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Neonatal encephalopathy

MedGen UID:
536453
Concept ID:
C0235820
Disease or Syndrome
Synonym: Neonatal Encephalopathy
SNOMED CT: Neonatal encephalopathy (95628005)

Definition

Abnormal functioning of the central nervous system in the newborn period that may be due to a variety of etiologies including hypoxia/ischemia, metabolic disturbance, or infection. [from NCI]

Professional guidelines

PubMed

Wiswell TE
Semin Fetal Neonatal Med 2020 Aug;25(4):101140. Epub 2020 Jul 10 doi: 10.1016/j.siny.2020.101140. PMID: 33158495
McNally MA, Soul JS
Clin Perinatol 2019 Jun;46(2):311-325. Epub 2019 Mar 26 doi: 10.1016/j.clp.2019.02.006. PMID: 31010562
Schump EA
Crit Care Nurs Clin North Am 2018 Dec;30(4):509-521. doi: 10.1016/j.cnc.2018.07.007. PMID: 30447810

Recent clinical studies

Etiology

Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Ferreira CR, van Karnebeek CDM
Handb Clin Neurol 2019;162:449-481. doi: 10.1016/B978-0-444-64029-1.00022-9. PMID: 31324325
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Redline RW, Ravishankar S
APMIS 2018 Jul;126(7):561-569. doi: 10.1111/apm.12849. PMID: 30129125
Marret S, Vanhulle C, Laquerriere A
Handb Clin Neurol 2013;111:169-76. doi: 10.1016/B978-0-444-52891-9.00016-6. PMID: 23622161

Diagnosis

Pascual-Alonso A, Martínez-Monseny AF, Xiol C, Armstrong J
Int J Mol Sci 2021 Sep 4;22(17) doi: 10.3390/ijms22179610. PMID: 34502518Free PMC Article
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Russ JB, Simmons R, Glass HC
Neoreviews 2021 Mar;22(3):e148-e162. doi: 10.1542/neo.22-3-e148. PMID: 33649088
Ferreira CR, van Karnebeek CDM
Handb Clin Neurol 2019;162:449-481. doi: 10.1016/B978-0-444-64029-1.00022-9. PMID: 31324325
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551

Therapy

Mathew JL, Kaur N, Dsouza JM
J Glob Health 2022;12:04030. Epub 2022 Apr 9 doi: 10.7189/jogh.12.04030. PMID: 35444799Free PMC Article
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Kariholu U, Montaldo P, Markati T, Lally PJ, Pryce R, Teiserskas J, Liow N, Oliveira V, Soe A, Shankaran S, Thayyil S
Arch Dis Child Fetal Neonatal Ed 2020 Mar;105(2):225-228. Epub 2018 Dec 19 doi: 10.1136/archdischild-2018-315711. PMID: 30567775
Gunn AJ, Thoresen M
Handb Clin Neurol 2019;162:217-237. doi: 10.1016/B978-0-444-64029-1.00010-2. PMID: 31324312
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551

Prognosis

El-Dib M, Abend NS, Austin T, Boylan G, Chock V, Cilio MR, Greisen G, Hellström-Westas L, Lemmers P, Pellicer A, Pressler RM, Sansevere A, Tsuchida T, Vanhatalo S, Wusthoff CJ; Newborn Brain Society Guidelines and Publications Committee
Pediatr Res 2023 Jul;94(1):64-73. Epub 2022 Dec 7 doi: 10.1038/s41390-022-02393-1. PMID: 36476747
Wisnowski JL, Wintermark P, Bonifacio SL, Smyser CD, Barkovich AJ, Edwards AD, de Vries LS, Inder TE, Chau V; Newborn Brain Society Guidelines and Publications Committee
Semin Fetal Neonatal Med 2021 Oct;26(5):101304. Epub 2021 Oct 29 doi: 10.1016/j.siny.2021.101304. PMID: 34736808Free PMC Article
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Del Rosario C, Slevin M, Molloy EJ, Quigley J, Nixon E
Arch Dis Child Educ Pract Ed 2021 Apr;106(2):108-112. Epub 2020 Aug 28 doi: 10.1136/archdischild-2020-319063. PMID: 32859738
Sarnat HB, Sarnat MS
Arch Neurol 1976 Oct;33(10):696-705. doi: 10.1001/archneur.1976.00500100030012. PMID: 987769

Clinical prediction guides

Wisnowski JL, Wintermark P, Bonifacio SL, Smyser CD, Barkovich AJ, Edwards AD, de Vries LS, Inder TE, Chau V; Newborn Brain Society Guidelines and Publications Committee
Semin Fetal Neonatal Med 2021 Oct;26(5):101304. Epub 2021 Oct 29 doi: 10.1016/j.siny.2021.101304. PMID: 34736808Free PMC Article
Del Rosario C, Slevin M, Molloy EJ, Quigley J, Nixon E
Arch Dis Child Educ Pract Ed 2021 Apr;106(2):108-112. Epub 2020 Aug 28 doi: 10.1136/archdischild-2020-319063. PMID: 32859738
Middleton P, Shepherd E, Crowther CA
Cochrane Database Syst Rev 2018 May 9;5(5):CD004945. doi: 10.1002/14651858.CD004945.pub4. PMID: 29741208Free PMC Article
GBD 2016 Causes of Death Collaborators
Lancet 2017 Sep 16;390(10100):1151-1210. doi: 10.1016/S0140-6736(17)32152-9. PMID: 28919116Free PMC Article
Marret S, Vanhulle C, Laquerriere A
Handb Clin Neurol 2013;111:169-76. doi: 10.1016/B978-0-444-52891-9.00016-6. PMID: 23622161

Recent systematic reviews

Mathew JL, Kaur N, Dsouza JM
J Glob Health 2022;12:04030. Epub 2022 Apr 9 doi: 10.7189/jogh.12.04030. PMID: 35444799Free PMC Article
Middleton P, Shepherd E, Morris J, Crowther CA, Gomersall JC
Cochrane Database Syst Rev 2020 Jul 15;7(7):CD004945. doi: 10.1002/14651858.CD004945.pub5. PMID: 32666584Free PMC Article
Finucane EM, Murphy DJ, Biesty LM, Gyte GM, Cotter AM, Ryan EM, Boulvain M, Devane D
Cochrane Database Syst Rev 2020 Feb 27;2(2):CD000451. doi: 10.1002/14651858.CD000451.pub3. PMID: 32103497Free PMC Article
Kariholu U, Montaldo P, Markati T, Lally PJ, Pryce R, Teiserskas J, Liow N, Oliveira V, Soe A, Shankaran S, Thayyil S
Arch Dis Child Fetal Neonatal Ed 2020 Mar;105(2):225-228. Epub 2018 Dec 19 doi: 10.1136/archdischild-2018-315711. PMID: 30567775
Middleton P, Shepherd E, Crowther CA
Cochrane Database Syst Rev 2018 May 9;5(5):CD004945. doi: 10.1002/14651858.CD004945.pub4. PMID: 29741208Free PMC Article

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