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Conjunctival amyloidosis

MedGen UID:
75676
•Concept ID:
C0268402
•
Disease or Syndrome
SNOMED CT: Conjunctival amyloidosis (59017008)
 
HPO: HP:0010637

Definition

A form of amyloidosis that affects the conjunctiva. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConjunctival amyloidosis

Professional guidelines

PubMed

Periocular and orbital amyloidosis: clinical characteristics, management, and outcome.
Leibovitch I, Selva D, Goldberg RA, Sullivan TJ, Saeed P, Davis G, McCann JD, McNab A, Rootman J
Ophthalmology 2006 Sep;113(9):1657-64. Epub 2006 Jul 7 doi: 10.1016/j.ophtha.2006.03.052. PMID: 16828514

Recent clinical studies

Etiology

Ocular Adnexal Amyloidosis: A Mass Spectrometric Analysis.
Blandford AD, Yordi S, Kapoor S, Yeaney G, Cotta CV, Valent J, Perry JD, Singh AD
Am J Ophthalmol 2018 Sep;193:28-32. Epub 2018 Jun 8 doi: 10.1016/j.ajo.2018.05.032. PMID: 29890159
Conjunctival amyloidosis -- clinical and histopathologic features.
Suesskind D, Ziemssen F, Rohrbach JM
Graefes Arch Clin Exp Ophthalmol 2015 Aug;253(8):1377-83. Epub 2015 Jan 27 doi: 10.1007/s00417-015-2932-3. PMID: 25619666
Diagnosis of ocular surface lesions using ultra-high-resolution optical coherence tomography.
Shousha MA, Karp CL, Canto AP, Hodson K, Oellers P, Kao AA, Bielory B, Matthews J, Dubovy SR, Perez VL, Wang J
Ophthalmology 2013 May;120(5):883-91. Epub 2013 Jan 21 doi: 10.1016/j.ophtha.2012.10.025. PMID: 23347984Free PMC Article
Conjunctival amyloidosis: report of six cases and review of the literature.
Demirci H, Shields CL, Eagle RC Jr, Shields JA
Surv Ophthalmol 2006 Jul-Aug;51(4):419-33. doi: 10.1016/j.survophthal.2006.04.007. PMID: 16818085
Conjunctival amyloidosis: is it related to trachoma?
Gupta VP, Aggarwal R, Aggarwal S
Acta Ophthalmol (Copenh) 1993 Dec;71(6):839-40. doi: 10.1111/j.1755-3768.1993.tb08611.x. PMID: 8154264

Diagnosis

Conjunctival Amyloidosis: Apples and Oranges.
Singla K, Sen M, Milman T, Shields CL
Ophthalmic Plast Reconstr Surg 2023 May-Jun 01;39(3):e98. Epub 2022 Dec 8 doi: 10.1097/IOP.0000000000002275. PMID: 36479876
Primary Localized Conjunctival Amyloidosis Presenting Corneal Whorl-like Opacity Patterns.
Sharma VK, Agarwal M, Tyagi A, Sati A
Cornea 2020 Jul;39(7):898-901. doi: 10.1097/ICO.0000000000002343. PMID: 32301810
Yellow subconjunctival deposits.
Zloto O, Rosner M, Vishnevskia-Dai V
BMJ Case Rep 2019 Aug 1;12(7) doi: 10.1136/bcr-2019-230370. PMID: 31371336Free PMC Article
Conjunctival amyloidosis -- clinical and histopathologic features.
Suesskind D, Ziemssen F, Rohrbach JM
Graefes Arch Clin Exp Ophthalmol 2015 Aug;253(8):1377-83. Epub 2015 Jan 27 doi: 10.1007/s00417-015-2932-3. PMID: 25619666
CONJUNCTIVAL AMYLOIDOSIS.
Madangopal AV
Br J Ophthalmol 1962 Dec;46(12):749-52. doi: 10.1136/bjo.46.12.749. PMID: 18170847Free PMC Article

Therapy

Localized conjunctival amyloidosis due to familial Mediterranean fever.
Yuce Inel T, Kocaer SB, Koken Avsar A, Can G
Clin Rheumatol 2021 Mar;40(3):1195-1196. Epub 2020 Oct 27 doi: 10.1007/s10067-020-05475-9. PMID: 33106928

Prognosis

Unilateral localized conjunctival amyloidosis in a patient with a history of contralateral orbit/eyelid lymphoma.
Byers JT, Qing X, Lo C, French SW, Ji P
Exp Mol Pathol 2018 Apr;104(2):151-154. Epub 2018 Mar 15 doi: 10.1016/j.yexmp.2018.03.003. PMID: 29551574
Diagnosis of ocular surface lesions using ultra-high-resolution optical coherence tomography.
Shousha MA, Karp CL, Canto AP, Hodson K, Oellers P, Kao AA, Bielory B, Matthews J, Dubovy SR, Perez VL, Wang J
Ophthalmology 2013 May;120(5):883-91. Epub 2013 Jan 21 doi: 10.1016/j.ophtha.2012.10.025. PMID: 23347984Free PMC Article
Liquid nitrogen cryotherapy for surface eye disease (an AOS thesis).
Fraunfelder FW
Trans Am Ophthalmol Soc 2008;106:301-24. PMID: 19277243Free PMC Article
Conjunctival amyloidosis: report of six cases and review of the literature.
Demirci H, Shields CL, Eagle RC Jr, Shields JA
Surv Ophthalmol 2006 Jul-Aug;51(4):419-33. doi: 10.1016/j.survophthal.2006.04.007. PMID: 16818085
Primary localized bilateral conjunctival amyloidosis and epiphora.
Pirouzmand F, Hurwitz J, Howarth D
Orbit 2002 Jun;21(2):139-44. doi: 10.1076/orbi.21.2.139.7183. PMID: 12029569

Clinical prediction guides

A rare cause of unilateral upper and lower eyelid swelling: isolated conjunctival amyloidosis.
Rodrigues G, Sanghvi V, Lala M
Korean J Ophthalmol 2001 Jun;15(1):38-40. doi: 10.3341/kjo.2001.15.1.38. PMID: 11530820

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