U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rectal Serrated Adenocarcinoma

MedGen UID:
474444
•Concept ID:
C3272811
•
Neoplastic Process

Definition

A rare, invasive rectal adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal Serrated Adenocarcinoma

Professional guidelines

PubMed

Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239

Recent clinical studies

Etiology

Atypical (non-V600E) BRAF mutations in metastatic colorectal cancer in population and real-world cohorts.
Osterlund E, Ristimäki A, Mäkinen MJ, Kytölä S, Kononen J, Pfeiffer P, Soveri LM, Keinänen M, Sorbye H, Nunes L, Salminen T, Nieminen L, Uutela A, Halonen P, Ålgars A, Sundström J, Kallio R, Ristamäki R, Lamminmäki A, Stedt H, Heervä E, Kuopio T, Sjöblom T, Isoniemi H, Glimelius B, Osterlund P
Int J Cancer 2024 Feb 1;154(3):488-503. Epub 2023 Sep 19 doi: 10.1002/ijc.34733. PMID: 37724848
Are large ileocecal valve lesions amenable with advanced endoscopic management to avoid bowel resection?
Ozgur I, Justiniano CF, Valente MA, Holubar SD, Steele SR, Gorgun E
Surg Endosc 2023 Jul;37(7):5320-5325. Epub 2023 Mar 29 doi: 10.1007/s00464-023-10014-z. PMID: 36991268
Findings on Colonoscopy after Diverticulitis: A Multicenter Review.
Studniarek A, Kochar K, Warner C, Eftaiha S, Naffouj S, Borsuk DJ, Mellgren A, Park JJ, Cintron J, Harrison J
Am Surg 2019 Dec 1;85(12):1381-1385. PMID: 31908222
Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice?
Sandmeier D, Seelentag W, Bouzourene H
Virchows Arch 2007 Jun;450(6):613-8. Epub 2007 Apr 21 doi: 10.1007/s00428-007-0413-8. PMID: 17450379

Diagnosis

Findings on Colonoscopy after Diverticulitis: A Multicenter Review.
Studniarek A, Kochar K, Warner C, Eftaiha S, Naffouj S, Borsuk DJ, Mellgren A, Park JJ, Cintron J, Harrison J
Am Surg 2019 Dec 1;85(12):1381-1385. PMID: 31908222
Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Molecular Subtypes of Colorectal Cancer and Their Clinicopathologic Features, With an Emphasis on the Serrated Neoplasia Pathway.
Bae JM, Kim JH, Kang GH
Arch Pathol Lab Med 2016 May;140(5):406-12. doi: 10.5858/arpa.2015-0310-RA. PMID: 27128298
Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice?
Sandmeier D, Seelentag W, Bouzourene H
Virchows Arch 2007 Jun;450(6):613-8. Epub 2007 Apr 21 doi: 10.1007/s00428-007-0413-8. PMID: 17450379
Primary and metastatic scirrrhous carcinoma of the rectum.
Balthazar EJ, Rosenberg HD, Davidian MM
AJR Am J Roentgenol 1979 May;132(5):711-5. doi: 10.2214/ajr.132.5.711. PMID: 219672

Prognosis

Atypical (non-V600E) BRAF mutations in metastatic colorectal cancer in population and real-world cohorts.
Osterlund E, Ristimäki A, Mäkinen MJ, Kytölä S, Kononen J, Pfeiffer P, Soveri LM, Keinänen M, Sorbye H, Nunes L, Salminen T, Nieminen L, Uutela A, Halonen P, Ålgars A, Sundström J, Kallio R, Ristamäki R, Lamminmäki A, Stedt H, Heervä E, Kuopio T, Sjöblom T, Isoniemi H, Glimelius B, Osterlund P
Int J Cancer 2024 Feb 1;154(3):488-503. Epub 2023 Sep 19 doi: 10.1002/ijc.34733. PMID: 37724848
Loss of HES1 expression is associated with extracellular matrix remodeling and tumor immune suppression in KRAS mutant colon adenocarcinomas.
Wang L, Gu W, Zou B, Kalady M, Xin W, Zhou L
Sci Rep 2023 Sep 25;13(1):15999. doi: 10.1038/s41598-023-42234-7. PMID: 37749297Free PMC Article
Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Molecular Subtypes of Colorectal Cancer and Their Clinicopathologic Features, With an Emphasis on the Serrated Neoplasia Pathway.
Bae JM, Kim JH, Kang GH
Arch Pathol Lab Med 2016 May;140(5):406-12. doi: 10.5858/arpa.2015-0310-RA. PMID: 27128298
Outcomes of EMR of defiant colorectal lesions directed to an endoscopy referral center.
Buchner AM, Guarner-Argente C, Ginsberg GG
Gastrointest Endosc 2012 Aug;76(2):255-63. Epub 2012 May 31 doi: 10.1016/j.gie.2012.02.060. PMID: 22657404

Clinical prediction guides

Endorobotic submucosal dissection of rectal lesions using the single port robot DaVinci-SP: initial experience of the first 10 cases.
Ozgur I, Cheong JY, Liska D, Holubar S, Valante MA, Steele SR, Gorgun E
ANZ J Surg 2024 Apr;94(4):691-696. Epub 2023 Nov 27 doi: 10.1111/ans.18796. PMID: 38012087
Atypical (non-V600E) BRAF mutations in metastatic colorectal cancer in population and real-world cohorts.
Osterlund E, Ristimäki A, Mäkinen MJ, Kytölä S, Kononen J, Pfeiffer P, Soveri LM, Keinänen M, Sorbye H, Nunes L, Salminen T, Nieminen L, Uutela A, Halonen P, Ålgars A, Sundström J, Kallio R, Ristamäki R, Lamminmäki A, Stedt H, Heervä E, Kuopio T, Sjöblom T, Isoniemi H, Glimelius B, Osterlund P
Int J Cancer 2024 Feb 1;154(3):488-503. Epub 2023 Sep 19 doi: 10.1002/ijc.34733. PMID: 37724848
Serrated adenomas with a BRAF mutation in a young patient with familial adenomatous polyposis.
Moriichi K, Tanabe H, Ono Y, Kobayashi Y, Murakami Y, Iwama T, Kunogi T, Sasaki T, Takahashi K, Ando K, Ueno N, Kashima S, Takei H, Mizukami Y, Fujiya M, Okumura T
Int J Colorectal Dis 2020 Oct;35(10):1967-1972. Epub 2020 Jun 5 doi: 10.1007/s00384-020-03657-0. PMID: 32504335
Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Outcomes of EMR of defiant colorectal lesions directed to an endoscopy referral center.
Buchner AM, Guarner-Argente C, Ginsberg GG
Gastrointest Endosc 2012 Aug;76(2):255-63. Epub 2012 May 31 doi: 10.1016/j.gie.2012.02.060. PMID: 22657404

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...