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Eccrine carcinoma

MedGen UID:
724404
•Concept ID:
C1302864
•
Neoplastic Process
Synonyms: carcinoma of eccrine sweat gland; carcinoma, eccrine gland, malignant; eccrine adenocarcinoma; eccrine adenocarcinoma (morphologic abnormality); Eccrine Carcinoma; eccrine carcinoma; Eccrine carcinoma of skin; eccrine carcinoma of skin; eccrine sweat gland adenocarcinoma; eccrine sweat gland carcinoma
SNOMED CT: Eccrine carcinoma of skin (400173004)
 
Monarch Initiative: MONDO:0024240

Definition

An adenocarcinoma with eccrine differentiation arising from the sweat glands. It includes the following subtypes: ductal eccrine adenocarcinoma, papillary eccrine carcinoma, and eccrine porocarcinoma. [from NCI]

Professional guidelines

PubMed

Treatment of Malignant Cutaneous Adnexal Neoplasms.
Bernárdez C, Requena L
Actas Dermosifiliogr (Engl Ed) 2018 Jan-Feb;109(1):6-23. Epub 2017 Oct 6 doi: 10.1016/j.ad.2017.04.005. PMID: 28988763
Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends.
Kallini JR, Hamed N, Khachemoune A
Int J Dermatol 2015 Feb;54(2):130-40. Epub 2014 Nov 27 doi: 10.1111/ijd.12553. PMID: 25428226
Clinical course, risk factors, and treatment of microcystic adnexal carcinoma: a short series report.
Abbate M, Zeitouni NC, Seyler M, Hicks W, Loree T, Cheney RT
Dermatol Surg 2003 Oct;29(10):1035-8. doi: 10.1046/j.1524-4725.2003.29296.x. PMID: 12974700

Recent clinical studies

Etiology

Polymorphous Sweat Gland Carcinoma: An Immunohistochemical and Molecular Study.
Ronen S, Aguilera-Barrantes I, Giorgadze T, Šteiner P, Grossmann P, Suster S
Am J Dermatopathol 2018 Aug;40(8):580-587. doi: 10.1097/DAD.0000000000001128. PMID: 29533280
Primary mucinous eccrine carcinoma of the buccal space: A case report and review of the literature.
Lozada KN, Qazi MS, Khorsandi AS, Chai RL
Am J Otolaryngol 2018 Mar-Apr;39(2):242-246. Epub 2018 Jan 5 doi: 10.1016/j.amjoto.2017.12.020. PMID: 29331306
Epidemiology and Prognosis of Primary Periocular Sweat Gland Carcinomas.
Baker MS, Yin VT, Ivan D, Allen RC, Carter KD, Esmaeli B, Shriver EM
Ophthalmic Plast Reconstr Surg 2017 Mar/Apr;33(2):101-105. doi: 10.1097/IOP.0000000000000658. PMID: 26974419
Squamoid Eccrine Ductal Carcinoma: A Clinicopathologic Study of 30 Cases.
van der Horst MP, Garcia-Herrera A, Markiewicz D, Martin B, Calonje E, Brenn T
Am J Surg Pathol 2016 Jun;40(6):755-60. doi: 10.1097/PAS.0000000000000599. PMID: 26796504
Syringoid eccrine carcinoma.
Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522

Diagnosis

Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors.
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269
Syringoid eccrine carcinoma.
Abedi SM, Yu R, Salama S, Alowami S
Cutis 2015 Sep;96(3):162,191-2. PMID: 26562272
It's more than you know.
McCalmont TH
J Cutan Pathol 2013 Aug;40(8):699-700. doi: 10.1111/cup.12194. PMID: 23859701
Perilipin and adipophilin expression in sebaceous carcinoma and mimics.
Boussahmain C, Mochel MC, Hoang MP
Hum Pathol 2013 Sep;44(9):1811-6. Epub 2013 May 1 doi: 10.1016/j.humpath.2013.02.003. PMID: 23642680
Syringoid eccrine carcinoma.
Moy RL, Rivkin JE, Lee H, Brooks WS, Zitelli JA
J Am Acad Dermatol 1991 May;24(5 Pt 2):857-60. doi: 10.1016/0190-9622(91)70133-m. PMID: 2050853

Therapy

Central Nervous System-Invading Eccrine Gland Carcinoma: A Clinicopathologic Case Series and Literature Review.
Gupta S, Hulsbergen AFC, Segar DJ, Hauser BM, Bernstock JD, Nazarian RM, Lawrence DP, Nahed BV, Broekman MLD, Smith TR
World Neurosurg 2020 Jun;138:e17-e25. Epub 2020 Mar 3 doi: 10.1016/j.wneu.2020.01.111. PMID: 32142948
Limax Nd:YAG laser-assisted thoracoscopic resection of pulmonary metastases; a single centre's initial experience.
Mc Loughlin JB, O'Sullivan KE, Brown RH, Eaton DA
Ir J Med Sci 2019 Aug;188(3):771-776. Epub 2018 Oct 31 doi: 10.1007/s11845-018-1924-9. PMID: 30382512
Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors.
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269
Dermal Substitutes Use in Reconstructive Surgery for Skin Tumors: A Single-Center Experience.
Campagnari M, Jafelicci AS, Carneiro HA, Brechtbühl ER, Bertolli E, Duprat Neto JP
Int J Surg Oncol 2017;2017:9805980. Epub 2017 Jul 2 doi: 10.1155/2017/9805980. PMID: 28751990Free PMC Article
Carcinoma of eccrine sweat gland: experience with chemotherapy, autopsy findings in a patient with metastatic eccrine carcinoma, and a review of the literature.
Morris DM, Sanusi ID, Lanehart WH
J Surg Oncol 1986 Jan;31(1):26-30. doi: 10.1002/jso.2930310105. PMID: 3511326

Prognosis

Central Nervous System-Invading Eccrine Gland Carcinoma: A Clinicopathologic Case Series and Literature Review.
Gupta S, Hulsbergen AFC, Segar DJ, Hauser BM, Bernstock JD, Nazarian RM, Lawrence DP, Nahed BV, Broekman MLD, Smith TR
World Neurosurg 2020 Jun;138:e17-e25. Epub 2020 Mar 3 doi: 10.1016/j.wneu.2020.01.111. PMID: 32142948
Behavior of Cutaneous Adnexal Malignancies: a Single Institution Experience.
Prieto-Granada C, Castner N, Chen A, Li J, Yue B, Wong JY, Iyengar S, Sondak VK, Zager JS, Messina JL
Pathol Oncol Res 2020 Jan;26(1):239-244. Epub 2018 Jun 14 doi: 10.1007/s12253-018-0427-3. PMID: 29948620Free PMC Article
Epidemiology and Prognosis of Primary Periocular Sweat Gland Carcinomas.
Baker MS, Yin VT, Ivan D, Allen RC, Carter KD, Esmaeli B, Shriver EM
Ophthalmic Plast Reconstr Surg 2017 Mar/Apr;33(2):101-105. doi: 10.1097/IOP.0000000000000658. PMID: 26974419
Unusual skin tumors: Merkel cell carcinoma, eccrine carcinoma, glomus tumors, and dermatofibrosarcoma protuberans.
Kampshoff JL, Cogbill TH
Surg Clin North Am 2009 Jun;89(3):727-38. doi: 10.1016/j.suc.2009.02.005. PMID: 19465208
Syringoid eccrine carcinoma.
Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522

Clinical prediction guides

Surgical management and lymph-node biopsy of rare malignant cutaneous adnexal carcinomas: a population-based analysis of 7591 patients.
Goyal A, Marghitu T, Goyal N, Rubin N, Patel K, Goyal K, O'Leary D, Bohjanen K, Maher I
Arch Dermatol Res 2021 Oct;313(8):623-632. Epub 2020 Sep 23 doi: 10.1007/s00403-020-02143-5. PMID: 32965516Free PMC Article
A case of eccrine porocarcinoma characterized by a progressive increase in the level of Ki-67 index: case report and review of literature.
Shen J, Pan X, Lu Y, Pan D, Ma Y, Zhan R
BMC Surg 2019 Oct 10;19(1):142. doi: 10.1186/s12893-019-0595-4. PMID: 31601219Free PMC Article
Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors.
Vaupel P, Piazena H, Müller W, Notter M
Int J Hyperthermia 2018;35(1):26-36. Epub 2018 May 10 doi: 10.1080/02656736.2018.1469169. PMID: 29745269
Primary mucinous eccrine carcinoma of the buccal space: A case report and review of the literature.
Lozada KN, Qazi MS, Khorsandi AS, Chai RL
Am J Otolaryngol 2018 Mar-Apr;39(2):242-246. Epub 2018 Jan 5 doi: 10.1016/j.amjoto.2017.12.020. PMID: 29331306
Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases.
Plaza JA, Ortega PF, Stockman DL, Suster S
J Cutan Pathol 2010 Apr;37(4):403-10. doi: 10.1111/j.1600-0560.2010.01517.x. PMID: 20377670

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