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Renal neoplasm

MedGen UID:
5967
Concept ID:
C0022665
Neoplastic Process
Synonym: Kidney neoplasm
SNOMED CT: Tumor of kidney (126880001); Renal tumor (126880001); Neoplasm of kidney (126880001)
 
HPO: HP:0009726
Monarch Initiative: MONDO:0021163

Definition

The presence of a neoplasm of the kidney. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal neoplasm

Conditions with this feature

Cowden syndrome 4
MedGen UID:
767431
Concept ID:
C3554517
Disease or Syndrome
\n\nThe features of Cowden syndrome overlap with those of another disorder called Bannayan-Riley-Ruvalcaba syndrome. People with Bannayan-Riley-Ruvalcaba syndrome also develop hamartomas and other noncancerous tumors.  Some people with Cowden syndrome have relatives diagnosed with Bannayan-Riley-Ruvalcaba syndrome, and other affected individuals have the characteristic features of both conditions. Based on these similarities, researchers have proposed that Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome represent a spectrum of overlapping features known as PTEN hamartoma tumor syndrome (named for the genetic cause of the conditions) instead of two distinct conditions.\n\nSome people do not meet the strict criteria for a clinical diagnosis of Cowden syndrome, but they have some of the characteristic features of the condition, particularly the cancers. These individuals are often described as having Cowden-like syndrome. Both Cowden syndrome and Cowden-like syndrome are caused by mutations in the same genes.\n\nCowden syndrome is associated with an increased risk of developing several types of cancer, particularly cancers of the breast, a gland in the lower neck called the thyroid, and the lining of the uterus (the endometrium). Other cancers that have been identified in people with Cowden syndrome include kidney cancer, colorectal cancer, and an agressive form of skin cancer called melanoma. Compared with the general population, people with Cowden syndrome develop these cancers at younger ages, often beginning in their thirties or forties. People with Cowden syndrome are also more likely to develop more than one cancer during their lifetimes compared to the general population. Other diseases of the breast, thyroid, and endometrium are also common in Cowden syndrome. Additional signs and symptoms can include an enlarged head (macrocephaly) and a rare, noncancerous brain tumor called Lhermitte-Duclos disease. A small percentage of affected individuals have delayed development, intellectual disability, or autism spectrum disorder, which can affect communication and social interaction.\n\nAlmost everyone with Cowden syndrome develops hamartomas. These growths are most commonly found on the skin and mucous membranes (such as the lining of the mouth and nose), but they can also occur in the intestine and other parts of the body. The growth of hamartomas on the skin and mucous membranes typically becomes apparent by a person's late twenties.\n\nCowden syndrome is a genetic disorder characterized by multiple noncancerous, tumor-like growths called hamartomas and an increased risk of developing certain cancers.
Birt-Hogg-Dube syndrome 1
MedGen UID:
1051978
Concept ID:
CN375946
Disease or Syndrome
Any Birt-Hogg-Dube (BHD) syndrome in which the cause of the disease is a variation in the FLCN gene.

Professional guidelines

PubMed

Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Zargar H, Atwell TD, Cadeddu JA, de la Rosette JJ, Janetschek G, Kaouk JH, Matin SF, Polascik TJ, Zargar-Shoshtari K, Thompson RH
Eur Urol 2016 Jan;69(1):116-28. Epub 2015 Mar 26 doi: 10.1016/j.eururo.2015.03.027. PMID: 25819723
Halpenny D, Snow A, McNeill G, Torreggiani WC
Clin Radiol 2010 Feb;65(2):99-108. Epub 2009 Dec 3 doi: 10.1016/j.crad.2009.09.014. PMID: 20103431

Recent clinical studies

Etiology

Lobo J, Ohashi R, Amin MB, Berney DM, Compérat EM, Cree IA, Gill AJ, Hartmann A, Menon S, Netto GJ, Raspollini MR, Rubin MA, Tan PH, Tickoo SK, Tsuzuki T, Turajlic S, Zhou M, Srigley JR, Moch H
Histopathology 2022 Oct;81(4):426-438. Epub 2022 Jun 10 doi: 10.1111/his.14700. PMID: 35596618
Tomaszewski Z, Littler Y
Int J Surg Pathol 2022 Oct;30(7):810-815. Epub 2022 Mar 11 doi: 10.1177/10668969221084265. PMID: 35274993
Hes O, Trpkov K
Mod Pathol 2022 Sep;35(9):1140-1150. Epub 2022 Mar 10 doi: 10.1038/s41379-022-01057-z. PMID: 35273336
Aldera AP, Pillay K
Arch Pathol Lab Med 2020 Jan;144(1):119-123. Epub 2019 Mar 27 doi: 10.5858/arpa.2018-0353-RS. PMID: 30917048
Petejova N, Martinek A
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2016 Jun;160(2):183-94. Epub 2015 Nov 3 doi: 10.5507/bp.2015.050. PMID: 26558360

Diagnosis

Lobo J, Ohashi R, Amin MB, Berney DM, Compérat EM, Cree IA, Gill AJ, Hartmann A, Menon S, Netto GJ, Raspollini MR, Rubin MA, Tan PH, Tickoo SK, Tsuzuki T, Turajlic S, Zhou M, Srigley JR, Moch H
Histopathology 2022 Oct;81(4):426-438. Epub 2022 Jun 10 doi: 10.1111/his.14700. PMID: 35596618
Hes O, Trpkov K
Mod Pathol 2022 Sep;35(9):1140-1150. Epub 2022 Mar 10 doi: 10.1038/s41379-022-01057-z. PMID: 35273336
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Castillo RP, Santoscoy JF, Pisani L, Madrazo BL, Casillas VJ
Curr Urol Rep 2019 Jan 21;20(1):5. doi: 10.1007/s11934-019-0867-7. PMID: 30663008
Petejova N, Martinek A
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2016 Jun;160(2):183-94. Epub 2015 Nov 3 doi: 10.5507/bp.2015.050. PMID: 26558360

Therapy

Neves JB, Varley R, Agnesi S, Withington J, Rodrigues FB, Warren H, Yuminaga Y, Capitanio U, Rode N, Grant L, Tran-Dang MA, El-Sheikh S, Walkden M, Cullen D, Aitchison M, Patki P, Mumtaz F, Barod R, Bex A, Tran MGB
BJU Int 2021 Dec;128(6):722-727. Epub 2021 Aug 9 doi: 10.1111/bju.15499. PMID: 34046981
Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ
Am J Surg Pathol 2019 Aug;43(8):1099-1111. doi: 10.1097/PAS.0000000000001288. PMID: 31135486
Petejova N, Martinek A
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2016 Jun;160(2):183-94. Epub 2015 Nov 3 doi: 10.5507/bp.2015.050. PMID: 26558360
Zargar H, Atwell TD, Cadeddu JA, de la Rosette JJ, Janetschek G, Kaouk JH, Matin SF, Polascik TJ, Zargar-Shoshtari K, Thompson RH
Eur Urol 2016 Jan;69(1):116-28. Epub 2015 Mar 26 doi: 10.1016/j.eururo.2015.03.027. PMID: 25819723
Andrés A
Crit Rev Oncol Hematol 2005 Oct;56(1):71-85. doi: 10.1016/j.critrevonc.2004.11.010. PMID: 15978827

Prognosis

Nova-Camacho LM, Martin-Arruti M, Díaz IR, Panizo-Santos Á
Arch Pathol Lab Med 2023 Jun 1;147(6):692-700. doi: 10.5858/arpa.2022-0156-OA. PMID: 36170616
Angori S, Lobo J, Moch H
Curr Opin Urol 2022 Jul 1;32(4):344-351. Epub 2022 Jun 9 doi: 10.1097/MOU.0000000000001000. PMID: 35674688Free PMC Article
Pampa-Saico S, Alexandru S, Pizarro-Sánchez MS, López-Picasso M, Puente-Suárez LG, Barba R, Liaño F
Nefrologia (Engl Ed) 2021 Jul-Aug;41(4):446-452. Epub 2021 Nov 4 doi: 10.1016/j.nefroe.2021.10.003. PMID: 36165113
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Aldera AP, Pillay K
Arch Pathol Lab Med 2020 Jan;144(1):119-123. Epub 2019 Mar 27 doi: 10.5858/arpa.2018-0353-RS. PMID: 30917048

Clinical prediction guides

Angori S, Lobo J, Moch H
Curr Opin Urol 2022 Jul 1;32(4):344-351. Epub 2022 Jun 9 doi: 10.1097/MOU.0000000000001000. PMID: 35674688Free PMC Article
Pampa-Saico S, Alexandru S, Pizarro-Sánchez MS, López-Picasso M, Puente-Suárez LG, Barba R, Liaño F
Nefrologia (Engl Ed) 2021 Jul-Aug;41(4):446-452. Epub 2021 Nov 4 doi: 10.1016/j.nefroe.2021.10.003. PMID: 36165113
Neves JB, Varley R, Agnesi S, Withington J, Rodrigues FB, Warren H, Yuminaga Y, Capitanio U, Rode N, Grant L, Tran-Dang MA, El-Sheikh S, Walkden M, Cullen D, Aitchison M, Patki P, Mumtaz F, Barod R, Bex A, Tran MGB
BJU Int 2021 Dec;128(6):722-727. Epub 2021 Aug 9 doi: 10.1111/bju.15499. PMID: 34046981
Kiyozawa D, Kohashi K, Takamatsu D, Yamamoto T, Eto M, Iwasaki T, Motoshita J, Shimokama T, Kinjo M, Oshiro Y, Yonemasu H, Oda Y
Hum Pathol 2021 Jun;112:48-58. Epub 2021 Apr 1 doi: 10.1016/j.humpath.2021.03.009. PMID: 33811832
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427

Recent systematic reviews

De Marchi D, Tafuri A, Mantica G, Shakir A, Scarfò F, Passaretti G, Smelzo S, Proietti S, Rigatti L, Luciano R, Antonelli A, Pagliarulo V, Leonardi R, Giusti G, Gaboardi F
Arch Ital Urol Androl 2021 Dec 21;93(4):481-488. doi: 10.4081/aiua.2021.4.481. PMID: 34933527
Perumal K, Huin WK, Yap NY, Ong TA, Gobe GC, Rajandram R
Med Hypotheses 2019 Aug;129:109239. Epub 2019 May 20 doi: 10.1016/j.mehy.2019.109239. PMID: 31371068
Ahn T, Roberts MJ, Navaratnam A, Chung E, Wood S
Int Urol Nephrol 2017 Nov;49(11):1897-1905. Epub 2017 Sep 4 doi: 10.1007/s11255-017-1694-8. PMID: 28871505
Mir MC, Derweesh I, Porpiglia F, Zargar H, Mottrie A, Autorino R
Eur Urol 2017 Apr;71(4):606-617. Epub 2016 Sep 7 doi: 10.1016/j.eururo.2016.08.060. PMID: 27614693

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