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Lithium Induced Birth Defect

MedGen UID:
476131
•Concept ID:
C3274498
•
Congenital Abnormality

Definition

Congenital abnormalities, mainly cardiovascular malformations, which develop in a fetus when the mother uses lithium medication during pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLithium Induced Birth Defect

Professional guidelines

PubMed

Risk factors for clozapine-induced central nervous system abnormalities in Japanese patients with treatment-resistant schizophrenia.
Kitagawa K, Uekusa S, Matsuo K, Moriyama K, Yamamoto T, Yada Y, Kodama M, Kishi Y, Yoshio T
Asian J Psychiatr 2021 Jun;60:102652. Epub 2021 Apr 6 doi: 10.1016/j.ajp.2021.102652. PMID: 33866283
Weighing the Risks: the Management of Bipolar Disorder During Pregnancy.
Thomson M, Sharma V
Curr Psychiatry Rep 2018 Mar 17;20(3):20. doi: 10.1007/s11920-018-0882-2. PMID: 29549608
Optimizing lithium treatment.
Dunner DL
J Clin Psychiatry 2000;61 Suppl 9:76-81. PMID: 10826665

Recent clinical studies

Etiology

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes.
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Dose-Dependent Teratology in Humans: Clinical Implications for Prevention.
Koren G, Berkovitch M, Ornoy A
Paediatr Drugs 2018 Aug;20(4):331-335. doi: 10.1007/s40272-018-0294-0. PMID: 29725877
Psychotropics in pregnancy: safety and other considerations.
Oyebode F, Rastogi A, Berrisford G, Coccia F
Pharmacol Ther 2012 Jul;135(1):71-7. Epub 2012 Mar 28 doi: 10.1016/j.pharmthera.2012.03.008. PMID: 22483705
Teratogenesis associated with antibipolar agents.
Nguyen HT, Sharma V, McIntyre RS
Adv Ther 2009 Mar;26(3):281-94. Epub 2009 Mar 28 doi: 10.1007/s12325-009-0011-z. PMID: 19330496
A reevaluation of risk of in utero exposure to lithium.
Cohen LS, Friedman JM, Jefferson JW, Johnson EM, Weiner ML
JAMA 1994 Jan 12;271(2):146-50. PMID: 8031346

Diagnosis

When lithium hurts: a look at Ebstein anomaly.
Osiro S, Tiwari KJ, Mathenge N, Rodriguez JR, Tubbs RS, Loukas M
Cardiol Rev 2013 Sep-Oct;21(5):257-63. doi: 10.1097/CRD.0b013e318280c966. PMID: 23269033
Risks of adverse pregnancy and birth outcomes in women treated or not treated with mood stabilisers for bipolar disorder: population based cohort study.
Bodén R, Lundgren M, Brandt L, Reutfors J, Andersen M, Kieler H
BMJ 2012 Nov 8;345:e7085. doi: 10.1136/bmj.e7085. PMID: 23137820Free PMC Article
Managing bipolar disorder during pregnancy: weighing the risks and benefits.
Viguera AC, Cohen LS, Baldessarini RJ, Nonacs R
Can J Psychiatry 2002 Jun;47(5):426-36. doi: 10.1177/070674370204700503. PMID: 12085677
Lithium use during pregnancy.
Chapman WS
J Fla Med Assoc 1989 May;76(5):454-6. PMID: 2693580
Maternal drugs and congenital heart disease.
Zierler S
Obstet Gynecol 1985 Feb;65(2):155-65. PMID: 3881709

Therapy

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes.
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Dose-Dependent Teratology in Humans: Clinical Implications for Prevention.
Koren G, Berkovitch M, Ornoy A
Paediatr Drugs 2018 Aug;20(4):331-335. doi: 10.1007/s40272-018-0294-0. PMID: 29725877
Psychotropics in pregnancy: safety and other considerations.
Oyebode F, Rastogi A, Berrisford G, Coccia F
Pharmacol Ther 2012 Jul;135(1):71-7. Epub 2012 Mar 28 doi: 10.1016/j.pharmthera.2012.03.008. PMID: 22483705
Optimizing lithium treatment.
Dunner DL
J Clin Psychiatry 2000;61 Suppl 9:76-81. PMID: 10826665
Mood drugs.
Baldessarini RJ
Dis Mon 1977 Nov;24(2):1-65. doi: 10.1016/s0011-5029(77)80016-3. PMID: 21061

Prognosis

When should we prescribe high-dose folic acid to prevent congenital heart defects?
Huhta JC, Linask K
Curr Opin Cardiol 2015 Jan;30(1):125-31. doi: 10.1097/HCO.0000000000000124. PMID: 25389654
When lithium hurts: a look at Ebstein anomaly.
Osiro S, Tiwari KJ, Mathenge N, Rodriguez JR, Tubbs RS, Loukas M
Cardiol Rev 2013 Sep-Oct;21(5):257-63. doi: 10.1097/CRD.0b013e318280c966. PMID: 23269033
QT alterations in psychopharmacology: proven candidates and suspects.
Alvarez PA, Pahissa J
Curr Drug Saf 2010 Jan;5(1):97-104. doi: 10.2174/157488610789869265. PMID: 20210726
Teratogenesis associated with antibipolar agents.
Nguyen HT, Sharma V, McIntyre RS
Adv Ther 2009 Mar;26(3):281-94. Epub 2009 Mar 28 doi: 10.1007/s12325-009-0011-z. PMID: 19330496
Managing bipolar disorder during pregnancy: weighing the risks and benefits.
Viguera AC, Cohen LS, Baldessarini RJ, Nonacs R
Can J Psychiatry 2002 Jun;47(5):426-36. doi: 10.1177/070674370204700503. PMID: 12085677

Clinical prediction guides

When should we prescribe high-dose folic acid to prevent congenital heart defects?
Huhta JC, Linask K
Curr Opin Cardiol 2015 Jan;30(1):125-31. doi: 10.1097/HCO.0000000000000124. PMID: 25389654
QT alterations in psychopharmacology: proven candidates and suspects.
Alvarez PA, Pahissa J
Curr Drug Saf 2010 Jan;5(1):97-104. doi: 10.2174/157488610789869265. PMID: 20210726
Teratogenesis associated with antibipolar agents.
Nguyen HT, Sharma V, McIntyre RS
Adv Ther 2009 Mar;26(3):281-94. Epub 2009 Mar 28 doi: 10.1007/s12325-009-0011-z. PMID: 19330496
The use of psychiatric drugs in pregnancy and lactation.
Arnon J, Shechtman S, Ornoy A
Isr J Psychiatry Relat Sci 2000;37(3):205-22. PMID: 11084808
A reevaluation of risk of in utero exposure to lithium.
Cohen LS, Friedman JM, Jefferson JW, Johnson EM, Weiner ML
JAMA 1994 Jan 12;271(2):146-50. PMID: 8031346

Recent systematic reviews

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes.
Fornaro M, Maritan E, Ferranti R, Zaninotto L, Miola A, Anastasia A, Murru A, Solé E, Stubbs B, Carvalho AF, Serretti A, Vieta E, Fusar-Poli P, McGuire P, Young AH, Dazzan P, Vigod SN, Correll CU, Solmi M
Am J Psychiatry 2020 Jan 1;177(1):76-92. Epub 2019 Oct 18 doi: 10.1176/appi.ajp.2019.19030228. PMID: 31623458
Psychotropics in pregnancy: safety and other considerations.
Oyebode F, Rastogi A, Berrisford G, Coccia F
Pharmacol Ther 2012 Jul;135(1):71-7. Epub 2012 Mar 28 doi: 10.1016/j.pharmthera.2012.03.008. PMID: 22483705
Mood stabilizers in pregnancy: a systematic review.
Galbally M, Roberts M, Buist A; Perinatal Psychotropic Review Group
Aust N Z J Psychiatry 2010 Nov;44(11):967-77. doi: 10.3109/00048674.2010.506637. PMID: 21034180

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