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Cardiogenic shock

MedGen UID:
48650
Concept ID:
C0036980
Pathologic Function
Synonyms: Cardiogenic Shock; Shock, Cardiogenic
SNOMED CT: Cardiogenic shock (89138009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0030149
Monarch Initiative: MONDO:0800175
Orphanet: ORPHA97292

Definition

Severely decreased cardiac output with evidence of inadequate end-organ perfusion (i.e., tissue hypoxia) in the presence of adequate intravascular volume. [from HPO]

Term Hierarchy

Conditions with this feature

Dilated cardiomyopathy 1GG
MedGen UID:
462248
Concept ID:
C3150898
Disease or Syndrome
Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the SDHA gene.
Arterial calcification, generalized, of infancy, 2
MedGen UID:
477791
Concept ID:
C3276161
Disease or Syndrome
Generalized arterial calcification of infancy (GACI) is characterized by infantile onset of widespread arterial calcification and/or narrowing of large and medium-sized vessels resulting in cardiovascular findings (which can include heart failure, respiratory distress, edema, cyanosis, hypertension, and/or cardiomegaly). Additional findings can include typical skin and retinal manifestations of pseudoxanthoma elasticum (PXE), periarticular calcifications, development of rickets after infancy, cervical spine fusion, and hearing loss. While mortality in infancy is high, survival into the third and fourth decades has occurred.
Cardiomyopathy, dilated, 2D
MedGen UID:
1782612
Concept ID:
C5543535
Disease or Syndrome
Dilated cardiomyopathy-2D (CMD2D) is characterized by neonatal onset of severe cardiomyopathy, with rapid progression to cardiac decompensation and death unless the patient undergoes heart transplantation (Ganapathi et al., 2020). For a general phenotypic description and a discussion of genetic heterogeneity of dilated cardiomyopathy, see 115200.
Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathy
MedGen UID:
1794147
Concept ID:
C5561937
Disease or Syndrome
Infantile-onset myofibrillar myopathy-12 with cardiomyopathy (MFM12) is a severe autosomal recessive disorder affecting both skeletal and cardiac muscle tissue that is apparent in the first weeks of life. Affected infants show tremor or clonus at birth, followed by onset of rapidly progressive generalized muscle weakness and dilated cardiomyopathy and cardiac failure, usually resulting in death by 6 months of age. Skeletal and cardiac muscle tissues show hypotrophy of type I muscle fibers and evidence of myofibrillar disorganization (summary by Weterman et al., 2013). For a discussion of genetic heterogeneity of myofibrillar myopathy, see MFM1 (601419).
Cardiomyopathy, dilated, 2G
MedGen UID:
1801983
Concept ID:
C5676995
Disease or Syndrome
Dilated cardiomyopathy-2G (CMD2G) is characterized by early-onset severe dilated cardiomyopathy that progresses rapidly to heart failure in the neonatal period without evidence of intervening hypertrophy. Cardiac tissue exhibits markedly shortened thin filaments, disorganized myofibrils, and reduced contractile force generation, resulting in the severe ventricular dysfunction observed. There is no evidence of skeletal muscle hypertrophy (Ahrens-Nicklas et al., 2019). For a general phenotypic description and a discussion of genetic heterogeneity of dilated cardiomyopathy, see 115200.

Professional guidelines

PubMed

Jentzer JC, Pöss J, Schaubroeck H, Morrow DA, Hollenberg SM, Mebazaa A
Crit Care Med 2023 Sep 1;51(9):1222-1233. Epub 2023 May 15 doi: 10.1097/CCM.0000000000005919. PMID: 37184336
Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW
Circulation 2022 May 3;145(18):e876-e894. Epub 2022 Apr 1 doi: 10.1161/CIR.0000000000001062. PMID: 35363500
Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW
Circulation 2022 May 3;145(18):e895-e1032. Epub 2022 Apr 1 doi: 10.1161/CIR.0000000000001063. PMID: 35363499

Recent clinical studies

Etiology

Bloom JE, Chan W, Kaye DM, Stub D
J Am Heart Assoc 2023 Aug;12(15):e029787. Epub 2023 Jul 25 doi: 10.1161/JAHA.123.029787. PMID: 37489740Free PMC Article
Samsky MD, Morrow DA, Proudfoot AG, Hochman JS, Thiele H, Rao SV
JAMA 2021 Nov 9;326(18):1840-1850. doi: 10.1001/jama.2021.18323. PMID: 34751704Free PMC Article
Kapur NK, Thayer KL, Zweck E
Methodist Debakey Cardiovasc J 2020 Jan-Mar;16(1):16-21. doi: 10.14797/mdcj-16-1-16. PMID: 32280413Free PMC Article
Brener MI, Rosenblum HR, Burkhoff D
Methodist Debakey Cardiovasc J 2020 Jan-Mar;16(1):7-15. doi: 10.14797/mdcj-16-1-7. PMID: 32280412Free PMC Article
van Diepen S, Katz JN, Albert NM, Henry TD, Jacobs AK, Kapur NK, Kilic A, Menon V, Ohman EM, Sweitzer NK, Thiele H, Washam JB, Cohen MG; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Mission: Lifeline
Circulation 2017 Oct 17;136(16):e232-e268. Epub 2017 Sep 18 doi: 10.1161/CIR.0000000000000525. PMID: 28923988

Diagnosis

Sarma D, Jentzer JC
Crit Care Clin 2024 Jan;40(1):37-56. Epub 2023 Jul 6 doi: 10.1016/j.ccc.2023.05.001. PMID: 37973356
VanDyck TJ, Pinsky MR
Curr Opin Crit Care 2021 Aug 1;27(4):454-459. doi: 10.1097/MCC.0000000000000838. PMID: 33967209Free PMC Article
Tehrani BN, Truesdell AG, Psotka MA, Rosner C, Singh R, Sinha SS, Damluji AA, Batchelor WB
JACC Heart Fail 2020 Nov;8(11):879-891. doi: 10.1016/j.jchf.2020.09.005. PMID: 33121700Free PMC Article
Tewelde SZ, Liu SS, Winters ME
Cardiol Clin 2018 Feb;36(1):53-61. doi: 10.1016/j.ccl.2017.08.009. PMID: 29173681
van Diepen S, Katz JN, Albert NM, Henry TD, Jacobs AK, Kapur NK, Kilic A, Menon V, Ohman EM, Sweitzer NK, Thiele H, Washam JB, Cohen MG; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Mission: Lifeline
Circulation 2017 Oct 17;136(16):e232-e268. Epub 2017 Sep 18 doi: 10.1161/CIR.0000000000000525. PMID: 28923988

Therapy

Ostadal P, Rokyta R, Karasek J, Kruger A, Vondrakova D, Janotka M, Naar J, Smalcova J, Hubatova M, Hromadka M, Volovar S, Seyfrydova M, Jarkovsky J, Svoboda M, Linhart A, Belohlavek J; ECMO-CS Investigators
Circulation 2023 Feb 7;147(6):454-464. Epub 2022 Nov 6 doi: 10.1161/CIRCULATIONAHA.122.062949. PMID: 36335478
Samsky MD, Morrow DA, Proudfoot AG, Hochman JS, Thiele H, Rao SV
JAMA 2021 Nov 9;326(18):1840-1850. doi: 10.1001/jama.2021.18323. PMID: 34751704Free PMC Article
Levy B, Buzon J, Kimmoun A
Curr Opin Crit Care 2019 Aug;25(4):384-390. doi: 10.1097/MCC.0000000000000632. PMID: 31166204
Maack C, Eschenhagen T, Hamdani N, Heinzel FR, Lyon AR, Manstein DJ, Metzger J, Papp Z, Tocchetti CG, Yilmaz MB, Anker SD, Balligand JL, Bauersachs J, Brutsaert D, Carrier L, Chlopicki S, Cleland JG, de Boer RA, Dietl A, Fischmeister R, Harjola VP, Heymans S, Hilfiker-Kleiner D, Holzmeister J, de Keulenaer G, Limongelli G, Linke WA, Lund LH, Masip J, Metra M, Mueller C, Pieske B, Ponikowski P, Ristić A, Ruschitzka F, Seferović PM, Skouri H, Zimmermann WH, Mebazaa A
Eur Heart J 2019 Nov 21;40(44):3626-3644. doi: 10.1093/eurheartj/ehy600. PMID: 30295807Free PMC Article
De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL; SOAP II Investigators
N Engl J Med 2010 Mar 4;362(9):779-89. doi: 10.1056/NEJMoa0907118. PMID: 20200382

Prognosis

Hill KL, Rustin MA, Asche MA, Bennett CE, Patel PC, Jentzer JC
Mayo Clin Proc 2023 May;98(5):771-783. Epub 2023 Apr 5 doi: 10.1016/j.mayocp.2022.12.007. PMID: 37028976
Palacios Ordonez C, Garan AR
Curr Opin Cardiol 2022 May 1;37(3):236-240. Epub 2022 Mar 11 doi: 10.1097/HCO.0000000000000957. PMID: 35275890
Garan AR, Kanwar M, Thayer KL, Whitehead E, Zweck E, Hernandez-Montfort J, Mahr C, Haywood JL, Harwani NM, Wencker D, Sinha SS, Vorovich E, Abraham J, O'Neill W, Burkhoff D, Kapur NK
JACC Heart Fail 2020 Nov;8(11):903-913. doi: 10.1016/j.jchf.2020.08.012. PMID: 33121702
Iborra-Egea O, Rueda F, García-García C, Borràs E, Sabidó E, Bayes-Genis A
Eur Heart J 2020 Oct 14;41(39):3839-3848. doi: 10.1093/eurheartj/ehz783. PMID: 31722370
Hollenberg SM, Kavinsky CJ, Parrillo JE
Ann Intern Med 1999 Jul 6;131(1):47-59. doi: 10.7326/0003-4819-131-1-199907060-00010. PMID: 10391815

Clinical prediction guides

Kapur NK, Thayer KL, Zweck E
Methodist Debakey Cardiovasc J 2020 Jan-Mar;16(1):16-21. doi: 10.14797/mdcj-16-1-16. PMID: 32280413Free PMC Article
Brener MI, Rosenblum HR, Burkhoff D
Methodist Debakey Cardiovasc J 2020 Jan-Mar;16(1):7-15. doi: 10.14797/mdcj-16-1-7. PMID: 32280412Free PMC Article
Tehrani BN, Truesdell AG, Sherwood MW, Desai S, Tran HA, Epps KC, Singh R, Psotka M, Shah P, Cooper LB, Rosner C, Raja A, Barnett SD, Saulino P, deFilippi CR, Gurbel PA, Murphy CE, O'Connor CM
J Am Coll Cardiol 2019 Apr 9;73(13):1659-1669. doi: 10.1016/j.jacc.2018.12.084. PMID: 30947919
van Diepen S, Katz JN, Albert NM, Henry TD, Jacobs AK, Kapur NK, Kilic A, Menon V, Ohman EM, Sweitzer NK, Thiele H, Washam JB, Cohen MG; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Mission: Lifeline
Circulation 2017 Oct 17;136(16):e232-e268. Epub 2017 Sep 18 doi: 10.1161/CIR.0000000000000525. PMID: 28923988
Harjola VP, Lassus J, Sionis A, Køber L, Tarvasmäki T, Spinar J, Parissis J, Banaszewski M, Silva-Cardoso J, Carubelli V, Di Somma S, Tolppanen H, Zeymer U, Thiele H, Nieminen MS, Mebazaa A; CardShock Study Investigators; GREAT network
Eur J Heart Fail 2015 May;17(5):501-9. Epub 2015 Mar 28 doi: 10.1002/ejhf.260. PMID: 25820680

Recent systematic reviews

Yoshida T, Yoshida T, Noma H, Nomura T, Suzuki A, Mihara T
Crit Care 2023 May 25;27(1):200. doi: 10.1186/s13054-023-04495-6. PMID: 37231510Free PMC Article
Yasmin F, Najeeb H, Naeem U, Moeed A, Atif AR, Asghar MS, Nimri N, Saleem M, Bandyopadhyay D, Krittanawong C, Fadelallah Eljack MM, Tahir MJ, Waqar F
Immun Inflamm Dis 2023 Mar;11(3):e807. doi: 10.1002/iid3.807. PMID: 36988252Free PMC Article
Araiza-Garaygordobil D, García-Martínez CE, Burgos LM, Saldarriaga C, Liblik K, Mendoza I, Martinez-Selles M, Scatularo CE, Farina JM, Baranchuk A; Neglected Tropical Diseases and other Infectious Diseases affecting the Heart (the NET‐Heart) project
Cardiovasc J Afr 2021 Sep-Oct 23;32(5):276-283. Epub 2021 Jul 20 doi: 10.5830/CVJA-2021-033. PMID: 34292294Free PMC Article
Schumann J, Henrich EC, Strobl H, Prondzinsky R, Weiche S, Thiele H, Werdan K, Frantz S, Unverzagt S
Cochrane Database Syst Rev 2018 Jan 29;1(1):CD009669. doi: 10.1002/14651858.CD009669.pub3. PMID: 29376560Free PMC Article
Ouweneel DM, Schotborgh JV, Limpens J, Sjauw KD, Engström AE, Lagrand WK, Cherpanath TGV, Driessen AHG, de Mol BAJM, Henriques JPS
Intensive Care Med 2016 Dec;42(12):1922-1934. Epub 2016 Sep 19 doi: 10.1007/s00134-016-4536-8. PMID: 27647331Free PMC Article

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