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Breast Solid Neuroendocrine Carcinoma

MedGen UID:: 475360
•Concept ID:: C3273727
•: Neoplastic Process

Definition

A neuroendocrine carcinoma that arises from the breast. It is characterized by the presence of cellular solid nests and trabeculae that contain spindle-shaped, plasmacytoid, and large neuroendocrine cells. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBreast Solid Neuroendocrine Carcinoma

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Neoplasm by Obsolete Classification
        Epithelial Neoplasm (Antiquated)
        Breast Solid Neuroendocrine Carcinoma

Professional guidelines

PubMed

Clinical features and treatment response of solid neuroendocrine breast carcinoma to adjuvant chemotherapy and endocrine therapy.

Zhu Y, Li Q, Gao J, He Z, Sun R, Shen G, Zhang H, Xia W, Xu J
Breast J 2013 Jul-Aug;19(4):382-7. Epub 2013 May 31 doi: 10.1111/tbj.12121. PMID: 23721399

See all (1)

Recent clinical studies

Etiology

Pan-cancer whole-genome comparison of primary and metastatic solid tumours.

Martínez-Jiménez F, Movasati A, Brunner SR, Nguyen L, Priestley P, Cuppen E, Van Hoeck A
Nature 2023 Jun;618(7964):333-341. Epub 2023 May 10 doi: 10.1038/s41586-023-06054-z. PMID: 37165194 Free PMC Article

Defining triple-negative breast cancer with neuroendocrine differentiation (TNBC-NED).

Hacking SM, Yakirevich E, Wang Y
J Pathol Clin Res 2023 Jul;9(4):313-321. Epub 2023 Apr 20 doi: 10.1002/cjp2.318. PMID: 37082801 Free PMC Article

Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.

Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S, Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I, Papotti M
Virchows Arch 2022 Dec;481(6):839-846. Epub 2022 Oct 15 doi: 10.1007/s00428-022-03426-0. PMID: 36243799 Free PMC Article

INSM1 immunostaining in solid papillary carcinoma of the breast.

Kudo N, Takano J, Kudoh S, Arima N, Ito T
Pathol Int 2021 Jan;71(1):51-59. Epub 2020 Nov 6 doi: 10.1111/pin.13043. PMID: 33156579

Neuroendocrine Tumors of the Breast.

Visscher DW, Yasir S
Endocr Pathol 2017 Jun;28(2):121-127. doi: 10.1007/s12022-017-9477-4. PMID: 28389994

See all (53)

Diagnosis

Defining triple-negative breast cancer with neuroendocrine differentiation (TNBC-NED).

Hacking SM, Yakirevich E, Wang Y
J Pathol Clin Res 2023 Jul;9(4):313-321. Epub 2023 Apr 20 doi: 10.1002/cjp2.318. PMID: 37082801 Free PMC Article

Neuroendocrine Tumors of the Breast.

Rosen LE, Gattuso P
Arch Pathol Lab Med 2017 Nov;141(11):1577-1581. doi: 10.5858/arpa.2016-0364-RS. PMID: 29072945

Neuroendocrine Carcinoma of the Breast: Current Evidence and Future Perspectives.

Inno A, Bogina G, Turazza M, Bortesi L, Duranti S, Massocco A, Zamboni G, Carbognin G, Alongi F, Salgarello M, Gori S
Oncologist 2016 Jan;21(1):28-32. Epub 2015 Dec 9 doi: 10.1634/theoncologist.2015-0309. PMID: 26659223 Free PMC Article

Papillary and neuroendocrine breast lesions: the WHO stance.

Tan PH, Schnitt SJ, van de Vijver MJ, Ellis IO, Lakhani SR
Histopathology 2015 May;66(6):761-70. Epub 2015 Jan 23 doi: 10.1111/his.12463. PMID: 24845113

Solid papillary carcinoma of the breast: a pathologically and clinically distinct breast tumor.

Saremian J, Rosa M
Arch Pathol Lab Med 2012 Oct;136(10):1308-11. doi: 10.5858/arpa.2011-0227-RS. PMID: 23020734

See all (90)

Therapy

High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast.

Xie D, Wang Z, Sun B, Qu L, Zeng M, Feng L, Guo M, Wang G, Hao J, Zhou G
Front Med 2023 Oct;17(5):907-923. Epub 2023 Sep 8 doi: 10.1007/s11684-023-1009-7. PMID: 37682378

Pooled Safety Analysis of Single-Agent Lurbinectedin in Patients With Advanced Solid Tumours.

Leary A, Oaknin A, Trigo JM, Moreno V, Delord JP, Boni V, Braña I, Fernández C, Kahatt C, Nieto A, Cullell-Young M, Zeaiter A, Subbiah V
Eur J Cancer 2023 Oct;192:113259. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113259. PMID: 37634282

RET signaling in breast cancer therapeutic resistance and metastasis.

Pecar G, Liu S, Hooda J, Atkinson JM, Oesterreich S, Lee AV
Breast Cancer Res 2023 Mar 14;25(1):26. doi: 10.1186/s13058-023-01622-7. PMID: 36918928 Free PMC Article

RET fusions in solid tumors.

Li AY, McCusker MG, Russo A, Scilla KA, Gittens A, Arensmeyer K, Mehra R, Adamo V, Rolfo C
Cancer Treat Rev 2019 Dec;81:101911. Epub 2019 Oct 30 doi: 10.1016/j.ctrv.2019.101911. PMID: 31715421

Suppression of mTOR pathway in solid tumors: lessons learned from clinical experience in renal cell carcinoma and neuroendocrine tumors and new perspectives.

Ortolani S, Ciccarese C, Cingarlini S, Tortora G, Massari F
Future Oncol 2015;11(12):1809-28. doi: 10.2217/fon.15.81. PMID: 26075448

See all (31)

Prognosis

Head to head: do neuroendocrine tumours in the breast truly exist?

Rakha E, Tan PH
Histopathology 2022 Jul;81(1):2-14. Epub 2022 Feb 28 doi: 10.1111/his.14627. PMID: 35133666

Neuroendocrine Tumors of the Breast.

Rosen LE, Gattuso P
Arch Pathol Lab Med 2017 Nov;141(11):1577-1581. doi: 10.5858/arpa.2016-0364-RS. PMID: 29072945

Neuroendocrine Tumors of the Breast.

Visscher DW, Yasir S
Endocr Pathol 2017 Jun;28(2):121-127. doi: 10.1007/s12022-017-9477-4. PMID: 28389994

Neuroendocrine Carcinoma of the Breast: Current Evidence and Future Perspectives.

Solid papillary carcinoma of the breast: a pathologically and clinically distinct breast tumor.

Saremian J, Rosa M
Arch Pathol Lab Med 2012 Oct;136(10):1308-11. doi: 10.5858/arpa.2011-0227-RS. PMID: 23020734

See all (57)

Clinical prediction guides

Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome.

Head to head: do neuroendocrine tumours in the breast truly exist?

Rakha E, Tan PH
Histopathology 2022 Jul;81(1):2-14. Epub 2022 Feb 28 doi: 10.1111/his.14627. PMID: 35133666

INSM1 immunostaining in solid papillary carcinoma of the breast.

Kudo N, Takano J, Kudoh S, Arima N, Ito T
Pathol Int 2021 Jan;71(1):51-59. Epub 2020 Nov 6 doi: 10.1111/pin.13043. PMID: 33156579

Merkel cell carcinoma, melanoma, metastatic mimics of breast cancer.

Troxell ML
Semin Diagn Pathol 2017 Sep;34(5):479-495. Epub 2017 May 31 doi: 10.1053/j.semdp.2017.05.009. PMID: 28645508

Solid neuroendocrine breast carcinoma: mammographic and sonographic features in thirteen cases.

Wu J, Yang QX, Wu YP, Wang DL, Liu XW, Cui CY, Wang L, Chen Y, Xie CM, Zhang R
Chin J Cancer 2012 Nov;31(11):549-56. Epub 2012 May 23 doi: 10.5732/cjc.011.10370. PMID: 22640624 Free PMC Article

See all (37)

Recent systematic reviews

Cytological study of 44 cases with solid papillary carcinoma and a systemic review of solid papillary carcinoma and neuroendocrine tumor of the breast.

Yamada M, Otsuki Y, Ikeya T, Shimizu SI, Tanioka F, Ogawa H, Kobayashi H
Diagn Cytopathol 2023 Jun;51(6):341-348. Epub 2023 Feb 7 doi: 10.1002/dc.25112. PMID: 36748676

Risk of gastrointestinal events with sorafenib, sunitinib and pazopanib in patients with solid tumors: a systematic review and meta-analysis of clinical trials.

Santoni M, Conti A, De Giorgi U, Iacovelli R, Pantano F, Burattini L, Muzzonigro G, Berardi R, Santini D, Cascinu S
Int J Cancer 2014 Aug 15;135(4):763-73. Epub 2013 Nov 18 doi: 10.1002/ijc.28544. PMID: 24127298

See all (2)

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Breast Solid Neuroendocrine Carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity