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Benign neoplasm of prostate

MedGen UID:
57577
Concept ID:
C0154009
Neoplastic Process
Synonyms: Benign Neoplasm of Prostate; benign neoplasm of prostate; Benign Neoplasm of the Prostate; benign neoplasm of the prostate; Benign Prostate Neoplasm; benign prostate neoplasm; Benign Prostate Tumor; benign prostate tumor; benign prostate tumour; Benign Prostatic Neoplasm; benign prostatic neoplasm; Benign prostatic tumor; Benign tumor of prostate; Benign Tumor of Prostate; benign tumor of prostate; Benign Tumor of the Prostate; benign tumor of the prostate; benign tumour of prostate; benign tumour of the prostate; prostate gland benign neoplasm
SNOMED CT: Benign prostatic tumor (92308005); Benign tumor of prostate (92308005); Benign neoplasm of prostate (92308005)
 
Monarch Initiative: MONDO:0021510

Definition

A neoplasm that arises from the prostate and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include benign phyllodes tumor, leiomyoma, and fibroma. [from NCI]

Professional guidelines

PubMed

Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724
Parker C, Castro E, Fizazi K, Heidenreich A, Ost P, Procopio G, Tombal B, Gillessen S; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2020 Sep;31(9):1119-1134. Epub 2020 Jun 25 doi: 10.1016/j.annonc.2020.06.011. PMID: 32593798
Litwin MS, Tan HJ
JAMA 2017 Jun 27;317(24):2532-2542. doi: 10.1001/jama.2017.7248. PMID: 28655021

Recent clinical studies

Etiology

Surasi DSS, Chapin B, Tang C, Ravizzini G, Bathala TK
Semin Ultrasound CT MR 2020 Apr;41(2):207-221. Epub 2020 Feb 18 doi: 10.1053/j.sult.2020.02.001. PMID: 32446432
Porter CM, Shrestha E, Peiffer LB, Sfanos KS
Prostate Cancer Prostatic Dis 2018 Sep;21(3):345-354. Epub 2018 May 23 doi: 10.1038/s41391-018-0041-1. PMID: 29795140
Yacoub JH, Oto A
Radiol Clin North Am 2018 Mar;56(2):197-209. Epub 2017 Dec 6 doi: 10.1016/j.rcl.2017.10.003. PMID: 29420976
Khan FU, Ihsan AU, Khan HU, Jana R, Wazir J, Khongorzul P, Waqar M, Zhou X
Biomed Pharmacother 2017 Oct;94:1064-1076. Epub 2017 Aug 16 doi: 10.1016/j.biopha.2017.08.016. PMID: 28813783
Nakai Y, Nonomura N
Int J Urol 2013 Feb;20(2):150-60. Epub 2012 Jul 31 doi: 10.1111/j.1442-2042.2012.03101.x. PMID: 22852773

Diagnosis

Dikov D, Koleva M, Mollova A, Fakirova A
Prostate 2023 Sep;83(13):1285-1289. Epub 2023 Jun 25 doi: 10.1002/pros.24590. PMID: 37357498
Khan FU, Ihsan AU, Khan HU, Jana R, Wazir J, Khongorzul P, Waqar M, Zhou X
Biomed Pharmacother 2017 Oct;94:1064-1076. Epub 2017 Aug 16 doi: 10.1016/j.biopha.2017.08.016. PMID: 28813783
Verze P, Cai T, Lorenzetti S
Nat Rev Urol 2016 Jul;13(7):379-86. Epub 2016 Jun 1 doi: 10.1038/nrurol.2016.89. PMID: 27245504
Freeman MR, Solomon KR
Differentiation 2011 Nov-Dec;82(4-5):244-52. Epub 2011 Aug 20 doi: 10.1016/j.diff.2011.04.005. PMID: 21862201Free PMC Article
Mitterberger M, Horninger W, Aigner F, Pinggera GM, Steppan I, Rehder P, Frauscher F
Cancer Imaging 2010 Mar 3;10(1):40-8. doi: 10.1102/1470-7330.2010.0004. PMID: 20199941Free PMC Article

Therapy

Van Poppel H, Albreht T, Basu P, Hogenhout R, Collen S, Roobol M
Nat Rev Urol 2022 Sep;19(9):562-572. Epub 2022 Aug 16 doi: 10.1038/s41585-022-00638-6. PMID: 35974245
Nordström T, Discacciati A, Bergman M, Clements M, Aly M, Annerstedt M, Glaessgen A, Carlsson S, Jäderling F, Eklund M, Grönberg H; STHLM3 study group
Lancet Oncol 2021 Sep;22(9):1240-1249. Epub 2021 Aug 13 doi: 10.1016/S1470-2045(21)00348-X. PMID: 34391509
Eklund M, Jäderling F, Discacciati A, Bergman M, Annerstedt M, Aly M, Glaessgen A, Carlsson S, Grönberg H, Nordström T; STHLM3 consortium
N Engl J Med 2021 Sep 2;385(10):908-920. Epub 2021 Jul 9 doi: 10.1056/NEJMoa2100852. PMID: 34237810
Swami U, McFarland TR, Nussenzveig R, Agarwal N
Trends Cancer 2020 Aug;6(8):702-715. Epub 2020 Jun 10 doi: 10.1016/j.trecan.2020.04.010. PMID: 32534790
Kasivisvanathan V, Rannikko AS, Borghi M, Panebianco V, Mynderse LA, Vaarala MH, Briganti A, Budäus L, Hellawell G, Hindley RG, Roobol MJ, Eggener S, Ghei M, Villers A, Bladou F, Villeirs GM, Virdi J, Boxler S, Robert G, Singh PB, Venderink W, Hadaschik BA, Ruffion A, Hu JC, Margolis D, Crouzet S, Klotz L, Taneja SS, Pinto P, Gill I, Allen C, Giganti F, Freeman A, Morris S, Punwani S, Williams NR, Brew-Graves C, Deeks J, Takwoingi Y, Emberton M, Moore CM; PRECISION Study Group Collaborators
N Engl J Med 2018 May 10;378(19):1767-1777. Epub 2018 Mar 18 doi: 10.1056/NEJMoa1801993. PMID: 29552975Free PMC Article

Prognosis

Ma C, Zhou Y, Fanelli GN, Stopsack KH, Fiorentino M, Zadra G, Mucci LA, Loda M, Tyekucheva S, Penney KL
Mol Cancer Res 2023 Mar 1;21(3):253-260. doi: 10.1158/1541-7786.MCR-22-0627. PMID: 36511902Free PMC Article
Rothberg MB, Enders JJ, Kozel Z, Gopal N, Turkbey B, Pinto PA
Curr Opin Urol 2022 May 1;32(3):231-238. Epub 2022 Mar 11 doi: 10.1097/MOU.0000000000000986. PMID: 35275101
Aminsharifi A, de la Rosette J, Polascik TJ
Curr Opin Urol 2018 Nov;28(6):491-492. doi: 10.1097/MOU.0000000000000552. PMID: 30239417
Bardan R, Dumache R, Dema A, Cumpanas A, Bucuras V
Clin Biochem 2014 Jul;47(10-11):909-15. Epub 2014 Feb 20 doi: 10.1016/j.clinbiochem.2014.02.008. PMID: 24560954
Nakai Y, Nonomura N
Int J Urol 2013 Feb;20(2):150-60. Epub 2012 Jul 31 doi: 10.1111/j.1442-2042.2012.03101.x. PMID: 22852773

Clinical prediction guides

Dikov D, Koleva M, Mollova A, Fakirova A
Prostate 2023 Sep;83(13):1285-1289. Epub 2023 Jun 25 doi: 10.1002/pros.24590. PMID: 37357498
Annamalai A, Fustok JN, Beltran-Perez J, Rashad AT, Krane LS, Triche BL
Curr Urol Rep 2022 Jan;23(1):1-10. Epub 2022 Feb 28 doi: 10.1007/s11934-022-01084-y. PMID: 35226257
Zelic R, Giunchi F, Lianas L, Mascia C, Zanetti G, Andrén O, Fridfeldt J, Carlsson J, Davidsson S, Molinaro L, Vincent PH, Richiardi L, Akre O, Fiorentino M, Pettersson A
Sci Rep 2021 Feb 5;11(1):3257. doi: 10.1038/s41598-021-82911-z. PMID: 33547336Free PMC Article
Broncy L, Paterlini-Bréchot P
Cells 2019 Jul 3;8(7) doi: 10.3390/cells8070676. PMID: 31277346Free PMC Article
Freeman MR, Solomon KR
Differentiation 2011 Nov-Dec;82(4-5):244-52. Epub 2011 Aug 20 doi: 10.1016/j.diff.2011.04.005. PMID: 21862201Free PMC Article

Recent systematic reviews

Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV
Eur Urol 2023 Aug;84(2):191-206. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.04.021. PMID: 37202314Free PMC Article
Chow KM, So WZ, Lee HJ, Lee A, Yap DWT, Takwoingi Y, Tay KJ, Tuan J, Thang SP, Lam W, Yuen J, Lawrentschuk N, Hofman MS, Murphy DG, Chen K
Eur Urol 2023 Jul;84(1):36-48. Epub 2023 Apr 7 doi: 10.1016/j.eururo.2023.03.001. PMID: 37032189
Rogowski P, Roach M 3rd, Schmidt-Hegemann NS, Trapp C, von Bestenbostel R, Shi R, Buchner A, Stief C, Belka C, Li M
Radiat Oncol 2021 Mar 9;16(1):50. doi: 10.1186/s13014-021-01776-8. PMID: 33750437Free PMC Article
Cornford P, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, der Kwast THV, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, der Poel HGV, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Mottet N
Eur Urol 2021 Feb;79(2):263-282. Epub 2020 Oct 7 doi: 10.1016/j.eururo.2020.09.046. PMID: 33039206
Wallis CJD, Saskin R, Choo R, Herschorn S, Kodama RT, Satkunasivam R, Shah PS, Danjoux C, Nam RK
Eur Urol 2016 Jul;70(1):21-30. Epub 2015 Dec 15 doi: 10.1016/j.eururo.2015.11.010. PMID: 26700655

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