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Recurrent spontaneous abortion

MedGen UID:
481069
•Concept ID:
C3279439
•
Finding; Pathologic Function
Synonym: Spontaneous abortion, recurrent
 
HPO: HP:0200067

Definition

Repeated episodes of abortion (Expulsion of the product of fertilization before completing the term of gestation) without deliberate interference. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent spontaneous abortion

Professional guidelines

PubMed

Management of Asherman's syndrome.
March CM
Reprod Biomed Online 2011 Jul;23(1):63-76. Epub 2010 Dec 4 doi: 10.1016/j.rbmo.2010.11.018. PMID: 21549641
Pathogenesis, diagnosis, and treatment of recurrent spontaneous abortion with immune type.
Lin QD, Qiu LH
Front Med China 2010 Sep;4(3):275-9. Epub 2010 Aug 10 doi: 10.1007/s11684-010-0101-y. PMID: 21191831
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027

Recent clinical studies

Etiology

Engineered extracellular vesicles in female reproductive disorders.
Zhang M, Xing J, Zhao S, Chen H, Yin X, Zhu X
Biomed Pharmacother 2023 Oct;166:115284. Epub 2023 Aug 10 doi: 10.1016/j.biopha.2023.115284. PMID: 37572637
Recent Advances in Treatment of Recurrent Spontaneous Abortion.
Deng T, Liao X, Zhu S
Obstet Gynecol Surv 2022 Jun;77(6):355-366. doi: 10.1097/OGX.0000000000001033. PMID: 35672876Free PMC Article
Inhibition of HMGB1 Ameliorates the Maternal-Fetal Interface Destruction in Unexplained Recurrent Spontaneous Abortion by Suppressing Pyroptosis Activation.
Zhu D, Zou H, Liu J, Wang J, Ma C, Yin J, Peng X, Li D, Yang Y, Ren Y, Zhang Z, Zhou P, Wang X, Cao Y, Xu X
Front Immunol 2021;12:782792. Epub 2021 Dec 23 doi: 10.3389/fimmu.2021.782792. PMID: 35003098Free PMC Article
Meta-analysis: association of homocysteine with recurrent spontaneous abortion.
Li J, Feng D, He S, Wu Q, Su Z, Ye H
Women Health 2021 Aug;61(7):713-720. Epub 2021 Aug 1 doi: 10.1080/03630242.2021.1957747. PMID: 34334120
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027

Diagnosis

Coenzyme Q10 Stimulate Reproductive Vatality.
Nie X, Dong X, Hu Y, Xu F, Hu C, Shu C
Drug Des Devel Ther 2023;17:2623-2637. Epub 2023 Aug 30 doi: 10.2147/DDDT.S386974. PMID: 37667786Free PMC Article
Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface.
Yang F, Zheng Q, Jin L
Front Immunol 2019;10:2317. Epub 2019 Oct 18 doi: 10.3389/fimmu.2019.02317. PMID: 31681264Free PMC Article
Asherman's syndrome.
March CM
Semin Reprod Med 2011 Mar;29(2):83-94. Epub 2011 Mar 24 doi: 10.1055/s-0031-1272470. PMID: 21437822
Management of spontaneous abortion.
Griebel CP, Halvorsen J, Golemon TB, Day AA
Am Fam Physician 2005 Oct 1;72(7):1243-50. PMID: 16225027
Recurrent spontaneous abortion.
McIntyre JA, Coulam CB, Faulk WP
Am J Reprod Immunol 1989 Nov-Dec;21(3-4):100-4. doi: 10.1111/j.1600-0897.1989.tb01011.x. PMID: 2534830

Therapy

Common mental disorders and risk of spontaneous abortion or recurrent spontaneous abortion: A two-sample Mendelian randomization study.
He Y, Wang L, Tang R, Jin H, Liu B, Chen S, Mu H, Wang X
J Affect Disord 2024 Jun 1;354:258-266. Epub 2024 Mar 13 doi: 10.1016/j.jad.2024.03.026. PMID: 38484879
Efficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis.
Fu LL, Xu Y, Yan J, Zhang XY, Li DD, Zheng LW
Reprod Biol Endocrinol 2023 Apr 3;21(1):34. doi: 10.1186/s12958-023-01063-z. PMID: 37013570Free PMC Article
Inhibition of HMGB1 Ameliorates the Maternal-Fetal Interface Destruction in Unexplained Recurrent Spontaneous Abortion by Suppressing Pyroptosis Activation.
Zhu D, Zou H, Liu J, Wang J, Ma C, Yin J, Peng X, Li D, Yang Y, Ren Y, Zhang Z, Zhou P, Wang X, Cao Y, Xu X
Front Immunol 2021;12:782792. Epub 2021 Dec 23 doi: 10.3389/fimmu.2021.782792. PMID: 35003098Free PMC Article
Asherman's syndrome.
March CM
Semin Reprod Med 2011 Mar;29(2):83-94. Epub 2011 Mar 24 doi: 10.1055/s-0031-1272470. PMID: 21437822
Recurrent spontaneous abortion.
McIntyre JA, Coulam CB, Faulk WP
Am J Reprod Immunol 1989 Nov-Dec;21(3-4):100-4. doi: 10.1111/j.1600-0897.1989.tb01011.x. PMID: 2534830

Prognosis

Is there an association between recurrent spontaneous abortion and mycoplasma infection?
Yu J, Yu S, Zhu L, Sun X, Lu B, Li J, Hu Y, Li P
J Infect Dev Ctries 2022 Aug 30;16(8):1302-1307. doi: 10.3855/jidc.15134. PMID: 36099373
Recent Advances in Treatment of Recurrent Spontaneous Abortion.
Deng T, Liao X, Zhu S
Obstet Gynecol Surv 2022 Jun;77(6):355-366. doi: 10.1097/OGX.0000000000001033. PMID: 35672876Free PMC Article
The relationship between semen factors and unexplained recurrent spontaneous abortion.
Zhang X, Wang H, Feng T, Yang J, Huang Q, Lu C, Guan Y, Sun R, Chen M, Qian Y
Clin Chim Acta 2020 Nov;510:605-612. Epub 2020 Aug 20 doi: 10.1016/j.cca.2020.08.022. PMID: 32827532
Insights of efferocytosis in normal and pathological pregnancy.
Sheng YR, Hu WT, Wei CY, Tang LL, Liu YK, Liu YY, Qiu JP, Li DJ, Zhu XY
Am J Reprod Immunol 2019 Aug;82(2):e13088. Epub 2019 Jun 21 doi: 10.1111/aji.13088. PMID: 30614132
Genetic regulation of recurrent spontaneous abortion in humans.
Vaiman D
Biomed J 2015 Jan-Feb;38(1):11-24. doi: 10.4103/2319-4170.133777. PMID: 25179715

Clinical prediction guides

Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.
Chen X, Song QL, Wang JY, Ji R, Li ZH, Cao ML, Mu XF, Guo DY, Zhang Y, Yang J
Am J Pathol 2023 Aug;193(8):1059-1071. Epub 2023 May 8 doi: 10.1016/j.ajpath.2023.04.008. PMID: 37164274
Role of kisspeptin in decidualization and unexplained recurrent spontaneous abortion via the ERK1/2 signalling pathway.
Zhang S, Xiao Y, Wang Y, Qian C, Zhang R, Liu J, Wang Q, Zhang H
Placenta 2023 Mar 3;133:1-9. Epub 2023 Jan 13 doi: 10.1016/j.placenta.2023.01.006. PMID: 36680818
Is there an association between recurrent spontaneous abortion and mycoplasma infection?
Yu J, Yu S, Zhu L, Sun X, Lu B, Li J, Hu Y, Li P
J Infect Dev Ctries 2022 Aug 30;16(8):1302-1307. doi: 10.3855/jidc.15134. PMID: 36099373
Recent Advances in Treatment of Recurrent Spontaneous Abortion.
Deng T, Liao X, Zhu S
Obstet Gynecol Surv 2022 Jun;77(6):355-366. doi: 10.1097/OGX.0000000000001033. PMID: 35672876Free PMC Article
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.
Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nat Commun 2021 Jun 8;12(1):3428. doi: 10.1038/s41467-021-23827-0. PMID: 34103526Free PMC Article

Recent systematic reviews

Efficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis.
Fu LL, Xu Y, Yan J, Zhang XY, Li DD, Zheng LW
Reprod Biol Endocrinol 2023 Apr 3;21(1):34. doi: 10.1186/s12958-023-01063-z. PMID: 37013570Free PMC Article
Decidual macrophages in recurrent spontaneous abortion.
Zhao QY, Li QH, Fu YY, Ren CE, Jiang AF, Meng YH
Front Immunol 2022;13:994888. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.994888. PMID: 36569856Free PMC Article
Efficacy of intravenous immunoglobulin in the treatment of recurrent spontaneous abortion: A systematic review and meta-analysis.
Shi Y, Tan D, Hao B, Zhang X, Geng W, Wang Y, Sun J, Zhao Y
Am J Reprod Immunol 2022 Nov;88(5):e13615. Epub 2022 Aug 30 doi: 10.1111/aji.13615. PMID: 36029201Free PMC Article
Recurrent Spontaneous Abortion (RSA) and Maternal KIR Genes: A Comprehensive Meta-Analysis.
Akbari S, Shahsavar F, Karami R, Yari F, Anbari K, Ahmadi SAY
JBRA Assist Reprod 2020 May 1;24(2):197-213. doi: 10.5935/1518-0557.20190067. PMID: 32049474Free PMC Article
Systematic review and meta-analysis of genetic association studies in idiopathic recurrent spontaneous abortion.
Pereza N, Ostojić S, Kapović M, Peterlin B
Fertil Steril 2017 Jan;107(1):150-159.e2. Epub 2016 Nov 11 doi: 10.1016/j.fertnstert.2016.10.007. PMID: 27842992

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      Clinical tests in GTR
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