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Meniere disease

MedGen UID:
7530
•Concept ID:
C0025281
•
Disease or Syndrome
Synonym: Ménière's disease
SNOMED CT: Ménière's disease (13445001); Auditory vertigo (13445001); Ménière's syndrome (13445001); Ménière's vertigo (13445001); Menieres disease (13445001); Otogenic vertigo (13445001); Meniere syndrome (13445001); Meniere disease (13445001); Meniere disorder (13445001)
 
Monarch Initiative: MONDO:0007972
OMIM®: 156000
Orphanet: ORPHA45360

Definition

Meniere disease is a chronic illness characterized by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating sensorineural hearing loss, tinnitus, and aural pressure (Sajjadi and Paparella, 2008). [from OMIM]

Clinical features

From HPO
Tinnitus
MedGen UID:
52760
•Concept ID:
C0040264
•
Disease or Syndrome
Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation.
See: Feature record | Search on this feature
Vertigo
MedGen UID:
53006
•Concept ID:
C0042571
•
Sign or Symptom
An abnormal sensation of spinning while the body is actually stationary.
See: Feature record | Search on this feature
Hearing impairment
MedGen UID:
235586
•Concept ID:
C1384666
•
Disease or Syndrome
A decreased magnitude of the sensory perception of sound.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeniere disease
Follow this link to review classifications for Meniere disease in Orphanet.

Professional guidelines

PubMed

European Position Statement on Diagnosis, and Treatment of Meniere's Disease.
Magnan J, Özgirgin ON, Trabalzini F, Lacour M, Escamez AL, Magnusson M, Güneri EA, Guyot JP, Nuti D, Mandalà M
J Int Adv Otol 2018 Aug;14(2):317-321. doi: 10.5152/iao.2018.140818. PMID: 30256205Free PMC Article
Dizziness: Approach to Evaluation and Management.
Muncie HL, Sirmans SM, James E
Am Fam Physician 2017 Feb 1;95(3):154-162. PMID: 28145669
Diagnostic criteria for Menière's disease.
Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandalà M, Newman-Toker DE, Strupp M, Suzuki M, Trabalzini F, Bisdorff A; Classification Committee of the Barany Society; Japan Society for Equilibrium Research; European Academy of Otology and Neurotology (EAONO); Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS); Korean Balance Society
J Vestib Res 2015;25(1):1-7. doi: 10.3233/VES-150549. PMID: 25882471

Recent clinical studies

Etiology

Ménière's disease and allergy: Epidemiology, pathogenesis, and therapy.
Xu W, Li X, Song Y, Kong L, Zhang N, Liu J, Li G, Fan Z, Lyu Y, Zhang D, Wang H, Li N
Clin Exp Med 2023 Nov;23(7):3361-3371. Epub 2023 Sep 24 doi: 10.1007/s10238-023-01192-0. PMID: 37743423
Recent surgical advances and continued controversies in medically refractory Meniere's disease.
Lucas JC, Hong RS
Curr Opin Otolaryngol Head Neck Surg 2023 Oct 1;31(5):325-331. Epub 2023 May 26 doi: 10.1097/MOO.0000000000000907. PMID: 37266594
Association Between Meniere Disease and Migraine.
Kim SY, Lee CH, Yoo DM, Kwon MJ, Kim JH, Kim JH, Park B, Lee HJ, Choi HG
JAMA Otolaryngol Head Neck Surg 2022 May 1;148(5):457-464. doi: 10.1001/jamaoto.2022.0331. PMID: 35389472Free PMC Article
European Position Statement on Diagnosis, and Treatment of Meniere's Disease.
Magnan J, Özgirgin ON, Trabalzini F, Lacour M, Escamez AL, Magnusson M, Güneri EA, Guyot JP, Nuti D, Mandalà M
J Int Adv Otol 2018 Aug;14(2):317-321. doi: 10.5152/iao.2018.140818. PMID: 30256205Free PMC Article
Bilateral Ménière's disease.
Nabi S, Parnes LS
Curr Opin Otolaryngol Head Neck Surg 2009 Oct;17(5):356-62. doi: 10.1097/MOO.0b013e3283304cb3. PMID: 19617826

Diagnosis

Ménière's disease: new guidelines, subtypes, imaging, and more.
Hoskin JL
Curr Opin Neurol 2022 Feb 1;35(1):90-97. doi: 10.1097/WCO.0000000000001021. PMID: 34864755
Meniere's Disease.
Gibson WPR
Adv Otorhinolaryngol 2019;82:77-86. Epub 2019 Jan 15 doi: 10.1159/000490274. PMID: 30947172
Menière's disease.
Espinosa-Sanchez JM, Lopez-Escamez JA
Handb Clin Neurol 2016;137:257-77. doi: 10.1016/B978-0-444-63437-5.00019-4. PMID: 27638077
What is Menière's disease? A contemporary re-evaluation of endolymphatic hydrops.
Gürkov R, Pyykö I, Zou J, Kentala E
J Neurol 2016 Apr;263 Suppl 1:S71-81. Epub 2016 Apr 15 doi: 10.1007/s00415-015-7930-1. PMID: 27083887Free PMC Article
Meniere's disease.
Sajjadi H, Paparella MM
Lancet 2008 Aug 2;372(9636):406-14. doi: 10.1016/S0140-6736(08)61161-7. PMID: 18675691

Therapy

Ménière's disease: new guidelines, subtypes, imaging, and more.
Hoskin JL
Curr Opin Neurol 2022 Feb 1;35(1):90-97. doi: 10.1097/WCO.0000000000001021. PMID: 34864755
Betahistine in Ménière's Disease or Syndrome: A Systematic Review.
Van Esch B, van der Zaag-Loonen H, Bruintjes T, van Benthem PP
Audiol Neurootol 2022;27(1):1-33. Epub 2021 Jul 7 doi: 10.1159/000515821. PMID: 34233329
Meniere's Disease.
Gibson WPR
Adv Otorhinolaryngol 2019;82:77-86. Epub 2019 Jan 15 doi: 10.1159/000490274. PMID: 30947172
European Position Statement on Diagnosis, and Treatment of Meniere's Disease.
Magnan J, Özgirgin ON, Trabalzini F, Lacour M, Escamez AL, Magnusson M, Güneri EA, Guyot JP, Nuti D, Mandalà M
J Int Adv Otol 2018 Aug;14(2):317-321. doi: 10.5152/iao.2018.140818. PMID: 30256205Free PMC Article
Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial).
Adrion C, Fischer CS, Wagner J, Gürkov R, Mansmann U, Strupp M; BEMED Study Group
BMJ 2016 Jan 21;352:h6816. doi: 10.1136/bmj.h6816. PMID: 26797774Free PMC Article

Prognosis

Association Between Meniere Disease and Migraine.
Kim SY, Lee CH, Yoo DM, Kwon MJ, Kim JH, Kim JH, Park B, Lee HJ, Choi HG
JAMA Otolaryngol Head Neck Surg 2022 May 1;148(5):457-464. doi: 10.1001/jamaoto.2022.0331. PMID: 35389472Free PMC Article
Aural fullness and transtympanic ventilation tubes in Ménière's disease: a scoping review.
Sevilla C, Goody J, Baguley DM, Kasbekar AV
J Laryngol Otol 2019 Jun;133(6):450-456. Epub 2019 Jun 7 doi: 10.1017/S002221511900094X. PMID: 31172892
Menière's disease.
Espinosa-Sanchez JM, Lopez-Escamez JA
Handb Clin Neurol 2016;137:257-77. doi: 10.1016/B978-0-444-63437-5.00019-4. PMID: 27638077
Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial).
Adrion C, Fischer CS, Wagner J, Gürkov R, Mansmann U, Strupp M; BEMED Study Group
BMJ 2016 Jan 21;352:h6816. doi: 10.1136/bmj.h6816. PMID: 26797774Free PMC Article
Menière's disease.
James AL, Thorp MA
BMJ Clin Evid 2007 Mar 1;2007 PMID: 19454061Free PMC Article

Clinical prediction guides

Pathogenesis and Etiology of Ménière Disease: A Scoping Review of a Century of Evidence.
Rizk HG, Mehta NK, Qureshi U, Yuen E, Zhang K, Nkrumah Y, Lambert PR, Liu YF, McRackan TR, Nguyen SA, Meyer TA
JAMA Otolaryngol Head Neck Surg 2022 Apr 1;148(4):360-368. doi: 10.1001/jamaoto.2021.4282. PMID: 35142800
Meniere disease subtyping: the direction of diagnosis and treatment in the future.
Zhang S, Guo Z, Tian E, Liu D, Wang J, Kong W
Expert Rev Neurother 2022 Feb;22(2):115-127. Epub 2022 Feb 22 doi: 10.1080/14737175.2022.2030221. PMID: 35057670
Menière's disease.
Espinosa-Sanchez JM, Lopez-Escamez JA
Handb Clin Neurol 2016;137:257-77. doi: 10.1016/B978-0-444-63437-5.00019-4. PMID: 27638077
Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial).
Adrion C, Fischer CS, Wagner J, Gürkov R, Mansmann U, Strupp M; BEMED Study Group
BMJ 2016 Jan 21;352:h6816. doi: 10.1136/bmj.h6816. PMID: 26797774Free PMC Article
Bilateral Ménière's disease.
Nabi S, Parnes LS
Curr Opin Otolaryngol Head Neck Surg 2009 Oct;17(5):356-62. doi: 10.1097/MOO.0b013e3283304cb3. PMID: 19617826

Recent systematic reviews

Lifestyle and dietary interventions for Ménière's disease.
Webster KE, George B, Lee A, Galbraith K, Harrington-Benton NA, Judd O, Kaski D, Maarsingh OR, MacKeith S, Murdin L, Ray J, Van Vugt VA, Burton MJ
Cochrane Database Syst Rev 2023 Feb 27;2(2):CD015244. doi: 10.1002/14651858.CD015244.pub2. PMID: 36848645Free PMC Article
Intratympanic gentamicin for Ménière's disease.
Webster KE, Galbraith K, Lee A, Harrington-Benton NA, Judd O, Kaski D, Maarsingh OR, MacKeith S, Ray J, Van Vugt VA, Burton MJ
Cochrane Database Syst Rev 2023 Feb 27;2(2):CD015246. doi: 10.1002/14651858.CD015246.pub2. PMID: 36847592Free PMC Article
Systemic pharmacological interventions for Ménière's disease.
Webster KE, Galbraith K, Harrington-Benton NA, Judd O, Kaski D, Maarsingh OR, MacKeith S, Ray J, Van Vugt VA, Burton MJ
Cochrane Database Syst Rev 2023 Feb 23;2(2):CD015171. doi: 10.1002/14651858.CD015171.pub2. PMID: 36827524Free PMC Article
Betahistine in Ménière's Disease or Syndrome: A Systematic Review.
Van Esch B, van der Zaag-Loonen H, Bruintjes T, van Benthem PP
Audiol Neurootol 2022;27(1):1-33. Epub 2021 Jul 7 doi: 10.1159/000515821. PMID: 34233329
Menière's disease.
James AL, Thorp MA
BMJ Clin Evid 2007 Mar 1;2007 PMID: 19454061Free PMC Article

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