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Alcoholic liver cirrhosis

MedGen UID:
6125
•Concept ID:
C0023891
•
Disease or Syndrome
Synonyms: Alcoholic Cirrhosis; Alcoholic Hepatic Cirrhosis; Alcoholic Liver Cirrhosis; Hepatic Cirrhosis, Alcoholic; Liver Cirrhosis, Alcoholic
SNOMED CT: Alcoholic cirrhosis (420054005); Alcoholic liver cirrhosis (420054005); Alcoholic cirrhosis of liver (420054005)
 
Monarch Initiative: MONDO:0006644

Definition

A disorder of the liver characterized by the presence of fibrotic scar tissue instead of healthy liver tissue. This condition is attributed to excessive consumption of alcoholic beverages. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlcoholic liver cirrhosis

Professional guidelines

PubMed

FcGBP and VCAM-1 are ponderable biomarkers for differential diagnosis of alcoholic liver cirrhosis.
Abassa KK, Xiao XP, Zhou HX, Wu XY, Guo YW, Wu B
Drug Alcohol Depend 2022 Apr 1;233:109377. Epub 2022 Feb 24 doi: 10.1016/j.drugalcdep.2022.109377. PMID: 35245761
Refractory CIDP: Clinical characteristics, antibodies and response to alternative treatment.
Godil J, Barrett MJ, Ensrud E, Chahin N, Karam C
J Neurol Sci 2020 Nov 15;418:117098. Epub 2020 Aug 15 doi: 10.1016/j.jns.2020.117098. PMID: 32841917
Management strategies in alcoholic liver disease.
Tilg H, Day CP
Nat Clin Pract Gastroenterol Hepatol 2007 Jan;4(1):24-34. doi: 10.1038/ncpgasthep0683. PMID: 17203086

Recent clinical studies

Etiology

Dysregulation of innate cell types in the hepatic immune microenvironment of alcoholic liver cirrhosis.
Ren A, He W, Rao J, Ye D, Cheng P, Jian Q, Fu Z, Zhang X, Deng R, Gao Y, Ma Y
Front Immunol 2023;14:1034356. Epub 2023 Feb 9 doi: 10.3389/fimmu.2023.1034356. PMID: 36845083Free PMC Article
Alcoholic liver fibrosis: detection and treatment.
Testino G, Leone S, Fagoonee S, Pellicano R
Minerva Med 2018 Dec;109(6):457-471. Epub 2018 Sep 13 doi: 10.23736/S0026-4806.18.05844-5. PMID: 30221911
Cardiac manifestations in alcoholic liver disease.
Milić S, Lulić D, Štimac D, Ružić A, Zaputović L
Postgrad Med J 2016 Apr;92(1086):235-9. Epub 2016 Feb 5 doi: 10.1136/postgradmedj-2015-133755. PMID: 26850503
Alcoholism and liver disease in Mexico: genetic and environmental factors.
Roman S, Zepeda-Carrillo EA, Moreno-Luna LE, Panduro A
World J Gastroenterol 2013 Nov 28;19(44):7972-82. doi: 10.3748/wjg.v19.i44.7972. PMID: 24307790Free PMC Article
Alcohol and liver fibrosis.
Cubero FJ, Urtasun R, Nieto N
Semin Liver Dis 2009 May;29(2):211-21. Epub 2009 Apr 22 doi: 10.1055/s-0029-1214376. PMID: 19387920

Diagnosis

Alcohol-Associated Cirrhosis.
Lucey MR
Clin Liver Dis 2019 Feb;23(1):115-126. doi: 10.1016/j.cld.2018.09.013. PMID: 30454826
Alcoholic liver fibrosis: detection and treatment.
Testino G, Leone S, Fagoonee S, Pellicano R
Minerva Med 2018 Dec;109(6):457-471. Epub 2018 Sep 13 doi: 10.23736/S0026-4806.18.05844-5. PMID: 30221911
Non-invasive diagnosis of alcoholic liver disease.
Mueller S, Seitz HK, Rausch V
World J Gastroenterol 2014 Oct 28;20(40):14626-41. doi: 10.3748/wjg.v20.i40.14626. PMID: 25356026Free PMC Article
Liver fibrosis markers in alcoholic liver disease.
Chrostek L, Panasiuk A
World J Gastroenterol 2014 Jul 7;20(25):8018-23. doi: 10.3748/wjg.v20.i25.8018. PMID: 25009372Free PMC Article
Alcoholic cirrhosis.
Burnett DA, Sorrell MF
Clin Gastroenterol 1981 May;10(2):443-55. PMID: 7018752

Therapy

A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis.
China L, Freemantle N, Forrest E, Kallis Y, Ryder SD, Wright G, Portal AJ, Becares Salles N, Gilroy DW, O'Brien A; ATTIRE Trial Investigators
N Engl J Med 2021 Mar 4;384(9):808-817. doi: 10.1056/NEJMoa2022166. PMID: 33657293
Alcoholic liver fibrosis: detection and treatment.
Testino G, Leone S, Fagoonee S, Pellicano R
Minerva Med 2018 Dec;109(6):457-471. Epub 2018 Sep 13 doi: 10.23736/S0026-4806.18.05844-5. PMID: 30221911
Pathophysiology and Management of Alcoholic Liver Disease: Update 2016.
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article
Alcoholism and liver disease in Mexico: genetic and environmental factors.
Roman S, Zepeda-Carrillo EA, Moreno-Luna LE, Panduro A
World J Gastroenterol 2013 Nov 28;19(44):7972-82. doi: 10.3748/wjg.v19.i44.7972. PMID: 24307790Free PMC Article
Alcohol and liver fibrosis.
Cubero FJ, Urtasun R, Nieto N
Semin Liver Dis 2009 May;29(2):211-21. Epub 2009 Apr 22 doi: 10.1055/s-0029-1214376. PMID: 19387920

Prognosis

Incidence, prevalence and mortality of chronic liver diseases in Sweden between 2005 and 2019.
Nasr P, von Seth E, Mayerhofer R, Ndegwa N, Ludvigsson JF, Hagström H
Eur J Epidemiol 2023 Sep;38(9):973-984. Epub 2023 Jul 25 doi: 10.1007/s10654-023-01028-x. PMID: 37490175Free PMC Article
Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors.
Huang DQ, Mathurin P, Cortez-Pinto H, Loomba R
Nat Rev Gastroenterol Hepatol 2023 Jan;20(1):37-49. Epub 2022 Oct 18 doi: 10.1038/s41575-022-00688-6. PMID: 36258033Free PMC Article
Alcohol-Associated Cirrhosis.
Lucey MR
Clin Liver Dis 2019 Feb;23(1):115-126. doi: 10.1016/j.cld.2018.09.013. PMID: 30454826
Alcohol use and smoking after liver transplantation; complications and prevention.
Ursic-Bedoya J, Donnadieu-Rigole H, Faure S, Pageaux GP
Best Pract Res Clin Gastroenterol 2017 Apr;31(2):181-185. Epub 2017 Apr 12 doi: 10.1016/j.bpg.2017.03.005. PMID: 28624106
The prognosis and outcome of alcoholic liver disease.
Morgan MY
Alcohol Alcohol Suppl 1994;2:335-43. PMID: 8974353

Clinical prediction guides

Serum interleukin-6 level predicts the prognosis for patients with alcohol-related acute-on-chronic liver failure.
Murakami S, Imamura M, Uchida T, Suehiro Y, Namba M, Fujii Y, Uchikawa S, Teraoka Y, Fujino H, Ono A, Nakahara T, Murakami E, Okamoto W, Yamauchi M, Kawaoka T, Miki D, Hayes NC, Tsuge M, Aikata H, Ohira M, Ohdan H, Oka S
Hepatol Int 2023 Oct;17(5):1225-1232. Epub 2023 Apr 26 doi: 10.1007/s12072-023-10532-x. PMID: 37101102
A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers.
Whitfield JB, Schwantes-An TH, Darlay R, Aithal GP, Atkinson SR, Bataller R, Botwin G, Chalasani NP, Cordell HJ, Daly AK, Day CP, Eyer F, Foroud T, Gleeson D, Goldman D, Haber PS, Jacquet JM, Liang T, Liangpunsakul S, Masson S, Mathurin P, Moirand R, McQuillin A, Moreno C, Morgan MY, Mueller S, Müllhaupt B, Nagy LE, Nahon P, Nalpas B, Naveau S, Perney P, Pirmohamed M, Seitz HK, Soyka M, Stickel F, Thompson A, Thursz MR, Trépo E, Morgan TR, Seth D; GenomALC Consortium
J Hepatol 2022 Feb;76(2):275-282. Epub 2021 Oct 14 doi: 10.1016/j.jhep.2021.10.005. PMID: 34656649Free PMC Article
Pathophysiology and Management of Alcoholic Liver Disease: Update 2016.
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article
Current Status of Alcoholic Liver Disease in Japan and Therapeutic Strategy.
Horie Y, Ebinuma H, Kikuchi M, Lamao Takanori
Nihon Arukoru Yakubutsu Igakkai Zasshi 2016 Aug;51(2):71-90. PMID: 30462383
Liver fibrosis markers in alcoholic liver disease.
Chrostek L, Panasiuk A
World J Gastroenterol 2014 Jul 7;20(25):8018-23. doi: 10.3748/wjg.v20.i25.8018. PMID: 25009372Free PMC Article

Recent systematic reviews

Prevalence of alcohol-associated liver disease: a systematic review and meta-analysis.
Amonker S, Houshmand A, Hinkson A, Rowe I, Parker R
Hepatol Commun 2023 May 1;7(5) Epub 2023 Apr 26 doi: 10.1097/HC9.0000000000000133. PMID: 37102767Free PMC Article
Hepatocellular Carcinoma Incidence in Alcohol-Associated Cirrhosis: Systematic Review and Meta-analysis.
Huang DQ, Tan DJH, Ng CH, Amangurbanova M, Sutter N, Lin Tay PW, Lim WH, Yong JN, Tang A, Syn N, Muthiah MD, Tan EXX, Dave S, Tay B, Majzoub AM, Gerberi D, Kim BK, Loomba R
Clin Gastroenterol Hepatol 2023 May;21(5):1169-1177. Epub 2022 Aug 5 doi: 10.1016/j.cgh.2022.06.032. PMID: 35940513Free PMC Article
Ultrasonography for diagnosis of alcoholic cirrhosis in people with alcoholic liver disease.
Pavlov CS, Casazza G, Semenistaia M, Nikolova D, Tsochatzis E, Liusina E, Ivashkin VT, Gluud C
Cochrane Database Syst Rev 2016 Mar 2;3(3):CD011602. doi: 10.1002/14651858.CD011602.pub2. PMID: 26934429Free PMC Article
Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis.
Kennedy OJ, Roderick P, Buchanan R, Fallowfield JA, Hayes PC, Parkes J
Aliment Pharmacol Ther 2016 Mar;43(5):562-74. Epub 2016 Jan 25 doi: 10.1111/apt.13523. PMID: 26806124
Colchicine for alcoholic and non-alcoholic liver fibrosis and cirrhosis.
Rambaldi A, Gluud C
Cochrane Database Syst Rev 2005 Apr 18;2005(2):CD002148. doi: 10.1002/14651858.CD002148.pub2. PMID: 15846629Free PMC Article

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