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Gray syndrome from chloramphenicol administration in newborn

MedGen UID:
542648
•Concept ID:
C0270276
•
Disease or Syndrome
Synonyms: Chloramphenicol toxicity in newborn; Gray Baby Syndrome; Gray baby syndrome; Gray Syndrome; Gray syndrome; Gray syndrome of newborn; Grey Syndrome
SNOMED CT: Chloramphenicol toxicity in newborn (7690000); Gray syndrome from chloramphenicol administration in newborn (7690000); Gray baby syndrome (7690000); Gray syndrome (7690000); Gray syndrome of newborn (7690000)

Definition

A disorder observed in a newborn who was exposed to chloramphenicol. Manifestations include hypotension, cyanosis, cardiovascular collapse and/or death. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGray syndrome from chloramphenicol administration in newborn

Professional guidelines

PubMed

Efficacy of chloramphenicol in the treatment of neonatal and infantile meningitis: a study of 70 cases.
Mulhall A, de Louvois J, Hurley R
Lancet 1983 Feb 5;1(8319):284-7. doi: 10.1016/s0140-6736(83)91697-5. PMID: 6130304

Recent clinical studies

Etiology

Efficacy of chloramphenicol in the treatment of neonatal and infantile meningitis: a study of 70 cases.
Mulhall A, de Louvois J, Hurley R
Lancet 1983 Feb 5;1(8319):284-7. doi: 10.1016/s0140-6736(83)91697-5. PMID: 6130304

Diagnosis

Excretion of drugs in human milk.
O'Brien TE
Am J Hosp Pharm 1974 Sep;31(9):844-54. PMID: 4608122

Therapy

Chloramphenicol: what we have learned in the last decade.
Feder HM Jr
South Med J 1986 Sep;79(9):1129-34. PMID: 3529436
Efficacy of chloramphenicol in the treatment of neonatal and infantile meningitis: a study of 70 cases.
Mulhall A, de Louvois J, Hurley R
Lancet 1983 Feb 5;1(8319):284-7. doi: 10.1016/s0140-6736(83)91697-5. PMID: 6130304
Chloramphenicol: properties and clinical use.
Laferriere CI, Marks MI
Pediatr Infect Dis 1982 Jul-Aug;1(4):257-64. PMID: 7177917

Clinical prediction guides

Efficacy of chloramphenicol in the treatment of neonatal and infantile meningitis: a study of 70 cases.
Mulhall A, de Louvois J, Hurley R
Lancet 1983 Feb 5;1(8319):284-7. doi: 10.1016/s0140-6736(83)91697-5. PMID: 6130304

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