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Inflammation

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
Synonym: Inflammations
SNOMED CT: Inflammation (257552002)

Definition

A localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInflammation

Recent clinical studies

Etiology

Izvolskaia M, Sharova V, Zakharova L
Inflammation 2020 Aug;43(4):1175-1183. doi: 10.1007/s10753-020-01220-1. PMID: 32279161
Xu Y, Niu Y, Li H, Pan G
Inflammation 2020 Aug;43(4):1362-1374. doi: 10.1007/s10753-020-01214-z. PMID: 32206944
Lucarini G, Zizzi A, Rubini C, Ciolino F, Aspriello SD
Inflammation 2019 Apr;42(2):682-689. doi: 10.1007/s10753-018-0926-0. PMID: 30406462
Yuan J, Liu R, Ma Y, Zhang Z, Xie Z
Inflammation 2018 Oct;41(5):1804-1814. doi: 10.1007/s10753-018-0823-6. PMID: 29961171
Wang C, Ha X, Li W, Xu P, Gu Y, Wang T, Wang Y, Xie J, Zhang J
Inflammation 2017 Feb;40(1):42-51. doi: 10.1007/s10753-016-0450-z. PMID: 27714571

Diagnosis

Wu S, Wang J, Li J, Li F
Inflammation 2020 Apr;43(2):441-454. doi: 10.1007/s10753-019-01117-8. PMID: 32008163
Lucarini G, Zizzi A, Rubini C, Ciolino F, Aspriello SD
Inflammation 2019 Apr;42(2):682-689. doi: 10.1007/s10753-018-0926-0. PMID: 30406462
Wang X, Buechler NL, Long DL, Furdui CM, Yoza BK, McCall CE, Vachharajani V
Inflammation 2019 Feb;42(1):156-169. doi: 10.1007/s10753-018-0881-9. PMID: 30203196Free PMC Article
Varela ML, Mogildea M, Moreno I, Lopes A
Inflammation 2018 Aug;41(4):1115-1127. doi: 10.1007/s10753-018-0739-1. PMID: 29404872
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article

Therapy

Tao MQ, Ji CL, Wu YJ, Dong JY, Li Y, Olatunji OJ, Zuo J
Inflammation 2020 Oct;43(5):1821-1831. doi: 10.1007/s10753-020-01256-3. PMID: 32468498
Qian H, Jia J, Yang Y, Bian Z, Ji Y
Inflammation 2020 Aug;43(4):1572-1585. doi: 10.1007/s10753-020-01234-9. PMID: 32303868
Li X, Sun M, Long Y
Inflammation 2020 Jun;43(3):1088-1096. doi: 10.1007/s10753-020-01194-0. PMID: 32248330
Xin L, Che B, Zhai B, Luo Q, Zhang C, Wang J, Wang S, Fan G, Liu Z, Feng J, Zhang Z
Inflammation 2019 Apr;42(2):702-713. doi: 10.1007/s10753-018-0928-y. PMID: 30430362
Zheng Z, Zeng Y, Zhu X, Tan Y, Li Y, Li Q, Yi G
Inflammation 2019 Apr;42(2):606-617. doi: 10.1007/s10753-018-0918-0. PMID: 30377890

Prognosis

Yen CH, Chang PS, Chiu CJ, Huang YY, Lin PT
Nutrients 2021 Jun 30;13(7) doi: 10.3390/nu13072280. PMID: 34209267Free PMC Article
Nøst TH, Alcala K, Urbarova I, Byrne KS, Guida F, Sandanger TM, Johansson M
Eur J Epidemiol 2021 Aug;36(8):841-848. Epub 2021 May 25 doi: 10.1007/s10654-021-00752-6. PMID: 34036468Free PMC Article
Vodovotz Y, Barclay D, Yin J, Squires RH, Zamora R
Front Immunol 2020;11:610861. Epub 2021 Jan 15 doi: 10.3389/fimmu.2020.610861. PMID: 33519820Free PMC Article
Ye L, Mao S, Fang S, Zhang J, Tan Y, Gu W
Inflammation 2019 Oct;42(5):1555-1560. doi: 10.1007/s10753-019-01017-x. PMID: 31049771
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article

Clinical prediction guides

Vodovotz Y, Barclay D, Yin J, Squires RH, Zamora R
Front Immunol 2020;11:610861. Epub 2021 Jan 15 doi: 10.3389/fimmu.2020.610861. PMID: 33519820Free PMC Article
Ye L, Mao S, Fang S, Zhang J, Tan Y, Gu W
Inflammation 2019 Oct;42(5):1555-1560. doi: 10.1007/s10753-019-01017-x. PMID: 31049771
Xin L, Che B, Zhai B, Luo Q, Zhang C, Wang J, Wang S, Fan G, Liu Z, Feng J, Zhang Z
Inflammation 2019 Apr;42(2):702-713. doi: 10.1007/s10753-018-0928-y. PMID: 30430362
Li JY, Wang N, Khoso MH, Shen CB, Guo MZ, Pang XX, Li DS, Wang WF
Inflammation 2018 Jun;41(3):751-759. doi: 10.1007/s10753-018-0729-3. PMID: 29427162
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article

Recent systematic reviews

Olsthoorn SEM, Wang X, Tillema B, Vanmierlo T, Kraan S, Leenen PJM, Mulder MT
Nutrients 2021 Jul 29;13(8) doi: 10.3390/nu13082613. PMID: 34444774Free PMC Article
Dziegielewska-Gesiak S
Clin Interv Aging 2021;16:1057-1070. Epub 2021 Jun 9 doi: 10.2147/CIA.S306982. PMID: 34135578Free PMC Article
Battineni G, Sagaro GG, Chintalapudi N, Amenta F, Tomassoni D, Tayebati SK
Int J Mol Sci 2021 Apr 30;22(9) doi: 10.3390/ijms22094798. PMID: 33946540Free PMC Article
Ahmed H, Khan MA, Kahlert UD, Niemelä M, Hänggi D, Chaudhry SR, Muhammad S
Int J Mol Sci 2021 Apr 18;22(8) doi: 10.3390/ijms22084185. PMID: 33919485Free PMC Article
Wu PY, Chen KM, Tsai WC
Adv Nutr 2021 Mar 31;12(2):363-373. doi: 10.1093/advances/nmaa116. PMID: 33002104Free PMC Article

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