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Thoracic cancer

MedGen UID:
56320
•Concept ID:
C0153661
•
Neoplastic Process
Synonyms: cancer of thoracic segment of trunk; Malignant Neoplasm of the Thorax; malignant neoplasm of the thorax; malignant neoplasm of thoracic segment of trunk; Malignant neoplasm of thorax; Malignant Neoplasm of Thorax; malignant neoplasm of thorax; Malignant Thoracic Neoplasm; malignant thoracic neoplasm; malignant thoracic segment of trunk neoplasm; Malignant Thoracic Tumor; malignant thoracic tumor; malignant thoracic tumour; Malignant Tumor of the Thorax; malignant tumor of the thorax; Malignant tumor of thorax; Malignant Tumor of Thorax; malignant tumor of thorax; malignant tumour of the thorax; malignant tumour of thorax; thoracic cancer; thoracic segment of trunk cancer; thorax cancer
SNOMED CT: Malignant neoplasm of thorax (188361007); Malignant tumor of thorax (188361007)
 
Monarch Initiative: MONDO:0003274

Definition

A primary or metastatic malignant neoplasm affecting the tissues of the thorax. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThoracic cancer

Professional guidelines

PubMed

Systemic Therapy for Small-Cell Lung Cancer: ASCO-Ontario Health (Cancer Care Ontario) Guideline.
Khurshid H, Ismaila N, Bian J, Dabney R, Das M, Ellis P, Feldman J, Hann C, Kulkarni S, Laskin J, Manochakian R, Mishra DR, Preeshagul I, Reddy P, Saxena A, Weinberg F, Kalemkerian GP
J Clin Oncol 2023 Dec 10;41(35):5448-5472. Epub 2023 Oct 11 doi: 10.1200/JCO.23.01435. PMID: 37820295
Therapy for Stage IV Non-Small-Cell Lung Cancer With Driver Alterations: ASCO Living Guideline.
Singh N, Temin S, Baker S Jr, Blanchard E, Brahmer JR, Celano P, Duma N, Ellis PM, Elkins IB, Haddad RY, Hesketh PJ, Jain D, Johnson DH, Leighl NB, Mamdani H, Masters G, Moffitt PR, Phillips T, Riely GJ, Robinson AG, Rosell R, Schiller JH, Schneider BJ, Spigel DR, Jaiyesimi IA
J Clin Oncol 2022 Oct 1;40(28):3310-3322. Epub 2022 Jul 11 doi: 10.1200/JCO.22.00824. PMID: 35816666
Management of Stage III Non-Small-Cell Lung Cancer: ASCO Guideline.
Daly ME, Singh N, Ismaila N, Antonoff MB, Arenberg DA, Bradley J, David E, Detterbeck F, Früh M, Gubens MA, Moore AC, Padda SK, Patel JD, Phillips T, Qin A, Robinson C, Simone CB 2nd
J Clin Oncol 2022 Apr 20;40(12):1356-1384. Epub 2021 Dec 22 doi: 10.1200/JCO.21.02528. PMID: 34936470

Recent clinical studies

Etiology

Identification of a novel anoikis-related gene signature to predict prognosis and tumor microenvironment in lung adenocarcinoma.
Diao X, Guo C, Li S
Thorac Cancer 2023 Jan;14(3):320-330. Epub 2022 Dec 11 doi: 10.1111/1759-7714.14766. PMID: 36507553Free PMC Article
Epidemiology of esophageal cancer in 2020 and projections to 2030 and 2040.
Liu CQ, Ma YL, Qin Q, Wang PH, Luo Y, Xu PF, Cui Y
Thorac Cancer 2023 Jan;14(1):3-11. Epub 2022 Dec 8 doi: 10.1111/1759-7714.14745. PMID: 36482832Free PMC Article
UNcommon EGFR Mutations: International Case Series on Efficacy of Osimertinib in Real-Life Practice in First-LiNe Setting (UNICORN).
Bar J, Peled N, Schokrpur S, Wolner M, Rotem O, Girard N, Aboubakar Nana F, Derijcke S, Kian W, Patel S, Gantz-Sorotsky H, Zer A, Moskovitz M, Metro G, Rottenberg Y, Calles A, Hochmair M, Cuppens K, Decoster L, Reck M, Limon D, Rodriguez E, Astaras C, Bettini A, Häfliger S, Addeo A
J Thorac Oncol 2023 Feb;18(2):169-180. Epub 2022 Oct 25 doi: 10.1016/j.jtho.2022.10.004. PMID: 36307041
Comparison of ultrasound and mammography for early diagnosis of breast cancer among Chinese women with suspected breast lesions: A prospective trial.
Wang Y, Li Y, Song Y, Chen C, Wang Z, Li L, Liu M, Liu G, Xu Y, Zhou Y, Sun Q, Shen S
Thorac Cancer 2022 Nov;13(22):3145-3151. Epub 2022 Sep 30 doi: 10.1111/1759-7714.14666. PMID: 36177910Free PMC Article
Epidemiology of lung cancer in China.
Cao M, Chen W
Thorac Cancer 2019 Jan;10(1):3-7. Epub 2018 Nov 28 doi: 10.1111/1759-7714.12916. PMID: 30485694Free PMC Article

Diagnosis

The role of microbiota in esophageal squamous cell carcinoma: A review of the literature.
Chiang HC, Hughes M, Chang WL
Thorac Cancer 2023 Oct;14(28):2821-2829. Epub 2023 Sep 7 doi: 10.1111/1759-7714.15096. PMID: 37675608Free PMC Article
Expert consensus of management of adverse drug reactions with anaplastic lymphoma kinase tyrosine kinase inhibitors.
Zhou F, Yang Y, Zhang L, Cheng Y, Han B, Lu Y, Wang C, Wang Z, Yang N, Fan Y, Wang L, Ma Z, Zhang L, Yao Y, Zhao J, Dong X, Zhu B, Zhou C
ESMO Open 2023 Jun;8(3):101560. Epub 2023 May 23 doi: 10.1016/j.esmoop.2023.101560. PMID: 37230029Free PMC Article
Comparison of ultrasound and mammography for early diagnosis of breast cancer among Chinese women with suspected breast lesions: A prospective trial.
Wang Y, Li Y, Song Y, Chen C, Wang Z, Li L, Liu M, Liu G, Xu Y, Zhou Y, Sun Q, Shen S
Thorac Cancer 2022 Nov;13(22):3145-3151. Epub 2022 Sep 30 doi: 10.1111/1759-7714.14666. PMID: 36177910Free PMC Article
Expression and role of p16 and GLUT1 in malignant diseases and lung cancer: A review.
Pezzuto A, D'Ascanio M, Ricci A, Pagliuca A, Carico E
Thorac Cancer 2020 Nov;11(11):3060-3070. Epub 2020 Sep 18 doi: 10.1111/1759-7714.13651. PMID: 32945604Free PMC Article
Application of electrochemical biosensors in tumor cell detection.
Zhang Z, Li Q, Du X, Liu M
Thorac Cancer 2020 Apr;11(4):840-850. Epub 2020 Feb 26 doi: 10.1111/1759-7714.13353. PMID: 32101379Free PMC Article

Therapy

Malignant Superior Vena Cava Syndrome: A Scoping Review.
Wright K, Digby GC, Gyawali B, Jad R, Menard A, Moraes FY, Wijeratne DT
J Thorac Oncol 2023 Oct;18(10):1268-1276. Epub 2023 May 3 doi: 10.1016/j.jtho.2023.04.019. PMID: 37146753
Therapy for Stage IV Non-Small-Cell Lung Cancer With Driver Alterations: ASCO Living Guideline.
Singh N, Temin S, Baker S Jr, Blanchard E, Brahmer JR, Celano P, Duma N, Ellis PM, Elkins IB, Haddad RY, Hesketh PJ, Jain D, Johnson DH, Leighl NB, Mamdani H, Masters G, Moffitt PR, Phillips T, Riely GJ, Robinson AG, Rosell R, Schiller JH, Schneider BJ, Spigel DR, Jaiyesimi IA
J Clin Oncol 2022 Oct 1;40(28):3310-3322. Epub 2022 Jul 11 doi: 10.1200/JCO.22.00824. PMID: 35816666
Management of Stage III Non-Small-Cell Lung Cancer: ASCO Guideline.
Daly ME, Singh N, Ismaila N, Antonoff MB, Arenberg DA, Bradley J, David E, Detterbeck F, Früh M, Gubens MA, Moore AC, Padda SK, Patel JD, Phillips T, Qin A, Robinson C, Simone CB 2nd
J Clin Oncol 2022 Apr 20;40(12):1356-1384. Epub 2021 Dec 22 doi: 10.1200/JCO.21.02528. PMID: 34936470
Epidemiology of lung cancer in China.
Cao M, Chen W
Thorac Cancer 2019 Jan;10(1):3-7. Epub 2018 Nov 28 doi: 10.1111/1759-7714.12916. PMID: 30485694Free PMC Article
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.
Skoulidis F, Goldberg ME, Greenawalt DM, Hellmann MD, Awad MM, Gainor JF, Schrock AB, Hartmaier RJ, Trabucco SE, Gay L, Ali SM, Elvin JA, Singal G, Ross JS, Fabrizio D, Szabo PM, Chang H, Sasson A, Srinivasan S, Kirov S, Szustakowski J, Vitazka P, Edwards R, Bufill JA, Sharma N, Ou SI, Peled N, Spigel DR, Rizvi H, Aguilar EJ, Carter BW, Erasmus J, Halpenny DF, Plodkowski AJ, Long NM, Nishino M, Denning WL, Galan-Cobo A, Hamdi H, Hirz T, Tong P, Wang J, Rodriguez-Canales J, Villalobos PA, Parra ER, Kalhor N, Sholl LM, Sauter JL, Jungbluth AA, Mino-Kenudson M, Azimi R, Elamin YY, Zhang J, Leonardi GC, Jiang F, Wong KK, Lee JJ, Papadimitrakopoulou VA, Wistuba II, Miller VA, Frampton GM, Wolchok JD, Shaw AT, Jänne PA, Stephens PJ, Rudin CM, Geese WJ, Albacker LA, Heymach JV
Cancer Discov 2018 Jul;8(7):822-835. Epub 2018 May 17 doi: 10.1158/2159-8290.CD-18-0099. PMID: 29773717Free PMC Article

Prognosis

Tepotinib Treatment in Patients With MET Exon 14-Skipping Non-Small Cell Lung Cancer: Long-term Follow-up of the VISION Phase 2 Nonrandomized Clinical Trial.
Mazieres J, Paik PK, Garassino MC, Le X, Sakai H, Veillon R, Smit EF, Cortot AB, Raskin J, Viteri S, Wu YL, Yang JCH, Ahn MJ, Ma R, Zhao J, O'Brate A, Berghoff K, Bruns R, Otto G, Johne A, Felip E, Thomas M
JAMA Oncol 2023 Sep 1;9(9):1260-1266. doi: 10.1001/jamaoncol.2023.1962. PMID: 37270698Free PMC Article
Identification of a novel anoikis-related gene signature to predict prognosis and tumor microenvironment in lung adenocarcinoma.
Diao X, Guo C, Li S
Thorac Cancer 2023 Jan;14(3):320-330. Epub 2022 Dec 11 doi: 10.1111/1759-7714.14766. PMID: 36507553Free PMC Article
Epidemiology of esophageal cancer in 2020 and projections to 2030 and 2040.
Liu CQ, Ma YL, Qin Q, Wang PH, Luo Y, Xu PF, Cui Y
Thorac Cancer 2023 Jan;14(1):3-11. Epub 2022 Dec 8 doi: 10.1111/1759-7714.14745. PMID: 36482832Free PMC Article
Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy.
Long H, Jia Q, Wang L, Fang W, Wang Z, Jiang T, Zhou F, Jin Z, Huang J, Zhou L, Hu C, Wang X, Zhang J, Ba Y, Gong Y, Zeng X, Zeng D, Su X, Alexander PB, Wang L, Wang L, Wan YY, Wang XF, Zhang L, Li QJ, Zhu B
Cancer Cell 2022 Jun 13;40(6):674-693.e7. Epub 2022 May 19 doi: 10.1016/j.ccell.2022.04.018. PMID: 35594863
The cutting-edge progress of immune-checkpoint blockade in lung cancer.
Zhou F, Qiao M, Zhou C
Cell Mol Immunol 2021 Feb;18(2):279-293. Epub 2020 Nov 11 doi: 10.1038/s41423-020-00577-5. PMID: 33177696Free PMC Article

Clinical prediction guides

The role of microbiota in esophageal squamous cell carcinoma: A review of the literature.
Chiang HC, Hughes M, Chang WL
Thorac Cancer 2023 Oct;14(28):2821-2829. Epub 2023 Sep 7 doi: 10.1111/1759-7714.15096. PMID: 37675608Free PMC Article
Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil.
Peng H, Wu X, Liu S, He M, Tang C, Wen Y, Xie C, Zhong R, Li C, Xiong S, Liu J, Zheng H, He J, Lu X, Liang W
Clin Transl Med 2023 Jul;13(7):e1340. doi: 10.1002/ctm2.1340. PMID: 37491740Free PMC Article
Identification of a novel anoikis-related gene signature to predict prognosis and tumor microenvironment in lung adenocarcinoma.
Diao X, Guo C, Li S
Thorac Cancer 2023 Jan;14(3):320-330. Epub 2022 Dec 11 doi: 10.1111/1759-7714.14766. PMID: 36507553Free PMC Article
The cutting-edge progress of immune-checkpoint blockade in lung cancer.
Zhou F, Qiao M, Zhou C
Cell Mol Immunol 2021 Feb;18(2):279-293. Epub 2020 Nov 11 doi: 10.1038/s41423-020-00577-5. PMID: 33177696Free PMC Article
Non-canonical functions of the mitotic kinesin Eg5.
Liu M, Ran J, Zhou J
Thorac Cancer 2018 Aug;9(8):904-910. Epub 2018 Jun 21 doi: 10.1111/1759-7714.12792. PMID: 29927078Free PMC Article

Recent systematic reviews

Efficacy and safety of immune checkpoint inhibitor rechallenge in non-small cell lung cancer: A systematic review and meta-analysis.
Feng Y, Tao Y, Chen H, Zhou Y, Tang L, Liu C, Hu X, Shi Y
Thorac Cancer 2023 Sep;14(25):2536-2547. Epub 2023 Aug 8 doi: 10.1111/1759-7714.15063. PMID: 37551891Free PMC Article
Evaluation of Clinical and Safety Outcomes of Neoadjuvant Immunotherapy Combined With Chemotherapy for Patients With Resectable Esophageal Cancer: A Systematic Review and Meta-analysis.
Ge F, Huo Z, Cai X, Hu Q, Chen W, Lin G, Zhong R, You Z, Wang R, Lu Y, Wang R, Huang Q, Zhang H, Song A, Li C, Wen Y, Jiang Y, Liang H, He J, Liang W, Liu J
JAMA Netw Open 2022 Nov 1;5(11):e2239778. doi: 10.1001/jamanetworkopen.2022.39778. PMID: 36322089Free PMC Article
Hyperthermic intrathoracic chemotherapy for the treatment of malignant pleural effusion caused by breast and ovarian cancer: A systematic literature review and pooled analysis.
Karampinis I, Dionysopoulou A, Galata C, Almstedt K, Grilli M, Hasenburg A, Roessner ED
Thorac Cancer 2022 Apr;13(7):883-888. Epub 2022 Feb 22 doi: 10.1111/1759-7714.14361. PMID: 35194945Free PMC Article
Lung cancer risk prediction models based on pulmonary nodules: A systematic review.
Wu Z, Wang F, Cao W, Qin C, Dong X, Yang Z, Zheng Y, Luo Z, Zhao L, Yu Y, Xu Y, Li J, Tang W, Shen S, Wu N, Tan F, Li N, He J
Thorac Cancer 2022 Mar;13(5):664-677. Epub 2022 Feb 8 doi: 10.1111/1759-7714.14333. PMID: 35137543Free PMC Article
Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease.
Jones S, Man WD, Gao W, Higginson IJ, Wilcock A, Maddocks M
Cochrane Database Syst Rev 2016 Oct 17;10(10):CD009419. doi: 10.1002/14651858.CD009419.pub3. PMID: 27748503Free PMC Article

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