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Benign neoplasm of spinal cord

MedGen UID:
56329
•Concept ID:
C0154034
•
Neoplastic Process
Synonym: Spinal Cord Neoplasms, Benign
SNOMED CT: Benign tumor of spinal cord (92405007); Benign neoplasm of spinal cord (92405007)
 
Monarch Initiative: MONDO:0021506

Definition

A neoplasm that arises from the spinal cord and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of spinal cord

Professional guidelines

PubMed

Ependymoma: Evaluation and Management Updates.
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Oncologic Emergencies: Recognition and Initial Management.
Higdon ML, Atkinson CJ, Lawrence KV
Am Fam Physician 2018 Jun 1;97(11):741-748. PMID: 30215936
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Recent clinical studies

Etiology

Paediatric spinal cord low-grade gliomas-evaluation and management of post-surgical residual disease.
Silva AHD, Constantinides M, Valetopoulou A, Sgardelis P, Mankad K, D'Arco F, Jankovic I, Thompson D
Childs Nerv Syst 2022 Mar;38(3):577-586. Epub 2021 Dec 2 doi: 10.1007/s00381-021-05412-4. PMID: 34855000
Spinal Cord Tumor Microenvironment.
Rauschenbach L
Adv Exp Med Biol 2020;1226:97-109. doi: 10.1007/978-3-030-36214-0_8. PMID: 32030679
Spinal cord ependymoma: a review of the literature and case series of ten patients.
Celano E, Salehani A, Malcolm JG, Reinertsen E, Hadjipanayis CG
J Neurooncol 2016 Jul;128(3):377-86. Epub 2016 May 6 doi: 10.1007/s11060-016-2135-8. PMID: 27154165Free PMC Article
Ependymoma.
Reni M, Gatta G, Mazza E, Vecht C
Crit Rev Oncol Hematol 2007 Jul;63(1):81-9. Epub 2007 May 4 doi: 10.1016/j.critrevonc.2007.03.004. PMID: 17482475
Spinal lipomas.
Blount JP, Elton S
Neurosurg Focus 2001 Jan 15;10(1):e3. doi: 10.3171/foc.2001.10.1.4. PMID: 16749755

Diagnosis

Intramedullary spinal cord lesions in children.
Hani U, Tebha SS, Bakhshi SK, Shamim MS
J Pak Med Assoc 2021 Feb;71(2(B)):775-777. PMID: 33941981
Rosette-forming glioneuronal tumor: an update.
Anyanwu CT, Robinson TM, Huang JH
Clin Transl Oncol 2020 May;22(5):623-630. Epub 2019 Jul 16 doi: 10.1007/s12094-019-02179-8. PMID: 31313067
Intradural spinal tumors in adults-update on management and outcome.
Ottenhausen M, Ntoulias G, Bodhinayake I, Ruppert FH, Schreiber S, Förschler A, Boockvar JA, Jödicke A
Neurosurg Rev 2019 Jun;42(2):371-388. Epub 2018 Feb 17 doi: 10.1007/s10143-018-0957-x. PMID: 29455369
Spinal cord ependymoma: a review of the literature and case series of ten patients.
Celano E, Salehani A, Malcolm JG, Reinertsen E, Hadjipanayis CG
J Neurooncol 2016 Jul;128(3):377-86. Epub 2016 May 6 doi: 10.1007/s11060-016-2135-8. PMID: 27154165Free PMC Article
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304

Therapy

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas.
Majzner RG, Ramakrishna S, Yeom KW, Patel S, Chinnasamy H, Schultz LM, Richards RM, Jiang L, Barsan V, Mancusi R, Geraghty AC, Good Z, Mochizuki AY, Gillespie SM, Toland AMS, Mahdi J, Reschke A, Nie EH, Chau IJ, Rotiroti MC, Mount CW, Baggott C, Mavroukakis S, Egeler E, Moon J, Erickson C, Green S, Kunicki M, Fujimoto M, Ehlinger Z, Reynolds W, Kurra S, Warren KE, Prabhu S, Vogel H, Rasmussen L, Cornell TT, Partap S, Fisher PG, Campen CJ, Filbin MG, Grant G, Sahaf B, Davis KL, Feldman SA, Mackall CL, Monje M
Nature 2022 Mar;603(7903):934-941. Epub 2022 Feb 7 doi: 10.1038/s41586-022-04489-4. PMID: 35130560Free PMC Article
Neoplastic myelopathies.
Chamberlain MC
Continuum (Minneap Minn) 2015 Feb;21(1 Spinal Cord Disorders):132-45. doi: 10.1212/01.CON.0000461089.02113.1b. PMID: 25651222
Malignant spinal-cord compression.
Prasad D, Schiff D
Lancet Oncol 2005 Jan;6(1):15-24. doi: 10.1016/S1470-2045(04)01709-7. PMID: 15629272
Ependymomas.
Chamberlain MC
Curr Neurol Neurosci Rep 2003 May;3(3):193-9. doi: 10.1007/s11910-003-0078-x. PMID: 12691623
Spine imaging.
Chin CT
Semin Neurol 2002 Jun;22(2):205-20. doi: 10.1055/s-2002-36544. PMID: 12524566

Prognosis

Rosette-forming glioneuronal tumor: an update.
Anyanwu CT, Robinson TM, Huang JH
Clin Transl Oncol 2020 May;22(5):623-630. Epub 2019 Jul 16 doi: 10.1007/s12094-019-02179-8. PMID: 31313067
Literature Review of Spinal Cord Glioblastoma.
Timmons JJ, Zhang K, Fong J, Lok E, Swanson KD, Gautam S, Wong ET
Am J Clin Oncol 2018 Dec;41(12):1281-1287. doi: 10.1097/COC.0000000000000434. PMID: 29528867
Spinal cord ependymoma: a review of the literature and case series of ten patients.
Celano E, Salehani A, Malcolm JG, Reinertsen E, Hadjipanayis CG
J Neurooncol 2016 Jul;128(3):377-86. Epub 2016 May 6 doi: 10.1007/s11060-016-2135-8. PMID: 27154165Free PMC Article
Ependymoma.
Reni M, Gatta G, Mazza E, Vecht C
Crit Rev Oncol Hematol 2007 Jul;63(1):81-9. Epub 2007 May 4 doi: 10.1016/j.critrevonc.2007.03.004. PMID: 17482475
Lipomyelomeningocele.
Sutton LN
Neurosurg Clin N Am 1995 Apr;6(2):325-38. PMID: 7620357

Clinical prediction guides

Clinical Prediction Modeling in Intramedullary Spinal Tumor Surgery.
Massaad E, Ha Y, Shankar GM, Shin JH
Acta Neurochir Suppl 2022;134:333-339. doi: 10.1007/978-3-030-85292-4_37. PMID: 34862557
Spinal Clear Cell Meningiomas: Clinical Features and Factors Predicting Recurrence.
Zhang H, Ma L, Shu C, Dong LQ, Ma YQ, Zhou Y
World Neurosurg 2020 Feb;134:e1062-e1076. Epub 2019 Nov 22 doi: 10.1016/j.wneu.2019.11.093. PMID: 31765868
Literature Review of Spinal Cord Glioblastoma.
Timmons JJ, Zhang K, Fong J, Lok E, Swanson KD, Gautam S, Wong ET
Am J Clin Oncol 2018 Dec;41(12):1281-1287. doi: 10.1097/COC.0000000000000434. PMID: 29528867
Lumbar paraganglioma.
Dillard-Cannon E, Atsina KB, Ghobrial G, Gnass E, Curtis MT, Heller J
J Clin Neurosci 2016 Aug;30:149-151. Epub 2016 Mar 28 doi: 10.1016/j.jocn.2016.01.019. PMID: 27032749
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304

Recent systematic reviews

A systematic review on the outcome of intramedullary spinal cord cavernous malformations.
Asimakidou E, Meszaros LT, Anestis DM, Tsitsopoulos PP
Eur Spine J 2022 Nov;31(11):3119-3129. Epub 2022 Aug 6 doi: 10.1007/s00586-022-07332-6. PMID: 35931791
Low Back Pain in the Emergency Department: Prevalence of Serious Spinal Pathologies and Diagnostic Accuracy of Red Flags.
Galliker G, Scherer DE, Trippolini MA, Rasmussen-Barr E, LoMartire R, Wertli MM
Am J Med 2020 Jan;133(1):60-72.e14. Epub 2019 Jul 3 doi: 10.1016/j.amjmed.2019.06.005. PMID: 31278933
Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review.
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329
Spinal cord ependymomas and the appearance of other de novo tumors: a systematic review.
Fotakopoulos G, Vagkopoulos K, Gatos C, Kotlia P, Brotis A
J Med Case Rep 2014 Dec 18;8:438. doi: 10.1186/1752-1947-8-438. PMID: 25519213Free PMC Article
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article

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