U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acute respiratory acidosis

MedGen UID:
541159
•Concept ID:
C0268047
•
Disease or Syndrome
SNOMED CT: Acute respiratory acidosis (70644008)
 
HPO: HP:0012467

Definition

Sudden onset of impairment in ventilation such that the removal of carbon dioxide by the respiratory system is less than the production of carbon dioxide in the tissues, leading to an elevation of the partial pressure of carbon dioxide (PaCO2) above the normal limits (more than 45 mm Hg) with an accompanying acidemia (pH less than 7.35). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute respiratory acidosis

Professional guidelines

PubMed

Treatment of respiratory failure due to kyphoscoliosis with nasal intermittent positive pressure ventilation (NIPPV).
Finlay G, Concannon D, McDonnell TJ
Ir J Med Sci 1995 Jan;164(1):28-30. doi: 10.1007/BF02968110. PMID: 7890530
Treatment of acute respiratory acidosis in chronic obstructive lung disease.
Kettel LJ, Diener CF, Morse JO, Stein HF, Burrows B
JAMA 1971 Sep 13;217(11):1503-8. PMID: 5109747
Acute respiratory acidosis, diagnosis and treatment (acute ventilatory insufficiency, acute alveolar hypoventilation).
Tysinger DS Jr
J Med Assoc State Ala 1967 Oct;37(4):411-6. PMID: 6062033

Recent clinical studies

Etiology

Sodium bicarbonate therapy for acute respiratory acidosis.
Chand R, Swenson ER, Goldfarb DS
Curr Opin Nephrol Hypertens 2021 Mar 1;30(2):223-230. doi: 10.1097/MNH.0000000000000687. PMID: 33395037
Potentially (near) fatal asthma.
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):403-405. doi: 10.2500/aap.2019.40.4257. PMID: 31690380
Chapter 13: Potentially (near) fatal asthma.
Sabin BR, Greenberger PA
Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:44-46. doi: 10.2500/aap.2012.33.3546. PMID: 22794686
Acute respiratory acidosis does not increase plasma potassium in normokalaemic anaesthetized patients. A controlled randomized trial.
Natalini G, Seramondi V, Fassini P, Foccoli P, Toninelli C, Cavaliere S, Candiani A
Eur J Anaesthesiol 2001 Jun;18(6):394-400. doi: 10.1046/j.1365-2346.2001.00863.x. PMID: 11412293
Respiratory acidosis.
Epstein SK, Singh N
Respir Care 2001 Apr;46(4):366-83. PMID: 11262556

Diagnosis

Potentially (near) fatal asthma.
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):403-405. doi: 10.2500/aap.2019.40.4257. PMID: 31690380
How important is the CO(2) chemoreflex for the control of breathing? Environmental and evolutionary considerations.
Santin JM
Comp Biochem Physiol A Mol Integr Physiol 2018 Jan;215:6-19. Epub 2017 Sep 29 doi: 10.1016/j.cbpa.2017.09.015. PMID: 28966145
Chapter 13: Potentially (near) fatal asthma.
Sabin BR, Greenberger PA
Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:44-46. doi: 10.2500/aap.2012.33.3546. PMID: 22794686
Respiratory acidosis.
Epstein SK, Singh N
Respir Care 2001 Apr;46(4):366-83. PMID: 11262556
Respiratory muscle failure.
Rochester DF, Arora NS
Med Clin North Am 1983 May;67(3):573-97. doi: 10.1016/s0025-7125(16)31190-7. PMID: 6341727

Therapy

Sodium bicarbonate therapy for acute respiratory acidosis.
Chand R, Swenson ER, Goldfarb DS
Curr Opin Nephrol Hypertens 2021 Mar 1;30(2):223-230. doi: 10.1097/MNH.0000000000000687. PMID: 33395037
Potentially (near) fatal asthma.
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):403-405. doi: 10.2500/aap.2019.40.4257. PMID: 31690380
Acute respiratory acidosis does not increase plasma potassium in normokalaemic anaesthetized patients. A controlled randomized trial.
Natalini G, Seramondi V, Fassini P, Foccoli P, Toninelli C, Cavaliere S, Candiani A
Eur J Anaesthesiol 2001 Jun;18(6):394-400. doi: 10.1046/j.1365-2346.2001.00863.x. PMID: 11412293
Respiratory acidosis.
Epstein SK, Singh N
Respir Care 2001 Apr;46(4):366-83. PMID: 11262556
Permissive hypercapnia in ARDS and its effect on tissue oxygenation.
Hickling KG, Joyce C
Acta Anaesthesiol Scand Suppl 1995;107:201-8. doi: 10.1111/j.1399-6576.1995.tb04359.x. PMID: 8599278

Prognosis

Acid-base balance and cerebrovascular regulation.
Caldwell HG, Carr JMJR, Minhas JS, Swenson ER, Ainslie PN
J Physiol 2021 Dec;599(24):5337-5359. Epub 2021 Nov 26 doi: 10.1113/JP281517. PMID: 34705265
Noninvasive ventilation in critically ill very old patients with pneumonia: A multicenter retrospective cohort study.
Besen BAMP, Park M, Ranzani OT
PLoS One 2021;16(1):e0246072. Epub 2021 Jan 27 doi: 10.1371/journal.pone.0246072. PMID: 33503042Free PMC Article
Potentially (near) fatal asthma.
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):403-405. doi: 10.2500/aap.2019.40.4257. PMID: 31690380
Clinical predictors of acute respiratory acidosis during exacerbation of asthma and chronic obstructive pulmonary disease.
Cham GW, Tan WP, Earnest A, Soh CH
Eur J Emerg Med 2002 Sep;9(3):225-32. doi: 10.1097/00063110-200209000-00004. PMID: 12394618
Heliox therapy in acute severe asthma.
Kass JE, Castriotta RJ
Chest 1995 Mar;107(3):757-60. doi: 10.1378/chest.107.3.757. PMID: 7874949

Clinical prediction guides

No change in plasma potassium concentration during 10 minutes of apnoea: An observational study on potential organ donors.
Benterud BP, Lindenskov PHH, Rosseland LA
Acta Anaesthesiol Scand 2021 Oct;65(9):1300-1304. Epub 2021 Jun 30 doi: 10.1111/aas.13940. PMID: 34137462
Mechanical determinants of early acute ventilatory failure in COPD patients: a physiologic study.
Purro A, Appendini L, Polillo C, Musso G, Taliano C, Mecca F, Colombo R, Carbone G
Intensive Care Med 2009 Apr;35(4):639-47. Epub 2008 Nov 26 doi: 10.1007/s00134-008-1353-8. PMID: 19034427
Clinical predictors of acute respiratory acidosis during exacerbation of asthma and chronic obstructive pulmonary disease.
Cham GW, Tan WP, Earnest A, Soh CH
Eur J Emerg Med 2002 Sep;9(3):225-32. doi: 10.1097/00063110-200209000-00004. PMID: 12394618
Clinical course of gamma-hydroxybutyrate overdose.
Chin RL, Sporer KA, Cullison B, Dyer JE, Wu TD
Ann Emerg Med 1998 Jun;31(6):716-22. PMID: 9624311
Acidosis and bone.
Bushinsky DA
Miner Electrolyte Metab 1994;20(1-2):40-52. PMID: 8202051

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...