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Benign neoplasm of small intestine

MedGen UID:
56324
•Concept ID:
C0153944
•
Neoplastic Process
Synonyms: Benign Neoplasm of Small Intestine; benign neoplasm of small intestine; Benign Neoplasm of the Small Intestine; benign neoplasm of the small intestine; Benign Small Intestinal Neoplasm; benign small intestinal neoplasm; Benign Small Intestinal Neoplasm NOS; Benign Small Intestinal Tumor; benign small intestinal tumor; benign small intestinal tumour; Benign Small Intestine Neoplasm; benign small intestine neoplasm; Benign Small Intestine Tumor; benign small intestine tumor; benign small intestine tumour; Benign tumor of small intestine; Benign Tumor of Small Intestine; benign tumor of small intestine; Benign Tumor of the Small Intestine; benign tumor of the small intestine; benign tumour of small intestine; benign tumour of the small intestine; small intestine benign neoplasm
SNOMED CT: Benign tumor of small intestine (92385005); Benign neoplasm of small intestine (92385005)
 
Monarch Initiative: MONDO:0021501

Definition

A neoplasm that arises from the small intestine and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults.
Yamamoto H, Sakamoto H, Kumagai H, Abe T, Ishiguro S, Uchida K, Kawasaki Y, Saida Y, Sano Y, Takeuchi Y, Tajika M, Nakajima T, Banno K, Funasaka Y, Hori S, Yamaguchi T, Yoshida T, Ishikawa H, Iwama T, Okazaki Y, Saito Y, Matsuura N, Mutoh M, Tomita N, Akiyama T, Yamamoto T, Ishida H, Nakayama Y
Digestion 2023;104(5):335-347. Epub 2023 Apr 13 doi: 10.1159/000529799. PMID: 37054692
Management of Incidentalomas.
Reidelberger K, Fingeret A
Surg Clin North Am 2021 Dec;101(6):1081-1096. doi: 10.1016/j.suc.2021.06.006. PMID: 34774270
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

Recent clinical studies

Etiology

Updates in the diagnosis and management of small-bowel tumors.
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Imaging and Screening of Cancer of the Small Bowel.
Kim JS, Park SH, Hansel S, Fletcher JG
Radiol Clin North Am 2017 Nov;55(6):1273-1291. Epub 2017 Sep 13 doi: 10.1016/j.rcl.2017.06.008. PMID: 28991566
Small intestinal neoplasms.
Gill SS, Heuman DM, Mihas AA
J Clin Gastroenterol 2001 Oct;33(4):267-82. doi: 10.1097/00004836-200110000-00004. PMID: 11588539
An overview of adenocarcinoma of the small intestine.
Neugut AI, Marvin MR, Rella VA, Chabot JA
Oncology (Williston Park) 1997 Apr;11(4):529-36; discussion 545, 549-50. PMID: 9130275

Diagnosis

Updates in the diagnosis and management of non-ampullary small-bowel polyposis.
Lucaciu L, Yano T, Saurin JC
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101852. Epub 2023 Jul 22 doi: 10.1016/j.bpg.2023.101852. PMID: 37652652
Updates in the diagnosis and management of small-bowel tumors.
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Progress in the Treatment of Small Intestine Cancer.
Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
Management of small bowel polyps: from small to big.
Saurin JC, Benech N, Pioche M
Curr Opin Gastroenterol 2019 May;35(3):250-256. doi: 10.1097/MOG.0000000000000518. PMID: 30844897
Small bowel tumours: update in diagnosis and management.
Rondonotti E, Koulaouzidis A, Georgiou J, Pennazio M
Curr Opin Gastroenterol 2018 May;34(3):159-164. doi: 10.1097/MOG.0000000000000428. PMID: 29438117

Therapy

Progress in the Treatment of Small Intestine Cancer.
Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
Long-term survival of metastatic small intestine neuroendocrine tumors: a meta-analysis.
Van Den Heede K, Chidambaram S, Van Slycke S, Brusselaers N, Warfvinge CF, Ohlsson H, Gustafsson R, Nordenström E, Almquist M
Endocr Relat Cancer 2022 Feb 7;29(3):163-173. doi: 10.1530/ERC-21-0354. PMID: 34982042
Lifestyle factors and small intestine adenocarcinoma risk: A systematic review and meta-analysis.
Bennett CM, Coleman HG, Veal PG, Cantwell MM, Lau CC, Murray LJ
Cancer Epidemiol 2015 Jun;39(3):265-73. Epub 2015 Feb 27 doi: 10.1016/j.canep.2015.02.001. PMID: 25736860
Small bowel adenocarcinoma.
Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ
Curr Treat Options Oncol 2008 Dec;9(4-6):388-99. Epub 2009 Apr 14 doi: 10.1007/s11864-009-0098-0. PMID: 19365735
Enteroscopy.
Mönkemüller K, Bellutti M, Fry LC, Malfertheiner P
Best Pract Res Clin Gastroenterol 2008;22(5):789-811. doi: 10.1016/j.bpg.2008.05.005. PMID: 18790433

Prognosis

Molecular genetic positioning of small intestine and papilla of Vater carcinomas including clinicopathological classification.
Nakamura M, Okamura Y, Ohshima K, Sugiura T, Ashida R, Ohgi K, Bando E, Fujiya K, Shiomi A, Kagawa H, Imamura T, Nakayama G, Kodera Y, Uesaka K, Ohike N, Norose T, Sasaki K, Sugino T, Ohnami S, Nagashima T, Urakami K, Akiyama Y, Yamaguchi K
Cancer Med 2023 May;12(10):11491-11502. Epub 2023 Mar 31 doi: 10.1002/cam4.5877. PMID: 36999887Free PMC Article
Management of Small Bowel Neuroendocrine Tumors.
Scott AT, Howe JR
Surg Oncol Clin N Am 2020 Apr;29(2):223-241. doi: 10.1016/j.soc.2019.11.006. PMID: 32151357
The Small Bowel Cancer Incidence Enigma.
Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R
Pathol Oncol Res 2020 Apr;26(2):635-639. Epub 2019 Jun 5 doi: 10.1007/s12253-019-00682-5. PMID: 31165996
Small intestinal neoplasms.
Gill SS, Heuman DM, Mihas AA
J Clin Gastroenterol 2001 Oct;33(4):267-82. doi: 10.1097/00004836-200110000-00004. PMID: 11588539
An overview of adenocarcinoma of the small intestine.
Neugut AI, Marvin MR, Rella VA, Chabot JA
Oncology (Williston Park) 1997 Apr;11(4):529-36; discussion 545, 549-50. PMID: 9130275

Clinical prediction guides

Metabolic programs of T cell tissue residency empower tumour immunity.
Reina-Campos M, Heeg M, Kennewick K, Mathews IT, Galletti G, Luna V, Nguyen Q, Huang H, Milner JJ, Hu KH, Vichaidit A, Santillano N, Boland BS, Chang JT, Jain M, Sharma S, Krummel MF, Chi H, Bensinger SJ, Goldrath AW
Nature 2023 Sep;621(7977):179-187. Epub 2023 Aug 30 doi: 10.1038/s41586-023-06483-w. PMID: 37648857
Safety and Efficacy of Avelumab in Small Bowel Adenocarcinoma.
Cardin DB, Gilbert J, Whisenant JG, Ayers GD, Jalikis F, Dahlman KB, O'Neal JF, Revetta F, Shi C, Berlin J
Clin Colorectal Cancer 2022 Sep;21(3):236-243. Epub 2022 Mar 24 doi: 10.1016/j.clcc.2022.03.003. PMID: 35450836
Gastrointestinal Stromal Tumours of the Small Intestine.
Uzunoglu H, Tosun Y, Akinci O, Baris B
J Coll Physicians Surg Pak 2021 Dec;31(12):1487-1493. doi: 10.29271/jcpsp.2021.12.1487. PMID: 34794293
The Small Bowel Cancer Incidence Enigma.
Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R
Pathol Oncol Res 2020 Apr;26(2):635-639. Epub 2019 Jun 5 doi: 10.1007/s12253-019-00682-5. PMID: 31165996
Enteroscopy.
Mönkemüller K, Bellutti M, Fry LC, Malfertheiner P
Best Pract Res Clin Gastroenterol 2008;22(5):789-811. doi: 10.1016/j.bpg.2008.05.005. PMID: 18790433

Recent systematic reviews

A systematic review of outcomes and quality of life after ileorectal anastomosis for ulcerative colitis.
Al-Rashedy M, Mukherjee T, Askari A, Gurjar S
Arab J Gastroenterol 2023 May;24(2):79-84. Epub 2023 Feb 20 doi: 10.1016/j.ajg.2023.01.007. PMID: 36813579
Somatostatinoma of the Ampulla of Vater: A Systematic Review.
Giannakodimos I, Giannakodimos A, Ziogou A, Frountzas M, Kritikos N, Vlachos K, Toutouzas KG, Schizas D
J Gastrointestin Liver Dis 2022 Dec 17;31(4):459-466. doi: 10.15403/jgld-4383. PMID: 36535044
A systematic review of symptomatic hamartomas of the jejunum and ileum.
Farkas N, Conroy M, Baig M
Ann R Coll Surg Engl 2022 Jan;104(1):18-23. Epub 2021 Sep 21 doi: 10.1308/rcsann.2021.0038. PMID: 34545759Free PMC Article
A systematic review of the possible carcinogenic role of the aristolochic acid.
Bara T Jr, Gurzu S, Sugimura H, Bara T, Beleaua MA, Jung I
Rom J Morphol Embryol 2017;58(1):41-44. PMID: 28523296
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

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