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Sulfhemoglobinemia

MedGen UID:
52562
•Concept ID:
C0038732
•
Disease or Syndrome
Synonym: Sulfhemoglobinemias
SNOMED CT: Sulfhemoglobinemia (32117000)
 
Monarch Initiative: MONDO:0006988

Definition

A morbid condition due to the presence of sulfmethemoglobin in the blood. It is marked by persistent cyanosis, but the blood count does not reveal any special abnormality in the blood. It is thought to be caused by the action of hydrogen sulfide absorbed from the intestine. (Stedman, 25th ed) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSulfhemoglobinemia

Recent clinical studies

Etiology

Three-wavelength method for the optical differentiation of methemoglobin and sulfhemoglobin in oxygenated blood.
Van Leeuwen SR, Baranoski GVG, Kimmel BW
Annu Int Conf IEEE Eng Med Biol Soc 2017 Jul;2017:4570-4573. doi: 10.1109/EMBC.2017.8037873. PMID: 29060914
Effects of long-term exposure to hydrogen sulfide on human red blood cells.
Saeedi A, Najibi A, Mohammadi-Bardbori A
Int J Occup Environ Med 2015 Jan;6(1):20-5. doi: 10.15171/ijoem.2015.482. PMID: 25588222Free PMC Article
Oxidative stress and antioxidative status of plasma and erythrocytes in patients with vivax malaria.
Erel O, Kocyigit A, Avci S, Aktepe N, Bulut V
Clin Biochem 1997 Dec;30(8):631-9. doi: 10.1016/s0009-9120(97)00119-7. PMID: 9455617

Diagnosis

Sulfhemoglobin under the spotlight - Detection and characterization of SHb and HbFe(III)-SH.
Stepanenko T, Zając G, Czajkowski A, Rutkowska W, Górecki A, Marzec KM, Dybas J
Biochim Biophys Acta Mol Cell Res 2023 Jan;1870(1):119378. Epub 2022 Oct 8 doi: 10.1016/j.bbamcr.2022.119378. PMID: 36220452
Case Report: Phenazopyridine-Induced Sulfhemoglobinemia in an 83-Year-Old Presenting with Dyspnea.
Morales A, Walsh R, Brown W, Checinski P, Williams SR
J Emerg Med 2021 Aug;61(2):147-150. Epub 2021 May 24 doi: 10.1016/j.jemermed.2021.03.002. PMID: 34034895
Neonatal Sulfhemoglobinemia and Hemolytic Anemia Associated With Intestinal Morganella morganii.
Murphy K, Ryan C, Dempsey EM, O'Toole PW, Ross RP, Stanton C, Ryan CA
Pediatrics 2015 Dec;136(6):e1641-5. Epub 2015 Nov 9 doi: 10.1542/peds.2015-0996. PMID: 26553186
Focus on diagnosis: co-oximetry.
Mack E
Pediatr Rev 2007 Feb;28(2):73-4. doi: 10.1542/pir.28-2-73. PMID: 17272524
Phenazopyridine-induced sulfhemoglobinemia.
Gopalachar AS, Bowie VL, Bharadwaj P
Ann Pharmacother 2005 Jun;39(6):1128-30. Epub 2005 May 10 doi: 10.1345/aph.1E557. PMID: 15886294

Therapy

Phenazopyridine-induced sulfhemoglobinemia.
Gopalachar AS, Bowie VL, Bharadwaj P
Ann Pharmacother 2005 Jun;39(6):1128-30. Epub 2005 May 10 doi: 10.1345/aph.1E557. PMID: 15886294
Metoclopramide-induced sulfhemoglobinemia.
Van Veldhuizen PJ, Wyatt A
Am J Gastroenterol 1995 Jun;90(6):1010-1. PMID: 7771397
Acute dapsone poisoning.
Chawla R, Gurnani A, Bhattacharya A
Anaesth Intensive Care 1993 Jun;21(3):349-51. doi: 10.1177/0310057X9302100319. PMID: 8342770
Phenacetin-induced hemolytic anemia.
Millar J, Péloquin R, De Leeuw NK
Can Med Assoc J 1972 Apr 8;106(7):770-5. PMID: 5016923Free PMC Article
Sulfhemoglobinemia.
FICHTER EG
AMA Am J Dis Child 1954 Dec;88(6):749-53. doi: 10.1001/archpedi.1954.02050100751007. PMID: 13206390

Prognosis

A Case of Sulfhemoglobinemia Secondary to a Urinary Tract Infection.
Campagna G, Espaillat A, Pfeiffer T, Powers JM, McClure M, Hess LM
J Pediatr Hematol Oncol 2020 Nov;42(8):e765-e767. doi: 10.1097/MPH.0000000000001591. PMID: 31568176
A newborn with cyanosis.
Agbeko RS, Semmekrot BA, Bongaerts GP, Neeleman C, Severijnen RS
Eur J Pediatr 1998 Dec;157(12):1026-9. doi: 10.1007/s004310050992. PMID: 9877046

Clinical prediction guides

Fatal inhalation of volcanic gases in three tourists of a geothermal area.
Carfora A, Campobasso CP, Cassandro P, La Sala F, Maiellaro A, Perna A, Petrella R, Borriello R
Forensic Sci Int 2019 Apr;297:e1-e7. Epub 2019 Feb 7 doi: 10.1016/j.forsciint.2019.01.044. PMID: 30777401
Effects of long-term exposure to hydrogen sulfide on human red blood cells.
Saeedi A, Najibi A, Mohammadi-Bardbori A
Int J Occup Environ Med 2015 Jan;6(1):20-5. doi: 10.15171/ijoem.2015.482. PMID: 25588222Free PMC Article
Oxidative stress and antioxidative status of plasma and erythrocytes in patients with vivax malaria.
Erel O, Kocyigit A, Avci S, Aktepe N, Bulut V
Clin Biochem 1997 Dec;30(8):631-9. doi: 10.1016/s0009-9120(97)00119-7. PMID: 9455617
Hematological and hemorheological effects of air pollution.
Baskurt OK, Levi E, Caglayan S, Dikmenoglu N, Kutman MN
Arch Environ Health 1990 Jul-Aug;45(4):224-8. doi: 10.1080/00039896.1990.9940806. PMID: 2400244
Delayed sulfhemoglobinemia after acute dapsone intoxication.
Lambert M, Sonnet J, Mahieu P, Hassoun A
J Toxicol Clin Toxicol 1982 Mar;19(1):45-50. doi: 10.3109/15563658208990365. PMID: 7154140

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