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Obstructive nephropathy

MedGen UID:
508456
•Concept ID:
C0149939
•
Disease or Syndrome
Synonyms: congenital obstructive nephropathy; Obstructive Nephropathy; obstructive nephropathy
SNOMED CT: Obstructive nephropathy (86249007)
 
Monarch Initiative: MONDO:0056796

Definition

Renal damage and impaired renal function secondary to urinary tract obstruction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVObstructive nephropathy

Professional guidelines

PubMed

GENETICS IN ENDOCRINOLOGY Pathophysiology, diagnosis and treatment of familial nephrogenic diabetes insipidus.
Bichet DG
Eur J Endocrinol 2020 Aug;183(2):R29-R40. doi: 10.1530/EJE-20-0114. PMID: 32580146
Crystal arthritides - gout and calcium pyrophosphate arthritis : Part 2: clinical features, diagnosis and differential diagnostics.
Schlee S, Bollheimer LC, Bertsch T, Sieber CC, Härle P
Z Gerontol Geriatr 2018 Jul;51(5):579-584. Epub 2017 Feb 23 doi: 10.1007/s00391-017-1198-2. PMID: 28233118
Renal and urologic problems: management of ureteric obstruction.
Liberman D, McCormack M
Curr Opin Support Palliat Care 2012 Sep;6(3):316-21. doi: 10.1097/SPC.0b013e328354a1d8. PMID: 22643703

Recent clinical studies

Etiology

COL28 promotes proliferation, migration, and EMT of renal tubular epithelial cells.
Li L, Ye H, Chen Q, Wei L
Ren Fail 2023 Dec;45(1):2187236. doi: 10.1080/0886022X.2023.2187236. PMID: 36883360Free PMC Article
Ultrasound and color Doppler applications in chronic kidney disease.
Petrucci I, Clementi A, Sessa C, Torrisi I, Meola M
J Nephrol 2018 Dec;31(6):863-879. Epub 2018 Sep 6 doi: 10.1007/s40620-018-0531-1. PMID: 30191413
Prognostic factors and biomarkers of congenital obstructive nephropathy.
Chevalier RL
Pediatr Nephrol 2016 Sep;31(9):1411-20. Epub 2015 Dec 14 doi: 10.1007/s00467-015-3291-3. PMID: 26667236
Acute and chronic kidney injury in nephrolithiasis.
Tang X, Lieske JC
Curr Opin Nephrol Hypertens 2014 Jul;23(4):385-90. doi: 10.1097/01.mnh.0000447017.28852.52. PMID: 24848936Free PMC Article
Current perspectives on congenital obstructive nephropathy.
Ingraham SE, McHugh KM
Pediatr Nephrol 2011 Sep;26(9):1453-61. Epub 2011 Feb 17 doi: 10.1007/s00467-011-1799-8. PMID: 21327776

Diagnosis

Immunoglobulin G4-Related Kidney Disease.
Grati R, Ariba YB, Labidi J
Saudi J Kidney Dis Transpl 2022 Jan-Feb;33(1):175-184. doi: 10.4103/1319-2442.367812. PMID: 36647992
Symmetric nephromegaly.
Shen CL, Pan CC, Yang CY
Clin Exp Nephrol 2019 Mar;23(3):427-428. Epub 2018 Sep 3 doi: 10.1007/s10157-018-1640-9. PMID: 30178235
Prognostic factors and biomarkers of congenital obstructive nephropathy.
Chevalier RL
Pediatr Nephrol 2016 Sep;31(9):1411-20. Epub 2015 Dec 14 doi: 10.1007/s00467-015-3291-3. PMID: 26667236
Development of the kidney medulla.
Song R, Yosypiv IV
Organogenesis 2012 Jan-Mar;8(1):10-7. Epub 2012 Jan 1 doi: 10.4161/org.19308. PMID: 22343825Free PMC Article
Drug-induced renal disease.
Curtis JR
Drugs 1979 Nov;18(5):377-91. doi: 10.2165/00003495-197918050-00003. PMID: 389601

Therapy

Mechanisms of antimicrobial-induced nephrotoxicity in children.
Downes KJ, Hayes M, Fitzgerald JC, Pais GM, Liu J, Zane NR, Goldstein SL, Scheetz MH, Zuppa AF
J Antimicrob Chemother 2020 Jan 1;75(1):1-13. doi: 10.1093/jac/dkz325. PMID: 31369087Free PMC Article
Petchiether A attenuates obstructive nephropathy by suppressing TGF-β/Smad3 and NF-κB signalling.
You YK, Luo Q, Wu WF, Zhang JJ, Zhu HJ, Lao L, Lan HY, Chen HY, Cheng YX
J Cell Mol Med 2019 Aug;23(8):5576-5587. Epub 2019 Jun 18 doi: 10.1111/jcmm.14454. PMID: 31211499Free PMC Article
Antiretroviral medications: adverse effects on the kidney.
Jao J, Wyatt CM
Adv Chronic Kidney Dis 2010 Jan;17(1):72-82. doi: 10.1053/j.ackd.2009.07.009. PMID: 20005491
Obstructive nephropathy.
Klahr S
Intern Med 2000 May;39(5):355-61. doi: 10.2169/internalmedicine.39.355. PMID: 10830173
Drug-induced renal disease.
Curtis JR
Drugs 1979 Nov;18(5):377-91. doi: 10.2165/00003495-197918050-00003. PMID: 389601

Prognosis

Immunoglobulin G4-Related Kidney Disease.
Grati R, Ariba YB, Labidi J
Saudi J Kidney Dis Transpl 2022 Jan-Feb;33(1):175-184. doi: 10.4103/1319-2442.367812. PMID: 36647992
Ultrasound and color Doppler applications in chronic kidney disease.
Petrucci I, Clementi A, Sessa C, Torrisi I, Meola M
J Nephrol 2018 Dec;31(6):863-879. Epub 2018 Sep 6 doi: 10.1007/s40620-018-0531-1. PMID: 30191413
Prognostic factors and biomarkers of congenital obstructive nephropathy.
Chevalier RL
Pediatr Nephrol 2016 Sep;31(9):1411-20. Epub 2015 Dec 14 doi: 10.1007/s00467-015-3291-3. PMID: 26667236
Obstructive uropathy.
Truong LD, Gaber L, Eknoyan G
Contrib Nephrol 2011;169:311-326. Epub 2011 Jan 20 doi: 10.1159/000314578. PMID: 21252529
Urinary tract obstruction.
Klahr S
Semin Nephrol 2001 Mar;21(2):133-45. doi: 10.1053/snep.2001.20942. PMID: 11245776

Clinical prediction guides

Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments.
Martínez-Klimova E, Aparicio-Trejo OE, Tapia E, Pedraza-Chaverri J
Biomolecules 2019 Apr 8;9(4) doi: 10.3390/biom9040141. PMID: 30965656Free PMC Article
Ultrasound and color Doppler applications in chronic kidney disease.
Petrucci I, Clementi A, Sessa C, Torrisi I, Meola M
J Nephrol 2018 Dec;31(6):863-879. Epub 2018 Sep 6 doi: 10.1007/s40620-018-0531-1. PMID: 30191413
Prognostic factors and biomarkers of congenital obstructive nephropathy.
Chevalier RL
Pediatr Nephrol 2016 Sep;31(9):1411-20. Epub 2015 Dec 14 doi: 10.1007/s00467-015-3291-3. PMID: 26667236
Obstructive nephropathy and renal fibrosis.
Klahr S, Morrissey J
Am J Physiol Renal Physiol 2002 Nov;283(5):F861-75. doi: 10.1152/ajprenal.00362.2001. PMID: 12372761
Urinary tract obstruction.
Klahr S
Semin Nephrol 2001 Mar;21(2):133-45. doi: 10.1053/snep.2001.20942. PMID: 11245776

Recent systematic reviews

Urinary and serum biomarkers in ureteropelvic junction obstruction: a systematic review.
Papachristou F, Pavlaki A, Printza N
Biomarkers 2014 Nov;19(7):531-40. Epub 2014 Aug 1 doi: 10.3109/1354750X.2014.943292. PMID: 25082300

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