Pas TM, Galetta D, Granone PL, Righi L, Rusca M, Spaggiari L, Tiseo M, Viale G, Volante M, Papotti M, Pelosi G
Endocr Relat Cancer 2014 Feb;21(1):1-16. Epub 2013 Dec 16 doi: 10.1530/ERC-13-0246. PMID: 24344249
Poiană C, Neamţu MC, Avramescu ET, Carşote M, Trifănescu R, Terzea D, Neamţu OM, Ferechide D, Dănciulescu Miulescu R
Rom J Morphol Embryol 2013;54(3 Suppl):717-20. PMID: 24322017

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...