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Cutaneous hamartoma

MedGen UID:
724285
•Concept ID:
C1302724
•
Neoplastic Process
Synonyms: Hamartoma of skin; Skin hamartoma
SNOMED CT: Hamartoma of skin (399921006); Cutaneous hamartoma (51697005)
 
HPO: HP:0031111

Definition

A hamartoma (tissue malformation consisting of an abnormal mixture of constitutive components) originating in the skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous hamartoma

Professional guidelines

PubMed

Genotype-phenotype associations in a large PTEN Hamartoma Tumor Syndrome (PHTS) patient cohort.
Hendricks LAJ, Hoogerbrugge N, Venselaar H, Aretz S, Spier I, Legius E, Brems H, de Putter R, Claes KBM, Evans DG, Woodward ER, Genuardi M, Brugnoletti F, van Ierland Y, Dijke K, Tham E, Tesi B, Schuurs-Hoeijmakers JHM, Branchaud M, Salvador H, Jahn A, Schnaiter S, Anastasiadou VC, Brunet J, Oliveira C, Roht L, Blatnik A, Irmejs A; PTEN Study Group, Mensenkamp AR, Vos JR
Eur J Med Genet 2022 Dec;65(12):104632. Epub 2022 Oct 18 doi: 10.1016/j.ejmg.2022.104632. PMID: 36270489
An update on Becker's nevus: Pathogenesis and treatment.
Zhou YJ, Zheng DL, Hamblin MR, Xu YD, Wen X
Dermatol Ther 2022 Jul;35(7):e15548. Epub 2022 May 12 doi: 10.1111/dth.15548. PMID: 35502558
Tuberous sclerosis complex: review based on new diagnostic criteria.
Portocarrero LKL, Quental KN, Samorano LP, Oliveira ZNP, Rivitti-Machado MCDM
An Bras Dermatol 2018 Jun;93(3):323-331. doi: 10.1590/abd1806-4841.20186972. PMID: 29924239Free PMC Article

Recent clinical studies

Etiology

Nevus Lipomatosus Cutaneous Superficialis of Hoffmann and Zurhelle: a rare cutaneous hamartoma.
Kc S , Aryal A , Jha A , Karn D
Kathmandu Univ Med J (KUMJ) 2022 Apr-Jun;20(78):238-239. PMID: 37017173
Sclerotherapy for atypical oral manifestation of Cowden syndrome.
Cherkas E, Champion AF, Gates JC
Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Oct;130(4):e290-e293. Epub 2020 Jun 10 doi: 10.1016/j.oooo.2020.05.018. PMID: 32636168
Nevus Lipomatosus Cutaneous Superficialis With Perifollicular Fibromas.
Anzai A, Halpern I, Rivitti-Machado MC
Am J Dermatopathol 2015 Sep;37(9):704-6. doi: 10.1097/DAD.0000000000000280. PMID: 25839891
Clinicopathologic analysis of 21 cases of nevus sebaceus: a retrospective study.
Simi CM, Rajalakshmi T, Correa M
Indian J Dermatol Venereol Leprol 2008 Nov-Dec;74(6):625-7. doi: 10.4103/0378-6323.45107. PMID: 19171988
Becker's nevus syndrome.
Angelo C, Grosso MG, Stella P, De Sio C, Passarelli F, Puddu P, Paradisi M
Cutis 2001 Aug;68(2):123-4. PMID: 11534913

Diagnosis

Clinical, pathological, and molecular correlation of folliculocystic and collagen hamartoma: A new potential diagnostic criterion for tuberous sclerosis complex?
Apam-Garduño D, Cazarín-Barrientos J, Hernández-Martínez NL, Reyna-Fabián ME, Magaña M, Alcántara-Ortigoza MA, González-Del Angel A, Rivera-Vega MR
J Cutan Pathol 2023 Jun;50(6):481-486. Epub 2022 Nov 23 doi: 10.1111/cup.14340. PMID: 36229934
Nevus Lipomatosus Cutaneous Superficialis of Hoffmann and Zurhelle: a rare cutaneous hamartoma.
Kc S , Aryal A , Jha A , Karn D
Kathmandu Univ Med J (KUMJ) 2022 Apr-Jun;20(78):238-239. PMID: 37017173
Folliculosebaceous Cystic Hamartoma Arising in Miescher-Type Melanocytic Nevi.
Ishihara Y, Ogita A, Ito K, Saeki H, Ansai SI
Am J Dermatopathol 2022 Nov 1;44(11):817-821. Epub 2022 Sep 1 doi: 10.1097/DAD.0000000000002290. PMID: 36066121
Becker's nevus syndrome.
Angelo C, Grosso MG, Stella P, De Sio C, Passarelli F, Puddu P, Paradisi M
Cutis 2001 Aug;68(2):123-4. PMID: 11534913
Perifollicular fibroma.
Cho S, Hahm JH
J Eur Acad Dermatol Venereol 1999 Jul;13(1):46-9. PMID: 10565630

Therapy

Inflammatory linear verrucous epidermal nevus: why a combined laser therapy.
Conti R, Bruscino N, Campolmi P, Bonan P, Cannarozzo G, Moretti S
J Cosmet Laser Ther 2013 Aug;15(4):242-5. Epub 2013 Jun 21 doi: 10.3109/14764172.2013.807115. PMID: 23692514
Ultrapulse carbon dioxide laser treatment of porokeratotic eccrine ostial and dermal duct nevus.
Jain S, Sardana K, Garg VK
Pediatr Dermatol 2013 Mar-Apr;30(2):264-6. Epub 2012 Feb 16 doi: 10.1111/j.1525-1470.2011.01659.x. PMID: 22339989

Prognosis

Neuro-folliculo-sebaceous cystic hamartoma is a unique entity.
Samaka RM, Alrahabi N
Pol J Pathol 2015 Mar;66(1):77-9. doi: 10.5114/pjp.2015.51157. PMID: 26017884
Hybrid eccrine gland and hair follicle hamartoma: a new entity of adnexal nevus.
Luo DQ, Huang CZ, Xie WL, Xu FF, Mo LQ
Am J Dermatopathol 2015 Feb;37(2):167-70. doi: 10.1097/DAD.0000000000000040. PMID: 24335519
Multicentric primary extramammary Paget disease: a Toker cell disorder?
Hashemi P, Kao GF, Konia T, Kauffman LC, Tam CC, Sina B
Cutis 2014 Jul;94(1):35-8. PMID: 25101342
Nasal folliculosebaceous hamartoma with vascular-mesenchymal overgrowth in an infant.
Selçuk ÖT, Osma U, Süren D, Eyigör H, Yılmaz D, Sezer C
J Craniomaxillofac Surg 2013 Apr;41(3):242-4. Epub 2012 Nov 3 doi: 10.1016/j.jcms.2012.09.008. PMID: 23127544
Becker's nevus syndrome.
Angelo C, Grosso MG, Stella P, De Sio C, Passarelli F, Puddu P, Paradisi M
Cutis 2001 Aug;68(2):123-4. PMID: 11534913

Clinical prediction guides

Folliculosebaceous Cystic Hamartoma Arising in Miescher-Type Melanocytic Nevi.
Ishihara Y, Ogita A, Ito K, Saeki H, Ansai SI
Am J Dermatopathol 2022 Nov 1;44(11):817-821. Epub 2022 Sep 1 doi: 10.1097/DAD.0000000000002290. PMID: 36066121
Neuro-folliculo-sebaceous cystic hamartoma is a unique entity.
Samaka RM, Alrahabi N
Pol J Pathol 2015 Mar;66(1):77-9. doi: 10.5114/pjp.2015.51157. PMID: 26017884
Hybrid eccrine gland and hair follicle hamartoma: a new entity of adnexal nevus.
Luo DQ, Huang CZ, Xie WL, Xu FF, Mo LQ
Am J Dermatopathol 2015 Feb;37(2):167-70. doi: 10.1097/DAD.0000000000000040. PMID: 24335519
Multicentric primary extramammary Paget disease: a Toker cell disorder?
Hashemi P, Kao GF, Konia T, Kauffman LC, Tam CC, Sina B
Cutis 2014 Jul;94(1):35-8. PMID: 25101342
Clinicopathologic analysis of 21 cases of nevus sebaceus: a retrospective study.
Simi CM, Rajalakshmi T, Correa M
Indian J Dermatol Venereol Leprol 2008 Nov-Dec;74(6):625-7. doi: 10.4103/0378-6323.45107. PMID: 19171988

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