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Neonatal aspiration syndrome

MedGen UID:
578767
•Concept ID:
C0349468
•
Disease or Syndrome
Synonyms: Neonatal Aspiration Syndrome; neonatal aspiration syndrome
SNOMED CT: Neonatal aspiration syndrome (276533002)
 
Monarch Initiative: MONDO:0024263

Definition

Aspiration of meconium, blood, amniotic fluid or gastric contents around the time of delivery resulting in clinical symptoms from airway obstruction, parenchymal injury, and ventilation-perfusion mismatch. This may lead to persistent pulmonary hypertension in the newborn. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal aspiration syndrome

Professional guidelines

PubMed

Multiorgan involvement and management in children with Down syndrome.
Lagan N, Huggard D, Mc Grane F, Leahy TR, Franklin O, Roche E, Webb D, O' Marcaigh A, Cox D, El-Khuffash A, Greally P, Balfe J, Molloy EJ
Acta Paediatr 2020 Jun;109(6):1096-1111. Epub 2020 Jan 24 doi: 10.1111/apa.15153. PMID: 31899550
Update on PPHN: mechanisms and treatment.
Nair J, Lakshminrusimha S
Semin Perinatol 2014 Mar;38(2):78-91. doi: 10.1053/j.semperi.2013.11.004. PMID: 24580763Free PMC Article
Surfactant replacement therapy for preterm and term neonates with respiratory distress.
Polin RA, Carlo WA; Committee on Fetus and Newborn; American Academy of Pediatrics
Pediatrics 2014 Jan;133(1):156-63. Epub 2013 Dec 30 doi: 10.1542/peds.2013-3443. PMID: 24379227

Recent clinical studies

Therapy

Clinical considerations when treating neonatal aspiration syndromes.
Calkovska A, Mokra D, Calkovsky V, Matasova K, Zibolen M
Expert Rev Respir Med 2019 Feb;13(2):193-203. Epub 2019 Jan 2 doi: 10.1080/17476348.2019.1562340. PMID: 30571925

Prognosis

Management for neonatal aspiration syndrome caused by vernix caseosa.
Nishijima K, Shukunami K, Inoue S, Kotsuji F
Fetal Diagn Ther 2005 May-Jun;20(3):194-6. doi: 10.1159/000083904. PMID: 15824497

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