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Myeloid leukemia

MedGen UID:
7320
Concept ID:
C0023470
Neoplastic Process
Synonyms: Granulocytic Leukemia; Granulocytic Leukemias; Leukemia, Granulocytic; Leukemia, Myelocytic; Leukemia, Myelogenous; Leukemia, Myeloid; Leukemias, Granulocytic; Leukemias, Myelocytic; Leukemias, Myelogenous; Leukemias, Myeloid; Myelocytic Leukemia; Myelocytic Leukemias; Myelogenous Leukemia; Myelogenous Leukemias; Myeloid Leukemia; Myeloid Leukemias
SNOMED CT: Myeloid leukemia (188732008); Granulocytic leukemia (188732008); Non-lymphocytic leukemia (1163439000); Myelogenous leukemia (1163439000); Myelocytic leukemia (1163439000); Granulocytic leukemia (1163439000); Myeloid leukemia (1163439000)
 
HPO: HP:0012324
Monarch Initiative: MONDO:0004643

Definition

A leukemia that originates from a myeloid cell, that is the blood forming cells of the bone marrow. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyeloid leukemia

Conditions with this feature

Monocytopenia with susceptibility to infections
MedGen UID:
481660
Concept ID:
C3280030
Disease or Syndrome
This primary immunodeficiency, designated IMD21, DCML, or MONOMAC, is characterized by profoundly decreased or absent monocytes, B lymphocytes, natural killer (NK) lymphocytes, and circulating and tissue dendritic cells (DCs), with little or no effect on T-cell numbers. Clinical features of IMD21 are variable and include susceptibility to disseminated nontuberculous mycobacterial infections, papillomavirus infections, opportunistic fungal infections, and pulmonary alveolar proteinosis. Bone marrow hypocellularity and dysplasia of myeloid, erythroid, and megakaryocytic lineages are present in most patients, as are karyotypic abnormalities, including monosomy 7 and trisomy 8. In the absence of cytogenetic abnormalities or overt dysplasia, hypoplastic bone marrow may initially be diagnosed as aplastic anemia. Bone marrow transplantation is the only cure. Some patients may have an increased risk of miscarriage. Both autosomal dominant transmission and sporadic cases occur. Less common manifestations of GATA2 deficiency include lymphedema and sensorineural hearing loss, a phenotype usually termed 'Emberger syndrome' (614038) (summary by Bigley et al. (2011), Hsu et al. (2011), and Spinner et al. (2014)).
Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 1
MedGen UID:
766531
Concept ID:
C3553617
Disease or Syndrome
Dyskeratosis congenita and related telomere biology disorders (DC/TBD) are caused by impaired telomere maintenance resulting in short or very short telomeres. The phenotypic spectrum of telomere biology disorders is broad and includes individuals with classic dyskeratosis congenita (DC) as well as those with very short telomeres and an isolated physical finding. Classic DC is characterized by a triad of dysplastic nails, lacy reticular pigmentation of the upper chest and/or neck, and oral leukoplakia, although this may not be present in all individuals. People with DC/TBD are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome or acute myelogenous leukemia, solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis. Other findings can include eye abnormalities (epiphora, blepharitis, sparse eyelashes, ectropion, entropion, trichiasis), taurodontism, liver disease, gastrointestinal telangiectasias, and avascular necrosis of the hips or shoulders. Although most persons with DC/TBD have normal psychomotor development and normal neurologic function, significant developmental delay is present in both forms; additional findings include cerebellar hypoplasia (Hoyeraal Hreidarsson syndrome) and bilateral exudative retinopathy and intracranial calcifications (Revesz syndrome and Coats plus syndrome). Onset and progression of manifestations of DC/TBD vary: at the mild end of the spectrum are those who have only minimal physical findings with normal bone marrow function, and at the severe end are those who have the diagnostic triad and early-onset BMF.
Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 2
MedGen UID:
766536
Concept ID:
C3553622
Disease or Syndrome
Dyskeratosis congenita and related telomere biology disorders (DC/TBD) are caused by impaired telomere maintenance resulting in short or very short telomeres. The phenotypic spectrum of telomere biology disorders is broad and includes individuals with classic dyskeratosis congenita (DC) as well as those with very short telomeres and an isolated physical finding. Classic DC is characterized by a triad of dysplastic nails, lacy reticular pigmentation of the upper chest and/or neck, and oral leukoplakia, although this may not be present in all individuals. People with DC/TBD are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome or acute myelogenous leukemia, solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis. Other findings can include eye abnormalities (epiphora, blepharitis, sparse eyelashes, ectropion, entropion, trichiasis), taurodontism, liver disease, gastrointestinal telangiectasias, and avascular necrosis of the hips or shoulders. Although most persons with DC/TBD have normal psychomotor development and normal neurologic function, significant developmental delay is present in both forms; additional findings include cerebellar hypoplasia (Hoyeraal Hreidarsson syndrome) and bilateral exudative retinopathy and intracranial calcifications (Revesz syndrome and Coats plus syndrome). Onset and progression of manifestations of DC/TBD vary: at the mild end of the spectrum are those who have only minimal physical findings with normal bone marrow function, and at the severe end are those who have the diagnostic triad and early-onset BMF.

Professional guidelines

PubMed

Tefferi A, Barbui T
Am J Hematol 2023 Sep;98(9):1465-1487. Epub 2023 Jun 26 doi: 10.1002/ajh.27002. PMID: 37357958
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514

Recent clinical studies

Etiology

Kayser S, Levis MJ
Haematologica 2023 Feb 1;108(2):308-320. doi: 10.3324/haematol.2022.280801. PMID: 36722402Free PMC Article
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Stubbins RJ, Francis A, Kuchenbauer F, Sanford D
Curr Oncol 2022 Aug 30;29(9):6245-6259. doi: 10.3390/curroncol29090491. PMID: 36135060Free PMC Article
Newell LF, Cook RJ
BMJ 2021 Oct 6;375:n2026. doi: 10.1136/bmj.n2026. PMID: 34615640
De Kouchkovsky I, Abdul-Hay M
Blood Cancer J 2016 Jul 1;6(7):e441. doi: 10.1038/bcj.2016.50. PMID: 27367478Free PMC Article

Diagnosis

Kayser S, Levis MJ
Haematologica 2023 Feb 1;108(2):308-320. doi: 10.3324/haematol.2022.280801. PMID: 36722402Free PMC Article
Pelcovits A, Niroula R
R I Med J (2013) 2020 Apr 1;103(3):38-40. PMID: 32236160
Shallis RM, Wang R, Davidoff A, Ma X, Zeidan AM
Blood Rev 2019 Jul;36:70-87. Epub 2019 Apr 29 doi: 10.1016/j.blre.2019.04.005. PMID: 31101526
De Kouchkovsky I, Abdul-Hay M
Blood Cancer J 2016 Jul 1;6(7):e441. doi: 10.1038/bcj.2016.50. PMID: 27367478Free PMC Article
Döhner H, Estey EH, Amadori S, Appelbaum FR, Büchner T, Burnett AK, Dombret H, Fenaux P, Grimwade D, Larson RA, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz MA, Sierra J, Tallman MS, Löwenberg B, Bloomfield CD; European LeukemiaNet
Blood 2010 Jan 21;115(3):453-74. Epub 2009 Oct 30 doi: 10.1182/blood-2009-07-235358. PMID: 19880497

Therapy

Pollyea DA, Pratz KW, Wei AH, Pullarkat V, Jonas BA, Recher C, Babu S, Schuh AC, Dail M, Sun Y, Potluri J, Chyla B, DiNardo CD
Clin Cancer Res 2022 Dec 15;28(24):5272-5279. doi: 10.1158/1078-0432.CCR-22-1183. PMID: 36007102Free PMC Article
Ivanov V, Yeh SP, Mayer J, Saini L, Unal A, Boyiadzis M, Hoffman DM, Kang K, Addo SN, Mendes WL, Fathi AT
Future Oncol 2022 Aug;18(26):2879-2889. Epub 2022 Jul 19 doi: 10.2217/fon-2022-0450. PMID: 35852098
Kim K, Konopleva M, DiNardo CD, Borthakur G, Loghavi S, Tang G, Daver N, Pemmaraju N, Jabbour E, Rausch CR, Yilmaz M, Sasaki K, Short NJ, Jain N, Brandt M, Pierce S, Garcia-Manero G, Ravandi F, Kantarjian H, Kadia TM
Am J Hematol 2022 Jul;97(7):885-894. Epub 2022 Apr 29 doi: 10.1002/ajh.26572. PMID: 35413152
Estey E, Gale RP
Leukemia 2017 Feb;31(2):269-271. Epub 2016 Nov 11 doi: 10.1038/leu.2016.306. PMID: 27833103
Cheson BD, Bennett JM, Kopecky KJ, Büchner T, Willman CL, Estey EH, Schiffer CA, Doehner H, Tallman MS, Lister TA, Lo-Coco F, Willemze R, Biondi A, Hiddemann W, Larson RA, Löwenberg B, Sanz MA, Head DR, Ohno R, Bloomfield CD; International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia
J Clin Oncol 2003 Dec 15;21(24):4642-9. doi: 10.1200/JCO.2003.04.036. PMID: 14673054

Prognosis

Schneider CV, Schneider KM, Teumer A, Rudolph KL, Hartmann D, Rader DJ, Strnad P
JAMA Intern Med 2022 Mar 1;182(3):291-300. doi: 10.1001/jamainternmed.2021.7804. PMID: 35040871Free PMC Article
Kantarjian HM, Hughes TP, Larson RA, Kim DW, Issaragrisil S, le Coutre P, Etienne G, Boquimpani C, Pasquini R, Clark RE, Dubruille V, Flinn IW, Kyrcz-Krzemien S, Medras E, Zanichelli M, Bendit I, Cacciatore S, Titorenko K, Aimone P, Saglio G, Hochhaus A
Leukemia 2021 Feb;35(2):440-453. Epub 2021 Jan 7 doi: 10.1038/s41375-020-01111-2. PMID: 33414482Free PMC Article
DiNardo CD, Pratz K, Pullarkat V, Jonas BA, Arellano M, Becker PS, Frankfurt O, Konopleva M, Wei AH, Kantarjian HM, Xu T, Hong WJ, Chyla B, Potluri J, Pollyea DA, Letai A
Blood 2019 Jan 3;133(1):7-17. Epub 2018 Oct 25 doi: 10.1182/blood-2018-08-868752. PMID: 30361262Free PMC Article
Siegel R, Naishadham D, Jemal A
CA Cancer J Clin 2013 Jan;63(1):11-30. Epub 2013 Jan 17 doi: 10.3322/caac.21166. PMID: 23335087
Deschler B, Lübbert M
Cancer 2006 Nov 1;107(9):2099-107. doi: 10.1002/cncr.22233. PMID: 17019734

Clinical prediction guides

Fu D, Zhang B, Wu S, Zhang Y, Xie J, Ning W, Jiang H
Front Immunol 2021;12:695865. Epub 2021 May 31 doi: 10.3389/fimmu.2021.695865. PMID: 34135913Free PMC Article
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
Asnafi AA, Deris Zayeri Z, Shahrabi S, Zibara K, Vosughi T
J Cell Physiol 2019 May;234(5):5798-5806. Epub 2018 Nov 14 doi: 10.1002/jcp.27505. PMID: 30430567
Nazha A
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):270-276. doi: 10.1182/asheducation-2018.1.270. PMID: 30504321Free PMC Article
Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES
Science 1999 Oct 15;286(5439):531-7. doi: 10.1126/science.286.5439.531. PMID: 10521349

Recent systematic reviews

Heuser M, Fernandez C, Hauch O, Klibanov OM, Chaudhary T, Rives V
Future Oncol 2023 Apr;19(11):789-810. Epub 2023 May 12 doi: 10.2217/fon-2022-1286. PMID: 37170899
Larsson SC, Burgess S
EBioMedicine 2022 Aug;82:104154. Epub 2022 Jul 8 doi: 10.1016/j.ebiom.2022.104154. PMID: 35816897Free PMC Article
Stemler J, de Jonge N, Skoetz N, Sinkó J, Brüggemann RJ, Busca A, Ben-Ami R, Ráčil Z, Piechotta V, Lewis R, Cornely OA
Lancet Haematol 2022 May;9(5):e361-e373. doi: 10.1016/S2352-3026(22)00073-4. PMID: 35483397
Short NJ, Zhou S, Fu C, Berry DA, Walter RB, Freeman SD, Hourigan CS, Huang X, Nogueras Gonzalez G, Hwang H, Qi X, Kantarjian H, Ravandi F
JAMA Oncol 2020 Dec 1;6(12):1890-1899. doi: 10.1001/jamaoncol.2020.4600. PMID: 33030517Free PMC Article
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, Goldberg JM, Khatcheressian JL, Leighl NB, Perkins CL, Somlo G, Wade JL, Wozniak AJ, Armitage JO; American Society of Clinical Oncology
J Clin Oncol 2015 Oct 1;33(28):3199-212. Epub 2015 Jul 13 doi: 10.1200/JCO.2015.62.3488. PMID: 26169616

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