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Epithelioid hemangioma

MedGen UID:
61449
Concept ID:
C0205788
Neoplastic Process
Synonyms: Hemangioma, Histiocytoid; Hemangiomas, Histiocytoid; Histiocytoid Hemangioma; Histiocytoid Hemangiomas
SNOMED CT: Angiolymphoid hyperplasia with eosinophilia (125574005); Histiocytoid hemangioma (33929001); Epithelioid hemangioma (189869009); Epithelioid hemangioma (33929001)
 
HPO: HP:0032060
Monarch Initiative: MONDO:0021169

Definition

A benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate, manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpithelioid hemangioma

Professional guidelines

PubMed

Tortorelli I, Bellan E, Chiusole B, Murtas F, Ruggieri P, Pala E, Cerchiaro M, Buzzaccarini MS, Scarzello G, Krengli M, Bisinella G, Battisti S, Di Maggio A, Zagonel V, Tos APD, Sbaraglia M, Brunello A
Crit Rev Oncol Hematol 2024 Mar;195:104268. Epub 2024 Jan 17 doi: 10.1016/j.critrevonc.2024.104268. PMID: 38237880
Ramírez Ramírez CR, Saavedra S, Ramírez Ronda CH
Bol Asoc Med P R 1996 Apr-Jun;88(4-6):46-51. PMID: 8916440
Ramírez Ramírez CR, Saavedra S, Ramírez Ronda C
Bol Asoc Med P R 1995 Jul-Sep;87(7-9):140-6. PMID: 8703269

Recent clinical studies

Etiology

Goto K, Ogawa K, Fukai T, Miura K, Yanagihara S, Honma K, Motoi T
J Cutan Pathol 2022 Sep;49(9):765-771. Epub 2022 May 10 doi: 10.1111/cup.14246. PMID: 35490255
Tsuda Y, Suurmeijer AJH, Sung YS, Zhang L, Healey JH, Antonescu CR
Genes Chromosomes Cancer 2021 Jan;60(1):17-25. Epub 2020 Oct 9 doi: 10.1002/gcc.22898. PMID: 33034932Free PMC Article
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Sun ZJ, Zhang L, Zhang WF, Alsharif MJ, Chen XM, Zhao YF
Oral Oncol 2006 May;42(5):441-7. Epub 2005 Nov 2 doi: 10.1016/j.oraloncology.2005.07.012. PMID: 16266821
Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM
Semin Diagn Pathol 1986 Nov;3(4):259-87. PMID: 3303234

Diagnosis

Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Papke DJ Jr, Hornick JL
Virchows Arch 2020 Jan;476(1):17-28. Epub 2019 Aug 28 doi: 10.1007/s00428-019-02651-4. PMID: 31463731
Shon W, Billings SD
Adv Anat Pathol 2019 May;26(3):186-197. doi: 10.1097/PAP.0000000000000228. PMID: 30762622
Habeeb O, Rubin BP
Surg Pathol Clin 2019 Mar;12(1):35-49. Epub 2018 Dec 4 doi: 10.1016/j.path.2018.10.002. PMID: 30709447
Guo R, Gavino AC
Arch Pathol Lab Med 2015 May;139(5):683-6. doi: 10.5858/arpa.2013-0334-RS. PMID: 25927152

Therapy

Alder B, Proia A, Liss J
Orbit 2013 Feb;32(1):51-3. doi: 10.3109/01676830.2012.739674. PMID: 23387457
Moss HB, Sines DT, Blatt J, Dutton JJ, Proia AD
Ophthalmic Plast Reconstr Surg 2012 Jul-Aug;28(4):e88-90. doi: 10.1097/IOP.0b013e31823645f9. PMID: 22186982
Ogura K, Shinoda Y, Okuma T, Ushiku T, Motoi T, Kawano H
J Orthop Sci 2012 Mar;17(2):194-8. Epub 2011 May 11 doi: 10.1007/s00776-011-0081-z. PMID: 21559957
López de Blanc S, Sambuelli R, Femopase F, Luna N, Gravotta M, David D, Bistoni A, Criscuolo MI
J Oral Pathol Med 2000 Feb;29(2):91-6. doi: 10.1034/j.1600-0714.2000.290207.x. PMID: 10718405
Ramírez Ramírez CR, Saavedra S, Ramírez Ronda C
Bol Asoc Med P R 1995 Jul-Sep;87(7-9):140-6. PMID: 8703269

Prognosis

Bansal D, Pasricha S, Sharma A, Pruthi M, Tiwari A, Gupta G, Durga G, Kamboj M, Mahawar V, Jajodia A, Mehta A
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):401-405. doi: 10.4103/IJPM.IJPM_1170_20. PMID: 35435379
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851
Errani C, Zhang L, Panicek DM, Healey JH, Antonescu CR
Clin Orthop Relat Res 2012 May;470(5):1498-506. Epub 2011 Sep 24 doi: 10.1007/s11999-011-2070-0. PMID: 21948309Free PMC Article
Hui PK, Chan JK, Ng CS, Kung IT, Gwi E
Am J Surg Pathol 1989 Mar;13(3):177-86. doi: 10.1097/00000478-198903000-00001. PMID: 2919716

Clinical prediction guides

Goto K, Ogawa K, Fukai T, Miura K, Yanagihara S, Honma K, Motoi T
J Cutan Pathol 2022 Sep;49(9):765-771. Epub 2022 May 10 doi: 10.1111/cup.14246. PMID: 35490255
Luzar B, Ieremia E, Antonescu CR, Zhang L, Calonje E
Mod Pathol 2020 Aug;33(8):1527-1536. Epub 2020 Feb 24 doi: 10.1038/s41379-020-0505-4. PMID: 32094426Free PMC Article
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851
Sun ZJ, Zhang L, Zhang WF, Alsharif MJ, Chen XM, Zhao YF
Oral Oncol 2006 May;42(5):441-7. Epub 2005 Nov 2 doi: 10.1016/j.oraloncology.2005.07.012. PMID: 16266821

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