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Papulovesicular eruption

MedGen UID:
536328
•Concept ID:
C0234920
•
Finding
Synonyms: Papulo-vesicular eruption; Papulovesicular rash
SNOMED CT: Papulovesicular eruption (4538007); Papulovesicular rash (4538007)
 
HPO: HP:0033700

Definition

An acute onset rash characterized by by multiple vesicles, which are circumscribed, fluid-containing, epidermal elevations with a diameter less than 10mm at the widest point, and by multiple papules, which are circumscribed, solid epidermal elevations with no visible fluid with a diameter less than 10mm at the widest point. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPapulovesicular eruption

Professional guidelines

PubMed

Grover disease: review of subtypes with a focus on management options.
Aldana PC, Khachemoune A
Int J Dermatol 2020 May;59(5):543-550. Epub 2019 Nov 14 doi: 10.1111/ijd.14700. PMID: 31724740
Annular Lesions: Diagnosis and Treatment.
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021
Photosensitivity disorders: cause, effect and management.
Millard TP, Hawk JL
Am J Clin Dermatol 2002;3(4):239-46. doi: 10.2165/00128071-200203040-00002. PMID: 12010069

Recent clinical studies

Etiology

Significant improvement of dermatitis herpetiformis with tofacitinib.
Kahn JS, Moody K, Rosmarin D
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754365. PMID: 34391330
Noninfectious dermatological diseases associated with chronic exposure to mine tailings in a Peruvian district.
Ramos W, Galarza C, Ronceros G, de Amat F, Teran M, Pichardo L, Juarez D, Anaya R, Mayhua A, Hurtado J, Ortega-Loayza AG
Br J Dermatol 2008 Jul;159(1):169-74. Epub 2008 Jul 1 doi: 10.1111/j.1365-2133.2008.08630.x. PMID: 18510675
Seasonal variation of transient acantholytic dyskeratosis (Grover's disease).
Scheinfeld N, Mones J
J Am Acad Dermatol 2006 Aug;55(2):263-8. doi: 10.1016/j.jaad.2006.01.029. PMID: 16844509
Estrogen dermatitis.
Leylek OA, Unlü S, Oztürkcan S, Cetin A, Sahin M, Yildiz E
Eur J Obstet Gynecol Reprod Biol 1997 Mar;72(1):97-103. doi: 10.1016/s0301-2115(96)02657-7. PMID: 9076430
Photoallergic contact dermatitis to oxybenzone.
Collins P, Ferguson J
Br J Dermatol 1994 Jul;131(1):124-9. doi: 10.1111/j.1365-2133.1994.tb08469.x. PMID: 8043404

Diagnosis

Gianotti-Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition.
Leung AKC, Sergi CM, Lam JM, Leong KF
World J Pediatr 2019 Dec;15(6):521-527. Epub 2019 May 27 doi: 10.1007/s12519-019-00269-9. PMID: 31134587
An acral papulovesicular eruption.
Gilhooley E, Hartel P, McKenna D
Clin Exp Dermatol 2019 Apr;44(3):319-321. Epub 2018 Sep 5 doi: 10.1111/ced.13729. PMID: 30187506
Purpuric agave dermatitis.
Ricks MR, Vogel PS, Elston DM, Hivnor C
J Am Acad Dermatol 1999 Feb;40(2 Pt 2):356-8. doi: 10.1016/s0190-9622(99)70485-8. PMID: 10025868
Estrogen dermatitis.
Leylek OA, Unlü S, Oztürkcan S, Cetin A, Sahin M, Yildiz E
Eur J Obstet Gynecol Reprod Biol 1997 Mar;72(1):97-103. doi: 10.1016/s0301-2115(96)02657-7. PMID: 9076430
Autoimmune progesterone dermatitis.
Herzberg AJ, Strohmeyer CR, Cirillo-Hyland VA
J Am Acad Dermatol 1995 Feb;32(2 Pt 2):333-8. doi: 10.1016/0190-9622(95)90398-4. PMID: 7829735

Therapy

Acral Papulovesicular Eruption in a Soldier Following Smallpox Vaccination.
Lenz B, Fillman E, Grenier L
Cutis 2022 Apr;109(4):194-196. doi: 10.12788/cutis.0502. PMID: 35659837
First report of tamoxifen-induced baboon syndrome.
Mofarrah R, Mofarrah R, Kränke B, Rahmani M, Jahani Amiri K, Ghasemi M, Jallab N, Ghobadiaski S, Rahmani N, Hashemi N
J Cosmet Dermatol 2021 Aug;20(8):2574-2578. Epub 2020 Dec 13 doi: 10.1111/jocd.13863. PMID: 33253493Free PMC Article
Gianotti-Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition.
Leung AKC, Sergi CM, Lam JM, Leong KF
World J Pediatr 2019 Dec;15(6):521-527. Epub 2019 May 27 doi: 10.1007/s12519-019-00269-9. PMID: 31134587
PERIORAL DERMATITIS: STILL A THERAPEUTIC CHALLENGE.
Mokos ZB, Kummer A, Mosler EL, Čeović R, Basta-Juzbašić A
Acta Clin Croat 2015 Jun;54(2):179-85. PMID: 26415314
Estrogen dermatitis.
Leylek OA, Unlü S, Oztürkcan S, Cetin A, Sahin M, Yildiz E
Eur J Obstet Gynecol Reprod Biol 1997 Mar;72(1):97-103. doi: 10.1016/s0301-2115(96)02657-7. PMID: 9076430

Prognosis

Paraviral eruptions in the era of COVID-19: Do some skin manifestations point to a natural resistance to SARS-CoV-2?
Lipsker D
Clin Dermatol 2020 Nov-Dec;38(6):757-761. Epub 2020 Jun 13 doi: 10.1016/j.clindermatol.2020.06.005. PMID: 33341210Free PMC Article
Presentation of Acute Megakaryoblastic Leukemia Associated with a GATA-1 Mutation Mimicking the Eruption of Transient Myeloproliferative Disorder.
Boos MD, Wine Lee L, Freedman JL, Novoa RA, Chu EY, Perman MJ
Pediatr Dermatol 2015 Sep-Oct;32(5):e204-7. Epub 2015 Jul 23 doi: 10.1111/pde.12643. PMID: 26205501
Primary cutaneous hydroa vacciniforme-like lymphoma with indolent clinical course: report of two cases and review of literature.
Li Y, Chen XH, Tian XY, Li B, Li Z
Int J Surg Pathol 2013 Apr;21(2):161-8. Epub 2012 Jul 17 doi: 10.1177/1066896912453200. PMID: 22807582
Seasonal variation of transient acantholytic dyskeratosis (Grover's disease).
Scheinfeld N, Mones J
J Am Acad Dermatol 2006 Aug;55(2):263-8. doi: 10.1016/j.jaad.2006.01.029. PMID: 16844509
Orf. Clinical and epidemiological study.
Bassioukas K, Orfanidou A, Stergiopoulou CH, Hatzis J
Australas J Dermatol 1993;34(3):119-23. doi: 10.1111/j.1440-0960.1993.tb00880.x. PMID: 8080415

Clinical prediction guides

Paraviral eruptions in the era of COVID-19: Do some skin manifestations point to a natural resistance to SARS-CoV-2?
Lipsker D
Clin Dermatol 2020 Nov-Dec;38(6):757-761. Epub 2020 Jun 13 doi: 10.1016/j.clindermatol.2020.06.005. PMID: 33341210Free PMC Article
Gianotti-Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition.
Leung AKC, Sergi CM, Lam JM, Leong KF
World J Pediatr 2019 Dec;15(6):521-527. Epub 2019 May 27 doi: 10.1007/s12519-019-00269-9. PMID: 31134587
Noninfectious dermatological diseases associated with chronic exposure to mine tailings in a Peruvian district.
Ramos W, Galarza C, Ronceros G, de Amat F, Teran M, Pichardo L, Juarez D, Anaya R, Mayhua A, Hurtado J, Ortega-Loayza AG
Br J Dermatol 2008 Jul;159(1):169-74. Epub 2008 Jul 1 doi: 10.1111/j.1365-2133.2008.08630.x. PMID: 18510675
A new cutaneous sign of mercury poisoning?
Dantzig PI
J Am Acad Dermatol 2003 Dec;49(6):1109-11. doi: 10.1016/s0190-9622(03)02485-x. PMID: 14639393
Focal and generalized folliculitis following smallpox vaccination among vaccinia-naive recipients.
Talbot TR, Bredenberg HK, Smith M, LaFleur BJ, Boyd A, Edwards KM
JAMA 2003 Jun 25;289(24):3290-4. doi: 10.1001/jama.289.24.3290. PMID: 12824211

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