U.S. flag

An official website of the United States government


Send to:

Choose Destination

Non-Hodgkin lymphoma(NHL)

MedGen UID:
Concept ID:
Neoplastic Process
Synonyms: LYMPHOMA, NON-HODGKIN, SOMATIC; Malignant lymphoma, non-Hodgkin; NHL
SNOMED CT: Malignant lymphoma, non-Hodgkin's type (118601006); Non-Hodgkin's lymphoma - disorder (118601006); NHL - Non-Hodgkin's lymphoma (118601006); Non-Hodgkin's lymphoma (clinical) (118601006); Non-Hodgkin's lymphoma (118601006); Non-Hodgkin lymphoma (118601006); Diffuse non-Hodgkin's small cleaved cell (diffuse) lymphoma (188675007); Malignant lymphoma, non-Hodgkin (1172592001); Diffuse malignant lymphoma (1172592001); Malignant lymphoma, non-Hodgkin's (1172592001); Non-Hodgkin lymphoma (1172592001); Non-Hodgkin's lymphoma (1172592001); Non-Hodgkin malignant lymphoma (1172592001); Non-Hodgkin's malignant lymphoma (1172592001)
Related genes: RAD54B, BCL10, RAD54L, PRF1, CASP10
HPO: HP:0012539
Monarch Initiative: MONDO:0018908
OMIM®: 191170
Orphanet: ORPHA547


A type of lymphoma characterized microscopically by the absence of multinucleated Reed-Sternberg cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
Follow this link to review classifications for Non-Hodgkin lymphoma in Orphanet.

Conditions with this feature

Ataxia-telangiectasia syndrome
MedGen UID:
Concept ID:
Disease or Syndrome
Classic ataxia-telangiectasia (A-T) is characterized by progressive cerebellar ataxia beginning between ages one and four years, oculomotor apraxia, choreoathetosis, telangiectasias of the conjunctivae, immunodeficiency, frequent infections, and an increased risk for malignancy, particularly leukemia and lymphoma. Individuals with A-T are unusually sensitive to ionizing radiation. Non-classic forms of A-T have included adult-onset A-T and A-T with early-onset dystonia.
Turcot syndrome
MedGen UID:
Concept ID:
Disease or Syndrome
Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.
Mismatch repair cancer syndrome 4
MedGen UID:
Concept ID:
Disease or Syndrome
Mismatch repair cancer syndrome-4 (MMRCS4) is an autosomal recessive childhood cancer predisposition syndrome characterized by early-onset leukemia/lymphoma, brain tumors, colorectal/gastrointestinal cancers, and other rare malignancies, including rhabdomyosarcoma (summary by Li et al., 2015). Cafe-au-lait spots are usually present (De Vos et al., 2006). For a discussion of genetic heterogeneity of mismatch repair cancer syndrome, see MMRCS1 (276300).

Professional guidelines


Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937
Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T
Dtsch Arztebl Int 2017 May 26;114(20):354-361. doi: 10.3238/arztebl.2017.0354. PMID: 28610655Free PMC Article

Recent clinical studies


Melani C, Wilson WH, Roschewski M
Hematol Oncol 2019 Jun;37 Suppl 1:70-74. doi: 10.1002/hon.2587. PMID: 31187522
Pearce L
Nurs Stand 2016 Sep 14;31(3):15. doi: 10.7748/ns.31.3.15.s16. PMID: 27745040
Bilodeau BA, Fessele KL
Semin Oncol Nurs 1998 Nov;14(4):273-83. doi: 10.1016/s0749-2081(98)80005-3. PMID: 9839340
Bierman PJ, Armitage JO
Curr Opin Hematol 1996 Jul;3(4):266-72. doi: 10.1097/00062752-199603040-00004. PMID: 9372087
Maloney DG
Curr Opin Hematol 1995 Jul;2(4):255-61. doi: 10.1097/00062752-199502040-00004. PMID: 9372005


Pearce L
Nurs Stand 2016 Sep 14;31(3):15. doi: 10.7748/ns.31.3.15.s16. PMID: 27745040
Ansell SM
Mayo Clin Proc 2015 Aug;90(8):1152-63. doi: 10.1016/j.mayocp.2015.04.025. PMID: 26250731
Shankland KR, Armitage JO, Hancock BW
Lancet 2012 Sep 1;380(9844):848-57. Epub 2012 Jul 25 doi: 10.1016/S0140-6736(12)60605-9. PMID: 22835603
Evans LS, Hancock BW
Lancet 2003 Jul 12;362(9378):139-46. doi: 10.1016/S0140-6736(03)13868-8. PMID: 12867117
Bilodeau BA, Fessele KL
Semin Oncol Nurs 1998 Nov;14(4):273-83. doi: 10.1016/s0749-2081(98)80005-3. PMID: 9839340


Hosseini I, Gadkar K, Stefanich E, Li CC, Sun LL, Chu YW, Ramanujan S
NPJ Syst Biol Appl 2020 Aug 28;6(1):28. doi: 10.1038/s41540-020-00145-7. PMID: 32859946Free PMC Article
Narkhede M, Cheson BD
Future Oncol 2020 Sep;16(26):1947-1955. Epub 2020 Jul 13 doi: 10.2217/fon-2020-0195. PMID: 32658557
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article
Cheson BD, Pfistner B, Juweid ME, Gascoyne RD, Specht L, Horning SJ, Coiffier B, Fisher RI, Hagenbeek A, Zucca E, Rosen ST, Stroobants S, Lister TA, Hoppe RT, Dreyling M, Tobinai K, Vose JM, Connors JM, Federico M, Diehl V; International Harmonization Project on Lymphoma
J Clin Oncol 2007 Feb 10;25(5):579-86. Epub 2007 Jan 22 doi: 10.1200/JCO.2006.09.2403. PMID: 17242396
Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM, Lister TA, Vose J, Grillo-López A, Hagenbeek A, Cabanillas F, Klippensten D, Hiddemann W, Castellino R, Harris NL, Armitage JO, Carter W, Hoppe R, Canellos GP
J Clin Oncol 1999 Apr;17(4):1244. doi: 10.1200/JCO.1999.17.4.1244. PMID: 10561185


Hirayama AV, Gauthier J, Hay KA, Voutsinas JM, Wu Q, Gooley T, Li D, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Acharya UH, Cassaday RD, Chapuis AG, Dhawale TM, Hendrie PC, Kiem HP, Lynch RC, Ramos J, Shadman M, Till BG, Riddell SR, Maloney DG, Turtle CJ
Blood 2019 Apr 25;133(17):1876-1887. Epub 2019 Feb 19 doi: 10.1182/blood-2018-11-887067. PMID: 30782611Free PMC Article
Sehn LH, Chua N, Mayer J, Dueck G, Trněný M, Bouabdallah K, Fowler N, Delwail V, Press O, Salles G, Gribben J, Lennard A, Lugtenburg PJ, Dimier N, Wassner-Fritsch E, Fingerle-Rowson G, Cheson BD
Lancet Oncol 2016 Aug;17(8):1081-1093. Epub 2016 Jun 23 doi: 10.1016/S1470-2045(16)30097-3. PMID: 27345636
Mehdi I
J Pak Med Assoc 1999 Jan;49(1):1. PMID: 10463005
Maloney DG
Curr Opin Hematol 1995 Jul;2(4):255-61. doi: 10.1097/00062752-199502040-00004. PMID: 9372005
International Non-Hodgkin's Lymphoma Prognostic Factors Project
N Engl J Med 1993 Sep 30;329(14):987-94. doi: 10.1056/NEJM199309303291402. PMID: 8141877

Clinical prediction guides

Zanoni L, Bezzi D, Nanni C, Paccagnella A, Farina A, Broccoli A, Casadei B, Zinzani PL, Fanti S
Semin Nucl Med 2023 May;53(3):320-351. Epub 2022 Dec 14 doi: 10.1053/j.semnuclmed.2022.11.001. PMID: 36522191
Younes A, Hilden P, Coiffier B, Hagenbeek A, Salles G, Wilson W, Seymour JF, Kelly K, Gribben J, Pfreunschuh M, Morschhauser F, Schoder H, Zelenetz AD, Rademaker J, Advani R, Valente N, Fortpied C, Witzig TE, Sehn LH, Engert A, Fisher RI, Zinzani PL, Federico M, Hutchings M, Bollard C, Trneny M, Elsayed YA, Tobinai K, Abramson JS, Fowler N, Goy A, Smith M, Ansell S, Kuruvilla J, Dreyling M, Thieblemont C, Little RF, Aurer I, Van Oers MHJ, Takeshita K, Gopal A, Rule S, de Vos S, Kloos I, Kaminski MS, Meignan M, Schwartz LH, Leonard JP, Schuster SJ, Seshan VE
Ann Oncol 2017 Jul 1;28(7):1436-1447. doi: 10.1093/annonc/mdx097. PMID: 28379322Free PMC Article
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
Gross TG, Termuhlen AM
Curr Oncol Rep 2007 Nov;9(6):459-65. doi: 10.1007/s11912-007-0064-6. PMID: 17991353
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138

Recent systematic reviews

Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article
Zhong H, Liu S, Wang Y, Xu D, Li M, Zhao Y, Zeng X
Autoimmun Rev 2022 May;21(5):103084. Epub 2022 Mar 24 doi: 10.1016/j.autrev.2022.103084. PMID: 35341972
Yasuda H, Yasuda M, Komatsu N
Cancer Sci 2021 Jul;112(7):2607-2624. Epub 2021 Jun 11 doi: 10.1111/cas.14933. PMID: 33938097Free PMC Article
Zhang L, Rana I, Shaffer RM, Taioli E, Sheppard L
Mutat Res Rev Mutat Res 2019 Jul-Sep;781:186-206. Epub 2019 Feb 10 doi: 10.1016/j.mrrev.2019.02.001. PMID: 31342895Free PMC Article
Wolach O, Ram R
Acta Haematol 2014;132(3-4):279-91. Epub 2014 Sep 10 doi: 10.1159/000360212. PMID: 25228553

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...