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Kidney papillary necrosis

MedGen UID:
7212
•Concept ID:
C0022667
•
Disease or Syndrome
Synonyms: Kidney Papillary Necrosis; Necrosis, Kidney Papillary; Necrosis, Renal Medullary; Necrotizing Renal Papillitides; Necrotizing Renal Papillitis; Papillary Necrosis, Kidney; Papillitides, Necrotizing Renal; Renal Medullary Necrosis; Renal Papillitides, Necrotizing; Renal Papillitis, Necrotizing
SNOMED CT: Necrotizing papillitis (90241004); Medullary necrosis (90241004); Papillary necrosis (90241004); Renal medullary necrosis (90241004); Necrotizing renal papillitis (90241004); Renal papillary necrosis (90241004)
 
HPO: HP:0032632
Monarch Initiative: MONDO:0006821

Definition

Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKidney papillary necrosis

Professional guidelines

PubMed

PAPILLARY NECROSIS. PATHOLOGY AND MANAGEMENT OF THE ACUTE ATTACK.
BONNIN N
Am Heart J 1964 Dec;68:842-3. doi: 10.1016/0002-8703(64)90137-1. PMID: 14235965

Recent clinical studies

Etiology

An update on sickle cell nephropathy.
Alhwiesh A
Saudi J Kidney Dis Transpl 2014 Mar;25(2):249-65. doi: 10.4103/1319-2442.128495. PMID: 24625990
Over-the-counter analgesic use.
De Broe ME, Elseviers MM
J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685
Herbs and the kidney.
Isnard Bagnis C, Deray G, Baumelou A, Le Quintrec M, Vanherweghem JL
Am J Kidney Dis 2004 Jul;44(1):1-11. doi: 10.1053/j.ajkd.2004.02.009. PMID: 15211432
Renal papillary necrosis--40 years on.
Bach PH, Nguyen TK
Toxicol Pathol 1998 Jan-Feb;26(1):73-91. doi: 10.1177/019262339802600110. PMID: 9502390
Non-steroidal anti-inflammatory drugs and the kidney.
Orme ML
Br Med J (Clin Res Ed) 1986 Jun 21;292(6536):1621-2. doi: 10.1136/bmj.292.6536.1621. PMID: 3087546Free PMC Article

Diagnosis

Over-the-counter analgesic use.
De Broe ME, Elseviers MM
J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685
Renal papillary necrosis: review and comparison of findings at multi-detector row CT and intravenous urography.
Jung DC, Kim SH, Jung SI, Hwang SI, Kim SH
Radiographics 2006 Nov-Dec;26(6):1827-36. doi: 10.1148/rg.266065039. PMID: 17102053
Emphysematous pyelonephritis.
Sean TG, Sheshadri S, Saravu K
J Assoc Physicians India 2002 Nov;50:1413-5. PMID: 12583474
Analgesic nephropathy.
De Broe ME, Elseviers MM
N Engl J Med 1998 Feb 12;338(7):446-52. doi: 10.1056/NEJM199802123380707. PMID: 9459649
Phenacetin nephritis.
Freeland JP
Urology 1975 Jul;6(1):37-8. doi: 10.1016/0090-4295(75)90589-0. PMID: 1145922

Therapy

Over-the-counter analgesic use.
De Broe ME, Elseviers MM
J Am Soc Nephrol 2009 Oct;20(10):2098-103. Epub 2009 May 7 doi: 10.1681/ASN.2008101097. PMID: 19423685
Renal papillary necrosis: review and comparison of findings at multi-detector row CT and intravenous urography.
Jung DC, Kim SH, Jung SI, Hwang SI, Kim SH
Radiographics 2006 Nov-Dec;26(6):1827-36. doi: 10.1148/rg.266065039. PMID: 17102053
Herbs and the kidney.
Isnard Bagnis C, Deray G, Baumelou A, Le Quintrec M, Vanherweghem JL
Am J Kidney Dis 2004 Jul;44(1):1-11. doi: 10.1053/j.ajkd.2004.02.009. PMID: 15211432
Analgesic nephropathy.
De Broe ME, Elseviers MM
N Engl J Med 1998 Feb 12;338(7):446-52. doi: 10.1056/NEJM199802123380707. PMID: 9459649
Renal papillary necrosis.
Lancet 1982 Sep 11;2(8298):588-90. PMID: 6125734

Prognosis

An update on sickle cell nephropathy.
Alhwiesh A
Saudi J Kidney Dis Transpl 2014 Mar;25(2):249-65. doi: 10.4103/1319-2442.128495. PMID: 24625990
Emphysematous pyelonephritis.
Sean TG, Sheshadri S, Saravu K
J Assoc Physicians India 2002 Nov;50:1413-5. PMID: 12583474
Analgesic nephropathy.
Henrich WL
Am J Med Sci 1988 Jun;295(6):561-8. doi: 10.1097/00000441-198806000-00012. PMID: 3291614
Diabetic nephropathy.
Beyer MM
Pediatr Clin North Am 1984 Jun;31(3):635-51. doi: 10.1016/s0031-3955(16)34611-9. PMID: 6374591
PHENACETIN NEPHROPATHY.
RAMSAY AG, WHITE DF
Can Med Assoc J 1965 Jan 9;92(2):55-9. PMID: 14228236Free PMC Article

Clinical prediction guides

Prevalence and associations of symptomatic renal papillary necrosis in sickle cell anemia patients in South-Eastern Nigeria.
Madu AJ, Okoye AE, Ajuba IC, Madu KA, Anigbo C, Agu K
Niger J Clin Pract 2016 Jul-Aug;19(4):471-4. doi: 10.4103/1119-3077.183299. PMID: 27251962
Analgesic nephropathy: is it caused by multi-analgesic abuse or single substance use?
Elseviers MM, De Broe ME
Drug Saf 1999 Jan;20(1):15-24. doi: 10.2165/00002018-199920010-00003. PMID: 9935274
Epidemiology and mechanistic basis of analgesic-associated nephropathy.
Gregg NJ, Elseviers MM, De Broe ME, Bach PH
Toxicol Lett 1989 Mar;46(1-3):141-51. doi: 10.1016/0378-4274(89)90123-9. PMID: 2650021
Diabetic nephropathy.
Beyer MM
Pediatr Clin North Am 1984 Jun;31(3):635-51. doi: 10.1016/s0031-3955(16)34611-9. PMID: 6374591
Analgesic abuse and kidney disease.
Stewart JH, Gallery ED
Aust N Z J Med 1976 Oct;6(5):498-508. doi: 10.1111/j.1445-5994.1976.tb03045.x. PMID: 1071883

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