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Ovarian germ cell tumor

MedGen UID:
65958
•Concept ID:
C0238324
•
Neoplastic Process
Synonyms: Germ Cell Neoplasm of Ovary; germ cell neoplasm of ovary; Germ Cell Neoplasm of the Ovary; germ cell neoplasm of the ovary; Germ cell tumor of ovary; Germ Cell Tumor of Ovary; germ cell tumor of ovary; Germ Cell Tumor of the Ovary; germ cell tumor of the ovary; germ cell tumour of ovary; germ cell tumour of the ovary; ovarian germ cell cancer; Ovarian Germ Cell Neoplasm; ovarian germ cell neoplasm; Ovarian Germ Cell Tumor; ovarian germ cell tumor; ovary germ cell tumor; ovary germ cell tumour
SNOMED CT: Germ cell tumor of ovary (237059008)
 
Monarch Initiative: MONDO:0011366

Definition

A neoplasm that arises from the ovary and originates from germ cells. Representative examples include teratoma, embryonal carcinoma, yolk sac tumor, and dysgerminoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian germ cell tumor

Professional guidelines

PubMed

Critical elements in the operative management of pediatric malignant ovarian germ cell tumors.
Weil BR, Rich BS, Madenci AL, Stambough KC, Schmoke N, Peace A, Bruny JL, Rescorla FJ, Dicken BJ, Dietrich JE, Billmire DF
Semin Pediatr Surg 2023 Oct;32(5):151342. Epub 2023 Nov 17 doi: 10.1016/j.sempedsurg.2023.151342. PMID: 38039829
Fertility management for malignant ovarian germ cell tumors patients.
Di Tucci C, Casorelli A, Morrocchi E, Palaia I, Muzii L, Panici PB
Crit Rev Oncol Hematol 2017 Dec;120:34-42. Epub 2017 Oct 16 doi: 10.1016/j.critrevonc.2017.10.005. PMID: 29198336
Update on the management of ovarian germ cell tumors.
Lu KH, Gershenson DM
J Reprod Med 2005 Jun;50(6):417-25. PMID: 16050566

Recent clinical studies

Etiology

Critical elements in the operative management of pediatric malignant ovarian germ cell tumors.
Weil BR, Rich BS, Madenci AL, Stambough KC, Schmoke N, Peace A, Bruny JL, Rescorla FJ, Dicken BJ, Dietrich JE, Billmire DF
Semin Pediatr Surg 2023 Oct;32(5):151342. Epub 2023 Nov 17 doi: 10.1016/j.sempedsurg.2023.151342. PMID: 38039829
Adjuvant and post-surgical treatment in non-epithelial ovarian cancer.
El Helali A, Kwok GST, Tse KY
Best Pract Res Clin Obstet Gynaecol 2022 Jan;78:74-85. Epub 2021 Aug 4 doi: 10.1016/j.bpobgyn.2021.06.001. PMID: 34493450
Incidence and outcomes of malignant ovarian germ cell tumors in Korea, 1999-2017.
Park M, Lim J, Lee JA, Park HJ, Park BK, Lim MC, Park SY, Won YJ
Gynecol Oncol 2021 Oct;163(1):79-84. Epub 2021 Aug 12 doi: 10.1016/j.ygyno.2021.07.037. PMID: 34392955
Fertility sparing surgery in malignant ovarian Germ cell tumor (MOGCT): 15 years experiences.
Zamani N, Rezaei Poor M, Ghasemian Dizajmehr S, Alizadeh S, Modares Gilani M
BMC Womens Health 2021 Aug 4;21(1):282. doi: 10.1186/s12905-021-01437-8. PMID: 34348686Free PMC Article
MR Imaging-Pathologic Correlation in Ovarian Cancer.
Stein EB, Wasnik AP, Sciallis AP, Kamaya A, Maturen KE
Magn Reson Imaging Clin N Am 2017 Aug;25(3):545-562. Epub 2017 Apr 29 doi: 10.1016/j.mric.2017.03.004. PMID: 28668159

Diagnosis

Critical elements in the operative management of pediatric malignant ovarian germ cell tumors.
Weil BR, Rich BS, Madenci AL, Stambough KC, Schmoke N, Peace A, Bruny JL, Rescorla FJ, Dicken BJ, Dietrich JE, Billmire DF
Semin Pediatr Surg 2023 Oct;32(5):151342. Epub 2023 Nov 17 doi: 10.1016/j.sempedsurg.2023.151342. PMID: 38039829
Adjuvant and post-surgical treatment in non-epithelial ovarian cancer.
El Helali A, Kwok GST, Tse KY
Best Pract Res Clin Obstet Gynaecol 2022 Jan;78:74-85. Epub 2021 Aug 4 doi: 10.1016/j.bpobgyn.2021.06.001. PMID: 34493450
Incidence and outcomes of malignant ovarian germ cell tumors in Korea, 1999-2017.
Park M, Lim J, Lee JA, Park HJ, Park BK, Lim MC, Park SY, Won YJ
Gynecol Oncol 2021 Oct;163(1):79-84. Epub 2021 Aug 12 doi: 10.1016/j.ygyno.2021.07.037. PMID: 34392955
Fertility sparing surgery in malignant ovarian Germ cell tumor (MOGCT): 15 years experiences.
Zamani N, Rezaei Poor M, Ghasemian Dizajmehr S, Alizadeh S, Modares Gilani M
BMC Womens Health 2021 Aug 4;21(1):282. doi: 10.1186/s12905-021-01437-8. PMID: 34348686Free PMC Article
MR Imaging-Pathologic Correlation in Ovarian Cancer.
Stein EB, Wasnik AP, Sciallis AP, Kamaya A, Maturen KE
Magn Reson Imaging Clin N Am 2017 Aug;25(3):545-562. Epub 2017 Apr 29 doi: 10.1016/j.mric.2017.03.004. PMID: 28668159

Therapy

Fertility outcomes following surgery and multiagent chemotherapy in malignant ovarian germ cell tumor survivors: a survey study.
Bergamini A, Ramaswami R, Froeling F, Papanastasopoulos P, Short D, Aguiar X, Savage PM, Sarwar N, Kaur B, Saso S, Fotopoulou C, Sharma A, Rustin GJS, Seckl M
Int J Gynecol Cancer 2023 Nov 6;33(11):1750-1756. doi: 10.1136/ijgc-2023-004699. PMID: 37931975
Fertility and prognosis assessment between bleomycin/etoposide/cisplatin and paclitaxel/carboplatin chemotherapy regimens in the conservative treatment of malignant ovarian germ cell tumors: a multicenter and retrospective study.
Chu R, Liu P, Chen J, Cheng X, Li K, Che Y, Wang J, Li L, Zhang X, Yao S, Song L, Zhao Y, Huang C, Xue Y, Pan X, Li J, Chen Z, Jiang J, Kong B, Song K
J Gynecol Oncol 2023 Mar;34(2):e12. doi: 10.3802/jgo.2023.34.e12. PMID: 36890292Free PMC Article
Fertility management for malignant ovarian germ cell tumors patients.
Di Tucci C, Casorelli A, Morrocchi E, Palaia I, Muzii L, Panici PB
Crit Rev Oncol Hematol 2017 Dec;120:34-42. Epub 2017 Oct 16 doi: 10.1016/j.critrevonc.2017.10.005. PMID: 29198336
Outcomes of pediatric and adolescent girls with malignant ovarian germ cell tumors.
Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT, Nam JH
Gynecol Oncol 2015 Jun;137(3):418-22. Epub 2015 Apr 1 doi: 10.1016/j.ygyno.2015.03.054. PMID: 25842162
Update on the management of ovarian germ cell tumors.
Lu KH, Gershenson DM
J Reprod Med 2005 Jun;50(6):417-25. PMID: 16050566

Prognosis

Fertility and prognosis assessment between bleomycin/etoposide/cisplatin and paclitaxel/carboplatin chemotherapy regimens in the conservative treatment of malignant ovarian germ cell tumors: a multicenter and retrospective study.
Chu R, Liu P, Chen J, Cheng X, Li K, Che Y, Wang J, Li L, Zhang X, Yao S, Song L, Zhao Y, Huang C, Xue Y, Pan X, Li J, Chen Z, Jiang J, Kong B, Song K
J Gynecol Oncol 2023 Mar;34(2):e12. doi: 10.3802/jgo.2023.34.e12. PMID: 36890292Free PMC Article
Nomograms to predict the prognosis in malignant ovarian germ cell tumors: a large cohort study.
Song Z, Wang Y, Zhou Y, Zhang D
BMC Cancer 2022 Mar 10;22(1):257. doi: 10.1186/s12885-022-09324-7. PMID: 35272629Free PMC Article
Incidence and outcomes of malignant ovarian germ cell tumors in Korea, 1999-2017.
Park M, Lim J, Lee JA, Park HJ, Park BK, Lim MC, Park SY, Won YJ
Gynecol Oncol 2021 Oct;163(1):79-84. Epub 2021 Aug 12 doi: 10.1016/j.ygyno.2021.07.037. PMID: 34392955
Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study.
Tamauchi S, Kajiyama H, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Utsumi F, Niimi K, Suzuki S, Kikkawa F
Am J Obstet Gynecol 2018 Oct;219(4):385.e1-385.e7. Epub 2018 Aug 4 doi: 10.1016/j.ajog.2018.07.021. PMID: 30086295
Malignant ovarian germ cell tumors: clinico-pathological presentation and survival outcomes.
Tangjitgamol S, Hanprasertpong J, Manusirivithaya S, Wootipoom V, Thavaramara T, Buhachat R
Acta Obstet Gynecol Scand 2010;89(2):182-9. doi: 10.3109/00016340903443684. PMID: 19961281

Clinical prediction guides

Fertility and prognosis assessment between bleomycin/etoposide/cisplatin and paclitaxel/carboplatin chemotherapy regimens in the conservative treatment of malignant ovarian germ cell tumors: a multicenter and retrospective study.
Chu R, Liu P, Chen J, Cheng X, Li K, Che Y, Wang J, Li L, Zhang X, Yao S, Song L, Zhao Y, Huang C, Xue Y, Pan X, Li J, Chen Z, Jiang J, Kong B, Song K
J Gynecol Oncol 2023 Mar;34(2):e12. doi: 10.3802/jgo.2023.34.e12. PMID: 36890292Free PMC Article
A 17-year experience on bilaterality of ovarian germ cell tumors in pediatric population and its clinical implications: A single-center study.
Gang S, Yang HB, Kim HY
J Pediatr Surg 2022 Jul;57(7):1221-1227. Epub 2022 Mar 13 doi: 10.1016/j.jpedsurg.2022.02.036. PMID: 35387741
Nomograms to predict the prognosis in malignant ovarian germ cell tumors: a large cohort study.
Song Z, Wang Y, Zhou Y, Zhang D
BMC Cancer 2022 Mar 10;22(1):257. doi: 10.1186/s12885-022-09324-7. PMID: 35272629Free PMC Article
Usefulness of intraoperative imprint cytology in ovarian germ cell tumors.
Abe A, Sugiyama Y, Furuta R, Furuta N, Matoda M, Takeshima N
Acta Cytol 2013;57(2):171-6. Epub 2013 Feb 28 doi: 10.1159/000345942. PMID: 23406948
Ovarian germ cell tumors in children: a clinical study of 66 patients.
De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW
Pediatr Blood Cancer 2006 Apr;46(4):459-64. doi: 10.1002/pbc.20633. PMID: 16206211

Recent systematic reviews

Ovarian cancer survivors' quality of life: a systematic review.
Ahmed-Lecheheb D, Joly F
J Cancer Surviv 2016 Oct;10(5):789-801. Epub 2016 Feb 17 doi: 10.1007/s11764-016-0525-8. PMID: 26884372

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