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Functioning gonadotropic adenoma

MedGen UID:
577353
•Concept ID:
C0346304
•
Neoplastic Process
Synonyms: functioning gonadotropic adenoma; Functioning pituitary gonadotropic adenoma; functioning pituitary gonadotropic adenoma; Gonadotrope Adenoma; Gonadotroph adenoma; gonadotroph adenoma; Gonadotroph Cell Adenoma; Gonadotroph PitNET/Adenoma; Gonadotroph pituitary adenoma; Gonadotroph Pituitary Neuroendocrine Tumor; Gonadotroph Pituitary Neuroendocrine Tumor/Adenoma; Gonadotrophin-secreting pituitary adenoma; Gonadotrophinoma; Gonadotropin Producing Pituitary Gland Adenoma; Gonadotropin-Producing Pituitary Gland Adenoma; Gonadotropin-Secreting Pituitary Gland Adenoma; Gonadotropinoma
SNOMED CT: Gonadotrophin-secreting pituitary adenoma (254960002); Gonadotrophinoma (254960002); Gonadotroph adenoma (254960002); Gonadotroph pituitary adenoma (1156908000)
 
Monarch Initiative: MONDO:0019612
Orphanet: ORPHA91348

Definition

Functioning gonadotropic adenoma is a very rare pituitary tumor, macroscopically characterized by a soft, well vascularized, variable sized adenoma, with occasional areas of hemorrage or necrosis, that secretes biologically active gonadotropins. In addition to common neurological signs due to mass effect (headache and/or visual field deterioration), additional clinical manifestations include menstrual irregularities (secondary amenorrhea, oligomenorhea or severe menorrhagia), galactorrhea, infertility or ovarian hyperstimulation syndrome (in premenopausal women), testicular enlargement and, occasionally, hypogonadism (in men) and isosexual precocious puberty (in children). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFunctioning gonadotropic adenoma
Follow this link to review classifications for Functioning gonadotropic adenoma in Orphanet.

Professional guidelines

PubMed

The epidemiology, diagnosis and treatment of Prolactinomas: The old and the new.
Chanson P, Maiter D
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101290. Epub 2019 Jul 10 doi: 10.1016/j.beem.2019.101290. PMID: 31326373
Biological and radiological exploration and management of non-functioning pituitary adenoma.
Raverot G, Assié G, Cotton F, Cogne M, Boulin A, Dherbomez M, Bonneville JF, Massart C
Ann Endocrinol (Paris) 2015 Jul;76(3):201-9. Epub 2015 Jun 26 doi: 10.1016/j.ando.2015.04.005. PMID: 26122495
Management of clinically non-functioning pituitary adenoma.
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284

Recent clinical studies

Etiology

Functioning gonadotroph adenomas in premenopausal women: clinical and molecular characterization and review of the literature.
Wang L, Liang H, Deng C, Yu Q, Gong F, Feng F, You H, Liang Z, Chen B, Deng K, Ma J, Wang R, Yao Y, Zhu H
Pituitary 2022 Jun;25(3):454-467. Epub 2022 Feb 9 doi: 10.1007/s11102-021-01205-9. PMID: 35138520
Management of non-functioning pituitary adenomas: surgery.
Penn DL, Burke WT, Laws ER
Pituitary 2018 Apr;21(2):145-153. doi: 10.1007/s11102-017-0854-2. PMID: 29280026
The Hypothalamic-Pituitary Axis and Autoantibody Related Disorders.
Cocco C, Brancia C, Corda G, Ferri GL
Int J Mol Sci 2017 Nov 3;18(11) doi: 10.3390/ijms18112322. PMID: 29099758Free PMC Article
Biological and radiological exploration and management of non-functioning pituitary adenoma.
Raverot G, Assié G, Cotton F, Cogne M, Boulin A, Dherbomez M, Bonneville JF, Massart C
Ann Endocrinol (Paris) 2015 Jul;76(3):201-9. Epub 2015 Jun 26 doi: 10.1016/j.ando.2015.04.005. PMID: 26122495
Management of clinically non-functioning pituitary adenoma.
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284

Diagnosis

The epidemiology, diagnosis and treatment of Prolactinomas: The old and the new.
Chanson P, Maiter D
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101290. Epub 2019 Jul 10 doi: 10.1016/j.beem.2019.101290. PMID: 31326373
Functioning gonadotroph adenoma.
Zhao Y, Lian W, Xing B, Feng M, Ma WB
Chin Med J (Engl) 2019 Apr 20;132(8):1003-1004. doi: 10.1097/CM9.0000000000000184. PMID: 30958450Free PMC Article
Biological and radiological exploration and management of non-functioning pituitary adenoma.
Raverot G, Assié G, Cotton F, Cogne M, Boulin A, Dherbomez M, Bonneville JF, Massart C
Ann Endocrinol (Paris) 2015 Jul;76(3):201-9. Epub 2015 Jun 26 doi: 10.1016/j.ando.2015.04.005. PMID: 26122495
Management of clinically non-functioning pituitary adenoma.
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284
Gonadotropinomas.
Chaidarun SS, Klibanski A
Semin Reprod Med 2002 Nov;20(4):339-48. doi: 10.1055/s-2002-36708. PMID: 12536357

Therapy

The epidemiology, diagnosis and treatment of Prolactinomas: The old and the new.
Chanson P, Maiter D
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101290. Epub 2019 Jul 10 doi: 10.1016/j.beem.2019.101290. PMID: 31326373
Functioning gonadotroph adenoma with severe ovarian hyperstimulation syndrome: A new emergency in pituitary adenoma surgery? Surgical considerations and literature review.
Graillon T, Castinetti F, Chabert-Orsini V, Morange I, Cuny T, Albarel F, Brue T, Dufour H
Ann Endocrinol (Paris) 2019 Apr;80(2):122-127. Epub 2019 Feb 7 doi: 10.1016/j.ando.2018.11.007. PMID: 30825998
Post-surgical management of non-functioning pituitary adenoma.
Cortet-Rudelli C, Bonneville JF, Borson-Chazot F, Clavier L, Coche Dequéant B, Desailloud R, Maiter D, Rohmer V, Sadoul JL, Sonnet E, Toussaint P, Chanson P
Ann Endocrinol (Paris) 2015 Jul;76(3):228-38. Epub 2015 Jun 23 doi: 10.1016/j.ando.2015.04.003. PMID: 26116412
Non-functioning pituitary adenomas: endocrinological and clinical outcome after transsphenoidal and transcranial surgery.
Wichers-Rother M, Hoven S, Kristof RA, Bliesener N, Stoffel-Wagner B
Exp Clin Endocrinol Diabetes 2004 Jun;112(6):323-7. doi: 10.1055/s-2004-820914. PMID: 15216450
Medical treatment of hyperprolactinemia.
Fossati P, Dewailly D, Thomas-Desrousseaux P, Buvat J, Fermon C, Lemaire A, Bourdelle-Hego MF, Pouyol-Motte H, Lemaitre G, Clarisse J
Horm Res 1985;22(3):228-38. doi: 10.1159/000180099. PMID: 4054843

Prognosis

Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis.
Lasolle H, Elsensohn MH, Wierinckx A, Alix E, Bonnefille C, Vasiljevic A, Cortet C, Decoudier B, Sturm N, Gaillard S, Ferrière A, Roy P, Jouanneau E, Bertolino P, Bardel C, Sanlaville D, Raverot G
Acta Neuropathol Commun 2020 Nov 10;8(1):190. doi: 10.1186/s40478-020-01067-5. PMID: 33168091Free PMC Article
The epidemiology, diagnosis and treatment of Prolactinomas: The old and the new.
Chanson P, Maiter D
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101290. Epub 2019 Jul 10 doi: 10.1016/j.beem.2019.101290. PMID: 31326373
Nonfunctioning Pituitary Adenoma Recurrence and Its Relationship with Sex, Size, and Hormonal Immunohistochemical Profile.
Batista RL, Trarbach EB, Marques MD, Cescato VA, da Silva GO, Herkenhoff CGB, Cunha-Neto MB, Musolino NR
World Neurosurg 2018 Dec;120:e241-e246. Epub 2018 Aug 20 doi: 10.1016/j.wneu.2018.08.043. PMID: 30138730
Gonadotrope Tumors.
Asa SL, Ezzat S
Prog Mol Biol Transl Sci 2016;143:187-210. Epub 2016 Sep 7 doi: 10.1016/bs.pmbts.2016.08.005. PMID: 27697203
Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma--Review.
Halupczok J, Kluba-Szyszka A, Bidzińska-Speichert B, Knychalski B
Adv Clin Exp Med 2015 Jul-Aug;24(4):695-703. doi: 10.17219/acem/25212. PMID: 26469116

Clinical prediction guides

Clinical characteristics of functioning gonadotroph adenoma in women presenting with ovarian hyperstimulation: Audit of UK pituitary centres.
Papanikolaou N, Millar O, Coulden A, Parker N, Sit L, Kelly C, Cox J, Dhillo WS, Meeran K, Al Memar M, Anderson R, Rees DA, Karavitaki N, Jayasena CN
Clin Endocrinol (Oxf) 2023 Oct;99(4):386-395. Epub 2023 Jul 10 doi: 10.1111/cen.14949. PMID: 37430451
Functioning gonadotroph adenomas in premenopausal women: clinical and molecular characterization and review of the literature.
Wang L, Liang H, Deng C, Yu Q, Gong F, Feng F, You H, Liang Z, Chen B, Deng K, Ma J, Wang R, Yao Y, Zhu H
Pituitary 2022 Jun;25(3):454-467. Epub 2022 Feb 9 doi: 10.1007/s11102-021-01205-9. PMID: 35138520
Gonadotroph Pituitary Adenoma Causing Treatable Infertility and Ovarian Hyperstimulation Syndrome in Female Patients: Neurosurgical, Endocrinologic, Gynecologic, and Reproductive Outcomes.
Hasegawa H, Nesvick CL, Erickson D, Cohen SC, Yolcu YU, Khan Z, Raghunathan A, Nippoldt TB, Atkinson JL, Van Gompel JJ
World Neurosurg 2021 Jun;150:e162-e175. Epub 2021 Mar 5 doi: 10.1016/j.wneu.2021.02.115. PMID: 33684575
Nonfunctioning Pituitary Adenoma Recurrence and Its Relationship with Sex, Size, and Hormonal Immunohistochemical Profile.
Batista RL, Trarbach EB, Marques MD, Cescato VA, da Silva GO, Herkenhoff CGB, Cunha-Neto MB, Musolino NR
World Neurosurg 2018 Dec;120:e241-e246. Epub 2018 Aug 20 doi: 10.1016/j.wneu.2018.08.043. PMID: 30138730
Ovarian Hyperstimulation Caused by Gonadotroph Pituitary Adenoma--Review.
Halupczok J, Kluba-Szyszka A, Bidzińska-Speichert B, Knychalski B
Adv Clin Exp Med 2015 Jul-Aug;24(4):695-703. doi: 10.17219/acem/25212. PMID: 26469116

Recent systematic reviews

Gonadotroph Pituitary Adenoma Causing Treatable Infertility and Ovarian Hyperstimulation Syndrome in Female Patients: Neurosurgical, Endocrinologic, Gynecologic, and Reproductive Outcomes.
Hasegawa H, Nesvick CL, Erickson D, Cohen SC, Yolcu YU, Khan Z, Raghunathan A, Nippoldt TB, Atkinson JL, Van Gompel JJ
World Neurosurg 2021 Jun;150:e162-e175. Epub 2021 Mar 5 doi: 10.1016/j.wneu.2021.02.115. PMID: 33684575

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