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Laryngeal granuloma

MedGen UID:
6674
•Concept ID:
C0018196
•
Disease or Syndrome
Synonyms: Granuloma of Larynx; Granuloma, Laryngeal; Granulomas, Laryngeal; Laryngeal Granuloma; Laryngeal Granulomas; Larynx Granuloma; Larynx Granulomas
SNOMED CT: Laryngeal granuloma (72211003)
 
Monarch Initiative: MONDO:0020974

Definition

An inflammatory lesion of the vocal cords. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal granuloma

Professional guidelines

PubMed

Arytenoid granuloma: a single-institution experience of management of 62 cases.
Gandhi S, Ganesuni D, Shenoy SS, Bhatta S, Ghanpur AD
J Laryngol Otol 2023 Feb;137(2):186-191. Epub 2021 Nov 25 doi: 10.1017/S0022215121003662. PMID: 34819183
Assessing the utility of non-surgical treatments in the management of vocal process granulomas.
Rudman JR, McGee CS, Diaz J, Rosow DE
J Laryngol Otol 2020 Jan;134(1):68-73. Epub 2020 Jan 10 doi: 10.1017/S0022215119002524. PMID: 31918788
Botulinum Toxin A for Treatment of Contact Granuloma.
Yılmaz T, Kayahan B, Günaydın RÖ, Kuşçu O, Sözen T
J Voice 2016 Nov;30(6):741-743. Epub 2015 Aug 19 doi: 10.1016/j.jvoice.2015.07.015. PMID: 26298840

Recent clinical studies

Etiology

Comparison of PPI and combined treatment in the treatment of recurrent laryngeal contact granuloma.
Nie Q, Li J, Zou S, Zhang R
Am J Otolaryngol 2021 Jan-Feb;42(1):102766. Epub 2020 Oct 22 doi: 10.1016/j.amjoto.2020.102766. PMID: 33125906
Operative and Conservative Management of Laryngeal Contact Granuloma: A Network Analysis and Systematic Review.
Tsai SW, Ma YF, Shih LC, Tsou YA, Sung CK
J Voice 2021 Mar;35(2):300-306. Epub 2019 Oct 15 doi: 10.1016/j.jvoice.2019.08.019. PMID: 31628044
Treatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysis.
Rimoli CF, Martins RHG, Catâneo DC, Imamura R, Catâneo AJM
Braz J Otorhinolaryngol 2018 Nov-Dec;84(6):781-789. Epub 2018 Apr 14 doi: 10.1016/j.bjorl.2018.03.003. PMID: 29699879Free PMC Article
Risk factors for laryngeal trauma and granuloma formation in pediatric intubations.
Jang M, Basa K, Levi J
Int J Pediatr Otorhinolaryngol 2018 Apr;107:45-52. Epub 2018 Jan 31 doi: 10.1016/j.ijporl.2018.01.008. PMID: 29501310
Vocal process granulomas: a systematic review of treatment.
Karkos PD, George M, Van Der Veen J, Atkinson H, Dwivedi RC, Kim D, Repanos C
Ann Otol Rhinol Laryngol 2014 May;123(5):314-20. Epub 2014 Mar 17 doi: 10.1177/0003489414525921. PMID: 24642585

Diagnosis

Operative and Conservative Management of Laryngeal Contact Granuloma: A Network Analysis and Systematic Review.
Tsai SW, Ma YF, Shih LC, Tsou YA, Sung CK
J Voice 2021 Mar;35(2):300-306. Epub 2019 Oct 15 doi: 10.1016/j.jvoice.2019.08.019. PMID: 31628044
Diagnosis and Treatment of Benign Pediatric Lesions.
Hron TA, Kavanagh KR, Murray N
Otolaryngol Clin North Am 2019 Aug;52(4):657-668. Epub 2019 May 11 doi: 10.1016/j.otc.2019.03.010. PMID: 31088693
Post-transplantation laryngeal actinomycosis.
Sei H, Nouta J, Miyaji S, Hato N
Auris Nasus Larynx 2019 Dec;46(6):917-920. Epub 2018 Dec 20 doi: 10.1016/j.anl.2018.12.006. PMID: 30579693
Vocal process granulomas: a systematic review of treatment.
Karkos PD, George M, Van Der Veen J, Atkinson H, Dwivedi RC, Kim D, Repanos C
Ann Otol Rhinol Laryngol 2014 May;123(5):314-20. Epub 2014 Mar 17 doi: 10.1177/0003489414525921. PMID: 24642585
Vocal process granuloma.
Hoffman HT, Overholt E, Karnell M, McCulloch TM
Head Neck 2001 Dec;23(12):1061-74. doi: 10.1002/hed.10014. PMID: 11774392

Therapy

Operative and Conservative Management of Laryngeal Contact Granuloma: A Network Analysis and Systematic Review.
Tsai SW, Ma YF, Shih LC, Tsou YA, Sung CK
J Voice 2021 Mar;35(2):300-306. Epub 2019 Oct 15 doi: 10.1016/j.jvoice.2019.08.019. PMID: 31628044
Updated Medical and Surgical Treatment for Common Benign Laryngeal Lesions.
Kraimer KL, Husain I
Otolaryngol Clin North Am 2019 Aug;52(4):745-757. Epub 2019 May 8 doi: 10.1016/j.otc.2019.03.017. PMID: 31078305
Treatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysis.
Rimoli CF, Martins RHG, Catâneo DC, Imamura R, Catâneo AJM
Braz J Otorhinolaryngol 2018 Nov-Dec;84(6):781-789. Epub 2018 Apr 14 doi: 10.1016/j.bjorl.2018.03.003. PMID: 29699879Free PMC Article
Risk factors for laryngeal trauma and granuloma formation in pediatric intubations.
Jang M, Basa K, Levi J
Int J Pediatr Otorhinolaryngol 2018 Apr;107:45-52. Epub 2018 Jan 31 doi: 10.1016/j.ijporl.2018.01.008. PMID: 29501310
Vocal process granulomas: a systematic review of treatment.
Karkos PD, George M, Van Der Veen J, Atkinson H, Dwivedi RC, Kim D, Repanos C
Ann Otol Rhinol Laryngol 2014 May;123(5):314-20. Epub 2014 Mar 17 doi: 10.1177/0003489414525921. PMID: 24642585

Prognosis

Noninvasive Detection of Arytenoid Cartilage Calcification Using Computed Tomography and Prediction of Prognosis in Laryngeal Contact Granuloma.
Zhang S, Liu W, Zheng M, Qiu Y
J Voice 2024 Mar;38(2):466-471. Epub 2021 Oct 8 doi: 10.1016/j.jvoice.2021.09.003. PMID: 34629228
Factors for Predicting the Therapeutic Efficacy of Laryngeal Contact Granuloma.
Nie Q, Li J, Zou S, Zhang R
J Voice 2022 Sep;36(5):737.e17-737.e23. Epub 2020 Sep 8 doi: 10.1016/j.jvoice.2020.08.017. PMID: 32917458
Conservative Treatment versus Surgery for Laryngeal Contact Granuloma: A Prospective Study.
Chen M, Chen J, Yang Y, Li CJ, Wu HT, Chen L
ORL J Otorhinolaryngol Relat Spec 2018;80(5-6):307-316. Epub 2018 Sep 11 doi: 10.1159/000492976. PMID: 30205367
Quantification of Vocal Fold Vibration in Various Laryngeal Disorders Using High-Speed Digital Imaging.
Yamauchi A, Yokonishi H, Imagawa H, Sakakibara K, Nito T, Tayama N, Yamasoba T
J Voice 2016 Mar;30(2):205-14. Epub 2015 May 21 doi: 10.1016/j.jvoice.2015.04.016. PMID: 26003886
Vocal process granuloma and glottal insufficiency: an overlooked etiology?
Carroll TL, Gartner-Schmidt J, Statham MM, Rosen CA
Laryngoscope 2010 Jan;120(1):114-20. doi: 10.1002/lary.20656. PMID: 19877195

Clinical prediction guides

Factors for Predicting the Therapeutic Efficacy of Laryngeal Contact Granuloma.
Nie Q, Li J, Zou S, Zhang R
J Voice 2022 Sep;36(5):737.e17-737.e23. Epub 2020 Sep 8 doi: 10.1016/j.jvoice.2020.08.017. PMID: 32917458
Treatment of Laryngeal Contact Granuloma: Surgical Therapy or Conservative Treatment.
Chang W, Xu W, Cheng L
ORL J Otorhinolaryngol Relat Spec 2019;81(5-6):348-353. Epub 2019 Nov 6 doi: 10.1159/000503975. PMID: 31694031
Post-transplantation laryngeal actinomycosis.
Sei H, Nouta J, Miyaji S, Hato N
Auris Nasus Larynx 2019 Dec;46(6):917-920. Epub 2018 Dec 20 doi: 10.1016/j.anl.2018.12.006. PMID: 30579693
Conservative Treatment versus Surgery for Laryngeal Contact Granuloma: A Prospective Study.
Chen M, Chen J, Yang Y, Li CJ, Wu HT, Chen L
ORL J Otorhinolaryngol Relat Spec 2018;80(5-6):307-316. Epub 2018 Sep 11 doi: 10.1159/000492976. PMID: 30205367
Treatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysis.
Rimoli CF, Martins RHG, Catâneo DC, Imamura R, Catâneo AJM
Braz J Otorhinolaryngol 2018 Nov-Dec;84(6):781-789. Epub 2018 Apr 14 doi: 10.1016/j.bjorl.2018.03.003. PMID: 29699879Free PMC Article

Recent systematic reviews

Operative and Conservative Management of Laryngeal Contact Granuloma: A Network Analysis and Systematic Review.
Tsai SW, Ma YF, Shih LC, Tsou YA, Sung CK
J Voice 2021 Mar;35(2):300-306. Epub 2019 Oct 15 doi: 10.1016/j.jvoice.2019.08.019. PMID: 31628044
Treatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysis.
Rimoli CF, Martins RHG, Catâneo DC, Imamura R, Catâneo AJM
Braz J Otorhinolaryngol 2018 Nov-Dec;84(6):781-789. Epub 2018 Apr 14 doi: 10.1016/j.bjorl.2018.03.003. PMID: 29699879Free PMC Article
Risk factors for laryngeal trauma and granuloma formation in pediatric intubations.
Jang M, Basa K, Levi J
Int J Pediatr Otorhinolaryngol 2018 Apr;107:45-52. Epub 2018 Jan 31 doi: 10.1016/j.ijporl.2018.01.008. PMID: 29501310
Vocal process granulomas: a systematic review of treatment.
Karkos PD, George M, Van Der Veen J, Atkinson H, Dwivedi RC, Kim D, Repanos C
Ann Otol Rhinol Laryngol 2014 May;123(5):314-20. Epub 2014 Mar 17 doi: 10.1177/0003489414525921. PMID: 24642585

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