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Anaplastic meningioma

MedGen UID:
75478
•Concept ID:
C0259785
•
Neoplastic Process
Synonyms: Malignant Meningioma; Malignant Meningiomas; Meningioma, Malignant; Meningiomas, Malignant
SNOMED CT: Meningioma, malignant (78303004); Meningioma, anaplastic (78303004)
 
Monarch Initiative: MONDO:0020635

Definition

A WHO grade III meningioma characterized by the presence of malignant morphologic features, including malignant cytology and a very high mitotic index (20 or more mitoses per ten high power fields). [from NCI]

Professional guidelines

PubMed

Management of Atypical and Anaplastic Meningiomas.
Higgins D, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2023 Jul;34(3):437-446. Epub 2023 Apr 18 doi: 10.1016/j.nec.2023.02.011. PMID: 37210132
Management of Atypical and Anaplastic Meningiomas.
Buttrick S, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2016 Apr;27(2):239-47. Epub 2016 Feb 20 doi: 10.1016/j.nec.2015.11.003. PMID: 27012388
An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas.
Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH
Neurosurg Focus 2015 Mar;38(3):E3. doi: 10.3171/2015.1.FOCUS14757. PMID: 25727225

Recent clinical studies

Etiology

Radiation therapy for atypical and anaplastic meningiomas: an overview of current results and controversial issues.
Vagnoni L, Aburas S, Giraffa M, Russo I, Chiarella V, Paolini S, Tini P, Minniti G
Neurosurg Rev 2022 Oct;45(5):3019-3033. Epub 2022 Jun 4 doi: 10.1007/s10143-022-01806-3. PMID: 35665867Free PMC Article
Differentiating atypical meningioma from anaplastic meningioma using diffusion weighted imaging.
Han T, Zhang J, Liu X, Zhang B, Deng L, Lin X, Jing M, Zhou J
Clin Imaging 2022 Feb;82:237-243. Epub 2021 Dec 11 doi: 10.1016/j.clinimag.2021.12.004. PMID: 34915318
Malignant meningiomas.
Fountain DM, Young AMH, Santarius T
Handb Clin Neurol 2020;170:245-250. doi: 10.1016/B978-0-12-822198-3.00044-6. PMID: 32586496
Pathology of meningiomas.
Solomon DA, Pekmezci M
Handb Clin Neurol 2020;169:87-99. doi: 10.1016/B978-0-12-804280-9.00005-6. PMID: 32553300
Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature.
Kessler RA, Garzon-Muvdi T, Yang W, Weingart J, Olivi A, Huang J, Brem H, Lim M
World Neurosurg 2017 May;101:47-56. Epub 2017 Jan 29 doi: 10.1016/j.wneu.2017.01.070. PMID: 28143726

Diagnosis

Differentiating atypical meningioma from anaplastic meningioma using diffusion weighted imaging.
Han T, Zhang J, Liu X, Zhang B, Deng L, Lin X, Jing M, Zhou J
Clin Imaging 2022 Feb;82:237-243. Epub 2021 Dec 11 doi: 10.1016/j.clinimag.2021.12.004. PMID: 34915318
Malignant meningiomas.
Fountain DM, Young AMH, Santarius T
Handb Clin Neurol 2020;170:245-250. doi: 10.1016/B978-0-12-822198-3.00044-6. PMID: 32586496
Prognostic factors and the management of anaplastic meningioma.
Zhang GJ, Zhang YS, Zhang GB, Li D, Zhang LW, Wu Z, Zhang JT
Clin Neurol Neurosurg 2018 Jul;170:13-19. Epub 2018 Mar 27 doi: 10.1016/j.clineuro.2018.03.028. PMID: 29715576
Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature.
Kessler RA, Garzon-Muvdi T, Yang W, Weingart J, Olivi A, Huang J, Brem H, Lim M
World Neurosurg 2017 May;101:47-56. Epub 2017 Jan 29 doi: 10.1016/j.wneu.2017.01.070. PMID: 28143726
Diagnosis and treatment of atypical and anaplastic meningiomas: a review.
Modha A, Gutin PH
Neurosurgery 2005 Sep;57(3):538-50; discussion 538-50. doi: 10.1227/01.neu.0000170980.47582.a5. PMID: 16145534

Therapy

Radiation therapy for atypical and anaplastic meningiomas: an overview of current results and controversial issues.
Vagnoni L, Aburas S, Giraffa M, Russo I, Chiarella V, Paolini S, Tini P, Minniti G
Neurosurg Rev 2022 Oct;45(5):3019-3033. Epub 2022 Jun 4 doi: 10.1007/s10143-022-01806-3. PMID: 35665867Free PMC Article
Malignant meningiomas.
Fountain DM, Young AMH, Santarius T
Handb Clin Neurol 2020;170:245-250. doi: 10.1016/B978-0-12-822198-3.00044-6. PMID: 32586496
Efficacy of adjuvant radiotherapy for atypical and anaplastic meningioma.
Zhu H, Bi WL, Aizer A, Hua L, Tian M, Den J, Tang H, Chen H, Wang Y, Mao Y, Dunn IF, Xie Q, Gong Y
Cancer Med 2019 Jan;8(1):13-20. doi: 10.1002/cam4.1531. PMID: 30680963Free PMC Article
Review of controversies in management of non-benign meningioma.
Paldor I, Awad M, Sufaro YZ, Kaye AH, Shoshan Y
J Clin Neurosci 2016 Sep;31:37-46. Epub 2016 Jun 20 doi: 10.1016/j.jocn.2016.03.014. PMID: 27338209
Historical benchmarks for medical therapy trials in surgery- and radiation-refractory meningioma: a RANO review.
Kaley T, Barani I, Chamberlain M, McDermott M, Panageas K, Raizer J, Rogers L, Schiff D, Vogelbaum M, Weber D, Wen P
Neuro Oncol 2014 Jun;16(6):829-40. Epub 2014 Feb 4 doi: 10.1093/neuonc/not330. PMID: 24500419Free PMC Article

Prognosis

Management of Atypical and Anaplastic Meningiomas.
Higgins D, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2023 Jul;34(3):437-446. Epub 2023 Apr 18 doi: 10.1016/j.nec.2023.02.011. PMID: 37210132
Malignant meningiomas.
Fountain DM, Young AMH, Santarius T
Handb Clin Neurol 2020;170:245-250. doi: 10.1016/B978-0-12-822198-3.00044-6. PMID: 32586496
Prognostic factors and the management of anaplastic meningioma.
Zhang GJ, Zhang YS, Zhang GB, Li D, Zhang LW, Wu Z, Zhang JT
Clin Neurol Neurosurg 2018 Jul;170:13-19. Epub 2018 Mar 27 doi: 10.1016/j.clineuro.2018.03.028. PMID: 29715576
Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature.
Kessler RA, Garzon-Muvdi T, Yang W, Weingart J, Olivi A, Huang J, Brem H, Lim M
World Neurosurg 2017 May;101:47-56. Epub 2017 Jan 29 doi: 10.1016/j.wneu.2017.01.070. PMID: 28143726
Management of Atypical and Anaplastic Meningiomas.
Buttrick S, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2016 Apr;27(2):239-47. Epub 2016 Feb 20 doi: 10.1016/j.nec.2015.11.003. PMID: 27012388

Clinical prediction guides

Efficacy of radiotherapy and stereotactic radiosurgery as adjuvant or salvage treatment in atypical and anaplastic (WHO grade II and III) meningiomas: a systematic review and meta-analysis.
Gagliardi F, De Domenico P, Snider S, Pompeo E, Roncelli F, Barzaghi LR, Acerno S, Mortini P
Neurosurg Rev 2023 Mar 17;46(1):71. doi: 10.1007/s10143-023-01969-7. PMID: 36928326
Radiation therapy for atypical and anaplastic meningiomas: an overview of current results and controversial issues.
Vagnoni L, Aburas S, Giraffa M, Russo I, Chiarella V, Paolini S, Tini P, Minniti G
Neurosurg Rev 2022 Oct;45(5):3019-3033. Epub 2022 Jun 4 doi: 10.1007/s10143-022-01806-3. PMID: 35665867Free PMC Article
Management trends for anaplastic meningioma with adjuvant radiotherapy and predictors of long-term survival.
Alhourani A, Aljuboori Z, Yusuf M, Woo SY, Hattab EM, Andaluz N, Williams BJ
Neurosurg Focus 2019 Jun 1;46(6):E4. doi: 10.3171/2019.3.FOCUS1960. PMID: 31153143
De novo and secondary anaplastic meningiomas: a study of clinical and histomolecular prognostic factors.
Peyre M, Gauchotte G, Giry M, Froehlich S, Pallud J, Graillon T, Bielle F, Cazals-Hatem D, Varlet P, Figarella-Branger D, Loiseau H, Kalamarides M
Neuro Oncol 2018 Jul 5;20(8):1113-1121. doi: 10.1093/neuonc/nox231. PMID: 29216385Free PMC Article
Analysis of prognostic factors and treatment of anaplastic meningioma in China.
Zhu H, Xie Q, Zhou Y, Chen H, Mao Y, Zhong P, Zheng K, Wang Y, Wang Y, Xie L, Zheng M, Tang H, Wang D, Chen X, Zhou L, Gong Y
J Clin Neurosci 2015 Apr;22(4):690-5. Epub 2015 Mar 3 doi: 10.1016/j.jocn.2014.10.023. PMID: 25744075

Recent systematic reviews

Efficacy of radiotherapy and stereotactic radiosurgery as adjuvant or salvage treatment in atypical and anaplastic (WHO grade II and III) meningiomas: a systematic review and meta-analysis.
Gagliardi F, De Domenico P, Snider S, Pompeo E, Roncelli F, Barzaghi LR, Acerno S, Mortini P
Neurosurg Rev 2023 Mar 17;46(1):71. doi: 10.1007/s10143-023-01969-7. PMID: 36928326
Survival Benefit of Prognostic Factors and Treatment in Adult Patients with Recurrent Anaplastic Meningioma: A Retrospective Case Series and Systematic Literature Review.
Zhang G, Wang W, Ma X, Li H, Wang L, Zhang L, Zhang J, Wu Z
World Neurosurg 2022 Oct;166:e758-e769. Epub 2022 Aug 6 doi: 10.1016/j.wneu.2022.07.099. PMID: 35944862
Apatinib in recurrent anaplastic meningioma: a retrospective case series and systematic literature review.
Wang Y, Li W, Jing N, Meng X, Zhou S, Zhu Y, Xu J, Tao R
Cancer Biol Ther 2020 Jul 2;21(7):583-589. Epub 2020 Mar 25 doi: 10.1080/15384047.2020.1740053. PMID: 32212907Free PMC Article
A Systematic Review of Ion Radiotherapy in Maintaining Local Control Regarding Atypical and Anaplastic Meningiomas.
Coggins WS, Pham NK, Nguyen AV, Branch DW, Guillet JY, Korst G, Lall RR
World Neurosurg 2019 Dec;132:282-291. Epub 2019 Aug 30 doi: 10.1016/j.wneu.2019.08.149. PMID: 31476452

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