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Primitive neuroectodermal tumor

MedGen UID:
64627
Concept ID:
C0206663
Neoplastic Process
Synonyms: Neoplasm, Primitive Neuroepithelial; Neoplasms, Primitive Neuroepithelial; Neuroectodermal Tumor, Primitive; Neuroectodermal Tumors, Primitive; Neuroepithelial Neoplasm, Primitive; Neuroepithelial Neoplasms, Primitive; Neuroepithelial Tumor, Primitive; Neuroepithelial Tumors, Primitive; PNET; PNETs; Primitive Neuroectodermal Tumor; Primitive Neuroectodermal Tumors; Primitive Neuroepithelial Neoplasm; Primitive Neuroepithelial Neoplasms; Primitive Neuroepithelial Tumor; Primitive Neuroepithelial Tumors; Tumor, Primitive Neuroectodermal; Tumor, Primitive Neuroepithelial; Tumors, Primitive Neuroectodermal; Tumors, Primitive Neuroepithelial
SNOMED CT: PNET - Primitive neuroectodermal tumor (39781001); PNET (39781001); Primitive neuroectodermal tumor (699028006); Primitive neuroectodermal tumor (39781001); Neuroepithelioma (55045006)
 
HPO: HP:0030065

Definition

A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm constitutes the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems and includes some glial cell precursors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Primitive neuroectodermal tumor
Follow this link to review classifications for Primitive neuroectodermal tumor in Orphanet.

Recent clinical studies

Etiology

Pancaldi A, Peng L, Rhee DS, Dunn E, Forcucci JA, Belchis D, Pratilas CA
Cold Spring Harb Mol Case Stud 2020 Oct;6(5) Epub 2020 Oct 7 doi: 10.1101/mcs.a005603. PMID: 33028642Free PMC Article
Woeste MR, Bhutiani N, Hong YK, Shah J, Kim W, E Egger M, Philips P, McMasters KM, Martin RCG  II, Scoggins CR
J Surg Oncol 2020 Nov;122(6):1145-1151. Epub 2020 Jul 30 doi: 10.1002/jso.26139. PMID: 32734604
Gupta A, Bhattarai D, Thapa BK, Parkhi M, Vignesh P, Vasishta RK, Tripathi M, Vyas S, Gupta A
J Trop Pediatr 2020 Feb 1;66(1):106-109. doi: 10.1093/tropej/fmz034. PMID: 31257424
El Ahmadieh TY, Raisanen JM, Botros J, Kabangu JL, Pan E, Gluf W
World Neurosurg 2018 Nov;119:340-344. Epub 2018 Aug 1 doi: 10.1016/j.wneu.2018.07.221. PMID: 30077020
Burcu A, Nazan Ç, Özgür Ö, Serra K, Mehmet K, Serap A, Bengü D, Canan V, Haldun Ö, Savaş K, Tuncer T, Taner A, Yeşim E, Ömer K, Yavuz A
Childs Nerv Syst 2018 Sep;34(9):1657-1662. Epub 2018 Jun 4 doi: 10.1007/s00381-018-3842-6. PMID: 29868932

Diagnosis

Wang J, Li J, Zhang X, Zhang X, Xiao Y
BMC Cardiovasc Disord 2021 Jun 16;21(1):305. doi: 10.1186/s12872-021-02113-3. PMID: 34134636Free PMC Article
Ye Y, Qiu X, Mei J, He D, Zou A
J Int Med Res 2021 Feb;49(2):300060520986681. doi: 10.1177/0300060520986681. PMID: 33530793Free PMC Article
Deshpande G, Epari S, Gupta C, Shetty O, Gurav M, Chinnaswamy G, Moiyadi A, Gupta T
Childs Nerv Syst 2021 Mar;37(3):839-849. Epub 2020 Aug 6 doi: 10.1007/s00381-020-04850-w. PMID: 32761378
Du TQ, Li X, Diao HR, Chen YZ, Yan Y, Zhao YX
J Adolesc Young Adult Oncol 2019 Dec;8(6):697-701. Epub 2019 Jul 16 doi: 10.1089/jayao.2019.0052. PMID: 31314635
Jagtap SV, Kale PP, Huddedar A, Hulwan AB, Jagtap SS
Indian J Pathol Microbiol 2018 Apr-Jun;61(2):252-254. doi: 10.4103/IJPM.IJPM_277_16. PMID: 29676370

Therapy

Takigami A, Yamasawa H, Kurosaki A, Sakamoto N, Onuki T, Mato N, Tetsuka K, Endo S, Niki T, Bando M, Hagiwara K
Intern Med 2019 May 1;58(9):1335-1339. Epub 2019 Jan 10 doi: 10.2169/internalmedicine.1549-18. PMID: 30626819Free PMC Article
El Ahmadieh TY, Raisanen JM, Botros J, Kabangu JL, Pan E, Gluf W
World Neurosurg 2018 Nov;119:340-344. Epub 2018 Aug 1 doi: 10.1016/j.wneu.2018.07.221. PMID: 30077020
Akazawa M, Saito T, Ariyoshi K, Okadome M, Yokoyama R, Taguchi K
J Obstet Gynaecol Res 2018 Oct;44(10):2008-2015. Epub 2018 Jul 26 doi: 10.1111/jog.13753. PMID: 30051552
Li Q, Liu Y, Yu Y
Medicine (Baltimore) 2017 Dec;96(51):e9272. doi: 10.1097/MD.0000000000009272. PMID: 29390485Free PMC Article
Yoshihara H, Kamiya T, Hosoya Y, Hasegawa D, Ogawa C, Asanuma H, Mizuno R, Hosoya R, Manabe A
Pediatr Int 2016 Aug;58(8):766-9. Epub 2016 Jun 21 doi: 10.1111/ped.12963. PMID: 27324740

Prognosis

Wang J, Li J, Zhang X, Zhang X, Xiao Y
BMC Cardiovasc Disord 2021 Jun 16;21(1):305. doi: 10.1186/s12872-021-02113-3. PMID: 34134636Free PMC Article
Deshpande G, Epari S, Gupta C, Shetty O, Gurav M, Chinnaswamy G, Moiyadi A, Gupta T
Childs Nerv Syst 2021 Mar;37(3):839-849. Epub 2020 Aug 6 doi: 10.1007/s00381-020-04850-w. PMID: 32761378
Woeste MR, Bhutiani N, Hong YK, Shah J, Kim W, E Egger M, Philips P, McMasters KM, Martin RCG  II, Scoggins CR
J Surg Oncol 2020 Nov;122(6):1145-1151. Epub 2020 Jul 30 doi: 10.1002/jso.26139. PMID: 32734604
Du TQ, Li X, Diao HR, Chen YZ, Yan Y, Zhao YX
J Adolesc Young Adult Oncol 2019 Dec;8(6):697-701. Epub 2019 Jul 16 doi: 10.1089/jayao.2019.0052. PMID: 31314635
Burcu A, Nazan Ç, Özgür Ö, Serra K, Mehmet K, Serap A, Bengü D, Canan V, Haldun Ö, Savaş K, Tuncer T, Taner A, Yeşim E, Ömer K, Yavuz A
Childs Nerv Syst 2018 Sep;34(9):1657-1662. Epub 2018 Jun 4 doi: 10.1007/s00381-018-3842-6. PMID: 29868932

Clinical prediction guides

Flood TA, Ulbright TM, Hirsch MS
Am J Surg Pathol 2021 Oct 1;45(10):1299-1302. doi: 10.1097/PAS.0000000000001703. PMID: 34232605
Liu B, Qi DJ, Zhang QF
Medicine (Baltimore) 2020 Aug 21;99(34):e21740. doi: 10.1097/MD.0000000000021740. PMID: 32846796Free PMC Article
Hou W, Xu L, Zhan H, Wang H, Xu M, Yu Y
J Comput Assist Tomogr 2017 Mar/Apr;41(2):224-230. doi: 10.1097/RCT.0000000000000496. PMID: 27680421
Song MJ, An S, Lee SS, Kim BS, Kim J
Int J Surg Pathol 2016 Sep;24(6):543-7. Epub 2016 Mar 21 doi: 10.1177/1066896916639371. PMID: 27006299
Akino T, Shinohara N, Hatanaka K, Kobayashi N, Yamamoto Y, Nonomura K
Int J Urol 2014 Jun;21(6):619-21. Epub 2013 Dec 18 doi: 10.1111/iju.12363. PMID: 24350647

Recent systematic reviews

Cherif El Asri A, Benzagmout M, Chakour K, Chaoui MF, Laaguili J, Chahdi H, Gazzaz M, El Mostarchid B
World Neurosurg 2018 Jul;115:346-356. Epub 2018 May 3 doi: 10.1016/j.wneu.2018.04.164. PMID: 29729469
Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646
Alexiou GA, Stefanaki K, Vartholomatos G, Sfakianos G, Prodromou N, Moschovi M
J Child Neurol 2013 Dec;28(12):1709-15. Epub 2013 Jan 17 doi: 10.1177/0883073812471434. PMID: 23334078

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