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Abnormality on pulmonary function testing

MedGen UID:
635153
•Concept ID:
C0476405
•
Finding
Synonyms: Abnormal pulmonary function test; Abnormal spirometry test; Lung function testing abnormal; Pulmonary function study abnormal
SNOMED CT: Lung function testing abnormal (165019004); Pulmonary function study abnormal (165019004)
 
HPO: HP:0030878

Definition

Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography. [from HPO]

Professional guidelines

PubMed

Diagnosis and management of bronchopulmonary dysplasia.
Gilfillan M, Bhandari A, Bhandari V
BMJ 2021 Oct 20;375:n1974. doi: 10.1136/bmj.n1974. PMID: 34670756
Evaluation and Management of Children with Obstructive Sleep Apnea Syndrome.
Bitners AC, Arens R
Lung 2020 Apr;198(2):257-270. Epub 2020 Mar 12 doi: 10.1007/s00408-020-00342-5. PMID: 32166426Free PMC Article
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.
Meyers DE, Basha HI, Koenig MK
Tex Heart Inst J 2013;40(4):385-94. PMID: 24082366Free PMC Article

Recent clinical studies

Etiology

Assessment of the fetal lungs in utero.
Avena-Zampieri CL, Hutter J, Rutherford M, Milan A, Hall M, Egloff A, Lloyd DFA, Nanda S, Greenough A, Story L
Am J Obstet Gynecol MFM 2022 Sep;4(5):100693. Epub 2022 Jul 17 doi: 10.1016/j.ajogmf.2022.100693. PMID: 35858660Free PMC Article
Pectus Excavatum: A Review of Diagnosis and Current Treatment Options.
Abid I, Ewais MM, Marranca J, Jaroszewski DE
J Am Osteopath Assoc 2017 Feb 1;117(2):106-113. doi: 10.7556/jaoa.2017.021. PMID: 28134952
Pulmonary Sarcoidosis.
Valeyre D, Bernaudin JF, Jeny F, Duchemann B, Freynet O, Planès C, Kambouchner M, Nunes H
Clin Chest Med 2015 Dec;36(4):631-41. doi: 10.1016/j.ccm.2015.08.006. PMID: 26593138
Lung function in pulmonary hypertension.
Low AT, Medford AR, Millar AB, Tulloh RM
Respir Med 2015 Oct;109(10):1244-9. Epub 2015 May 27 doi: 10.1016/j.rmed.2015.05.022. PMID: 26033642
Which preoperative respiratory evaluation?
Zraier S, Haouache H, Dhonneur G
Ann Fr Anesth Reanim 2014 Jul-Aug;33(7-8):453-6. Epub 2014 Aug 29 doi: 10.1016/j.annfar.2014.07.743. PMID: 25168302

Diagnosis

Practical guide to cardiopulmonary exercise testing in adults.
Glaab T, Taube C
Respir Res 2022 Jan 12;23(1):9. doi: 10.1186/s12931-021-01895-6. PMID: 35022059Free PMC Article
ERS statement on tracheomalacia and bronchomalacia in children.
Wallis C, Alexopoulou E, Antón-Pacheco JL, Bhatt JM, Bush A, Chang AB, Charatsi AM, Coleman C, Depiazzi J, Douros K, Eber E, Everard M, Kantar A, Masters IB, Midulla F, Nenna R, Roebuck D, Snijders D, Priftis K
Eur Respir J 2019 Sep;54(3) Epub 2019 Sep 28 doi: 10.1183/13993003.00382-2019. PMID: 31320455
Pectus Excavatum: A Review of Diagnosis and Current Treatment Options.
Abid I, Ewais MM, Marranca J, Jaroszewski DE
J Am Osteopath Assoc 2017 Feb 1;117(2):106-113. doi: 10.7556/jaoa.2017.021. PMID: 28134952
This is what COPD looks like.
Sheikh K, Coxson HO, Parraga G
Respirology 2016 Feb;21(2):224-36. Epub 2015 Aug 26 doi: 10.1111/resp.12611. PMID: 26333307
Interpreting pulmonary function tests: recognize the pattern, and the diagnosis will follow.
Al-Ashkar F, Mehra R, Mazzone PJ
Cleve Clin J Med 2003 Oct;70(10):866, 868, 871-3, passim. doi: 10.3949/ccjm.70.10.866. PMID: 14621232

Therapy

Pulmonary function after lobectomy in children: a systematic review and meta-analysis.
Liu C, Liu J, Yuan M, Cheng K, Luo D, Zeng L, Xu C
BMJ Paediatr Open 2023 Oct;7(1) doi: 10.1136/bmjpo-2023-001979. PMID: 37848263Free PMC Article
Screening Strategies for Pulmonary Hypertension in Patients With Interstitial Lung Disease: A Multidisciplinary Delphi Study.
Rahaghi FF, Kolaitis NA, Adegunsoye A, de Andrade JA, Flaherty KR, Lancaster LH, Lee JS, Levine DJ, Preston IR, Safdar Z, Saggar R, Sahay S, Scholand MB, Shlobin OA, Zisman DA, Nathan SD
Chest 2022 Jul;162(1):145-155. Epub 2022 Feb 15 doi: 10.1016/j.chest.2022.02.012. PMID: 35176276Free PMC Article
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Primary ciliary dyskinesia.
Lobo J, Zariwala MA, Noone PG
Semin Respir Crit Care Med 2015 Apr;36(2):169-79. Epub 2015 Mar 31 doi: 10.1055/s-0035-1546748. PMID: 25826585Free PMC Article
Primary pulmonary hypertension.
Gaine SP, Rubin LJ
Lancet 1998 Aug 29;352(9129):719-25. doi: 10.1016/S0140-6736(98)02111-4. PMID: 9729004

Prognosis

Combined Pulmonary Fibrosis and Emphysema: Pulmonary Function Testing and a Pathophysiology Perspective.
Amariei DE, Dodia N, Deepak J, Hines SE, Galvin JR, Atamas SP, Todd NW
Medicina (Kaunas) 2019 Sep 10;55(9) doi: 10.3390/medicina55090580. PMID: 31509942Free PMC Article
Primary ciliary dyskinesia.
Lobo J, Zariwala MA, Noone PG
Semin Respir Crit Care Med 2015 Apr;36(2):169-79. Epub 2015 Mar 31 doi: 10.1055/s-0035-1546748. PMID: 25826585Free PMC Article
Which preoperative respiratory evaluation?
Zraier S, Haouache H, Dhonneur G
Ann Fr Anesth Reanim 2014 Jul-Aug;33(7-8):453-6. Epub 2014 Aug 29 doi: 10.1016/j.annfar.2014.07.743. PMID: 25168302
A stepwise approach to the interpretation of pulmonary function tests.
Johnson JD, Theurer WM
Am Fam Physician 2014 Mar 1;89(5):359-66. PMID: 24695507
Pulmonary function tests.
Behr J, Furst DE
Rheumatology (Oxford) 2008 Oct;47 Suppl 5:v65-7. doi: 10.1093/rheumatology/ken313. PMID: 18784151

Clinical prediction guides

Combined Pulmonary Fibrosis and Emphysema: Pulmonary Function Testing and a Pathophysiology Perspective.
Amariei DE, Dodia N, Deepak J, Hines SE, Galvin JR, Atamas SP, Todd NW
Medicina (Kaunas) 2019 Sep 10;55(9) doi: 10.3390/medicina55090580. PMID: 31509942Free PMC Article
Cardiopulmonary Exercise Testing: What Is its Value?
Guazzi M, Bandera F, Ozemek C, Systrom D, Arena R
J Am Coll Cardiol 2017 Sep 26;70(13):1618-1636. doi: 10.1016/j.jacc.2017.08.012. PMID: 28935040
Lung function in pulmonary hypertension.
Low AT, Medford AR, Millar AB, Tulloh RM
Respir Med 2015 Oct;109(10):1244-9. Epub 2015 May 27 doi: 10.1016/j.rmed.2015.05.022. PMID: 26033642
Which preoperative respiratory evaluation?
Zraier S, Haouache H, Dhonneur G
Ann Fr Anesth Reanim 2014 Jul-Aug;33(7-8):453-6. Epub 2014 Aug 29 doi: 10.1016/j.annfar.2014.07.743. PMID: 25168302
A stepwise approach to the interpretation of pulmonary function tests.
Johnson JD, Theurer WM
Am Fam Physician 2014 Mar 1;89(5):359-66. PMID: 24695507

Recent systematic reviews

A systematic review and meta-analysis of long term physical and mental sequelae of COVID-19 pandemic: call for research priority and action.
Zeng N, Zhao YM, Yan W, Li C, Lu QD, Liu L, Ni SY, Mei H, Yuan K, Shi L, Li P, Fan TT, Yuan JL, Vitiello MV, Kosten T, Kondratiuk AL, Sun HQ, Tang XD, Liu MY, Lalvani A, Shi J, Bao YP, Lu L
Mol Psychiatry 2023 Jan;28(1):423-433. Epub 2022 Jun 6 doi: 10.1038/s41380-022-01614-7. PMID: 35668159Free PMC Article
Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-analysis.
Durstenfeld MS, Sun K, Tahir P, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY
JAMA Netw Open 2022 Oct 3;5(10):e2236057. doi: 10.1001/jamanetworkopen.2022.36057. PMID: 36223120Free PMC Article
Pulmonary function and chest computed tomography abnormalities 6-12 months after recovery from COVID-19: a systematic review and meta-analysis.
Lee JH, Yim JJ, Park J
Respir Res 2022 Sep 6;23(1):233. doi: 10.1186/s12931-022-02163-x. PMID: 36068582Free PMC Article
Pulse oximetry screening for critical congenital heart defects.
Plana MN, Zamora J, Suresh G, Fernandez-Pineda L, Thangaratinam S, Ewer AK
Cochrane Database Syst Rev 2018 Mar 1;3(3):CD011912. doi: 10.1002/14651858.CD011912.pub2. PMID: 29494750Free PMC Article
Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome.
Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ
Crit Care Med 1995 Oct;23(10):1638-52. doi: 10.1097/00003246-199510000-00007. PMID: 7587228

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