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Intermittent claudication

MedGen UID:
7115
Concept ID:
C0021775
Disease or Syndrome
Synonyms: Claudication, Intermittent; Intermittent Claudication
SNOMED CT: Intermittent claudication (63491006); Myasthenia angiosclerotica (63491006); IC - Intermittent claudication (63491006); Claudication (63491006)
 
HPO: HP:0004417
Monarch Initiative: MONDO:0005295

Definition

Intermittent claudication is a symptom of peripheral arterial occlusive disease. After having walked over a distance which is individually characteristic, the patients experience pain or cramps in the calves, feet or thighs which typically subsides on standing still. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntermittent claudication

Conditions with this feature

Fibromuscular dysplasia
MedGen UID:
4700
Concept ID:
C0016052
Disease or Syndrome
Fibromuscular dysplasia (FMDA) is a nonatherosclerotic, noninflammatory arterial disease that most commonly involves the renal and carotid arteries. The prevalence of symptomatic renal artery FMDA is about 4 in 1,000 and the prevalence of cervicocranial FMDA is about half of that. Histologic classification includes 3 main subtypes, intimal, medial, and perimedial, which may be associated in a single patient. Angiographic classification includes the multifocal type, with multiple stenoses and the 'string of beads' appearance that is related to medial FMDA, and tubular and focal types, which are not clearly related to specific histologic lesions (summary by Plouin et al., 2007)
Primary hyperoxaluria, type I
MedGen UID:
75658
Concept ID:
C0268164
Disease or Syndrome
Primary hyperoxaluria type 1 (PH1) is caused by a deficiency of the liver peroxisomal enzyme alanine:glyoxylate-aminotransferase (AGT), which catalyzes the conversion of glyoxylate to glycine. When AGT activity is absent, glyoxylate is converted to oxalate, which forms insoluble calcium oxalate crystals that accumulate in the kidney and other organs. Individuals with PH1 are at risk for recurrent nephrolithiasis (deposition of calcium oxalate in the renal pelvis / urinary tract), nephrocalcinosis (deposition of calcium oxalate in the renal parenchyma), or end-stage renal disease (ESRD). Age at onset of symptoms ranges from infancy to the sixth decade. Approximately 10% of affected individuals present in infancy or early childhood with nephrocalcinosis, with or without nephrolithiasis, and failure to thrive related to renal failure. The majority of individuals with PH1 present in childhood or early adolescence, usually with symptomatic nephrolithiasis and normal or reduced kidney function. The remainder of affected individuals present in adulthood with recurrent renal stones and a mild-to-moderate reduction in kidney function. The natural history of untreated PH1 is one of progressive decline in renal function as a result of calcium oxalate deposits in kidney tissue and complications of nephrolithiasis (e.g., obstruction and infection) with eventual progression to oxalosis (widespread tissue deposition of calcium oxalate) and death from ESRD and/or complications of oxalosis.
Autosomal recessive inherited pseudoxanthoma elasticum
MedGen UID:
698415
Concept ID:
C1275116
Disease or Syndrome
Pseudoxanthoma elasticum (PXE) is a systemic disorder that affects the elastic tissue of the skin, the eye, and vascular system. Individuals most commonly present with angioid streaks of the retina found on routine eye examination or associated with retinal hemorrhage and/or characteristic papules in the skin. The most frequent cause of morbidity and disability in PXE is reduced vision due to complications of subretinal neovascularizations and macular atrophy. Other manifestations include premature gastrointestinal angina and/or bleeding, intermittent claudication of arm and leg muscles, stroke, renovascular hypertension, and cardiovascular complications (angina/myocardial infarction). Most affected individuals live a normal life span.
Platelet prostacyclin receptor defect
MedGen UID:
337912
Concept ID:
C1849774
Disease or Syndrome
Hereditary arterial and articular multiple calcification syndrome
MedGen UID:
347132
Concept ID:
C1859372
Disease or Syndrome
Adult-onset calcification of the lower extremity arteries (CALJA), including the iliac, femoral, and tibial arteries, and hand and foot capsule joints, is an autosomal recessive condition that represents only the second mendelian disorder of isolated calcification (see generalized arterial calcification of infancy (GACI), 208000). Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands (St. Hilaire et al., 2011).

Professional guidelines

PubMed

Mandaglio-Collados D, Marín F, Rivera-Caravaca JM
Med Clin (Barc) 2023 Oct 27;161(8):344-350. Epub 2023 Jul 28 doi: 10.1016/j.medcli.2023.06.005. PMID: 37517924
Firnhaber JM, Powell CS
Am Fam Physician 2019 Mar 15;99(6):362-369. PMID: 30874413
Kalichman L, Hunter DJ
Eur Spine J 2008 Mar;17(3):327-335. Epub 2007 Nov 17 doi: 10.1007/s00586-007-0543-3. PMID: 18026865Free PMC Article

Recent clinical studies

Etiology

Stonko DP, Hicks CW
Adv Surg 2023 Sep;57(1):103-113. Epub 2023 May 29 doi: 10.1016/j.yasu.2023.04.009. PMID: 37536847Free PMC Article
Beckman JA, Schneider PA, Conte MS
Circ Res 2021 Jun 11;128(12):1885-1912. Epub 2021 Jun 10 doi: 10.1161/CIRCRESAHA.121.318261. PMID: 34110904
Criqui MH, Aboyans V
Circ Res 2015 Apr 24;116(9):1509-26. doi: 10.1161/CIRCRESAHA.116.303849. PMID: 25908725
Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG; TASC II Working Group
J Vasc Surg 2007 Jan;45 Suppl S:S5-67. doi: 10.1016/j.jvs.2006.12.037. PMID: 17223489
Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG; TASC II Working Group, Bell K, Caporusso J, Durand-Zaleski I, Komori K, Lammer J, Liapis C, Novo S, Razavi M, Robbs J, Schaper N, Shigematsu H, Sapoval M, White C, White J, Clement D, Creager M, Jaff M, Mohler E 3rd, Rutherford RB, Sheehan P, Sillesen H, Rosenfield K
Eur J Vasc Endovasc Surg 2007;33 Suppl 1:S1-75. Epub 2006 Nov 29 doi: 10.1016/j.ejvs.2006.09.024. PMID: 17140820

Diagnosis

Stonko DP, Hicks CW
Adv Surg 2023 Sep;57(1):103-113. Epub 2023 May 29 doi: 10.1016/j.yasu.2023.04.009. PMID: 37536847Free PMC Article
Beckman JA, Schneider PA, Conte MS
Circ Res 2021 Jun 11;128(12):1885-1912. Epub 2021 Jun 10 doi: 10.1161/CIRCRESAHA.121.318261. PMID: 34110904
Criqui MH, Aboyans V
Circ Res 2015 Apr 24;116(9):1509-26. doi: 10.1161/CIRCRESAHA.116.303849. PMID: 25908725
Lejay A, Ohana M, Lee JT, Georg Y, Delay C, Lucereau B, Thaveau F, Gaertner S, Chakfé N; Groupe Européen de Recherche sur les Prothèses Appliquées à la Chirurgie Vasculaire (GEPROVAS)
J Cardiovasc Surg (Torino) 2014 Apr;55(2 Suppl 1):225-37. PMID: 24796917
Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG; TASC II Working Group
J Vasc Surg 2007 Jan;45 Suppl S:S5-67. doi: 10.1016/j.jvs.2006.12.037. PMID: 17223489

Therapy

Kamoen V, Vander Stichele R, Campens L, De Bacquer D, Van Bortel L, de Backer TL
Cochrane Database Syst Rev 2021 Dec 26;12(12):CD010117. doi: 10.1002/14651858.CD010117.pub2. PMID: 34954832Free PMC Article
Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH
Cochrane Database Syst Rev 2017 Apr 24;4(4):CD011279. doi: 10.1002/14651858.CD011279.pub3. PMID: 28436583Free PMC Article
Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH
Cochrane Database Syst Rev 2017 Jan 14;1(1):CD011279. doi: 10.1002/14651858.CD011279.pub2. PMID: 28087891Free PMC Article
Med Lett Drugs Ther 2004 Nov 22;46(1196):95-6. PMID: 15557875
Sorkin EM, Markham A
Drugs Aging 1999 Jan;14(1):63-71; discussion 72-3. doi: 10.2165/00002512-199914010-00005. PMID: 10069409

Prognosis

Ferreira JMM, Cunha P, Carneiro A, Vila I, Cunha C, Silva C, Longatto-Filho A, Mesquita A, Cotter J, Mansilha A, Correia-Neves M
Ann Vasc Surg 2021 Jul;74:460-474. Epub 2021 Feb 5 doi: 10.1016/j.avsg.2021.01.076. PMID: 33556522
Gardner AW, Addison O, Katzel LI, Montgomery PS, Prior SJ, Serra MC, Sorkin JD
Med Sci Sports Exerc 2021 Apr 1;53(4):732-739. doi: 10.1249/MSS.0000000000002526. PMID: 32991346Free PMC Article
Criqui MH, Aboyans V
Circ Res 2015 Apr 24;116(9):1509-26. doi: 10.1161/CIRCRESAHA.116.303849. PMID: 25908725
Davies MG
Methodist Debakey Cardiovasc J 2012 Oct-Dec;8(4):10-4. doi: 10.14797/mdcj-8-4-10. PMID: 23342182Free PMC Article
Criado E, Ramadan F, Keagy BA, Johnson G Jr
Surg Gynecol Obstet 1991 Aug;173(2):163-70. PMID: 1925871

Clinical prediction guides

Bearne LM, Volkmer B, Peacock J, Sekhon M, Fisher G, Galea Holmes MN, Douiri A, Amirova A, Farran D, Quirke-McFarlane S, Modarai B, Sackley C, Weinman J, Bieles J; MOSAIC Trial Collaboration
JAMA 2022 Apr 12;327(14):1344-1355. doi: 10.1001/jama.2022.3391. PMID: 35412564Free PMC Article
Giusca S, Hagstotz S, Lichtenberg M, Heinrich U, Eisenbach C, Andrassy M, Korosoglou G
EuroIntervention 2022 Aug 5;18(5):e432-e442. doi: 10.4244/EIJ-D-21-01070. PMID: 35389346Free PMC Article
Nativel M, Potier L, Alexandre L, Baillet-Blanco L, Ducasse E, Velho G, Marre M, Roussel R, Rigalleau V, Mohammedi K
Cardiovasc Diabetol 2018 Oct 23;17(1):138. doi: 10.1186/s12933-018-0781-1. PMID: 30352589Free PMC Article
Lejay A, Ohana M, Lee JT, Georg Y, Delay C, Lucereau B, Thaveau F, Gaertner S, Chakfé N; Groupe Européen de Recherche sur les Prothèses Appliquées à la Chirurgie Vasculaire (GEPROVAS)
J Cardiovasc Surg (Torino) 2014 Apr;55(2 Suppl 1):225-37. PMID: 24796917
Sinha S, Houghton J, Holt PJ, Thompson MM, Loftus IM, Hinchliffe RJ
J Vasc Surg 2012 Jan;55(1):252-262.e30. Epub 2011 Nov 23 doi: 10.1016/j.jvs.2011.08.050. PMID: 22116047

Recent systematic reviews

Kamoen V, Vander Stichele R, Campens L, De Bacquer D, Van Bortel L, de Backer TL
Cochrane Database Syst Rev 2021 Dec 26;12(12):CD010117. doi: 10.1002/14651858.CD010117.pub2. PMID: 34954832Free PMC Article
Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH
Cochrane Database Syst Rev 2017 Apr 24;4(4):CD011279. doi: 10.1002/14651858.CD011279.pub3. PMID: 28436583Free PMC Article
Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH
Cochrane Database Syst Rev 2017 Jan 14;1(1):CD011279. doi: 10.1002/14651858.CD011279.pub2. PMID: 28087891Free PMC Article
Lurie J, Tomkins-Lane C
BMJ 2016 Jan 4;352:h6234. doi: 10.1136/bmj.h6234. PMID: 26727925Free PMC Article
Cassar K
BMJ Clin Evid 2011 Jan 11;2011 PMID: 21477401Free PMC Article

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