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Neonatal aspiration of amniotic fluid

MedGen UID:
578768
•Concept ID:
C0349470
•
Disease or Syndrome
Synonyms: Aspiration of amniotic fluid in newborn; Aspiration of liquor in newborn; Neonatal Aspiration of Amniotic Fluid; Neonatal aspiration of liquor
SNOMED CT: Neonatal aspiration of amniotic fluid (276540001); Aspiration of amniotic fluid in newborn (276540001); Aspiration of liquor in newborn (276540001); Neonatal aspiration of liquor (276540001)

Definition

Inhalation of fluid from the amniotic sac into the lungs by the neonate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal aspiration of amniotic fluid

Professional guidelines

PubMed

Contemporary management of infants born through meconium stained amniotic fluid.
Strand ML, Perlman JM
Semin Perinatol 2022 Oct;46(6):151625. Epub 2022 May 21 doi: 10.1016/j.semperi.2022.151625. PMID: 35717246
Current Concepts in the Management of Meconium Aspiration Syndrome.
Chettri S, Bhat BV, Adhisivam B
Indian J Pediatr 2016 Oct;83(10):1125-30. Epub 2016 May 21 doi: 10.1007/s12098-016-2128-9. PMID: 27206687
Treatment of congenital tuberculosis.
Patel S, DeSantis ER
Am J Health Syst Pharm 2008 Nov 1;65(21):2027-31. doi: 10.2146/ajhp080054. PMID: 18945861

Recent clinical studies

Etiology

Meconium-stained amniotic fluid and neonatal morbidity in nulliparous patients with prolonged pregnancy.
Attali I, Korb D, Azria E, Lepercq J, Goffinet F, Schmitz T; Groupe de Recherche en Obstétrique et Gynécologie (GROG)
Acta Obstet Gynecol Scand 2023 Aug;102(8):1092-1099. Epub 2023 Jun 28 doi: 10.1111/aogs.14619. PMID: 37377254Free PMC Article
Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Meconium aspiration syndrome.
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962
Amnioinfusion.
Hofmeyr GJ, Gulmezoglu AM, Nikodem VC, de Jager M
Eur J Obstet Gynecol Reprod Biol 1996 Feb;64(2):159-65. doi: 10.1016/0301-2115(95)02330-5. PMID: 8819996

Diagnosis

Meconium-stained amniotic fluid and histologic signs of fetal distress in stillbirths.
Avagliano L, Massa V, Bulfamante G
Eur J Obstet Gynecol Reprod Biol 2021 Nov;266:55-62. Epub 2021 Sep 16 doi: 10.1016/j.ejogrb.2021.09.016. PMID: 34592650
Meconium "aspiration" (or respiratory distress associated with meconium-stained amniotic fluid?).
Vain NE, Batton DG
Semin Fetal Neonatal Med 2017 Aug;22(4):214-219. Epub 2017 Apr 11 doi: 10.1016/j.siny.2017.04.002. PMID: 28411000
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
What is the role of amnioinfusion in modern day obstetrics?
Dad N, Abushama M, Konje JC, Ahmed B
J Matern Fetal Neonatal Med 2016 Sep;29(17):2823-7. Epub 2015 Dec 2 doi: 10.3109/14767058.2015.1105953. PMID: 26461043
Meconium aspiration syndrome.
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962

Therapy

Meconium-stained amniotic fluid and neonatal morbidity in nulliparous patients with prolonged pregnancy.
Attali I, Korb D, Azria E, Lepercq J, Goffinet F, Schmitz T; Groupe de Recherche en Obstétrique et Gynécologie (GROG)
Acta Obstet Gynecol Scand 2023 Aug;102(8):1092-1099. Epub 2023 Jun 28 doi: 10.1111/aogs.14619. PMID: 37377254Free PMC Article
Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Amnioinfusion.
Hofmeyr GJ, Gulmezoglu AM, Nikodem VC, de Jager M
Eur J Obstet Gynecol Reprod Biol 1996 Feb;64(2):159-65. doi: 10.1016/0301-2115(95)02330-5. PMID: 8819996

Prognosis

Prediction of adverse neonatal outcome among newborns born through meconium-stained amniotic fluid.
Levin G, Tsur A, Shai D, Cahan T, Shapira M, Meyer R
Int J Gynaecol Obstet 2021 Sep;154(3):515-520. Epub 2021 Feb 11 doi: 10.1002/ijgo.13592. PMID: 33448026
The utility of amniotic fluid pH and electrolytes for prediction of neonatal respiratory disorders.
Yılmaz Semerci S, Yücel B, Erbas IM, Gunkaya OS, Talmac M, Çetinkaya M
J Matern Fetal Neonatal Med 2020 Jan;33(2):253-257. Epub 2018 Jul 22 doi: 10.1080/14767058.2018.1488961. PMID: 30033781
Meconium "aspiration" (or respiratory distress associated with meconium-stained amniotic fluid?).
Vain NE, Batton DG
Semin Fetal Neonatal Med 2017 Aug;22(4):214-219. Epub 2017 Apr 11 doi: 10.1016/j.siny.2017.04.002. PMID: 28411000
Maternal and neonatal outcomes of elective induction of labor.
Caughey AB, Sundaram V, Kaimal AJ, Cheng YW, Gienger A, Little SE, Lee JF, Wong L, Shaffer BL, Tran SH, Padula A, McDonald KM, Long EF, Owens DK, Bravata DM
Evid Rep Technol Assess (Full Rep) 2009 Mar;(176):1-257. PMID: 19408970Free PMC Article
Meconium aspiration syndrome.
Wiedemann JR, Saugstad AM, Barnes-Powell L, Duran K
Neonatal Netw 2008 Mar-Apr;27(2):81-7. doi: 10.1891/0730-0832.27.2.81. PMID: 18431962

Clinical prediction guides

Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Prediction of meconium aspiration syndrome by data available before delivery.
Amitai Komem D, Meyer R, Yinon Y, Levin G
Int J Gynaecol Obstet 2022 Sep;158(3):551-556. Epub 2021 Dec 9 doi: 10.1002/ijgo.14034. PMID: 34796482
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Amnioinfusion.
Hofmeyr GJ, Gulmezoglu AM, Nikodem VC, de Jager M
Eur J Obstet Gynecol Reprod Biol 1996 Feb;64(2):159-65. doi: 10.1016/0301-2115(95)02330-5. PMID: 8819996

Recent systematic reviews

Intrapartum amnioinfusion reduces meconium aspiration syndrome and improves neonatal outcomes in patients with meconium-stained fluid: a systematic review and meta-analysis.
Davis JD, Sanchez-Ramos L, McKinney JA, Lin L, Kaunitz AM
Am J Obstet Gynecol 2023 May;228(5S):S1179-S1191.e19. Epub 2023 Mar 18 doi: 10.1016/j.ajog.2022.07.047. PMID: 37164492
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Tracheal suctioning of meconium at birth for non-vigorous infants: a systematic review and meta-analysis.
Trevisanuto D, Strand ML, Kawakami MD, Fabres J, Szyld E, Nation K, Wyckoff MH, Rabi Y, Lee HC; International Liaison Committee on Resuscitation Neonatal Life Support Task Force
Resuscitation 2020 Apr;149:117-126. Epub 2020 Feb 22 doi: 10.1016/j.resuscitation.2020.01.038. PMID: 32097677
Oligohydramnios in complicated and uncomplicated pregnancy: a systematic review and meta-analysis.
Rabie N, Magann E, Steelman S, Ounpraseuth S
Ultrasound Obstet Gynecol 2017 Apr;49(4):442-449. doi: 10.1002/uog.15929. PMID: 27062200
Antibiotics for meconium-stained amniotic fluid in labour for preventing maternal and neonatal infections.
Siriwachirachai T, Sangkomkamhang US, Lumbiganon P, Laopaiboon M
Cochrane Database Syst Rev 2014 Nov 6;2014(11):CD007772. doi: 10.1002/14651858.CD007772.pub3. PMID: 25374369Free PMC Article

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