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Conjunctival Melanocytic Intraepithelial Neoplasia

MedGen UID:
757693
•Concept ID:
C3263719
•
Neoplastic Process
Synonyms: Conjunctival Melanocytic Intraepithelial Neoplasia (C-MIN Score of 2-4); Conjunctival Melanoma In Situ; Conjunctival Primary Acquired Melanosis; Conjunctival Primary Acquired Melanosis with Atypia/Melanoma In Situ; PAM - Primary acquired melanosis of conjunctiva; PAM with Atypia; Primary acquired melanocytic nevus of conjunctiva; Primary acquired melanosis of conjunctiva
SNOMED CT: Primary acquired melanosis of conjunctiva (415172002); Primary acquired melanocytic nevus of conjunctiva (415172002); PAM - Primary acquired melanosis of conjunctiva (415172002)

Definition

A spectrum of neoplastic changes that occur in the conjunctiva and range from melanocytic hyperplasia through degrees of atypia to melanoma in situ. The lesions are generally unilateral but often multifocal and appear as flat, irregular brown discolorations of the conjunctiva. They usually affect middle-aged and elderly Caucasians. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConjunctival Melanocytic Intraepithelial Neoplasia

Professional guidelines

PubMed

Management of Primary Acquired Melanosis, Nevus, and Conjunctival Melanoma.
Kao A, Afshar A, Bloomer M, Damato B
Cancer Control 2016 Apr;23(2):117-25. doi: 10.1177/107327481602300205. PMID: 27218788

Recent clinical studies

Etiology

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Validation of the Newly Proposed World Health Organization Classification System for Conjunctival Melanocytic Intraepithelial Lesions: A Comparison with the C-MIN and PAM Classification Schemes.
Milman T, Eiger-Moscovich M, Henry RK, Folberg R, Coupland SE, Grossniklaus HE, Mudhar HS, Eberhart CG, Heegaard S, Auw-Hädrich C, Herwig-Carl MC, Löffler KU, Cherepanoff S, Zhang Q, Sharpe JE, See TRO, Shields CL, Eagle RC Jr
Am J Ophthalmol 2021 Mar;223:60-74. Epub 2020 Oct 30 doi: 10.1016/j.ajo.2020.10.020. PMID: 33130046
Conjunctival pigmented lesion: Clinicopathological analysis of 85 cases in Korean population.
Lee YJ, Lee C, Kim MK, Khwarg SI, Oh JY
Sci Rep 2019 Dec 3;9(1):18204. doi: 10.1038/s41598-019-54786-8. PMID: 31796811Free PMC Article
Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging.
Damato B, Coupland SE
Clin Exp Ophthalmol 2008 Nov;36(8):786-95. doi: 10.1111/j.1442-9071.2008.01888.x. PMID: 19128387

Diagnosis

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Validation of the Newly Proposed World Health Organization Classification System for Conjunctival Melanocytic Intraepithelial Lesions: A Comparison with the C-MIN and PAM Classification Schemes.
Milman T, Eiger-Moscovich M, Henry RK, Folberg R, Coupland SE, Grossniklaus HE, Mudhar HS, Eberhart CG, Heegaard S, Auw-Hädrich C, Herwig-Carl MC, Löffler KU, Cherepanoff S, Zhang Q, Sharpe JE, See TRO, Shields CL, Eagle RC Jr
Am J Ophthalmol 2021 Mar;223:60-74. Epub 2020 Oct 30 doi: 10.1016/j.ajo.2020.10.020. PMID: 33130046
Management of Primary Acquired Melanosis, Nevus, and Conjunctival Melanoma.
Kao A, Afshar A, Bloomer M, Damato B
Cancer Control 2016 Apr;23(2):117-25. doi: 10.1177/107327481602300205. PMID: 27218788
Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging.
Damato B, Coupland SE
Clin Exp Ophthalmol 2008 Nov;36(8):786-95. doi: 10.1111/j.1442-9071.2008.01888.x. PMID: 19128387

Prognosis

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Validation of the Newly Proposed World Health Organization Classification System for Conjunctival Melanocytic Intraepithelial Lesions: A Comparison with the C-MIN and PAM Classification Schemes.
Milman T, Eiger-Moscovich M, Henry RK, Folberg R, Coupland SE, Grossniklaus HE, Mudhar HS, Eberhart CG, Heegaard S, Auw-Hädrich C, Herwig-Carl MC, Löffler KU, Cherepanoff S, Zhang Q, Sharpe JE, See TRO, Shields CL, Eagle RC Jr
Am J Ophthalmol 2021 Mar;223:60-74. Epub 2020 Oct 30 doi: 10.1016/j.ajo.2020.10.020. PMID: 33130046
Management of Primary Acquired Melanosis, Nevus, and Conjunctival Melanoma.
Kao A, Afshar A, Bloomer M, Damato B
Cancer Control 2016 Apr;23(2):117-25. doi: 10.1177/107327481602300205. PMID: 27218788
Tumor-associated lymphangiogenesis in the development of conjunctival melanoma.
Heindl LM, Hofmann-Rummelt C, Adler W, Bosch JJ, Holbach LM, Naumann GO, Kruse FE, Cursiefen C
Invest Ophthalmol Vis Sci 2011 Sep 9;52(10):7074-83. doi: 10.1167/iovs.11-7902. PMID: 21849428

Clinical prediction guides

Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.
Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B
Cornea 2021 Dec 1;40(12):1519-1524. doi: 10.1097/ICO.0000000000002681. PMID: 33591034
Validation of the Newly Proposed World Health Organization Classification System for Conjunctival Melanocytic Intraepithelial Lesions: A Comparison with the C-MIN and PAM Classification Schemes.
Milman T, Eiger-Moscovich M, Henry RK, Folberg R, Coupland SE, Grossniklaus HE, Mudhar HS, Eberhart CG, Heegaard S, Auw-Hädrich C, Herwig-Carl MC, Löffler KU, Cherepanoff S, Zhang Q, Sharpe JE, See TRO, Shields CL, Eagle RC Jr
Am J Ophthalmol 2021 Mar;223:60-74. Epub 2020 Oct 30 doi: 10.1016/j.ajo.2020.10.020. PMID: 33130046
Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging.
Damato B, Coupland SE
Clin Exp Ophthalmol 2008 Nov;36(8):786-95. doi: 10.1111/j.1442-9071.2008.01888.x. PMID: 19128387

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