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Pituitary macroadenoma

MedGen UID:
577357
•Concept ID:
C0346308
•
Neoplastic Process
Synonyms: PitNET/Macroadenoma; Pituitary Gland Macroadenoma; Pituitary gland macroadenoma; Pituitary Neuroendocrine Tumor/Macroadenoma
SNOMED CT: Pituitary macroadenoma (254965007)
 
HPO: HP:0025693

Definition

A pituitary gland adenoma that is larger than 10mm. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPituitary macroadenoma

Professional guidelines

PubMed

The PI3K/AKT/mTOR pathway in the pathophysiology and treatment of pituitary adenomas.
Monsalves E, Juraschka K, Tateno T, Agnihotri S, Asa SL, Ezzat S, Zadeh G
Endocr Relat Cancer 2014 Aug;21(4):R331-44. doi: 10.1530/ERC-14-0188. PMID: 25052915
Octreotide for acromegaly treatment: a reappraisal.
Giustina A, Karamouzis I, Patelli I, Mazziotti G
Expert Opin Pharmacother 2013 Dec;14(17):2433-47. Epub 2013 Oct 14 doi: 10.1517/14656566.2013.847090. PMID: 24124691
Pituitary tumor apoplexy: characteristics, treatment, and outcomes.
Verrees M, Arafah BM, Selman WR
Neurosurg Focus 2004 Apr 15;16(4):E6. doi: 10.3171/foc.2004.16.4.7. PMID: 15191335

Recent clinical studies

Etiology

Pituitary Stalk Stretch Predicts Postoperative Diabetes Insipidus After Pituitary Macroadenoma Transsphenoidal Resection.
Hoang AN, McGahan BG, Cua S, Magill ST, Nayak P, Montaser AS, Ghalib L, Prevedello LM, Hardesty DA, Carrau RL, Prevedello DM
Oper Neurosurg (Hagerstown) 2023 Mar 1;24(3):248-255. Epub 2022 Nov 10 doi: 10.1227/ons.0000000000000501. PMID: 36701694
Correlation of Pituitary Descent and Diabetes Insipidus After Transsphenoidal Pituitary Macroadenoma Resection.
Ma J, Gooderham P, Akagami R, Makarenko S
Neurosurgery 2023 Jun 1;92(6):1269-1275. Epub 2023 Jan 18 doi: 10.1227/neu.0000000000002360. PMID: 36700759
Extra-pseudocapsular Transnasal Transsphenoidal Resection of Pituitary Macroadenoma: Technique Note and Evaluation of Endocrine Function.
Xu Y, Wan XY, Li LH, Chen J, Wang JW, Shu K, Buchfelder M, Fahlbusch R, Lei T
Curr Med Sci 2022 Dec;42(6):1148-1156. Epub 2022 Dec 21 doi: 10.1007/s11596-022-2674-5. PMID: 36542323
Chiasmal herniation following treatment of pituitary macroadenoma.
Tabak M, Pelsma ICM, Kruit MC, van Furth WR, Biermasz NR, Notting IC
Pituitary 2021 Feb;24(1):68-78. Epub 2020 Oct 15 doi: 10.1007/s11102-020-01088-2. PMID: 33057947Free PMC Article
Coexistence of a pituitary macroadenoma and pheochromocytoma--a case report and review of the literature.
Breckenridge SM, Hamrahian AH, Faiman C, Suh J, Prayson R, Mayberg M
Pituitary 2003;6(4):221-5. doi: 10.1023/b:pitu.0000023429.89644.7b. PMID: 15237934

Diagnosis

Cardiac myxoma presenting with multisystem involvement.
Ageely GA, Alsulami SS, Alkenani AA, Albeshri EE
Saudi Med J 2022 Sep;43(9):1057-1061. doi: 10.15537/smj.2022.43.9.20220346. PMID: 36104063Free PMC Article
Pituitary Macroadenoma: Fooling the Ophthalmologist before Giving Him the Role of the Whistle-Blower.
Tran L, Papasavvas I, Herbort CP Jr
Klin Monbl Augenheilkd 2022 Apr;239(4):468-475. Epub 2022 Apr 26 doi: 10.1055/a-1778-3249. PMID: 35472789
Non-functioning pituitary adenomas and pregnancy: one-center experience and review of the literature.
Rosmino J, Tkatch J, Di Paolo MV, Berner S, Lescano S, Guitelman M
Arch Endocrinol Metab 2021 May 18;64(5):614-622. doi: 10.20945/2359-3997000000232. PMID: 34033303Free PMC Article
Pituitary Dysfunction Among Men Presenting with Hypogonadism.
Levy S, Arguello M, Macki M, Rao SD
Curr Urol Rep 2019 Nov 16;20(11):78. doi: 10.1007/s11934-019-0935-z. PMID: 31734886
Endocranial lesions.
Vattoth S, DeLappe RS Jr, Chapman PR
Semin Ultrasound CT MR 2013 Oct;34(5):393-411. doi: 10.1053/j.sult.2013.08.002. PMID: 24216450

Therapy

Pituitary Dysfunction Among Men Presenting with Hypogonadism.
Levy S, Arguello M, Macki M, Rao SD
Curr Urol Rep 2019 Nov 16;20(11):78. doi: 10.1007/s11934-019-0935-z. PMID: 31734886
The PI3K/AKT/mTOR pathway in the pathophysiology and treatment of pituitary adenomas.
Monsalves E, Juraschka K, Tateno T, Agnihotri S, Asa SL, Ezzat S, Zadeh G
Endocr Relat Cancer 2014 Aug;21(4):R331-44. doi: 10.1530/ERC-14-0188. PMID: 25052915
Octreotide for acromegaly treatment: a reappraisal.
Giustina A, Karamouzis I, Patelli I, Mazziotti G
Expert Opin Pharmacother 2013 Dec;14(17):2433-47. Epub 2013 Oct 14 doi: 10.1517/14656566.2013.847090. PMID: 24124691
Pituitary-directed medical therapy with pasireotide for a corticotroph macroadenoma: pituitary volume reduction and literature review.
Shimon I, Rot L, Inbar E
Pituitary 2012 Dec;15(4):608-13. doi: 10.1007/s11102-012-0427-3. PMID: 22918543
Transsphenoidal diplopia.
Foroozan R, Bhatti MT, Rhoton AL
Surv Ophthalmol 2004 May-Jun;49(3):349-58. doi: 10.1016/j.survophthal.2004.02.008. PMID: 15110671

Prognosis

Pituitary Stalk Stretch Predicts Postoperative Diabetes Insipidus After Pituitary Macroadenoma Transsphenoidal Resection.
Hoang AN, McGahan BG, Cua S, Magill ST, Nayak P, Montaser AS, Ghalib L, Prevedello LM, Hardesty DA, Carrau RL, Prevedello DM
Oper Neurosurg (Hagerstown) 2023 Mar 1;24(3):248-255. Epub 2022 Nov 10 doi: 10.1227/ons.0000000000000501. PMID: 36701694
Extra-pseudocapsular Transnasal Transsphenoidal Resection of Pituitary Macroadenoma: Technique Note and Evaluation of Endocrine Function.
Xu Y, Wan XY, Li LH, Chen J, Wang JW, Shu K, Buchfelder M, Fahlbusch R, Lei T
Curr Med Sci 2022 Dec;42(6):1148-1156. Epub 2022 Dec 21 doi: 10.1007/s11596-022-2674-5. PMID: 36542323
Chiasmal herniation following treatment of pituitary macroadenoma.
Tabak M, Pelsma ICM, Kruit MC, van Furth WR, Biermasz NR, Notting IC
Pituitary 2021 Feb;24(1):68-78. Epub 2020 Oct 15 doi: 10.1007/s11102-020-01088-2. PMID: 33057947Free PMC Article
Pituitary Macroadenoma and Visual Impairment: Postoperative Outcome Prediction with Contrast-Enhanced FIESTA.
Hisanaga S, Kakeda S, Yamamoto J, Watanabe K, Moriya J, Nagata T, Fujino Y, Kondo H, Nishizawa S, Korogi Y
AJNR Am J Neuroradiol 2017 Nov;38(11):2067-2072. Epub 2017 Sep 14 doi: 10.3174/ajnr.A5394. PMID: 28912278Free PMC Article
Turner syndrome and pituitary adenomas: a case report and review of literature.
Yeh T, Soto AG, Quintos JB, Topor LS
J Pediatr Endocrinol Metab 2017 Feb 1;30(2):231-235. doi: 10.1515/jpem-2016-0202. PMID: 28099131

Clinical prediction guides

Pituitary Stalk Stretch Predicts Postoperative Diabetes Insipidus After Pituitary Macroadenoma Transsphenoidal Resection.
Hoang AN, McGahan BG, Cua S, Magill ST, Nayak P, Montaser AS, Ghalib L, Prevedello LM, Hardesty DA, Carrau RL, Prevedello DM
Oper Neurosurg (Hagerstown) 2023 Mar 1;24(3):248-255. Epub 2022 Nov 10 doi: 10.1227/ons.0000000000000501. PMID: 36701694
Correlation of Pituitary Descent and Diabetes Insipidus After Transsphenoidal Pituitary Macroadenoma Resection.
Ma J, Gooderham P, Akagami R, Makarenko S
Neurosurgery 2023 Jun 1;92(6):1269-1275. Epub 2023 Jan 18 doi: 10.1227/neu.0000000000002360. PMID: 36700759
Extra-pseudocapsular Transnasal Transsphenoidal Resection of Pituitary Macroadenoma: Technique Note and Evaluation of Endocrine Function.
Xu Y, Wan XY, Li LH, Chen J, Wang JW, Shu K, Buchfelder M, Fahlbusch R, Lei T
Curr Med Sci 2022 Dec;42(6):1148-1156. Epub 2022 Dec 21 doi: 10.1007/s11596-022-2674-5. PMID: 36542323
Chiasmal herniation following treatment of pituitary macroadenoma.
Tabak M, Pelsma ICM, Kruit MC, van Furth WR, Biermasz NR, Notting IC
Pituitary 2021 Feb;24(1):68-78. Epub 2020 Oct 15 doi: 10.1007/s11102-020-01088-2. PMID: 33057947Free PMC Article
Pituitary Macroadenoma and Visual Impairment: Postoperative Outcome Prediction with Contrast-Enhanced FIESTA.
Hisanaga S, Kakeda S, Yamamoto J, Watanabe K, Moriya J, Nagata T, Fujino Y, Kondo H, Nishizawa S, Korogi Y
AJNR Am J Neuroradiol 2017 Nov;38(11):2067-2072. Epub 2017 Sep 14 doi: 10.3174/ajnr.A5394. PMID: 28912278Free PMC Article

Recent systematic reviews

Isolated Pituitary Metastasis of Renal Cell Carcinoma: A Case Report and Systematic Review of the Literature.
Öven BB, Demir MK, Çelik S, Moujawaz R, Somay A, Kılıc T
Curr Med Imaging 2022;18(13):1426-1432. doi: 10.2174/0929866529666220426121245. PMID: 35490330
Evolving Strategies for Resection of Sellar/Parasellar Synchronous Tumors via Endoscopic Endonasal Approach: A Technical Case Report and Systematic Review of the Literature.
Roethlisberger M, Jayapalan RR, Hostettler IC, Bin Abd Kadir KA, Mun KS, Brand Y, Mariani L, Prepageran N, Waran V
World Neurosurg 2020 Jan;133:381-391.e2. Epub 2019 Aug 30 doi: 10.1016/j.wneu.2019.08.102. PMID: 31476461
Abducens palsy after lumbar drain placement: a rare complication in endoscopic skull base surgery.
Cain RB, Patel NP, Hoxworth JM, Lal D
Laryngoscope 2013 Nov;123(11):2633-8. Epub 2013 May 13 doi: 10.1002/lary.24177. PMID: 23670572
Place of preoperative treatment of acromegaly with somatostatin analog on surgical outcome: a systematic review and meta-analysis.
Pita-Gutierrez F, Pertega-Diaz S, Pita-Fernandez S, Pena L, Lugo G, Sangiao-Alvarellos S, Cordido F
PLoS One 2013;8(4):e61523. Epub 2013 Apr 25 doi: 10.1371/journal.pone.0061523. PMID: 23634209Free PMC Article

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