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Pseudoporphyria

MedGen UID:: 636709
•Concept ID:: C0521616
•: Disease or Syndrome

SNOMED CT:

Pseudoporphyria (95565000)

Definition

A drug-induced photodermatosis characterized by skin fragility, erythema, and the appearance of tense bullae, erosions and scarring in the absence of abnormalities in porphyrin metabolism. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPseudoporphyria

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Skin disorder
        Pseudoporphyria

Professional guidelines

PubMed

Re-emergence of an orphan therapeutic target for the treatment of resistant prostate cancer - a thorough conformational and binding analysis for ROR-γ protein.

Ndagi U, Mhlongo NN, Soliman ME
J Biomol Struct Dyn 2018 Feb;36(2):335-350. Epub 2017 Jan 16 doi: 10.1080/07391102.2016.1277555. PMID: 28027708

The sensitivity and specificity of "caterpillar bodies" in the differential diagnosis of subepidermal blistering disorders.

Fung MA, Murphy MJ, Hoss DM, Berke A, Grant-Kels JM
Am J Dermatopathol 2003 Aug;25(4):287-90. doi: 10.1097/00000372-200308000-00002. PMID: 12876485

Porphyria cutanea tarda. Diagnosis, management, and differentiation from other hepatic porphyrias.

Grossman ME, Poh-Fitzpatrick MB
Dermatol Clin 1986 Apr;4(2):297-309. PMID: 3955900

See all (3)

Recent clinical studies

Etiology

Bullous Amyloidosis Masquerading as Pseudoporphyria.

Darji K, Butala N, Manders SM, Green JJ
Cutis 2021 Sep;108(3):E25-E28. doi: 10.12788/cutis.0370. PMID: 34826289

Direct Immunofluorescence of Mechanobullous Epidermolysis Bullosa Acquisita, Porphyria Cutanea Tarda and Pseudoporphyria.

de Groot HJ, Jonkman MF, Pas HH, Diercks GFH
Acta Derm Venereol 2019 Jan 1;99(1):26-32. doi: 10.2340/00015555-3021. PMID: 30176039

Porphyria cutanea tarda: an intriguing genetic disease and marker.

Handler NS, Handler MZ, Stephany MP, Handler GA, Schwartz RA
Int J Dermatol 2017 Jun;56(6):e106-e117. Epub 2017 Mar 21 doi: 10.1111/ijd.13580. PMID: 28321838

Dermatologic conditions seen in end-stage renal disease.

Cordova KB, Oberg TJ, Malik M, Robinson-Bostom L
Semin Dial 2009 Jan-Feb;22(1):45-55. doi: 10.1111/j.1525-139X.2008.00534.x. PMID: 19250446

Porphyria. From Sir Walter Raleigh to molecular biology.

Sarkany RP
Adv Exp Med Biol 1999;455:235-41. PMID: 10599349

See all (20)

Diagnosis

Photosensitizing drug reactions.

Montgomery S, Worswick S
Clin Dermatol 2022 Jan-Feb;40(1):57-63. Epub 2021 Aug 8 doi: 10.1016/j.clindermatol.2021.08.014. PMID: 35190066

Direct Immunofluorescence of Mechanobullous Epidermolysis Bullosa Acquisita, Porphyria Cutanea Tarda and Pseudoporphyria.

de Groot HJ, Jonkman MF, Pas HH, Diercks GFH
Acta Derm Venereol 2019 Jan 1;99(1):26-32. doi: 10.2340/00015555-3021. PMID: 30176039

Photoonycholysis.

Baran R, Juhlin L
Photodermatol Photoimmunol Photomed 2002 Aug;18(4):202-7. doi: 10.1034/j.1600-0781.2002.00760.x. PMID: 12390677

Pseudoporphyria.

Green JJ, Manders SM
J Am Acad Dermatol 2001 Jan;44(1):100-8. doi: 10.1067/mjd.2000.111338. PMID: 11148469

Phototoxicity and photoallergy.

Epstein JH
Semin Cutan Med Surg 1999 Dec;18(4):274-84. doi: 10.1016/s1085-5629(99)80026-1. PMID: 10604793

See all (49)

Therapy

Photosensitizing drug reactions.

Montgomery S, Worswick S
Clin Dermatol 2022 Jan-Feb;40(1):57-63. Epub 2021 Aug 8 doi: 10.1016/j.clindermatol.2021.08.014. PMID: 35190066

Photoonycholysis: new findings.

Baran R, Mascaro JM, Aguilera P
J Eur Acad Dermatol Venereol 2019 Jan;33(1):56-62. Epub 2018 Jul 20 doi: 10.1111/jdv.15151. PMID: 29953667

N-acetylcysteine in dermatology.

Adil M, Amin SS, Mohtashim M
Indian J Dermatol Venereol Leprol 2018 Nov-Dec;84(6):652-659. doi: 10.4103/ijdvl.IJDVL_33_18. PMID: 30246706

Phototoxicity and photoallergy.

Epstein JH
Semin Cutan Med Surg 1999 Dec;18(4):274-84. doi: 10.1016/s1085-5629(99)80026-1. PMID: 10604793

Drug induced pseudoporphyria.

Ramsay CA
J Rheumatol 1991 Jun;18(6):799-800. PMID: 1895258

See all (84)

Prognosis

Direct Immunofluorescence of Mechanobullous Epidermolysis Bullosa Acquisita, Porphyria Cutanea Tarda and Pseudoporphyria.

de Groot HJ, Jonkman MF, Pas HH, Diercks GFH
Acta Derm Venereol 2019 Jan 1;99(1):26-32. doi: 10.2340/00015555-3021. PMID: 30176039

Cutaneous changes in patients with chronic renal failure on hemodialysis.

Onelmis H, Sener S, Sasmaz S, Ozer A
Cutan Ocul Toxicol 2012 Dec;31(4):286-91. Epub 2012 Feb 15 doi: 10.3109/15569527.2012.657726. PMID: 22335460

Melanoma associated with long-term voriconazole therapy: a new manifestation of chronic photosensitivity.

Miller DD, Cowen EW, Nguyen JC, McCalmont TH, Fox LP
Arch Dermatol 2010 Mar;146(3):300-4. Epub 2010 Jan 18 doi: 10.1001/archdermatol.2009.362. PMID: 20083676 Free PMC Article

Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus.

Paradela S, Martínez-Gómez W, Fernández-Jorge B, Castiñeiras I, Yebra-Pimentel T, Llinares P, Fonseca Capdevila E
Lupus 2007;16(9):741-5. doi: 10.1177/0961203307079498. PMID: 17728369

New syndromes in mushroom poisoning.

Saviuc P, Danel V
Toxicol Rev 2006;25(3):199-209. doi: 10.2165/00139709-200625030-00004. PMID: 17192123

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Clinical prediction guides

Direct Immunofluorescence of Mechanobullous Epidermolysis Bullosa Acquisita, Porphyria Cutanea Tarda and Pseudoporphyria.

de Groot HJ, Jonkman MF, Pas HH, Diercks GFH
Acta Derm Venereol 2019 Jan 1;99(1):26-32. doi: 10.2340/00015555-3021. PMID: 30176039

Effect of tetracycline and UV radiation on melanization and antioxidant status of melanocytes.

Rok J, Buszman E, Delijewski M, Otręba M, Beberok A, Wrześniok D
J Photochem Photobiol B 2015 Jul;148:168-173. Epub 2015 Apr 27 doi: 10.1016/j.jphotobiol.2015.04.009. PMID: 25935746

New syndromes in mushroom poisoning.

Saviuc P, Danel V
Toxicol Rev 2006;25(3):199-209. doi: 10.2165/00139709-200625030-00004. PMID: 17192123

Photoonycholysis.

Baran R, Juhlin L
Photodermatol Photoimmunol Photomed 2002 Aug;18(4):202-7. doi: 10.1034/j.1600-0781.2002.00760.x. PMID: 12390677

Nonsteroidal antiinflammatory drug-induced pseudoporphyria: a case series.

LaDuca JR, Bouman PH, Gaspari AA
J Cutan Med Surg 2002 Jul-Aug;6(4):320-6. Epub 2002 Jul 16 doi: 10.1007/s10227-001-0051-8. PMID: 12118363

See all (12)