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Oral cavity cancer

MedGen UID:
56298
•Concept ID:
C0153381
•
Neoplastic Process
Synonyms: Cancer of Mouth; Cancer of the Mouth; Cancer, Mouth; Cancer, Oral; Cancers, Mouth; Cancers, Oral; Mouth Cancer; Mouth Cancers; Oral Cancer; Oral Cancers
SNOMED CT: Malignant tumor of mouth (363505006); Cancer of oral cavity (363505006); CA - Mouth cancer (363505006); Mouth cancer (363505006); Malignant neoplasm of mouth (363505006); Malignant tumor of oral cavity (363505006)
 
Monarch Initiative: MONDO:0005515

Definition

A primary or metastatic malignant neoplasm that affects the lip and/or oral cavity. The majority of cases are carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral cavity cancer

Professional guidelines

PubMed

Expert Consensus Statement: Management of Dysphagia in Head and Neck Cancer Patients.
Kuhn MA, Gillespie MB, Ishman SL, Ishii LE, Brody R, Cohen E, Dhar SI, Hutcheson K, Jefferson G, Johnson F, Rameau A, Sher D, Starmer H, Strohl M, Ulmer K, Vaitaitis V, Begum S, Batjargal M, Dhepyasuwan N
Otolaryngol Head Neck Surg 2023 Apr;168(4):571-592. doi: 10.1002/ohn.302. PMID: 36965195
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline.
Koyfman SA, Ismaila N, Crook D, D'Cruz A, Rodriguez CP, Sher DJ, Silbermins D, Sturgis EM, Tsue TT, Weiss J, Yom SS, Holsinger FC
J Clin Oncol 2019 Jul 10;37(20):1753-1774. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01921. PMID: 30811281Free PMC Article

Curated

NCCN, Head and Neck, 2.2022

Recent clinical studies

Etiology

The Prevalence of HPV in Oral Cavity Squamous Cell Carcinoma.
Katirachi SK, Grønlund MP, Jakobsen KK, Grønhøj C, von Buchwald C
Viruses 2023 Feb 6;15(2) doi: 10.3390/v15020451. PMID: 36851665Free PMC Article
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Oral Cavity Cancer.
Ettinger KS, Ganry L, Fernandes RP
Oral Maxillofac Surg Clin North Am 2019 Feb;31(1):13-29. Epub 2018 Oct 25 doi: 10.1016/j.coms.2018.08.002. PMID: 30454788
Cancer of the oral cavity.
Montero PH, Patel SG
Surg Oncol Clin N Am 2015 Jul;24(3):491-508. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.006. PMID: 25979396Free PMC Article

Diagnosis

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Cancer of the oral cavity.
Montero PH, Patel SG
Surg Oncol Clin N Am 2015 Jul;24(3):491-508. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.006. PMID: 25979396Free PMC Article

Therapy

Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study.
Gao H, Zheng S, Yuan X, Xie J, Xu L
BMC Med 2023 Oct 10;21(1):389. doi: 10.1186/s12916-023-03096-y. PMID: 37817217Free PMC Article
Expert Consensus Statement: Management of Dysphagia in Head and Neck Cancer Patients.
Kuhn MA, Gillespie MB, Ishman SL, Ishii LE, Brody R, Cohen E, Dhar SI, Hutcheson K, Jefferson G, Johnson F, Rameau A, Sher D, Starmer H, Strohl M, Ulmer K, Vaitaitis V, Begum S, Batjargal M, Dhepyasuwan N
Otolaryngol Head Neck Surg 2023 Apr;168(4):571-592. doi: 10.1002/ohn.302. PMID: 36965195
Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline.
Koyfman SA, Ismaila N, Crook D, D'Cruz A, Rodriguez CP, Sher DJ, Silbermins D, Sturgis EM, Tsue TT, Weiss J, Yom SS, Holsinger FC
J Clin Oncol 2019 Jul 10;37(20):1753-1774. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01921. PMID: 30811281Free PMC Article

Prognosis

Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study.
Gao H, Zheng S, Yuan X, Xie J, Xu L
BMC Med 2023 Oct 10;21(1):389. doi: 10.1186/s12916-023-03096-y. PMID: 37817217Free PMC Article
Obesity and head and neck cancer risk: a mendelian randomization study.
Gui L, He X, Tang L, Yao J, Pi J
BMC Med Genomics 2023 Aug 24;16(1):200. doi: 10.1186/s12920-023-01634-4. PMID: 37620971Free PMC Article
Delays in oral cavity cancer.
Gigliotti J, Madathil S, Makhoul N
Int J Oral Maxillofac Surg 2019 Sep;48(9):1131-1137. Epub 2019 Mar 13 doi: 10.1016/j.ijom.2019.02.015. PMID: 30878273
The Global Burden of Cancer 2013.
Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, Wolfe C, Hamadeh RR, Moore A, Werdecker A, Gessner BD, Te Ao B, McMahon B, Karimkhani C, Yu C, Cooke GS, Schwebel DC, Carpenter DO, Pereira DM, Nash D, Kazi DS, De Leo D, Plass D, Ukwaja KN, Thurston GD, Yun Jin K, Simard EP, Mills E, Park EK, Catalá-López F, deVeber G, Gotay C, Khan G, Hosgood HD 3rd, Santos IS, Leasher JL, Singh J, Leigh J, Jonas JB, Sanabria J, Beardsley J, Jacobsen KH, Takahashi K, Franklin RC, Ronfani L, Montico M, Naldi L, Tonelli M, Geleijnse J, Petzold M, Shrime MG, Younis M, Yonemoto N, Breitborde N, Yip P, Pourmalek F, Lotufo PA, Esteghamati A, Hankey GJ, Ali R, Lunevicius R, Malekzadeh R, Dellavalle R, Weintraub R, Lucas R, Hay R, Rojas-Rueda D, Westerman R, Sepanlou SG, Nolte S, Patten S, Weichenthal S, Abera SF, Fereshtehnejad SM, Shiue I, Driscoll T, Vasankari T, Alsharif U, Rahimi-Movaghar V, Vlassov VV, Marcenes WS, Mekonnen W, Melaku YA, Yano Y, Artaman A, Campos I, MacLachlan J, Mueller U, Kim D, Trillini M, Eshrati B, Williams HC, Shibuya K, Dandona R, Murthy K, Cowie B, Amare AT, Antonio CA, Castañeda-Orjuela C, van Gool CH, Violante F, Oh IH, Deribe K, Soreide K, Knibbs L, Kereselidze M, Green M, Cardenas R, Roy N, Tillmann T, Li Y, Krueger H, Monasta L, Dey S, Sheikhbahaei S, Hafezi-Nejad N, Kumar GA, Sreeramareddy CT, Dandona L, Wang H, Vollset SE, Mokdad A, Salomon JA, Lozano R, Vos T, Forouzanfar M, Lopez A, Murray C, Naghavi M
JAMA Oncol 2015 Jul;1(4):505-27. doi: 10.1001/jamaoncol.2015.0735. PMID: 26181261Free PMC Article
Cancer of the oral cavity.
Montero PH, Patel SG
Surg Oncol Clin N Am 2015 Jul;24(3):491-508. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.006. PMID: 25979396Free PMC Article

Clinical prediction guides

Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study.
Gao H, Zheng S, Yuan X, Xie J, Xu L
BMC Med 2023 Oct 10;21(1):389. doi: 10.1186/s12916-023-03096-y. PMID: 37817217Free PMC Article
Effect of early interventions with manual lymphatic drainage and rehabilitation exercise on morbidity and lymphedema in patients with oral cavity cancer.
Tsai KY, Liao SF, Chen KL, Tang HW, Huang HY
Medicine (Baltimore) 2022 Oct 21;101(42):e30910. doi: 10.1097/MD.0000000000030910. PMID: 36281150Free PMC Article
Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.
Hajdú SF, Wessel I, Dalton SO, Eskildsen SJ, Johansen C
Dysphagia 2022 Aug;37(4):749-762. Epub 2021 Jun 11 doi: 10.1007/s00455-021-10320-5. PMID: 34117531Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline.
Koyfman SA, Ismaila N, Crook D, D'Cruz A, Rodriguez CP, Sher DJ, Silbermins D, Sturgis EM, Tsue TT, Weiss J, Yom SS, Holsinger FC
J Clin Oncol 2019 Jul 10;37(20):1753-1774. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01921. PMID: 30811281Free PMC Article

Recent systematic reviews

The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019.
GBD 2019 Lip, Oral, and Pharyngeal Cancer Collaborators, Cunha ARD, Compton K, Xu R, Mishra R, Drangsholt MT, Antunes JLF, Kerr AR, Acheson AR, Lu D, Wallace LE, Kocarnik JM, Fu W, Dean FE, Pennini A, Henrikson HJ, Alam T, Ababneh E, Abd-Elsalam S, Abdoun M, Abidi H, Abubaker Ali H, Abu-Gharbieh E, Adane TD, Addo IY, Ahmad A, Ahmad S, Ahmed Rashid T, Akonde M, Al Hamad H, Alahdab F, Alimohamadi Y, Alipour V, Al-Maweri SA, Alsharif U, Ansari-Moghaddam A, Anwar SL, Anyasodor AE, Arabloo J, Aravkin AY, Aruleba RT, Asaad M, Ashraf T, Athari SS, Attia S, Azadnajafabad S, Azangou-Khyavy M, Badar M, Baghcheghi N, Banach M, Bardhan M, Barqawi HJ, Bashir NZ, Bashiri A, Benzian H, Bernabe E, Bhagat DS, Bhojaraja VS, Bjørge T, Bouaoud S, Braithwaite D, Briko NI, Calina D, Carreras G, Chakraborty PA, Chattu VK, Chaurasia A, Chen MX, Cho WCS, Chu DT, Chukwu IS, Chung E, Cruz-Martins N, Dadras O, Dai X, Dandona L, Dandona R, Daneshpajouhnejad P, Darvishi Cheshmeh Soltani R, Darwesh AM, Debela SA, Derbew Molla M, Dessalegn FN, Dianati-Nasab M, Digesa LE, Dixit SG, Dixit A, Djalalinia S, El Sayed I, El Tantawi M, Enyew DB, Erku DA, Ezzeddini R, Fagbamigbe AF, Falzone L, Fetensa G, Fukumoto T, Gaewkhiew P, Gallus S, Gebrehiwot M, Ghashghaee A, Gill PS, Golechha M, Goleij P, Gomez RS, Gorini G, Guimaraes ALS, Gupta B, Gupta S, Gupta VB, Gupta VK, Haj-Mirzaian A, Halboub ES, Halwani R, Hanif A, Hariyani N, Harorani M, Hasani H, Hassan AM, Hassanipour S, Hassen MB, Hay SI, Hayat K, Herrera-Serna BY, Holla R, Horita N, Hosseinzadeh M, Hussain S, Ilesanmi OS, Ilic IM, Ilic MD, Isola G, Jaiswal A, Jani CT, Javaheri T, Jayarajah U, Jayaram S, Joseph N, Kadashetti V, Kandaswamy E, Karanth SD, Karaye IM, Kauppila JH, Kaur H, Keykhaei M, Khader YS, Khajuria H, Khanali J, Khatib MN, Khayat Kashani HR, Khazeei Tabari MA, Kim MS, Kompani F, Koohestani HR, Kumar GA, Kurmi OP, La Vecchia C, Lal DK, Landires I, Lasrado S, Ledda C, Lee YH, Libra M, Lim SS, Listl S, Lopukhov PD, Mafi AR, Mahumud RA, Malik AA, Mathur MR, Maulud SQ, Meena JK, Mehrabi Nasab E, Mestrovic T, Mirfakhraie R, Misganaw A, Misra S, Mithra P, Mohammad Y, Mohammadi M, Mohammadi E, Mokdad AH, Moni MA, Moraga P, Morrison SD, Mozaffari HR, Mubarik S, Murray CJL, Nair TS, Narasimha Swamy S, Narayana AI, Nassereldine H, Natto ZS, Nayak BP, Negru SM, Nggada HA, Nouraei H, Nuñez-Samudio V, Oancea B, Olagunju AT, Omar Bali A, Padron-Monedero A, Padubidri JR, Pandey A, Pardhan S, Patel J, Pezzani R, Piracha ZZ, Rabiee N, Radhakrishnan V, Radhakrishnan RA, Rahmani AM, Rahmanian V, Rao CR, Rao SJ, Rath GK, Rawaf DL, Rawaf S, Rawassizadeh R, Razeghinia MS, Rezaei N, Rezaei N, Rezaei N, Rezapour A, Riad A, Roberts TJ, Romero-Rodríguez E, Roshandel G, S M, S N C, Saddik B, Saeb MR, Saeed U, Safaei M, Sahebazzamani M, Sahebkar A, Salek Farrokhi A, Samy AM, Santric-Milicevic MM, Sathian B, Satpathy M, Šekerija M, Senthilkumaran S, Seylani A, Shafaat O, Shahsavari HR, Shamsoddin E, Sharew MM, Sharifi-Rad J, Shetty JK, Shivakumar KM, Shobeiri P, Shorofi SA, Shrestha S, Siddappa Malleshappa SK, Singh P, Singh JA, Singh G, Sinha DN, Solomon Y, Suleman M, Suliankatchi Abdulkader R, Taheri Abkenar Y, Talaat IM, Tan KK, Tbakhi A, Thiyagarajan A, Tiyuri A, Tovani-Palone MR, Unnikrishnan B, Vo B, Volovat SR, Wang C, Westerman R, Wickramasinghe ND, Xiao H, Yu C, Yuce D, Yunusa I, Zadnik V, Zare I, Zhang ZJ, Zoladl M, Force LM, Hugo FN
JAMA Oncol 2023 Oct 1;9(10):1401-1416. doi: 10.1001/jamaoncol.2023.2960. PMID: 37676656Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment.
Worthington HV, Bulsara VM, Glenny AM, Clarkson JE, Conway DI, Macluskey M
Cochrane Database Syst Rev 2023 Aug 31;8(8):CD006205. doi: 10.1002/14651858.CD006205.pub5. PMID: 37650478Free PMC Article
The incidence of oral cavity cancer in Iran: A systematic review and meta-analysis.
Jokar M, Namavari N, Moshiri SA, Jahromi HK, Rahmanian V
Cancer Rep (Hoboken) 2023 Jun;6(6):e1836. Epub 2023 May 16 doi: 10.1002/cnr2.1836. PMID: 37191384Free PMC Article
Expert Consensus Statement: Management of Dysphagia in Head and Neck Cancer Patients.
Kuhn MA, Gillespie MB, Ishman SL, Ishii LE, Brody R, Cohen E, Dhar SI, Hutcheson K, Jefferson G, Johnson F, Rameau A, Sher D, Starmer H, Strohl M, Ulmer K, Vaitaitis V, Begum S, Batjargal M, Dhepyasuwan N
Otolaryngol Head Neck Surg 2023 Apr;168(4):571-592. doi: 10.1002/ohn.302. PMID: 36965195
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article

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