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Infectious mononucleosis

MedGen UID:
7069
•Concept ID:
C0021345
•
Disease or Syndrome
Synonyms: Fever, Glandular; Glandular Fever; Infectious Mononucleosis; Mononucleosis, Infectious
SNOMED CT: Pfeiffer's disease (271558008); Gammaherpesviral mononucleosis (186668002); Infectious mononucleosis (271558008); Infective mononucleosis (271558008); Glandular fever (271558008); GF - Glandular fever (271558008); Monocytic angina (271558008); IM - Infective mononucleosis (271558008); IM - Infectious mononucleosis (271558008)
 
Monarch Initiative: MONDO:0005810

Definition

A clinical syndrome of fever, sore throat, fatigue, and lymphadenopathy caused by infection with the Epstein-Barr virus. Subsequent physical findings may include hepatomegaly, palatal petechiae, jaundice, uvular edema, and splenomegaly. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfectious mononucleosis

Professional guidelines

PubMed

Hodgkin Lymphoma and Its Differential Diagnosis: New Twists on an Old Challenge.
Sohani AR
Surg Pathol Clin 2023 Jun;16(2):287-346. Epub 2023 Mar 30 doi: 10.1016/j.path.2023.02.002. PMID: 37149361
Splenomegaly: Diagnosis and Management in Adults.
Aldulaimi S, Mendez AM
Am Fam Physician 2021 Sep 1;104(3):271-276. PMID: 34523897
Infectious Mononucleosis Management in Athletes.
Ceraulo AS, Bytomski JR
Clin Sports Med 2019 Oct;38(4):555-561. Epub 2019 Jul 29 doi: 10.1016/j.csm.2019.06.002. PMID: 31472766

Recent clinical studies

Etiology

Infectious Mononucleosis: An Updated Review.
Leung AKC, Lam JM, Barankin B
Curr Pediatr Rev 2024;20(3):305-322. doi: 10.2174/1573396320666230801091558. PMID: 37526456
Infectious Mononucleosis: Rapid Evidence Review.
Sylvester JE, Buchanan BK, Silva TW
Am Fam Physician 2023 Jan;107(1):71-78. PMID: 36689975
Epstein-Barr virus and its association with disease - a review of relevance to general practice.
Fugl A, Andersen CL
BMC Fam Pract 2019 May 14;20(1):62. doi: 10.1186/s12875-019-0954-3. PMID: 31088382Free PMC Article
Common questions about infectious mononucleosis.
Womack J, Jimenez M
Am Fam Physician 2015 Mar 15;91(6):372-6. PMID: 25822555
Infectious mononucleosis.
Cozad J
Nurse Pract 1996 Mar;21(3):14-6, 23, 27-8. PMID: 8710247

Diagnosis

Infectious Mononucleosis: Rapid Evidence Review.
Sylvester JE, Buchanan BK, Silva TW
Am Fam Physician 2023 Jan;107(1):71-78. PMID: 36689975
Infectious Mononucleosis Management in Athletes.
Ceraulo AS, Bytomski JR
Clin Sports Med 2019 Oct;38(4):555-561. Epub 2019 Jul 29 doi: 10.1016/j.csm.2019.06.002. PMID: 31472766
Infectious mononucleosis.
Cozad J
Nurse Pract 1996 Mar;21(3):14-6, 23, 27-8. PMID: 8710247
Infectious mononucleosis.
Shurin SB
Pediatr Clin North Am 1979 May;26(2):315-26. doi: 10.1016/s0031-3955(16)33708-7. PMID: 223111
INFECTIOUS MONONUCLEOSIS.
DAVIDSOHN I, LEE CL
Chic Med Sch Q 1964;24:1-9. PMID: 14156108

Therapy

Amoxicillin Rash in Infectious Mononucleosis.
Mergoum AM
N Engl J Med 2021 Sep 9;385(11):1033. doi: 10.1056/NEJMicm2104358. PMID: 34496177
Infections of the Oropharynx.
Klein MR
Emerg Med Clin North Am 2019 Feb;37(1):69-80. doi: 10.1016/j.emc.2018.09.002. PMID: 30454781
Vaccine Development for Epstein-Barr Virus.
Cohen JI
Adv Exp Med Biol 2018;1045:477-493. doi: 10.1007/978-981-10-7230-7_22. PMID: 29896681Free PMC Article
Infectious mononucleosis.
Luzuriaga K, Sullivan JL
N Engl J Med 2010 May 27;362(21):1993-2000. doi: 10.1056/NEJMcp1001116. PMID: 20505178
Epstein-Barr virus infectious mononucleosis.
Ebell MH
Am Fam Physician 2004 Oct 1;70(7):1279-87. PMID: 15508538

Prognosis

The Evolving Epidemiology of Nasopharyngeal Carcinoma.
Chang ET, Ye W, Zeng YX, Adami HO
Cancer Epidemiol Biomarkers Prev 2021 Jun;30(6):1035-1047. Epub 2021 Apr 13 doi: 10.1158/1055-9965.EPI-20-1702. PMID: 33849968
Infectious Mononucleosis: diagnosis and clinical interpretation.
Naughton P, Healy M, Enright F, Lucey B
Br J Biomed Sci 2021 Jul;78(3):107-116. Epub 2021 Apr 14 doi: 10.1080/09674845.2021.1903683. PMID: 33721513
The rash with maculopapules and fever in adults.
Muzumdar S, Rothe MJ, Grant-Kels JM
Clin Dermatol 2019 Mar-Apr;37(2):109-118. Epub 2018 Dec 5 doi: 10.1016/j.clindermatol.2018.12.004. PMID: 30981291
Antibiotic-Induced Rash in Patients With Infectious Mononucleosis.
Thompson DF, Ramos CL
Ann Pharmacother 2017 Feb;51(2):154-162. Epub 2016 Oct 1 doi: 10.1177/1060028016669525. PMID: 27620494
Epstein-Barr virus infectious mononucleosis.
Ebell MH
Am Fam Physician 2004 Oct 1;70(7):1279-87. PMID: 15508538

Clinical prediction guides

Infectious Mononucleosis: An Updated Review.
Leung AKC, Lam JM, Barankin B
Curr Pediatr Rev 2024;20(3):305-322. doi: 10.2174/1573396320666230801091558. PMID: 37526456
Infectious Mononucleosis: diagnosis and clinical interpretation.
Naughton P, Healy M, Enright F, Lucey B
Br J Biomed Sci 2021 Jul;78(3):107-116. Epub 2021 Apr 14 doi: 10.1080/09674845.2021.1903683. PMID: 33721513
Lipschütz's acute vulvar ulcer: a systematic review.
Vismara SA, Lava SAG, Kottanattu L, Simonetti GD, Zgraggen L, Clericetti CM, Bianchetti MG, Milani GP
Eur J Pediatr 2020 Oct;179(10):1559-1567. Epub 2020 Apr 15 doi: 10.1007/s00431-020-03647-y. PMID: 32296983
Primary Epstein-Barr virus infection.
Dunmire SK, Verghese PS, Balfour HH Jr
J Clin Virol 2018 May;102:84-92. Epub 2018 Mar 5 doi: 10.1016/j.jcv.2018.03.001. PMID: 29525635
Tonsillitis.
Georgalas CC, Tolley NS, Narula A
BMJ Clin Evid 2009 Oct 26;2009 PMID: 21718574Free PMC Article

Recent systematic reviews

The utility of liver function tests and abdominal ultrasound in infectious mononucleosis-A systematic review.
Tan ET, Wilkinson D, Edafe O
Clin Otolaryngol 2022 Nov;47(6):611-619. Epub 2022 Jul 29 doi: 10.1111/coa.13965. PMID: 35834363
Lipschütz's acute vulvar ulcer: a systematic review.
Vismara SA, Lava SAG, Kottanattu L, Simonetti GD, Zgraggen L, Clericetti CM, Bianchetti MG, Milani GP
Eur J Pediatr 2020 Oct;179(10):1559-1567. Epub 2020 Apr 15 doi: 10.1007/s00431-020-03647-y. PMID: 32296983
Does This Patient Have Infectious Mononucleosis?: The Rational Clinical Examination Systematic Review.
Ebell MH, Call M, Shinholser J, Gardner J
JAMA 2016 Apr 12;315(14):1502-9. doi: 10.1001/jama.2016.2111. PMID: 27115266
Tonsillitis.
Georgalas CC, Tolley NS, Narula PA
BMJ Clin Evid 2014 Jul 22;2014 PMID: 25051184Free PMC Article
Tonsillitis.
Georgalas CC, Tolley NS, Narula A
BMJ Clin Evid 2009 Oct 26;2009 PMID: 21718574Free PMC Article

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