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Breastfeeding Jaundice

MedGen UID:
502506
•Concept ID:
C3502107
•
Disease or Syndrome

Definition

Yellow coloring of skin, mucous membranes and eyes in an otherwise healthy breast-fed newborn due to insufficient intake of maternally-expressed milk. It commonly appears four to seven days after birth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreastfeeding Jaundice

Professional guidelines

PubMed

A quality project to improve compliance with AAP guidelines for inpatient management of neonatal hyperbilirubinemia.
Tartaglia KM, Campbell J, Shaniuk P, McClead RE
Hosp Pediatr 2013 Jul;3(3):251-7. doi: 10.1542/hpeds.2012-0103. PMID: 24313095

Recent clinical studies

Etiology

Is hyperbilirubinemia a contraindication for neonatal circumcision? A survey of practice patterns of pediatric urologists and a review of the literature.
Huen KH, Fong C, Roach G, Singer J
J Pediatr Urol 2021 Feb;17(1):88.e1-88.e6. Epub 2020 Oct 10 doi: 10.1016/j.jpurol.2020.10.008. PMID: 33268314
Association of serum bilirubin in newborns affected by jaundice with gut microbiota dysbiosis.
Zhou S, Wang Z, He F, Qiu H, Wang Y, Wang H, Zhou J, Zhou J, Cheng G, Zhou W, Xu R, Wang M
J Nutr Biochem 2019 Jan;63:54-61. Epub 2018 Sep 26 doi: 10.1016/j.jnutbio.2018.09.016. PMID: 30342317
The Association of Breastfeeding Practices with Neonatal Jaundice.
Ketsuwan S, Baiya N, Maelhacharoenporn K, Puapornpong P
J Med Assoc Thai 2017 Mar;100(3):255-61. PMID: 29911780
Neonatal jaundice and human milk.
Soldi A, Tonetto P, Varalda A, Bertino E
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:85-7. doi: 10.3109/14767058.2011.607612. PMID: 21942599
Breastfeeding and jaundice.
Gartner LM
J Perinatol 2001 Dec;21 Suppl 1:S25-9; discussion S35-9. doi: 10.1038/sj.jp.7210629. PMID: 11803412

Diagnosis

Gestational Age-Specific Nomogram of Transcutaneous Bilirubin in First 120 h of Life for Term and Late Preterm Indian Neonates.
Shaw SC, Negi V, Bhat V, Kumar A, Joshi RK, Venkatnarayan K, Gupta R, Kunwar BRB, Gopalakrishnan S, Tewari VV, Kanitkar M
J Trop Pediatr 2022 Jun 6;68(4) doi: 10.1093/tropej/fmac047. PMID: 35666181
Association of serum bilirubin in newborns affected by jaundice with gut microbiota dysbiosis.
Zhou S, Wang Z, He F, Qiu H, Wang Y, Wang H, Zhou J, Zhou J, Cheng G, Zhou W, Xu R, Wang M
J Nutr Biochem 2019 Jan;63:54-61. Epub 2018 Sep 26 doi: 10.1016/j.jnutbio.2018.09.016. PMID: 30342317
Neonatal jaundice and human milk.
Soldi A, Tonetto P, Varalda A, Bertino E
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:85-7. doi: 10.3109/14767058.2011.607612. PMID: 21942599
Breastfeeding and jaundice.
Gartner LM
J Perinatol 2001 Dec;21 Suppl 1:S25-9; discussion S35-9. doi: 10.1038/sj.jp.7210629. PMID: 11803412
Breastfeeding and breast milk jaundice.
Leung AK, Sauve RS
J R Soc Health 1989 Dec;109(6):213-7. doi: 10.1177/146642408910900615. PMID: 2513410

Therapy

Association of breast-fed neonatal hyperbilirubinemia with UGT1A1 polymorphisms: 211G>A (G71R) mutation becomes a risk factor under inadequate feeding.
Sato H, Uchida T, Toyota K, Kanno M, Hashimoto T, Watanabe M, Nakamura T, Tamiya G, Aoki K, Hayasaka K
J Hum Genet 2013 Jan;58(1):7-10. Epub 2012 Sep 27 doi: 10.1038/jhg.2012.116. PMID: 23014115
Neonatal jaundice and human milk.
Soldi A, Tonetto P, Varalda A, Bertino E
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:85-7. doi: 10.3109/14767058.2011.607612. PMID: 21942599
211 G to a variation of UDP-glucuronosyl transferase 1A1 gene and neonatal breastfeeding jaundice.
Chou HC, Chen MH, Yang HI, Su YN, Hsieh WS, Chen CY, Chen HL, Chang MH, Tsao PN
Pediatr Res 2011 Feb;69(2):170-4. doi: 10.1203/PDR.0b013e31820263d2. PMID: 20975617
Breastfeeding and jaundice.
Gartner LM
J Perinatol 2001 Dec;21 Suppl 1:S25-9; discussion S35-9. doi: 10.1038/sj.jp.7210629. PMID: 11803412
Serum bilirubin levels at 72 hours by selected characteristics in breastfed and formula-fed term infants delivered by cesarean section.
Hintz SR, Gaylord TD, Oh W, Fanaroff AA, Mele L, Stevenson DK, Nichd FT; NICHD, Neonatal Research Network
Acta Paediatr 2001 Jul;90(7):776-81. PMID: 11519981

Prognosis

Effect of Early Skin-to-Skin Contact to Breast Milk Volume and Breastfeeding Jaundice at 48 Hours after Delivery.
Hemachandra A, Puapornpong P, Ketsuwan S, Imchit C
J Med Assoc Thai 2016 Nov;99 Suppl 8:S63-S69. PMID: 29901914
Association of breast-fed neonatal hyperbilirubinemia with UGT1A1 polymorphisms: 211G>A (G71R) mutation becomes a risk factor under inadequate feeding.
Sato H, Uchida T, Toyota K, Kanno M, Hashimoto T, Watanabe M, Nakamura T, Tamiya G, Aoki K, Hayasaka K
J Hum Genet 2013 Jan;58(1):7-10. Epub 2012 Sep 27 doi: 10.1038/jhg.2012.116. PMID: 23014115
Prolonged jaundice in neonates.
Paul SP, Hall V, Taylor TM
Pract Midwife 2012 Jun;15(6):14-7. PMID: 22860353

Clinical prediction guides

The Association of Breastfeeding Practices with Neonatal Jaundice.
Ketsuwan S, Baiya N, Maelhacharoenporn K, Puapornpong P
J Med Assoc Thai 2017 Mar;100(3):255-61. PMID: 29911780
A quality project to improve compliance with AAP guidelines for inpatient management of neonatal hyperbilirubinemia.
Tartaglia KM, Campbell J, Shaniuk P, McClead RE
Hosp Pediatr 2013 Jul;3(3):251-7. doi: 10.1542/hpeds.2012-0103. PMID: 24313095
Development of icterus gravis in a preterm infant with G71R UGT1A1 polymorphism.
Kaga A, Ohkubo Y, Watanabe Y, Saito S, Matsuki T, Usuda H, Kanda S, Suzuki Y, Tanabu M, Kure S
BMC Res Notes 2013 Feb 6;6:51. doi: 10.1186/1756-0500-6-51. PMID: 23388413Free PMC Article
Differential risk for early breastfeeding jaundice in a multi-ethnic Asian cohort.
Huang A, Tai BC, Wong LY, Lee J, Yong EL
Ann Acad Med Singap 2009 Mar;38(3):217-24. PMID: 19347075
Serum bilirubin levels at 72 hours by selected characteristics in breastfed and formula-fed term infants delivered by cesarean section.
Hintz SR, Gaylord TD, Oh W, Fanaroff AA, Mele L, Stevenson DK, Nichd FT; NICHD, Neonatal Research Network
Acta Paediatr 2001 Jul;90(7):776-81. PMID: 11519981

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